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Investigations On The Structure Of Solid Lipid Nanoparticles (SLN) And Oil-loaded Solid Lipid Nanoparticles By Photon Correlation Spectroscopy, Field-flow Fractionation And Transmission Electron Microscopy.

K. Jores, W. Mehnert, M. Drechsler, H. Bunjes, C. Johann, K. Mäder
Published 2004 · Medicine, Chemistry

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Recently, colloidal dispersions made from mixtures of solid and liquid lipids were described to combine controlled release characteristics with higher drug loading capacities than solid lipid nanoparticles (SLN). It has been proposed that these nanostructured lipid carriers (NLC) are composed of oily droplets which solubilize the drug and which are embedded in a solid lipid matrix. The structures of SLN and NLC based on glyceryl behenate and medium chain triglycerides were characterized by photon correlation spectroscopy (PCS) and laser diffraction (LD), field-flow fractionation (FFF) with multi-angle light scattering detection (MALS), and cryo transmission electron microscopy (cryo TEM). PCS indicates that SLN and NLC differ from a nanoemulsion with respect to Brownian motion due to asymmetric particle shapes. Non-spherical particles, in case of SLN and NLC, lead to higher polydispersity indices compared to the nanoemulsion. In FFF, the nanodroplets elute much earlier than SLN- and NLC-platelets although their PCS and LD data show similar particle sizes. In TEM platelet (for SLN), oil loaded platelet ("nanospoons"; for NLC) and droplet (for nanoemulsion) structures were observed. In contrast to literature reports, the investigated SLN appear as thin platelets. NLC are found to be lipid platelets with oil spots sticking on the surface. Very short diffusion pathways in platelets, increased water-lipid interfaces and low drug incorporation in crystalline lipids are the drawback of SLN and NLC compared to conventional nanoemulsions.
This paper references
Food colloids: fundamentals of formulation.
E. Dickinson (2001)
10.1039/9781847550842-00103
Colloidal dispersions based on solid lipids
E. Dickinson (2001)
10.1016/S0378-5173(02)00180-1
Nanostructured lipid matrices for improved microencapsulation of drugs.
R. Mueller (2002)
10.1023/A:1025065418309
Physicochemical Investigations on Solid Lipid Nanoparticles and on Oil-Loaded Solid Lipid Nanoparticles: A Nuclear Magnetic Resonance and Electron Spin Resonance Study
K. Jores (2004)
10.1023/A:1016278302046
Structures of Nanoparticles Prepared from Oil-in-Water Emulsions
B. Sjoestroem (2004)
10.1021/JP9912612
Observation of Size-Dependent Melting in Lipid Nanoparticles
T. Unruh (1999)
10.1016/0300-9440(95)00584-6
Field flow fractionation for particle size determination
L. Dulog (1996)
Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery
R. Mueller (1995)
Field-flow fractionation handbook
M. Schimpf (2000)
Techniques for the study of biological structure and function
C. Cantor (1980)
10.1016/0927-7757(94)03028-X
Poly(ethylene oxide)-poly(propylene oxide )-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling
P. Alexandridis (1995)
10.1080/026520499288690
Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products.
A. Dingler (1999)
10.1021/LA990856L
Effect of Particle Size on Colloidal Solid Triglycerides
H. Bunjes (2000)
10.1016/S0169-409X(01)00105-3
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
10.1016/S0378-5173(00)00462-2
Solid lipid nanoparticles (SLN™) based on binary mixtures of liquid and solid lipids: a 1H-NMR study
V. Jenning (2000)
10.1126/SCIENCE.8502990
Field-flow fractionation: analysis of macromolecular, colloidal, and particulate materials.
J. Giddings (1993)
10.1016/S0939-6411(00)00087-4
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
10.1016/S0378-5173(97)04890-4
Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles
K. Westesen (1997)
10.1016/S0378-5173(99)00426-3
Comparison of wax and glyceride solid lipid nanoparticles (SLN).
V. Jenning (2000)
10.1016/0378-5173(95)04286-5
Crystallization tendency and polymorphic transitions in triglyceride nanoparticles
H. Bunjes (1996)
10.1016/S0169-409X(02)00118-7
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
R. Mueller (2002)
10.1021/ED006P1090
Biophysical chemistry. Part II
V. Cofman (1929)
10.1016/S0168-3659(97)00046-1
Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential
K. Westesen (1997)
10.1016/S0378-5173(00)00378-1
Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids.
V. Jenning (2000)
10.1023/A:1011042627714
Incorporation of the Model Drug Ubidecarenone into Solid Lipid Nanoparticles
H. Bunjes (2004)



