Please confirm you are human (Sign Up for free to never see this)
← Back to Search
W/O Microemulsions For Ocular Delivery: Evaluation Of Ocular Irritation And Precorneal Retention.
R. Alany, T. Rades, J. Nicoll, I. Tucker, N. Davies
Published 2006 · Chemistry, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
Water-in-oil microemulsions (w/o ME) capable of undergoing a phase-transition to lamellar liquid crystals (LC) or bicontinuous ME upon aqueous dilution were formulated using Crodamol EO, Crill 1 and Crillet 4, an alkanol or alkanediol as cosurfactant and water. The hypothesis that phase-transition of ME to LC may be induced by tears and serve to prolong precorneal retention was tested. The ocular irritation potential of components and formulations was assessed using a modified hen's egg chorioallantoic membrane test (HET-CAM) and the preocular retention of selected formulations was investigated in rabbit eye using gamma scintigraphy. Results showed that Crill 1, Crillet 4 and Crodamol EO were non-irritant. However, all other cosurfactants investigated were irritant and their irritation was dependent on their carbon chain length. A w/o ME formulated without cosurfactant showed a protective effect when a strong irritant (0.1 M NaOH) was used as the aqueous phase. Precorneal clearance studies revealed that the retention of colloidal and coarse dispersed systems was significantly greater than an aqueous solution with no significant difference between ME systems (containing 5% and 10% water) as well as o/w emulsion containing 85% water. Conversely, a LC system formulated without cosurfactant displayed a significantly greater retention compared to other formulations.
This paper references
Eudragit RS100 nanosuspensions for the ophthalmic controlled delivery of ibuprofen.
R. Pignatello (2002)
The Development and Evaluation of In Vitro Tests by the FRAME Alternatives Laboratory
R. Clothier (1995)
COLIPA validation project on in vitro eye irritation tests for cosmetic ingredients and finished products (phase I): the red blood cell test for the estimation of acute eye irritation potentials. Present status.
W. Pape (1999)
Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. II. Polymer-Coated Vesicles
N. Davies (2004)
Evaluation of the vascular components of the chorioallantoic membrane assay as a model for eye irritation potential: II
M. Daniel (1991)
Influence of molecular weight and formulation pH on the precorneal clearance rate of hyaluronic acid in the rabbit eye
A. M. Durrani (1995)
Effect of poloxamer 407 gel on the miotic activity of pilocarpine nitrate in rabbits
S. Miller (1982)
Direct physical demonstration of oily layer on tear film surface.
G. Brauninger (1972)
A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man
I. Zaki (1986)
Evaluation of Mucoadhesive Polymers in Ocular Drug Delivery. I. Viscous Solutions
N. Davies (2004)
RECENT DEVELOPMENTS IN OPHTHALMIC DRUG DELIVERY
Shulin Ding (1998)
The chick embryo in toxicology: an alternative to the rabbit eye.
J. Leighton (1985)
Characterizing Colloidal Structures of Pseudoternary Phase Diagrams Formed by Oil/Water/Amphiphile Systems
R. Alany (2001)
Effects of alcohols and diols on the phase behaviour of quaternary systems.
R. Alany (2000)
Hen's egg chorioallantoic membrane test for irritation potential.
N. P. Luepke (1985)
Precorneal Clearance of Mucoadhesive Microspheres from the Rabbit Eye
A. M. Durrani (1995)
A γ-scintigraphic evaluation of microparticulate ophthalmic delivery systems: liposomes and nanoparticles
P. Fitzgerald (1987)
Preparing Nontoxic Microemulsions with Alkyl Monoglucosides and the Role of Alkanediols as Cosolvents
M. Kahlweit (1996)
Evaluation of seven alternative assays on the main ingredients in cosmetics as predictors of Draize eye irritation scores.
H. Kojima (1995)
Ophthalmic drug delivery systems—Recent advances
C. L. Bourlais (1998)
Ocular drug delivery conventional ocular formulations
John C. Lang (1995)
Factors affecting use of the hen's egg chorioallantoic membrane as a model for predicting eye irritation potential: I
M. Daniel (1991)
Comparison of two in vitro and two in vivo methods for the measurement of irritancy.
W. Sterzel (1990)
Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers
P. Calvo (1997)
Preparing nontoxic microemulsions
M. Kahlweit (1995)
Topical use of chitosan in ophthalmology: tolerance assessment and evaluation of precorneal retention.
