Online citations, reference lists, and bibliographies.
← Back to Search

Poly(trimethylene Carbonate) And Monomethoxy Poly(ethylene Glycol)-block-poly(trimethylene Carbonate) Nanoparticles For The Controlled Release Of Dexamethasone.

Z. Zhang, D. Grijpma, J. Feijen
Published 2006 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
In this study, single emulsion and salting out methods were employed to prepare poly(trimethylene carbonate) (PTMC) and monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG-PTMC) nanoparticles. Well-defined nanoparticles of a PTMC homopolymer were prepared using poly(vinyl alcohol) (PVA) as a stabilizer. The average size of the nanoparticles can be adjusted by varying the stirring speed and polymer concentration. These particles can be readily freeze-dried and redispersed, with little influence on the average particle size and size distribution. Nanoparticles based on amphiphilic mPEG-PTMC can be prepared without an additional stabilizer. In this case, the size of the obtained nanoparticles did not vary much and ranged between 95 and 120 nm. These nanoparticles could be freeze-dried and redispersed as well. Using the salting out method, dexamethasone was loaded into PTMC and mPEG-PTMC nanoparticles at a highest efficiency of respectively 54% and 88%. With the single emulsion method, the loading efficiencies were, respectively, 91% and 72%. These drug-loaded particles were stable in time for at least 20 weeks. It was found that the release of dexamethasone from these nanoparticles was diffusion-controlled and could be sustained for 14 to 60 days. Depending on the nature of the polymer employed and the preparation method, dexamethasone diffusion coefficients varied between 4.8 x 10(-18) and 22.6 x 10(-18) cm(2)/s.
This paper references
10.1016/0168-3659(91)90040-K
Nanoparticle-based dmg delivery systems
J. Kreuter (1991)
10.1016/0378-5173(94)00324-X
Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery
L. Brannon-Peppas (1995)
10.1021/CR940351U
Polymeric systems for controlled drug release.
K. Uhrich (1999)
10.1016/J.BIOMATERIALS.2005.09.017
The in vivo and in vitro degradation behavior of poly(trimethylene carbonate).
Z. Zhang (2006)
10.1023/A:1007582911958
Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
K. Fu (2004)
Controlled Release of Biologically Active Agents
R. W. Baker (1987)
Controlled drug delivery with nanoparticles : current possibilities and future trends
P. Couvreur (1995)
10.1016/0142-9612(88)90033-6
Effect of the size and surface charge of polymer microspheres on their phagocytosis by macrophage.
Y. Tabata (1988)
10.1111/j.2042-7158.1979.tb13510.x
Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties
P. Couvreur (1979)
10.1016/S0378-5173(01)00866-3
Determination of dexamethasone and two excipients (creatinine and propylparaben) in injections by using UV-spectroscopy and multivariate calibrations.
M. S. Collado (2001)
Controlled release: mechanisms and release.
R. W. Baker (1974)
10.1016/J.BIOMATERIALS.2004.06.004
Synthesis and drug release behavior of poly (trimethylene carbonate)-poly (ethylene glycol)-poly (trimethylene carbonate) nanoparticles.
Y. Zhang (2005)
10.1161/01.CIR.94.6.1441
Local intraluminal infusion of biodegradable polymeric nanoparticles. A novel approach for prolonged drug delivery after balloon angioplasty.
L. A. Guzman (1996)
10.1126/SCIENCE.8128245
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
10.1002/(SICI)1097-4628(19990411)72:2<227::AID-APP8>3.0.CO;2-Z
Copolymerization and polymer blending of trimethylene carbonate and adipic anhydride for tailored drug delivery
U. Edlund (1999)
10.1016/0168-3659(95)00164-6
Biodegradable nanoparticles — From sustained release formulations to improved site specific drug delivery
J. Leroux (1996)
10.1016/J.JCONREL.2004.09.006
PTMC and MPEG-PTMC microparticles for hydrophilic drug delivery.
Z. Zhang (2005)
10.1002/(SICI)1099-0518(199806)36:8<1301::AID-POLA13>3.0.CO;2-A
Synthesis of poly (1,4-dioxan-2-one-co-trimethylene carbonate) for application in drug delivery systems
H. Wang (1998)
10.1016/J.JCONREL.2004.09.003
The role of branched polyesters and their modifications in the development of modern drug delivery vehicles.
L. A. Dailey (2005)
10.1016/0168-3659(87)90020-4
Modification of the rates of chain cleavage of poly(ϵ-caprolactone) and related polyesters in the solid state
C. Pitt (1987)
10.1016/0378-5173(92)90277-9
Physicochemical aspects of drug release. XV. Investigation of diffusional transport in dissolution of suspended, sparingly soluble drugs
M. Bisrat (1992)
10.1002/JBM.B.10046
The preparation of monodisperse biodegradable polyester nanoparticles with a controlled size.
Miechel L T Zweers (2003)
10.1016/0169-409X(95)00025-3
Long circulating microparticulate drug carriers
S. Stolnik (1995)
10.1002/MACP.200300184
Triblock Copolymers Based on 1,3‐Trimethylene Carbonate and Lactide as Biodegradable Thermoplastic Elastomers
Zheng Zhang (2003)
10.1002/JBM.A.10121
In vivo behavior of poly(1,3-trimethylene carbonate) and copolymers of 1,3-trimethylene carbonate with D,L-lactide or epsilon-caprolactone: Degradation and tissue response.
A. Pêgo (2003)
10.1080/10601329808002013
Studies on Properties and Drug Delivery Systems of PTMC-b-PEG-b-PTMC Block Copolymers
H. Wang (1998)
10.1016/J.JCONREL.2004.10.022
Self-assembling PEG-p(CL-co-TMC) copolymers for oral delivery of poorly water-soluble drugs: a case study with risperidone.
L. Ould-Ouali (2005)
10.1002/JPS.2600651217
Polymerized micelles and their use as adjuvants in immunology.
G. Birrenbach (1976)



