Online citations, reference lists, and bibliographies.
← Back to Search

Mixed Polymeric Micelles For Combination Cancer Chemotherapy Through The Concurrent Delivery Of Multiple Chemotherapeutic Agents.

Y. Bae, Thomas A Diezi, A. Zhao, G. Kwon
Published 2007 · Medicine, Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
As a novel drug nanocarrier for combination delivery of multiple anticancer agents, mixed polymeric micelles were developed and characterized in this study. A DNA-damaging anthracycline agent doxorubicin (DOX) and a phosphatidylinositol-3 kinase inhibitor wortmannin (WOR) were conjugated alone or combination onto poly(ethylene glycol)-poly(aspartate hydrazide) block copolymers through a hydrazone bond. Polymer-drug conjugates assembled into a unimodal micelle structure with a <100 nm particle size, in which the drug mixing ratios between DOX/WOR were precisely controlled. Cytotoxicity assay against a human breast cancer MCF-7 cell line showed that drug nanocarrier based on mixed polymeric micelles can reduce DOX required for cytotoxicity while maintaining the biological activity of the independent polymeric micelles. It is postulated that WOR enhances the efficacy of DOX through an efficient combination delivery accompanied by synergistic drug action. These findings, therefore, bring an effective drug delivery methodology that might reduce the effective dose as well as toxicity in vivo compared to the conventional drug formulations.
This paper references
10.1146/ANNUREV.BIOCHEM.70.1.535
Synthesis and function of 3-phosphorylated inositol lipids.
B. Vanhaesebroeck (2001)
10.1038/nrc1958
Polymer conjugates as anticancer nanomedicines
R. Duncan (2006)
10.1073/pnas.0611660104
Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-β signaling
M. Kano (2007)
10.1038/nrc1893
Drug penetration in solid tumours
A. Minchinton (2006)
10.1016/0168-3659(94)90237-2
Improved synthesis of adriamycin-conjugated poly (ethylene oxide)-poly (aspartic acid) block copolymer and formation of unimodal micellar structure with controlled amount of physically entrapped adriamycin
M. Yokoyama (1994)
Reconstitution of caspase 3 sensitizes MCF-7 breast cancer cells to doxorubicin- and etoposide-induced apoptosis.
X. Yang (2001)
10.1039/B500266D
Multifunctional polymeric micelles with folate-mediated cancer cell targeting and pH-triggered drug releasing properties for active intracellular drug delivery.
Y. Bae (2005)
10.1021/BC0498166
Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property: tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy.
Y. Bae (2005)
10.1016/S0939-6411(00)00075-8
HPMA copolymer-anticancer drug conjugates: design, activity, and mechanism of action.
J. Kopeček (2000)
10.1128/MCB.16.4.1722
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.
M. Wymann (1996)
10.1021/BC00016A007
Preparation of micelle-forming polymer-drug conjugates.
M. Yokoyama (1992)
In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin.
R. Schultz (1995)
10.1002/ANIE.200462960
Polymer therapeutics designed for a combination therapy of hormone-dependent cancer.
M. Vicent (2005)
10.1016/0168-3659(93)90172-2
Block copolymer micelles as vehicles for drug delivery
Kataoka Kazunori (1993)
10.1016/S1097-2765(05)00089-4
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine.
E. Walker (2000)
10.1039/B504418A
Chemistry and biology of wortmannin.
P. Wipf (2005)
10.1016/J.BBRC.2005.12.039
Inhibition of the PI3 kinase/Akt pathway enhances doxorubicin-induced apoptotic cell death in tumor cells in a p53-dependent manner.
Yusuke Fujiwara (2006)
10.1073/pnas.0530118100
Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin
Amani Zewail (2003)
10.1016/J.JCONREL.2004.02.012
Thermal characterization of poly(ethylene glycol)-poly(D,L-lactide) block copolymer micelles based on pyrene excimer formation.
Eduardo Jule (2004)
10.1038/nrc1887
Drug interactions in cancer therapy
C. Scripture (2006)
10.1002/ANIE.200250653
Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change.
Y. Bae (2003)
10.1016/S0168-3659(97)00237-X
Delivery of molecular and cellular medicine to solid tumors.
Jain (1997)
10.1016/S0169-409X(02)00015-7
Poly(ethylene oxide)-block-poly(L-amino acid) micelles for drug delivery.
A. Lavasanifar (2002)
Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics.
J. Sparano (1999)
10.1016/J.PHARMTHERA.2006.05.006
Current state, achievements, and future prospects of polymeric micelles as nanocarriers for drug and gene delivery.
N. Nishiyama (2006)
10.1158/1535-7163.MCT-06-0084
Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases
K. S. Smalley (2006)
10.1016/0005-2787(80)90073-8
The interaction of daunorubicin and doxorubicin with DNA and chromatin.
F. Zunino (1980)