O. Felt (1999)
This paper is referenced by
Cubic liquid crystalline nanoparticles: optimization and evaluation for ocular delivery of tropicamide
P. Verma (2016)
Development of thermosensitive in situ gel nanoemulsions for ocular delivery of acyclovir
Mohammad Mehdi Mahboobian (2020)
FORMULATION AND EVALUATION OF INJECTABLE IN SITU GELLING MATRIX SYSTEM OF DILTIAZEM HYDROCHLORIDE FOR CONTROLLED DRUG RELEASE
Tamizh Mani (2017)
Topical instillation of triamcinolone acetonide-loaded emulsomes for posterior ocular delivery: statistical optimization and in vitro-in vivo studies
R. Kapadia (2020)
Microbiological Chitosan: Potential Application as Anticariogenic Agent
Thayza Christina Montenegro Stamford (2013)
Microemulsion: New Insights into the Ocular Drug Delivery
R. R. Hegde (2013)
Impediment of selenite-induced cataract in rats by combinatorial drug laden liposomal preparation
Caixuan Huang (2019)
Aspectos fundamentais no desenvolvimento de sistemas microemulsionados contendo anfotericina B para uso oftálmico
W. L. L. Silveira (2013)
Microemulsions as novel drug carriers: the formation, stability, applications and toxicity
H. Karasulu (2008)
A critical appraisal of microemulsions for drug delivery: part II.
B. Sapra (2014)
Lipid-based nanocarriers for ocular drug delivery
R. M. Farid (2017)
In-vivo Evaluation and Characterization of Novel In-Situ Gelling System as Controlled Delivery System Containing Ciprofloxacin for Ocular Drug Delivery
Fatima Eram (2020)
Development and optimization of vitamin E TPGS based PLGA nanoparticles for improved and safe ocular delivery of ketorolac
M. Warsi (2020)
Prospective Corollary of Ophthalmic Nanomedicine: A Concept Shift toward Chitosan-Based Mucoadhesive Nanomedicine
Farhan J Ahmad (2013)
Microemulsion: A Versatile Tool for Ocular Drug Delivery
Shashikant Chandrakar (2014)
Investigation of self-microemulsifying and microemulsion systems for protection of prednisolone from gamma radiation
Gamal M. El Maghraby (2011)
Nanoemulsion as a Potential Ophthalmic Delivery System for Dorzolamide Hydrochloride
H. Ammar (2009)
Fatty Acid Based Microemulsions to Combat Ophthalmia Neonatorum Caused by Neisseria gonorrhoeae and Staphylococcus aureus
Ummara Butt (2018)
A NEW TREND: OCULAR DRUG DELIVERY SYSTEM
S. Dixit (2011)
The chicken chorioallantoic membrane model in biology, medicine and bioengineering
P. Nowak-Sliwinska (2014)
Viability of Nanotechnology in Ocular Therapeutics
Mukesh K. Pathak (2012)
In vitro and in vivo evaluation of novel implantation technology in hydrogel contact lenses for controlled drug delivery.
Furqan A. Maulvi (2016)
MEDICAL OR THERAPEUTICAL APPLICATIONS OF OIL‐IN‐WATER NANOSIZED EMULSIONS
Oly Katari (2020)
Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods.
A. Kishore (2009)
Ophthalmic gels: Past, present and future
Ali A Al-Kinani (2018)
Delivery of gatifloxacin using microemulsion as vehicle: formulation, evaluation, transcorneal permeation and aqueous humor drug determination
M. A. Kalam (2016)
Use of cyclodextrins in topical formulations: practical aspects.
K. Cal (2008)
Prednisolone-loaded nanocapsules as ocular drug delivery system: development, in vitro drug release and eye toxicity
T. Katzer (2014)
Development of a microemulsion for encapsulation and delivery of gallic acid. The role of chitosan.
Evgenia Mitsou (2020)
PREPARATION AND CHARACTERIZATION OF pH BASED CARBOPOL 934P IN-SITU HYDROGELS FOR THE TREATMENT OF HARMFUL BACTERIAL INFECTIONS
Bharathi Anbarasan (2018)
Formulation of the Model Fluconazole Eye Drop and Its Comparison with the Available Fluconazole Eye Drops
S. Thakral (2012)
Nanotechnology in Ophthalmic Drug Delivery
Ali A Al-Kinani (2012)See more