Online citations, reference lists, and bibliographies.
← Back to Search

Polyionic Hydrocolloids For The Intestinal Delivery Of Protein Drugs: Alginate And Chitosan--a Review.

M. George, T. E. Abraham
Published 2006 · Chemistry, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The protein pharmaceutical market is rapidly growing, since it is gaining support from the recombinant DNA technology. To deliver these drugs via the oral route, the most preferred route, is the toughest challenge. In the design of oral delivery of peptide or protein drugs, pH sensitive hydrogels like alginate and chitosan have attracted increasing attention, since most of the synthetic polymers are immunogenic and the incorporation of proteins in to these polymers require harsh environment which may denature and inactivate the desired protein. Alginate is a water-soluble linear polysaccharide composed of alternating blocks of 1-4 linked alpha-L-guluronic and beta-D-mannuronic acid residues where as chitosan is a co polymer of D-glucosamine and N-acetyl glucosamine. The incorporation of protein into these two matrices can be done under relatively mild environment and hence the chances of protein denaturation are minimal. The limitations of these polymers, like drug leaching during preparation can be overcome by different techniques which increase their encapsulation efficiency. Alginate, being an anionic polymer with carboxyl end groups, is a good mucoadhesive agent. The pore size of alginate gel microbeads has been shown to be between 5 and 200 nm and coated beads and microspheres are found to be better oral delivery vehicles. Cross-linked alginate has more capacity to retain the entrapped drugs and mixing of alginate with other polymers such as neutral gums, pectin, chitosan, and eudragit have been found to solve the problem of drug leaching. Chitosan has only limited ability for controlling the release of encapsulated compound due to its hydrophilic nature and easy solubility in acidic medium. By simple covalent modifications of the polymer, its physicochemical properties can be changed and can be made suitable for the peroral drug delivery purpose. Ionic interactions between positively charged amino groups in chitosan and the negatively charged mucus gel layer make it mucoadhesive. The favourable properties like biocompatibility, biodegradability, pH sensitiveness, mucoadhesiveness, etc. has enabled these polymers to become the choice of the pharmacologists as oral delivery matrices for proteins.
This paper references
Hemoglobin encapsulation in chitosan/calcium alginate beads
M. L. Huguet (1994)
10.1023/A:1012160102740
Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement
N. G. Schipper (2004)
Schnürch, ThiolatedChitosan: InVitro Evaluation of its Permeation Enhancing Properties, 30th Annual Meeting and Exposition of the Controlled Release
N. Langoth (2003)
10.1021/MA971619X
Synthesis and 13C CP-MAS NMR Characterization of a New Chitosan-Based Polymeric Network
A. D. Angelis (1998)
10.1042/BJ3480557
Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems.
M. Deacon (2000)
10.1358/MF.1999.21.5.793477
Decrease in serum LDL cholesterol with microcrystalline chitosan.
E. Wuolijoki (1999)
10.1007/BF00227561
Comparative study on the diffusion of an IgG from various hydrogel beads
P. Chevalier (1987)
Chitin enzymology—chitinase
D. Koga (1998)
10.1016/S0928-4931(02)00024-3
Preparation of chitosan-coated alginate filament
H. Tamura (2002)
10.1016/S1381-5148(01)00057-8
Preparation and properties of chitosan-poly(N-isopropylacrylamide) full-IPN hydrogels
Mingzhen Wang (2001)
Junginger, Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation of Caco-2 cell monolayers
A. F. Kotze (1997)
10.1016/S0939-6411(02)00162-5
In vitro evaluation of the viscoelastic properties of chitosan-thioglycolic acid conjugates.
Margit D Hornof (2003)
10.1016/S0378-5173(03)00090-5
Enhancing effect of chitosan on nasal absorption of salmon calcitonin in rats: comparison with hydroxypropyl- and dimethyl-beta-cyclodextrins.
Prapasri Sinswat (2003)
10.1016/0167-7799(90)90139-O
Alginate as immobilization matrix for cells.
O. Smidsrød (1990)
10.1002/(SICI)1097-4628(19980207)67:6<983::AID-APP3>3.0.CO;2-I
Studies on dynamic behavior of water in crosslinked chitosan hydrogel
Guoxiang Cheng (1998)
10.1016/S0142-9612(00)00421-X
Thiolated polymers--thiomers: development and in vitro evaluation of chitosan-thioglycolic acid conjugates.
C. Kast (2001)
10.1016/S0939-6411(03)00147-4
Review articleThiolated chitosans
A. Bernkop-Schnürch (2004)
10.3109/10731199409117400
FT-IR of membranes made with alginate/polylysine complexes. Variations with the mannuronic or guluronic content of the polysaccharides.
B. Dupuy (1994)
N,O-Carboxymethyl chitosan and preparative method therefor, U.S
E. R. Hayes (1986)
10.1016/S0378-5173(99)00152-0
Instability, stabilization, and formulation of liquid protein pharmaceuticals.
W. Wang (1999)
Chitin enzymology — chitinase , in : R . Chen , H . C . Chen ( Eds . )
A. G. Jolliffe Gåserød (1998)
10.1016/0144-8617(95)00105-0
Transmission electron microscopy studies on pig gastric mucin and its interactions with chitosan
I. Fiebrig (1995)
Chitosan based water-resistant adhesive
K. Yamada (2000)
10.1016/J.IJBIOMAC.2004.03.010
Study of the interpolyelectrolyte reaction between chitosan and alginate: influence of alginate composition and chitosan molecular weight.
L. Becherán-Marón (2004)
K.B.Hicks, Pectin-based systems for colonspecific drug delivery via oral route, Biomaterials
L. S. Liu (2003)
10.1002/1099-0518(20000801)38:15<2804::AID-POLA210>3.0.CO;2-Y
Synthesis and characterization of a novel chitosan‐based network prepared using naturally occurring crosslinker
F. L. Mi (2000)
10.1385/ABAB:81:1:67
Electrophoretic extraction and analysis of DNA from chitosan or poly-l-lysine-coated alginate beads
D. Quong (1999)
10.1016/J.IJPHARM.2005.03.017
Buccal penetration enhancement properties of N-trimethyl chitosan: Influence of quaternization degree on absorption of a high molecular weight molecule.
G. Sandri (2005)
10.1016/S0378-5173(03)00271-0
Thiolated polymers--thiomers: synthesis and in vitro evaluation of chitosan-2-iminothiolane conjugates.
A. Bernkop-Schnürch (2003)
10.1016/J.BIOMATERIALS.2004.06.011
Physically crosslinked alginate/N,O-carboxymethyl chitosan hydrogels with calcium for oral delivery of protein drugs.
Y. Lin (2005)
10.1515/9783111548050-024
M
M. Sankar (1824)
10.1002/EJI.1830230140
The involvement of CD14 in stimulation of cytokine production by uronic acid polymers
T. Espevik (1993)
10.1080/026520499288636
Release characteristics of chitosan treated alginate beads: I. Sustained release of a macromolecular drug from chitosan treated alginate beads.
A. Sezer (1999)
10.3109/10717549709051894
Amidated Pectin Hydrogel Beads for Colonic Drug Delivery-An in vitro Study
O. Munjeri (1997)
10.1016/S0168-3659(02)00280-8
Mucosal immune responses following oral immunization with rotavirus antigens encapsulated in alginate microspheres.
B. Kim (2002)
10.1016/J.BIOMATERIALS.2003.09.100
Synthesis and pH sensitivity of carboxymethyl chitosan-based polyampholyte hydrogels for protein carrier matrices.
L. Chen (2004)
10.1016/0168-3659(95)00011-V
Bioadhesive microspheres. I: A novel electrobalance-based method to study adhesive interactions between individual microspheres and intestinal mucosa
Donald E. Chickering (1995)
10.1016/J.BIOMATERIALS.2004.10.005
Self-cross-linking biopolymers as injectable in situ forming biodegradable scaffolds.
B. Balakrishnan (2005)
10.1016/S0142-9612(03)00408-3
Preparation and modification of N-(2-hydroxyl) propyl-3-trimethyl ammonium chitosan chloride nanoparticle as a protein carrier.
Y. Xu (2003)
10.1016/J.EJPS.2003.10.028
Assessment of chitosan derivatives as buccal and vaginal penetration enhancers.
G. Sandri (2004)
Chitosan microspheres for the specific delivery of amoxycillin to the gastric cavity
C. Remuñán‐López (2000)
10.1007/978-3-0348-8757-1
Chitin and chitinases.
P. Jollès (1999)
10.1016/S0168-3659(02)00077-9
Design and in vitro evaluation of a novel bioadhesive vaginal drug delivery system for clotrimazole.
C. Kast (2002)
10.1111/j.2042-7158.1989.tb06338.x
Characterization of Albumin‐Alginic Acid Complex Coacervation
O. Singh (1989)
10.1016/S0378-5173(99)00173-8
Microencapsulation of lipophilic drugs in chitosan-coated alginate microspheres.
A. Ribeiro (1999)
10.1016/0168-3659(93)90067-F
Influence of erosion of calcium-induced alginate gel matrix on the release of Brilliant Blue
Y. Murata (1993)
Transmission electron microscopy on pig gastric mucin and its interactions with chitosan
I. Fiebrig (1995)
Chitosan Derivatives in Drug Delivery. Trimethylated and Carboxymethylated Chitosans as Safe Enhancers for the Intestinal Absorption of Hydrophilic Drugs
M Thanou (2000)
10.1016/0032-9592(95)00076-3
Calcium-alginate beads coated with polycationic polymers: Comparison of chitosan and DEAE-dextran
M. L. Huguet (1996)
10.1515/9783111576855-015
J
Seguin Hen (1824)
10.1081/DDC-100100278
Preparation of Cross-Linked Sodium Alginate Microparticles Using Glutaraldehyde in Methanol
A. R. Kulkarni (2000)
10.1248/CPB.35.1555
CALCIUM-INDUCED GELATION OF ALGINIC ACID AND PH SENSITIVE RESWELLING OF DRIED GELS
T. Yotsuyanagi (1987)
The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region.
J. Gum (1992)
10.1016/0378-5173(92)90088-J
The controlled release of blue dextran from alginate beads
C. Kim (1992)
10.1002/MASY.200451203
Chitosan‐Pectin Composite Gel Spheres: Effect of Some Formulation Variables on Drug Release
P. Sriamornsak (2004)
Association between capsule diameter
P. De Vos (1996)
10.1016/0142-9612(96)84680-1
Alginate polycation microcapsules. I. Interaction between alginate and polycation.
B. Thu (1996)
Secondary and tertiary structure of polysaccharides in solution and gels
D. A. Rees (1977)
10.1163/156856299X00478
Polyelectroylte complex composed of chitosan and sodium alginate for wound dressing application.
H. Kim (1999)
10.1016/S0966-7822(98)00032-X
Rheological study of the chitosan/glutaraldehyde chemical gel system
W. Argüelles-Monal (1998)
Alginates
I. W. Sutherland (1991)
Chitin Chemistry
G.A.F. Roberts (1992)
Synthesis and in vitro evaluation of chitosancysteine conjugates
A. B. Schnürch (1999)
Chitosan Derivatives in Drug Delivery
M. Thanou (2000)
10.1002/BIT.260260111
Diffusion characteristics of substrates in Ca‐alginate gel beads
H. Tanaka (1984)
10.1016/J.BIOMATERIALS.2004.03.011
Synthesis and in vitro evaluation of a novel thiolated chitosan.
K. Kafedjiiski (2005)
10.1201/b14099-14
CHITOSAN AND CHITOSAN DERIVATIVES AS ABSORPTION ENHANCERS FOR PEPTIDE DRUGS ACROSS MUCOSAL EPITHELIA
A. Kotzé (1999)
Microcapsules of alginate– chitosan: I
O. Gåserød (1998)
10.1016/S0378-5173(02)00531-8
Investigations into the stabilisation of drugs by sugar glasses: I. Tablets prepared from stabilised alkaline phosphatase.
H. Eriksson (2002)
10.1016/0378-5173(93)90221-Z
Preparation of chitosan-reinforced alginate gel beads — effects of chitosan on gel matrix erosion
Y. Murata (1993)
10.5040/9781474284028.0024
S
A. Kumar (1824)
10.1021/BM0003009
Chitosan based water-resistant adhesive. Analogy to mussel glue.
K. Yamada (2000)
10.1002/JPS.2600820215
Microencapsulation of drugs with aqueous colloidal polymer dispersions.
R. Bodmeier (1993)
10.1016/S0378-5173(99)00100-3
Screening of cationic compounds as an absorption enhancer for nasal drug delivery.
H. Natsume (1999)
10.1007/978-94-011-5942-5
Advances in chitin and chitosan
C. Brine (1992)
10.1016/0168-3659(94)90030-2
Calcium-alginate beads for the oral delivery of transforming growth factor-β1 (TGF-β1) : stabilization of TGF-β1 by the addition of polyacrylic acid within acid-treated beads
R. Mumper (1994)
10.2307/j.ctvrnfqk1.10
? ? ? ? f ? ? ? ? ?
A. ADoefaa (2003)
10.1016/S0141-8130(99)00068-9
Some studies of crosslinking chitosan-glutaraldehyde interaction in a homogeneous system.
O. A. Monteiro (1999)
10.1002/(SICI)1097-0126(200004)49:4<337::AID-PI375>3.0.CO;2-B
Investigation of different natural sources of chitin: influence of the source and deacetylation process on the physicochemical characteristics of chitosan
M. Rhazi (2000)
10.1016/S0168-3659(96)01607-0
Hydrogel beads based on amidated pectins for colon-specific drug delivery: the role of chitosan in modifying drug release
O. Munjeri (1997)
10.1016/S0144-8617(01)00355-1
Production of fungal chitosan by solid state and submerged fermentation
N. Nwe (2002)
10.1002/(SICI)1099-0488(19990715)37:14<1551::AID-POLB1>3.0.CO;2-H
Kinetic study of chitosan-tripolyphosphate complex reaction and acid-resistive properties of the chitosan-tripolyphosphate gel beads prepared by in-liquid curing method
F. Mi (1999)
Swelling properties and mechanical characterization of a semiinterpenetrating chitosan/polyethylene oxide network
M. N. Khalid (1999)
10.1016/J.IJPHARM.2004.11.015
Chitosan-alginate multilayer beads for controlled release of ampicillin.
A. K. Anal (2005)
10.1016/J.EJPS.2004.10.010
Coating alginate microspheres with a serum albumin-alginate membrane: application to the encapsulation of a peptide.
R. Hurteaux (2005)
10.1016/S0144-8617(00)00145-4
Swelling behavior and the release of protein from chitosan–pectin composite particles
K. Chang (2000)
10.1016/S0168-3659(98)00168-0
The potential use of mixed films of pectin, chitosan and HPMC for bimodal drug release.
G. S. Macleod (1999)
10.1002/ELPS.1150130156
Production of mitogen‐contamination free alginates with variable ratios of mannuronic acid to guluronic acid by free flow electrophoresis
U. Zimmermann (1992)
10.1016/S0168-3659(99)00131-5
Effect of degree of quaternization of N-trimethyl chitosan chloride for enhanced transport of hydrophilic compounds across intestinal caco-2 cell monolayers.
M. Thanou (2000)
10.1016/S0168-3659(03)00299-2
Systemic peptide delivery via the stomach: in vivo evaluation of an oral dosage form for salmon calcitonin.
D. Guggi (2003)
10.1080/026520499289176
Release characteristics of chitosan treated alginate beads: II. Sustained release of a low molecular drug from chitosan treated alginate beads.
A. Sezer (1999)
10.1016/J.JCONREL.2004.03.015
Cross-linked alginate-gelatine beads: a new matrix for controlled release of pindolol.
P. Ferreira Almeida (2004)
Sterile microencapsulation of BCG in alginate–poly-L-lysine by an air spraying technique
K. K. Kwok (1989)
10.1002/(SICI)1522-9505(19981001)259:1<13::AID-APMC13>3.0.CO;2-T
Self-dissolving chitosan, I. Preparation, characterization and evaluation for drug delivery system
A. S. Aly (1998)
10.1016/J.JCONREL.2004.05.009
Hydrophobically modified alginate hydrogels as protein carriers with specific controlled release properties.
M. Léonard (2004)
10.1002/POLA.1994.080320702
Swelling kinetics and release characteristic of crosslinked chitosan : polyether polymer network (semi-IPN) hydrogels
K. Yao (1994)
10.1081/DDC-100105182
Bioadhesive Characteristics of Chitosan Microspheres to the Mucosa of Rat Small Intestine
J. Shimoda (2001)
10.1081/DDC-100104314
Chitosan-Alginate Microparticles as a Protein Carrier
G. Coppi (2001)
10.1002/APP.1994.070510810
Hemolglobin encapsulation in chitosan/calcium alginate beads
M. L. Huguet (1994)
10.1016/S0378-5173(02)00553-7
Release of albumin from chitosan-coated pectin beads in vitro.
T. Kim (2003)
10.1016/0142-9612(88)90092-0
Biological activity of chitosan: ultrastructural study.
R. Muzzarelli (1988)
10.1016/J.JCONREL.2003.08.019
Oral colon-specific drug delivery for bee venom peptide: development of a coated calcium alginate gel beads-entrapped liposome.
L. Xing (2003)
10.1016/S0378-5173(98)00017-9
Basic studies on bioadhesive delivery systems for peptide and protein drugs
A. Bernkop-Schnürch (1998)
10.1002/(SICI)1099-0518(20000201)38:3<474::AID-POLA12>3.0.CO;2-B
Preparation and properties of chitosan‐poly(N‐isopropylacrylamide) semi‐IPN hydrogels
Mingzhen Wang (2000)
10.1016/S0928-0987(99)00032-9
Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement.
N. G. Schipper (1999)
Swelling properties and mechanical characterization of a semi-interpenetrating chitosan/polyethylene oxide network : Comparison with a chitosan reference gel
M. Khalid (1999)
10.1016/S0939-6411(03)00061-4
Thiolated polymers: evidence for the formation of disulphide bonds with mucus glycoproteins.
V. Leitner (2003)
10.1023/A:1018901302450
Chitosan as a Novel Nasal Delivery System for Peptide Drugs
L. Illum (2004)
10.1016/0378-5173(93)90241-7
Effect of interpolymer complex formation of chitosan with pectin or acacia on the release behaviour of chlorpromazine HCl
M. Meshali (1993)
10.1016/0378-5173(92)90353-4
In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers
C. Lehr (1992)
10.1016/S0924-2244(99)00017-5
Food applications of chitin and chitosans
F. Shahidi (1999)
10.1002/BIT.260310613
Retention of insulin in alginate gel beads.
C. Gray (1988)
10.1016/S0008-6215(00)90036-3
Monomer sequence and acetylation pattern in some bacterial alginates.
G. Skjåk-Braek (1986)
10.1016/S0039-6060(96)80096-1
Prevention of experimental postoperative peritoneal adhesions by N,O-carboxymethyl chitosan.
R. Kennedy (1996)
10.1002/JPS.2600740407
Bioadhesive polymers as platforms for oral controlled drug delivery II: synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers.
H. S. Ch'ng (1985)
10.1007/978-3-0348-8757-1_22
Microparticulate drug delivery systems.
I. Genta (1999)
10.1080/026520400405660
Lipoinsulin encapsulated alginate-chitosan capsules: intestinal delivery in diabetic rats.
M. Ramadas (2000)
10.1023/A:1018524207224
Chitosan functional properties
R. Shepherd (2004)
in: P
R.A.A. Muzzarelli (1999)
10.1016/S0378-5173(99)00030-7
Effect of chitosan on epithelial permeability and structure.
V. Dodane (1999)
10.1016/J.EJPB.2004.08.002
pH- and temperature-sensitive release behaviors from polyelectrolyte complex films composed of chitosan and PAOMA copolymer.
T. Yoshizawa (2005)
10.3109/10837459809028495
Formulation and characterization of calcium alginate beads containing ampicillin.
M. L. Torre (1998)
10.1271/BBB.59.786
Mechanism for the inhibition of fat digestion by chitosan and for the synergistic effect of ascorbate.
O. Kanauchi (1995)
Biomaterials: Novel Materials from Biological Sources
David ed. Byrom (1991)
10.1016/S0142-9612(00)00154-X
Perivascular graft heparin delivery using biodegradable polymer wraps.
E. Edelman (2000)
A novel pHsensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug
S. C. Chen (2004)
10.1016/J.JCONREL.2004.02.002
A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery.
Sung-Ching Chen (2004)
10.1016/J.AQUACULTURE.2004.02.028
Oral immunization using alginate microparticles as a useful strategy for booster vaccination against fish lactoccocosis
J. Romalde (2004)
Transplantation of minimal volume microcapsules in diabetic highmammalians
R. Calafiore (1999)
10.1081/DDC-120016684
Evaluation of the Mucoadhesive Properties of N-Trimethyl Chitosan Chloride
D. Snyman (2003)
10.1016/S1461-5347(98)00100-X
Macromolecules as safe penetration enhancers for hydrophilic drugs—a fiction?
H. Junginger (1998)
10.1007/978-94-011-5942-5_56
New Forms of Chitosan Polyelectrolyte Complexes
J. Dutkiewicz (1992)
10.1023/B:PHAM.0000012150.60180.e3
Effect of Chitosan on Epithelial Cell Tight Junctions
J. Smith (2004)
10.1023/A:1016188312399
Alginate/Poly-L-Lysine Microparticles for the Intestinal Delivery of Antisense Oligonucleotides
María González Ferreiro (2004)
10.1016/S0032-9592(96)00032-5
Calcium alginate beads coated with chitosan: Effect of the structure of encapsulated materials on their release
M. L. Huguet (1996)
10.1023/A:1016488623022
Mucoadhesive Polymers in Peroral Peptide Drug Delivery. VI. Carbomer and Chitosan Improve the Intestinal Absorption of the Peptide Drug Buserelin In Vivo
H. L. Luessen (2004)
Thiolated polymers–thiomers: modification of chitosanwith 2-iminothiolane
A. B. Schnürch (2003)
10.1007/3-540-26367-5_1
A
A. Spring (2005)
Self-dissolving chitosan: I
A. S. Aly (1998)
Skjåk-Braek, Microcapsules of alginatechitosan: I. A quantitative study of the interaction between alginate and chitosan
O Gåserød (1998)
10.1515/9783111697888-004
B
B. A. R. Kernfach (1824)
10.1016/S0008-6215(00)82430-1
The relative extension of alginates having different chemical composition
O. Smidsrød (1973)
10.3109/02652049609052905
Coating alginate beads with cross-linked biopolymers: a novel method based on a transacylation reaction.
M. C. Levy (1996)
10.1002/JPS.2600830213
Controlled release of albumin from chitosan-alginate microcapsules.
A. Polk (1994)
10.1016/0144-8617(91)90031-7
Comparison of different methods for determination of molecular weight and molecular weight distribution of alginates
A. Martinsen (1991)
10.7326/0003-4819-94-6-826_2
Applied biopharmaceutics and pharmacokinetics
L. Shargel (1980)
10.1016/S0378-5173(98)00027-1
In vitro evaluation of the mucoadhesive properties of chitosan microspheres
P. He (1998)
10.1016/S0378-5173(97)00287-1
Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers
A. Kotzé (1997)
10.1017/9781107588431.010
頚椎部 instability の計測法
見松 健太郎 (1997)
Skjåk-Bræk, Alginate polycation microcapsules: I. Interaction between alginate and polycation, Biomaterials
B.Thu (1996)
10.1016/j.addr.2012.09.007
Protein release from alginate matrices.