This paper is referenced by
Novel functionalized polymers for nanoparticle formulations with anti cancer drugs
Sanyogitta Puri (2007)
Towards in vivo application of oxygen-releasing microspheres for enhancing bone regeneration
Arina T. Buizer (2018)
10.2147/IJN.S10393
In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
Min-ting Wang (2010)
EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES AND STABILITY OF SOLID LIPID NANOPARTICLES DESIGNED FOR THE DELIVERY OF DEXAMETHASONE TO TUMORS
Melissa Howard (2011)
10.1016/j.biochi.2016.07.008
Nano-formulations of drugs: Recent developments, impact and challenges.
J. Jeevanandam (2016)
10.1016/j.addr.2012.10.003
Advanced materials and processing for drug delivery: the past and the future.
Y. Zhang (2013)
poly(trimethylene carbonate) microspheres for tissue engineering
Arina T. Buizer (2018)
10.1016/j.ejps.2008.12.006
Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles.
F. Crisante (2009)
10.1016/j.jsps.2015.01.012
Permeation measurement of gestodene for some biodegradable materials using Franz diffusion cells
D. Liu (2015)
The RAPIDOS projectdEuropean and Chinese collaborative research on
D. Eglin (2015)
10.1016/J.IJPHARM.2006.11.028
Encapsulation of dexamethasone into biodegradable polymeric nanoparticles.
Carolina Gómez-Gaete (2007)
10.1016/J.IJPHARM.2006.09.015
Tumor necrosis factor alpha blocking peptide loaded PEG-PLGA nanoparticles: preparation and in vitro evaluation.
Anshu Yang (2007)
10.1208/s12248-008-9013-z
Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants: Optimization and In Vitro Characterization
X. Lu (2008)
10.1201/B14802-11
Formulations of Nanoparticles in Drug Delivery
Sushama Talegaonkar (2013)
10.1201/B17271-7
Drug Delivery Systems Based on Tyrosine-Derived Nanospheres (TyroSpheres™): Drug Delivery Systems Based on Tyrosine-Derived Nanospheres (TyroSpheres™)
Z. Zhang (2014)
10.1016/J.JCONREL.2007.09.009
Drug incorporation and release of water soluble drugs from novel functionalized poly(glycerol adipate) nanoparticles.
S. Puri (2008)
10.1002/jps.24059
pH-Sensitive cationic copolymers of different macromolecular architecture as potential dexamethasone sodium phosphate delivery systems.
D. Georgieva (2014)
10.25177/jfst.4.9.ra.612
Microencapsulation of oregano (Origanum vulgare L.), rosemary (Rosmarinus officinalis L.) and sage (Salvia officinalis L.) essential oils in β-lactoglobulin
Xiaoyu Luo (2019)
10.1080/09205063.2013.801702
F127/Calcium phosphate hybrid nanoparticles: a promising vector for improving siRNA delivery and gene silencing
Liubin Qin (2013)
10.3109/10717544.2011.589087
Anti-inflammatory activity of injectable dexamethasone acetate-loaded nanostructured lipid carriers
Xuefan Xu (2011)
10.1007/12_2012_198
Biodegradable Polymers for Potential Delivery Systems for Therapeutics
S. K. Pandey (2013)
Élaboration de nano- et microparticules pour l'encapsulation et la libération de molécules polyphénoliques ayant des applications dans le traitement de milieux aquatiques
A. Chebil (2016)
10.1177/0883911520933916
Thermosensitive nanoparticle of mPEG-PTMC for oligopeptide delivery into osteoclast precursors
P. Wang (2020)
Transport characteristics using nor-dihydroguaiaretic acid (NDGA)-polymerized collagen fibers as a local drug delivery system
Eric Guegan (2007)
10.1201/9780849379741.PT4
Synthetic and Natural Degradable Polymeric Biomaterials
S. Deb (2008)
10.1201/B20045-5
Overview of Methods of Making Polyester Nano- and Microparticulate Systems for Drug Delivery
N. Ahamad (2016)
10.1016/B978-0-444-53349-4.00107-2
ROP of Cyclic Carbonates and ROP of Macrocycles
G. Rokicki (2012)
10.1016/j.xphs.2020.01.007
Exploring poly(ethylene glycol)-poly(trimethylene carbonate) nanoparticles as carriers of hydrophobic drugs to modulate osteoblastic activity.
D. Leite (2020)
10.1016/j.jconrel.2010.06.031
Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.
J. Jansen (2010)
10.1016/j.jconrel.2010.07.123
A simple method to achieve high doxorubicin loading in biodegradable polymersomes.
Charles Sanson (2010)
10.1039/c6bm00584e
Synthesis, properties and biomedical applications of hydrolytically degradable materials based on aliphatic polyesters and polycarbonates.
Ruairí P Brannigan (2016)
10.1016/J.CLAY.2015.06.017
In vitro prolonged gastric residence and sustained release of atenolol using novel clay polymer nanocomposite
S. Lal (2015)
See more
Semantic Scholar Logo Some data provided by SemanticScholar