This paper is referenced by
10.7897/2230-8407.04408
NANOPARTICLE: AN OVERVIEW OF PREPARATION, CHARACTERIZATION AND APPLICATION
K. Ranjit (2016)
10.1016/J.COLSURFA.2009.11.006
Optimization of nanostructured lipid carriers for lutein delivery
C. Liu (2010)
10.1021/la301435k
Distribution of encapsulated materials in colloidal particles and its impact on oxidative stability of encapsulated materials.
Rohan V Tikekar (2012)
10.1016/j.ejpb.2014.12.006
Biodistribution of nanostructured lipid carriers: a tomographic study.
Elisabetta Esposito (2015)
10.1016/J.INDCROP.2018.03.042
Design of multifunctional nanostructured lipid carriers enriched with α-tocopherol using vegetable oils
F. Pinto (2018)
10.3892/OR_00000517
The antitumor immune responses induced by nanoemulsion-encapsulated MAGE1-HSP70/SEA complex protein vaccine following different administration routes.
W. Ge (2009)
10.1016/j.ijpharm.2019.118918
Formulation development of lipid nanoparticles: improved lipid screening and development of tacrolimus loaded nanostructured lipid carriers (NLC).
Anđelka B. Kovačević (2019)
10.4333/KPS.2008.38.1.039
Physical properties of cyclosporin A-loaded nanostructured lipid carriers
C. K. Song (2008)
10.1088/0957-4484/21/12/125102
Chemical and structural investigation of lipid nanoparticles: drug-lipid interaction and molecular distribution.
Suranan Anantachaisilp (2010)
10.1007/978-3-7091-0154-4_14
Characterization of Liposomes by FFF
Susanne K Wiedmer (2012)
Preparation, Characterization and In Vitro Evaluation of Indomethacin Loaded Solid Lipid Nanoparticles
Hend M. Abu Amara (2014)
10.1097/MCP.0b013e32835eff08
Advances in nanotechnology for diagnosis and treatment of tuberculosis
S. Banyal (2013)
10.2174/1381612821666150428143730
Lipid nanoparticles for dermal drug delivery.
Pratibha G. Kakadia (2015)
FORMULATION, CHARACTERIZATION & EVALUATION OF SOLID LIPID NANOPARTICLES OF CARVEDILOL
Neeraj (2016)
10.1080/21691401.2017.1394872
Solid lipid nanoparticles for nose to brain delivery of donepezil: formulation, optimization by Box–Behnken design, in vitro and in vivo evaluation
M. Yasir (2017)
10.1179/016164107X187017
Solid lipid nanoparticles: could they help to improve the efficacy of pharmacologic treatments for brain tumors?
A. Brioschi (2007)
10.1016/J.ADDR.2007.04.013
Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering.
H. Bunjes (2007)
10.1002/9781118444726.CH4
Solid Lipid Nanoparticles for Drug Delivery
S. Joseph (2013)
10.1016/j.nano.2008.03.003
Preparation and characterization of biocompatible oil-loaded polyelectrolyte nanocapsules.
Claudia Preetz (2008)
Characterization of SLN in o/w-emulsions
Johanna Heisler (2013)
10.1002/MACP.201600208
Field Flow Fractionation for the Size, Molar Mass, and Gel Content Analysis of Emulsion Polymers for Water-Based Coatings
Ashwell Craig Makan (2016)
10.1007/s10973-011-1613-7
Crystallinity of Dynasan®114 and Dynasan®118 matrices for the production of stable Miglyol®-loaded nanoparticles
P. Severino (2011)
10.1007/978-3-030-34544-0_13
Solid Lipid Nanoparticles
Akhlesh Kumar Jain (2020)
10.3109/08982104.2014.911314
Lipid-based capsaicin-loaded nano-colloidal biocompatible topical carriers with enhanced analgesic potential and decreased dermal irritation
Kaisar Raza (2014)
10.1016/j.msec.2014.12.012
Cannabinoid antagonist in nanostructured lipid carriers (NLCs): design, characterization and in vivo study.
E. Esposito (2015)
10.1007/978-3-662-47862-2_11
Nanostructured Lipid Carriers (NLC): The Second Generation of Solid Lipid Nanoparticles
R. Mueller (2016)
10.1016/j.colsurfb.2015.12.029
Transport of stearic acid-based solid lipid nanoparticles (SLNs) into human epithelial cells.
Rohan M. Shah (2016)
10.1016/J.JFOODENG.2018.12.005
Adsorption of β-lactoglobulin to solid lipid nanoparticles (SLN) depends on encapsulated compounds
Kathleen Oehlke (2019)
Nanostructured Lipid Carrier (NLC) -A Promising Drug Delivery for Transdermal Application
Laxmidhar Sahoo (2020)
10.1016/J.COLSURFB.2004.12.017
Dialkylphosphatidylcholine and egg yolk lecithin for emulsification of various triglycerides.
Tomoko Nii (2005)
10.1007/s13346-012-0110-2
SLN approach for nose-to-brain delivery of alprazolam
A. Singh (2012)
10.1007/978-3-319-41129-3_2
Nanoparticles Types, Classification, Characterization, Fabrication Methods and Drug Delivery Applications
Saurabh Bhatia (2016)
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