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Poly(trimethylene Carbonate) And Monomethoxy Poly(ethylene Glycol)-block-poly(trimethylene Carbonate) Nanoparticles For The Controlled Release Of Dexamethasone.
Z. Zhang, D. Grijpma, J. Feijen
Published 2006 · Chemistry, Medicine
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In this study, single emulsion and salting out methods were employed to prepare poly(trimethylene carbonate) (PTMC) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG-PTMC) nanoparticles. Well-defined nanoparticles of a PTMC homopolymer were prepared using poly(vinyl alcohol) (PVA) as a stabilizer. The average size of the nanoparticles can be adjusted by varying the stirring speed and polymer concentration. These particles can be readily freeze-dried and redispersed, with little influence on the average particle size and size distribution. Nanoparticles based on amphiphilic mPEG-PTMC can be prepared without an additional stabilizer. In this case, the size of the obtained nanoparticles did not vary much and ranged between 95 and 120 nm. These nanoparticles could be freeze-dried and redispersed as well. Using the salting out method, dexamethasone was loaded into PTMC and mPEG-PTMC nanoparticles at a highest efficiency of respectively 54% and 88%. With the single emulsion method, the loading efficiencies were, respectively, 91% and 72%. These drug-loaded particles were stable in time for at least 20 weeks. It was found that the release of dexamethasone from these nanoparticles was diffusion-controlled and could be sustained for 14 to 60 days. Depending on the nature of the polymer employed and the preparation method, dexamethasone diffusion coefficients varied between 4.8 x 10(-18) and 22.6 x 10(-18) cm(2)/s.
This paper references
Nanoparticle-based dmg delivery systems
J. Kreuter (1991)
Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery
L. Brannon-Peppas (1995)
Polymeric systems for controlled drug release.
K. Uhrich (1999)
The in vivo and in vitro degradation behavior of poly(trimethylene carbonate).
Z. Zhang (2006)
Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
K. Fu (2004)
Controlled Release of Biologically Active Agents
R. W. Baker (1987)
Controlled drug delivery with nanoparticles : current possibilities and future trends
P. Couvreur (1995)
Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage.
Y. Tabata (1988)
Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties
P. Couvreur (1979)
Determination of dexamethasone and two excipients (creatinine and propylparaben) in injections by using UV-spectroscopy and multivariate calibrations.
M. S. Collado (2001)
Controlled release: mechanisms and release.
R. W. Baker (1974)
Synthesis and drug release behavior of poly (trimethylene carbonate)-poly (ethylene glycol)-poly (trimethylene carbonate) nanoparticles.
Y. Zhang (2005)
Local intraluminal infusion of biodegradable polymeric nanoparticles. A novel approach for prolonged drug delivery after balloon angioplasty.
L. A. Guzman (1996)
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
Copolymerization and polymer blending of trimethylene carbonate and adipic anhydride for tailored drug delivery
U. Edlund (1999)
Biodegradable nanoparticles — From sustained release formulations to improved site specific drug delivery
J. Leroux (1996)
PTMC and MPEG-PTMC microparticles for hydrophilic drug delivery.
Z. Zhang (2005)
Synthesis of poly (1,4-dioxan-2-one-co-trimethylene carbonate) for application in drug delivery systems
H. Wang (1998)
The role of branched polyesters and their modifications in the development of modern drug delivery vehicles.
L. A. Dailey (2005)
Modification of the rates of chain cleavage of poly(ϵ-caprolactone) and related polyesters in the solid state
C. Pitt (1987)
Physicochemical aspects of drug release. XV. Investigation of diffusional transport in dissolution of suspended, sparingly soluble drugs
M. Bisrat (1992)
The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size.
Miechel L T Zweers (2003)
Long circulating microparticulate drug carriers
S. Stolnik (1995)
Triblock Copolymers Based on 1,3‐Trimethylene Carbonate and Lactide as Biodegradable Thermoplastic Elastomers
Zheng Zhang (2003)
In vivo behavior of poly(1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with D,L-lactide or epsilon-caprolactone: Degradation and tissue response.
A. Pêgo (2003)
Studies on Properties and Drug Delivery Systems of PTMC-b-PEG-b-PTMC Block Copolymers
H. Wang (1998)
Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone.
L. Ould-Ouali (2005)
Polymerized micelles and their use as adjuvants in immunology.
G. Birrenbach (1976)
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Arina T. Buizer (2018)
Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles.
F. Crisante (2009)
Permeation measurement of gestodene for some biodegradable materials using Franz diffusion cells
D. Liu (2015)
The RAPIDOS projectdEuropean and Chinese collaborative research on
D. Eglin (2015)
Encapsulation of dexamethasone into biodegradable polymeric nanoparticles.
Carolina Gómez-Gaete (2007)
Tumor necrosis factor alpha blocking peptide loaded PEG-PLGA nanoparticles: preparation and in vitro evaluation.
Anshu Yang (2007)
Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants: Optimization and In Vitro Characterization
X. Lu (2008)
Formulations of Nanoparticles in Drug Delivery
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Drug Delivery Systems Based on Tyrosine-Derived Nanospheres (TyroSpheres™): Drug Delivery Systems Based on Tyrosine-Derived Nanospheres (TyroSpheres™)
Z. Zhang (2014)
Drug incorporation and release of water soluble drugs from novel functionalized poly(glycerol adipate) nanoparticles.
S. Puri (2008)
pH-Sensitive cationic copolymers of different macromolecular architecture as potential dexamethasone sodium phosphate delivery systems.
D. Georgieva (2014)
Microencapsulation of oregano (Origanum vulgare L.), rosemary (Rosmarinus officinalis L.) and sage (Salvia officinalis L.) essential oils in β-lactoglobulin
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F127/Calcium phosphate hybrid nanoparticles: a promising vector for improving siRNA delivery and gene silencing
Liubin Qin (2013)
Anti-inflammatory activity of injectable dexamethasone acetate-loaded nanostructured lipid carriers
Xuefan Xu (2011)
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
S. K. Pandey (2013)
Élaboration de nano- et microparticules pour l'encapsulation et la libération de molécules polyphénoliques ayant des applications dans le traitement de milieux aquatiques
A. Chebil (2016)
Thermosensitive nanoparticle of mPEG-PTMC for oligopeptide delivery into osteoclast precursors
P. Wang (2020)
Transport characteristics using nor-dihydroguaiaretic acid (NDGA)-polymerized collagen fibers as a local drug delivery system
Eric Guegan (2007)
Synthetic and Natural Degradable Polymeric Biomaterials
S. Deb (2008)
Overview of Methods of Making Polyester Nano- and Microparticulate Systems for Drug Delivery
N. Ahamad (2016)
ROP of Cyclic Carbonates and ROP of Macrocycles
G. Rokicki (2012)
Exploring poly(ethylene glycol)-poly(trimethylene carbonate) nanoparticles as carriers of hydrophobic drugs to modulate osteoblastic activity.
D. Leite (2020)
Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.
J. Jansen (2010)
A simple method to achieve high doxorubicin loading in biodegradable polymersomes.
Charles Sanson (2010)
Synthesis, properties and biomedical applications of hydrolytically degradable materials based on aliphatic polyesters and polycarbonates.
Ruairí P Brannigan (2016)
In vitro prolonged gastric residence and sustained release of atenolol using novel clay polymer nanocomposite
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