This paper is referenced by
10.33588/RN.5805.2013314
Afecciones neurológicas y barrera hematoencefálica. Limitaciones y estrategias para la liberación de fármacos al cerebro
Alazne Domínguez (2014)
10.1039/C5TB00576K
A polymer-(multifunctional single-drug) conjugate for combination therapy.
Dongfang Zhou (2015)
NANOTRANSPORTERS FOR ANTICANCER DRUG DELIVERY
P. Kopel (2015)
A novel approach to formulation of anticancer drugs in nanoparticles
X. Gu (2008)
10.1007/s11094-015-1204-1
Synthesis of a Polymeric Doxorubicin Derivative and its Evaluation Using IR and UV Spectroscopy
Ol’ga V. Zhukova (2015)
10.1016/j.ijbiomac.2018.07.198
Amphiphilic graft copolymeric micelle using dextrin and poly (N-vinyl caprolactam) via RAFT polymerization: Development and application.
A. L. Pal (2018)
10.3109/10717544.2010.520355
In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel
Jizhu Liu (2011)
10.1016/j.jconrel.2010.10.027
Materializing sequential killing of tumor vasculature and tumor cells via targeted polymeric micelle system.
Y. Wang (2011)
10.1007/s11095-013-1060-1
Brushed Block Copolymer Micelles with pH-Sensitive Pendant Groups for Controlled Drug Delivery
H. Lee (2013)
10.1201/B11620-5
Polyethylene Glycol Polyester Block Copolymers: Biocompatible Carriers for Nanoparticulate Drug Delivery
Dan Peer (2012)
TITLE:A REVIEW ON NANOPARTICLES: TINY SOLDIERS FOR GIANT TUMORS
Nikita Vinodbhai Khetani (2016)
10.1016/J.PROGPOLYMSCI.2015.11.002
WITHDRAWN: Polymer assembly: Promising carriers as co-delivery systems for cancer therapy
Nuannuan Li (2015)
10.1016/j.jconrel.2008.01.018
Polymeric micelles in oral chemotherapy.
L. Bromberg (2008)
10.1021/acsnano.6b00900
Nanomedicines Eradicating Cancer Stem-like Cells in Vivo by pH-Triggered Intracellular Cooperative Action of Loaded Drugs.
Hiroaki Kinoh (2016)
Diblock Copolymers for Magnetically Triggered Drug Delivery Systems
S. M. Nikles (2010)
10.1039/c5bm00002e
Trigger responsive polymeric nanocarriers for cancer therapy.
Shahdeep Kaur (2015)
Formation of nanostructured biomaterials in lab-on-a-chip microsystems
L. Capretto (2011)
10.1016/j.actbio.2012.05.022
Cerasomal doxorubicin with long-term storage stability and controllable sustained release.
Y. Jin (2012)
10.1021/mp200243k
Polymeric nanoparticles with precise ratiometric control over drug loading for combination therapy.
S. Aryal (2011)
10.1016/J.PROGPOLYMSCI.2014.07.009
Polyphophazenes as anti-cancer drug carriers: From synthesis to application
M. Akram (2014)
10.2147/IJN.S2824
Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy
Xiang-hong Peng (2008)
10.1002/mabi.200800248
Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery.
Ozana Onaca (2009)
10.1007/s11095-011-0470-1
Polymer Micelles with Hydrazone-Ester Dual Linkers for Tunable Release of Dexamethasone
Melissa D. Howard (2011)
10.1088/0957-4484/26/14/145101
Combination chemotherapy of doxorubicin, all-trans retinoic acid and low molecular weight heparin based on self-assembled multi-functional polymeric nanoparticles.
T. Zhang (2015)
10.1007/978-1-4614-2305-8_7
Polymeric Micelles for Multiple-Drug Delivery
G. Kwon (2012)
10.1016/j.carbpol.2013.12.069
Augmenting protein release from layer-by-layer functionalized agarose hydrogels.
Daniel A Lynam (2014)
10.3109/10717544.2012.724473
Long-circulating PEG-PE micelles co-loaded with paclitaxel and elacridar (GG918) overcome multidrug resistance
Can Sarisozen (2012)
10.1039/C6RA20437F
PTX encapsulated by an XG–DOX conjugate for combination therapy against multi-drug resistance
Zhuli Huang (2016)
POLYMER MICELLES FOR TUNABLE DRUG RELEASE AND ENHANCED ANTITUMOR EFFICACY
Andrei Ponta (2013)
10.1007/978-3-319-11355-5_16
Polymeric Micelles in Targeted Drug Delivery
Rayasa S. Ramachandra Murthy (2015)
10.1016/B978-0-323-42863-7.00013-X
Nanotechnology for cancer therapy
Kalyani Chimajirao Patil (2016)
10.1007/s40005-016-0252-1
Nanoparticle-based combination drug delivery systems for synergistic cancer treatment
J. Choi (2016)
See more
Semantic Scholar Logo Some data provided by SemanticScholar