Wee (1998)
10.1080/02652040010019578
Evaluation of protein release from chitosan-alginate microcapsules produced using external or internal gelation.
G. Vandenberg (2001)
10.1016/S0168-3659(01)00227-9
Improvement in the mucoadhesive properties of alginate by the covalent attachment of cysteine.
A. Bernkop-Schnürch (2001)
10.1016/S0168-3659(01)00269-3
Drug permeation enhancement via buccal route: possibilities and limitations.
S. Şenel (2001)
10.1016/S0168-3659(01)00517-X
Factors affecting protein release from alginate-chitosan coacervate microcapsules during production and gastric/intestinal simulation.
G. Vandenberg (2001)
10.1097/00007890-199610150-00004
Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts.
P. de Vos (1996)
10.1016/0378-5173(94)00396-M
Drug release from oral mucosal adhesive tablets of chitosan and sodium alginate
S. Miyazaki (1995)
10.1016/0142-9612(95)94149-F
Collagen and its interaction with chitosan. II. Influence of the physicochemical characteristics of collagen.
M. Taravel (1995)
10.1016/S0928-0987(97)10004-5
Bioadhesive drug delivery systems. I. Characterisation of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate.
L. S. Nielsen (1998)
10.1016/S0378-5173(98)00114-8
Pectin/chitosan mixtures as coatings for colon-specific drug delivery: an in vitro evaluation
M. J. Fernández-Hervás (1998)
10.1016/S0376-7388(00)00314-8
Implantable 5-fluorouracil loaded chitosan scaffolds prepared by wet spinning
E. Denkbaş (2000)
10.1016/S0378-5173(98)00277-4
The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan
O. Gåserød (1998)
10.1016/S0142-9612(98)00073-8
Microcapsules of alginate-chitosan--I. A quantitative study of the interaction between alginate and chitosan.
O. Gåserød (1998)
In vitro evaluation of the viscoelastic behavior of chitosan–thioglycolic acid conjugates
M. D. Hornof (2003)
10.1023/A:1016054306763
Preparation and Characterization of Freeze-dried Chitosan-Poly(Ethylene Oxide) Hydrogels for Site-Specific Antibiotic Delivery in the Stomach
V. Patel (2004)
10.1016/S0939-6411(01)00247-8
The release behavior of brilliant blue from calcium-alginate gel beads coated by chitosan: the preparation method effect.
X. Shu (2002)
10.1016/S0939-6411(03)00153-X
Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems.
Cristián Tapia (2004)
Bioadhesive microspheres: I
D. E. Chickering (1995)
10.1007/BF00400922
Microencapsulated islet grafts in the BB/E rat: a possible role for cytokines in graft failure
D. R. Cole (2004)
10.1016/S0939-6411(00)00150-8
In-vitro release kinetics of cefadroxil-loaded sodium alginate interpenetrating network beads.
A. R. Kulkarni (2001)
10.1002/PI.1995.210380110
Investigation of pH‐sensitive drug delivery system of chitosan/gelatin hybrid polymer network
K. Yao (1995)
10.3891/ACTA.CHEM.SCAND.21-0691
Studies on the Sequence of Uronic Acid Residues in Alginic Acid.
A. Haug (1967)
10.1023/A:1015841531372
Production of 5–15 µm Diameter Alginate-Polylysine Microcapsules by an Air-Atomization Technique
K. Kwok (2004)
10.1016/S0168-3659(99)00176-5
Glutaraldehyde crosslinked sodium alginate beads containing liquid pesticide for soil application.
A. R. Kulkarni (2000)
10.1002/APP.1991.070431120
Coated alginate microspheres : factors influencing the controlled delivery of macromolecules
M. Wheatley (1991)
10.1016/0008-6215(90)84231-I
A chitosan oxalate gel: its conversion to an N-acetylchitosan gel via a chitosan gel
S. Hirano (1990)
10.1002/JPS.2600820909
Development of a new drug carrier made from alginate.
M. Rajaonarivony (1993)
10.1023/A:1018963626248
The Controlled Release of Prednisolone Using Alginate Gel
S. Sugawara (2004)
Collagen and
M. N. Taravel (1996)
10.1016/S0378-5173(96)04723-0
Oral controlled release of melatonin using polymer-reinforced and coated alginate beads
B. Lee (1996)
10.1016/S0922-338X(98)80059-7
Microencapsulation of islets in PEG-amine modified alginate-poly(l-lysine)-alginate microcapsules for constructing bioartificial pancreas
J. Chen (1998)
10.1016/s1773-2247(10)50007-8
Thiolated chitosans.
A. Bernkop-Schnürch (2004)
10.3109/02652049809008245
Preparation and tabletting of dipyridamole alginate-Eudragit microspheres.
A. Gürsoy (1998)
10.1021/BK-1977-0048.CH024
Some Biological Functions of Matrix Components in Benthic Algae in Relation to Their Chemistry and the Composition of Seawater
I. Andresen (1977)
10.1211/0022357991772259
Alginate‐Pectin‐Poly‐L‐lysine Particulate as a Potential Controlled Release Formulation
P. Liu (1999)
Investigation of different natural sources of chitin: influence of the source and 13 M
M. Rhazi (2000)
10.1016/J.EJPB.2004.03.023
Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs.
S. M. van der Merwe (2004)
10.1023/A:1018967116988
Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)
P. Artursson (2004)
10.1016/S0378-5173(00)00470-1
Immobilization of antibodies on alginate-chitosan beads.
M. Albarghouthi (2000)
10.1016/0168-3659(95)00146-8
The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III: Effects of chitosan-glutamate and carbomer on epithelial tight junctions in vitro
G. Borchard (1996)
10.1016/0142-9612(96)89663-3
Collagen and its interactions with chitosan, III some biological and mechanical properties.
M. Taravel (1996)
10.1007/PL00000584
Human enzymatic activities related to the therapeutic administration of chitin derivatives
R. Muzzarelli (1997)
10.1016/S0142-9612(03)00213-8
Pectin-based systems for colon-specific drug delivery via oral route.
L. Liu (2003)
10.1016/S0168-3659(03)00262-1
Numerical modelling of insulin and amyloglucosidase release from swelling Ca-alginate beads.
M. Rasmussen (2003)
10.1016/S0928-4931(01)00316-2
Calcium alginate gel-entrapped liposomes
M. Hara (2001)
10.1201/9781482292244-59
____ : ..... '"i-t.-
U. Chatterjee (2001)
10.1016/S0168-3659(98)00044-3
Design and evaluation of chitosan/ethylcellulose mucoadhesive bilayered devices for buccal drug delivery.
C. Remuñán‐López (1998)
10.1038/NBT0497-358
An encapsulation system for the immunoisolation of pancreatic islets
T. Wang (1997)
10.1002/ANIE.197702141
Secondary and Tertiary Structure of Polysaccharides in Solutions and Gels
D. Rees (1977)
10.3891/ACTA.CHEM.SCAND.16-1908
Qunantitative Determination of the Uronic Acid Composition of Alginates.
A. Haug (1962)
10.3797/SCIPHARM.AUT-01-12
Synthesis and In Vitro Evaluation of Chitosan-Thioglycolic Acid Conjugates
A. Bernkop-Schnürch (2001)
Biomedical Applications of Polymeric Materials
T. Tsuruta (1993)
10.1016/S0142-9612(01)00250-2
Effects of aldehydes and methods of cross-linking on properties of calcium alginate microspheres prepared by emulsification.
L. Chan (2002)
10.1016/S0378-5173(03)00201-1
Development and optimisation of alginate-PMCG-alginate microcapsules for cell immobilisation.
G. Orive (2003)
10.1016/S0966-7822(97)00003-8
Swelling of poly-L-lysine and chitosan-coated superswelling sodium-alginate gel beads
M. H. Ottøy (1997)
10.1016/S0144-8617(01)00212-0
Drug release from chitosan–alginate complex beads reinforced by a naturally occurring cross-linking agent
F. L. Mi (2002)
10.1016/S0378-5173(03)00074-7
Influence of chitosan and polycarbophil on permeation of a model hydrophilic drug into the urinary bladder wall.
I. Grabnar (2003)
10.1248/CPB.37.3092
Interaction of Calcium-Induced Alginate Gel Beads with Propranolol
Naoki Segi (1989)
10.1002/JPS.2600740408
Bioadhesive polymers as platforms for oral controlled drug delivery III: oral delivery of chlorothiazide using a bioadhesive polymer.
M. Longer (1985)
10.1002/(SICI)1097-4628(19960314)59:11<1795::AID-APP16>3.0.CO;2-T
Chitosan/calcium–alginate beads for oral delivery of insulin
P. Hari (1996)



This paper is referenced by
PREPARATION AND CHARACTERIZATION OF NITROSOTHIOLS AS NITRIC OXIDE DONORS
K. Antlej (2014)
10.1080/09205063.2020.1803034
Preparation, characterization, and in vitro drug release behaviour of thiolated-alginate nanoparticles loaded budesonide as a potential drug delivery system towards inflammatory bowel diseases.
Muhammad Arif (2020)
10.1016/j.tifs.2020.04.028
Dietary fiber-based colon-targeted delivery systems for polyphenols
Hsi-Yang Tang (2020)
10.1016/j.ijbiomac.2020.07.166
Utilization of different polymers for the improvement of catalytic properties and recycling efficiency of bacterial maltase.
Muhammad Shoib Nawaz (2020)
10.1007/s00253-008-1664-2
Modifications and applications of the Acinetobacter venetianus RAG-1 exopolysaccharide, the emulsan complex and its components
Hanna Dams-Kozłowska (2008)
10.1016/j.foodchem.2012.04.140
Complex coacervation of soybean protein isolate and chitosan.
G. Huang (2012)
Investigation of the in vitro bioavailability of luteolin from modified preparations of Artemisia afra
Anjong Nkengla (2014)
Continuous production of wine in a tower fermentor using entrapped yeast cells in double layer alginate – chitosan beads
Πάνος Δριχούτης (2015)
10.1081/E-EBPP-120050385
Colonic Drug Delivery: Biopolymers and Enteric Polymers
Priscileila Colerato Ferrari (2015)
Application of aquaculture biotechnology to fish reproductive endocrinology
Pablo J Sanchís-Benlloch (2017)
10.4995/Thesis/10251/89094
Different strategies to obtain antimicrobial biodegradable films for food applications, using starch and/or chitosan with or without essential oils
Valencia Sullca (2017)
10.1007/s11581-018-2672-6
Facile synthesis of metal ion-cross-linked alginate electrode for efficient organic dye removal
X. Tao (2018)
Engineering bacteriophage encapsulation processes to improve stability and controlled release using pH responsive formulations
Gurinder K. Vinner (2018)
DEVELOPMENT AND OPTIMIZATION OF CHITOSAN-CA-PECTINATE BEADS OF AMORPHOUS CELECOXIB BY RESPONSE SURFACE METHODOLOGY
Yogesh Dadaji Pawar (2017)
Développement de formulations polymériques de S-nitrosoglutathion comme traitement per os pour prévenir les maladies inflammatoires chroniques de l’intestin
Hui Ming (2017)
FINAL DETERMINATION IN THE MATTER OF
D. G. Gilliland (2009)
A Collagen Cardiac Patch Incorporating Alginate Microparticles Permits the Controlled Release of HGF and IGF-1 to Enhance Cardiac Stem Cell Migration and Proliferation
H. O'Neill (2017)
10.1007/978-3-030-39962-7
Thermal Properties of Bio-based Polymers
M. D. Lorenzo (2019)
10.1002/9781118998922.CH9
Chitosan‐based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers
B. Čalija (2015)
10.1016/j.ijpharm.2015.08.028
Alginate coated chitosan microparticles mediated oral delivery of diphtheria toxoid. Part A. Systematic optimization, development and characterization.
A. Shukla (2015)
Interactions between ß-lactoglobulin and nutraceutical ligands riboflavin, vitamin D₃ and lysozyme : formation, physico-chemical and biological characterization of functional delivery scaffolds
Fatoumata Diarrassouba (2013)
10.1016/j.msec.2017.03.218
Photothermal conversion efficiency and cytotoxic effect of gold nanorods stabilized with chitosan, alginate and poly(vinyl alcohol).
M. Almada (2017)
10.3109/03639045.2012.660950
Development and characterization of coated-microparticles based on whey protein/alginate using the Encapsulator device
G. Hébrard (2013)
10.1016/j.carbpol.2012.06.069
Synthesis of chitosan networks: Swelling, drug release, and magnetically assisted BSA separation using Fe3O4 nanoparticles.
M. Ghaemy (2012)
10.1016/j.jenvman.2018.12.105
Enhanced adsorption of arsenic using calcined alginate bead containing alum sludge from water treatment facilities.
Seunghee Kang (2019)
10.1063/1.4819274
Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications.
Tiantian Kong (2013)
10.1007/s10989-012-9299-7
Orally Administered Therapeutic Peptide Delivery: Enhanced Absorption Through the Small Intestine Using Permeation Enhancers
V. Pillay (2012)
10.3109/1061186X.2012.693499
Strategies for non-invasive delivery of biologics
S. J. Chung (2012)
10.1002/9781118747896.CH2
Challenges of Drug Delivery
P. Wardwell (2014)
10.1016/j.meatsci.2011.06.023
Emulsion properties of pork myofibrillar protein in combination with microbial transglutaminase and calcium alginate under various pH conditions.
G. Hong (2012)
10.1016/j.foodchem.2007.11.047
An innovative method for preparation of acid-free-water-soluble low-molecular-weight chitosan (AFWSLMWC).
W. Yue (2008)
10.1016/j.addr.2013.05.009
Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery.
Chun-Xia Zhao (2013)
See more
Semantic Scholar Logo Some data provided by SemanticScholar