Online citations, reference lists, and bibliographies.
← Back to Search

Hyaluronic Acid And Its Derivative As A Multi-functional Gene Expression Enhancer: Protection From Non-specific Interactions, Adhesion To Targeted Cells, And Transcriptional Activation.

T. Ito, N. Iida-Tanaka, T. Niidome, Takahito Kawano, Koji Kubo, K. Yoshikawa, T. Sato, Zhi-hong Yang, Y. Koyama
Published 2006 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Hyaluronic acid (HA), a natural anionic mucopolysaccharide, can be deposited onto the cationic surface of DNA/polyethyleneimine (PEI) complexes to recharge the surface potential and reduce nonspecific interactions with proteins. HA can also be used as a ligand to target specific cell receptors. Furthermore, HA-coating enhanced the transcriptional activity of the plasmid/PEI complexes, probably by loosening the tight binding between DNA and PEI, which facilitated the approach of transcription factors. Amphoteric HA derivative having spermine side chains (Spn-HA) with a structure similar to HMG protein showed higher transcription-enhancing activity than HA. Plasmid/PEI/Spn-HA ternary complex exhibited 29-fold higher transgene expression efficiency than naked plasmid/PEI complexes in CHO cells.
This paper references
Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery.
C. Plank (1996)
DNA complexes with polycations for the delivery of genetic material into cells.
A. Kabanov (1995)
Novel poly(ethylene glycol) derivatives with carboxylic acid pendant groups: synthesis and their protection and enhancing effect on non-viral gene transfection systems
Y. Koyama (2003)
Protection of primary human T cells from HIV infection by Trev: a transdominant fusion gene.
J. Chinen (1997)
Sugar-containing polyanions as a self-assembled coating of plasmid/polycation complexes for receptor-mediated gene delivery
Yoshiyuki Koyama (2002)
Nonviral vectors in the new millennium: delivery barriers in gene transfer.
M. Nishikawa (2001)
CD44: the hyaluronan receptor.
C. Underhill (1992)
Association and Dissociation Characteristics of Polymer/DNA Complexes Used for Gene Delivery
C. Arigita (2004)
Interactions of polymeric and liposomal gene delivery systems with extracellular glycosaminoglycans: physicochemical and transfection studies.
M. Ruponen (1999)
High-mobility-group chromosomal proteins: architectural components that facilitate chromatin function.
M. Bustin (1996)
Acidic C-tail of HMGB1 is required for its target binding to nucleosome linker DNA and transcription stimulation.
T. Ueda (2004)
Transfer of growth inhibition between normal and virus-transformed cells: autoradiographic studies using marked cells.
M. Stoker (1967)
A versatile system for receptor-mediated gene delivery permits increased entry of DNA into target cells, enhanced delivery to the nucleus and elevated rates of transgene expression
K. Fisher (2000)
Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin*
P. R. Dash (2000)
Novel receptor-mediated gene delivery system comprising plasmid/protamine/sugar-containing polyanion ternary complex.
K. Maruyama (2004)
Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition
K. Miyake (1990)

This paper is referenced by
A core-shell nanoparticle approach to photoreversible fluorescence modulation of a hydrophobic dye in aqueous media.
J. Chen (2008)
Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2.
C. Needham (2014)
A novel penetratin-modified complex for noninvasive intraocular delivery of antisense oligonucleotides.
Lingyu Tai (2017)
Development of a carrier system containing hyaluronic acid and protamine for siRNA delivery in the treatment of melanoma
J. Yang (2020)
Hyaluronic Acid in Drug Delivery Systems
Yujin Jin (2010)
Cationic derivatives of biocompatible hyaluronic acids for delivery of siRNA and antisense oligonucleotides
Su-Eun Han (2009)
In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran.
Y. Hayashi (2018)
RGD targeting hyaluronic acid coating system for PEI-PBLG polycation gene carriers.
Huayu Tian (2011)
Target-specific gene silencing of layer-by-layer assembled gold-cysteamine/siRNA/PEI/HA nanocomplex.
M. Lee (2011)
Amphoteric nano-, micro-, and macrogels, membranes, and thin films
S. Kudaibergenov (2012)
Zinc-chelated poly(1-vinylimidazole) and a carbohydrate ligand polycation form DNA ternary complexes for gene delivery.
S. Asayama (2011)
Novel hyaluronic acid-chitosan nanoparticles for ocular gene therapy.
M. de la Fuente (2008)
Efficient DNA and siRNA delivery with biodegradable cationic hyaluronic acid conjugates
S. Tripathi (2013)
Combination of chondroitin sulfate and polyplex micelles from Poly(ethylene glycol)-poly{N'-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} block copolymer for prolonged in vivo gene transfection with reduced toxicity.
S. Uchida (2011)
Low molecular weight hyaluronan shielding of DNA/PEI polyplexes facilitates CD44 receptor mediated uptake in human corneal epithelial cells
M. Hornof (2008)
Synthesis of Carboxymethyl Poly(1-vinylimidazole) as a Polyampholyte for Biocompatibility
S. Asayama (2013)
Gold half-shell coated hyaluronic acid-doxorubicin conjugate micelles for theranostic applications
K. Kim (2012)
Structures based on semi-degradable biomaterials for neural regeneration in the central nervous system
M. P. Garnes (2015)
Self-assembled ternary complexes stabilized with hyaluronic acid-green tea catechin conjugates for targeted gene delivery.
Kun Liang (2016)
Chitosan-hyaluronic acid nanoparticles for gene silencing: the role of hyaluronic acid on the nanoparticles' formation and activity.
S. Al-Qadi (2013)
What can we learn from virus in designing nonviral gene vectors
C. Xu (2011)
Formation et caractérisation physico-chimique des complexes ADN/chitosane pour la thérapie génique
P. Ma (2010)
Design of novel polysaccharidic nanostructures for gene delivery.
M. de la Fuente (2008)
Effect of preparation parameters on ultra low molecular weight chitosan/hyaluronic acid nanoparticles.
N. Nazeri (2013)
The effects of coating pDNA/chitosan complexes with chondroitin sulfate on physicochemical characteristics and cell transfection.
Kenji Hagiwara (2012)
In vitro and in vivo gene delivery using chitosan/hyaluronic acid nanoparticles: Influences of molecular mass of hyaluronic acid and lyophilization on transfection efficiency
T. Sato (2017)
A novel gene therapy vector based on hyaluronic acid and solid lipid nanoparticles for ocular diseases.
P. S. Apaolaza (2014)
The development of a gene vector electrostatically assembled with a polysaccharide capsule.
T. Kurosaki (2009)
Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy
So Yun Lee (2020)
Nanoparticles as protein and gene carriers to mucosal surfaces.
M. de la Fuente (2008)
Chitosan-based nanoparticles studied by isothermal titration calorimetry
Iolanda Fotticchia (2016)
High-molecular weight biopolymer
A. M. Omer (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar