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CO2 Assisted Deposition Of R/S-ibuprofen On Different Porous Carrier Materials: Influence Of Carrier Properties On Loading And Dissolution Behavior

Sarah Reiser, M. Shaban, A. Weber, M. Türk
Published 2018 · Materials Science

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Abstract With regard to bioavailability of poorly water-soluble drugs a big goal in research is to improve their dissolution behavior in the gastrointestinal tract. One suitable way to enhance the bioavailability is the use of drug loaded carrier materials. However, the effect of carrier properties such as specific surface area, pore size and pore volume on the dissolution of drugs is not well known yet. To investigate this, carrier materials with defined properties were produced by Salt Assisted Spray Pyrolysis (SASP) and loaded with racemic ibuprofen by the Controlled Particle Deposition (CPD) process. Their loadings and dissolution rates were compared to those of MCM-41 and SBA-15. It was found that the ibuprofen loading on the SASP carrier materials is lower due to their smaller specific surface areas, whereas their dissolution rates were higher in comparison to CPD processed MCM-41 and SBA-15. Furthermore, it was observed that pore size and pore volume influence the loading capacity of carrier materials. Wider mesopores lead to multilayer formation where crystalline ibuprofen structures were detected by XRD analysis. N2-adsorption/desorption experiments at T  = 77 K on the CPD processed carriers lead to the assumption that the small mesopores of MCM-41 or SBA-15 were occupied by ibuprofen due to the shift of the typical capillary condensation step at p/p0 = 0.3–0.4 (untreated material) towards lower relative pressures of the CPD processed carriers.
This paper references
Reporting physisorption data for gas/solid systems with special reference to the determination of surface area and porosity (Recommendations 1984)
K. S. Sing (1985)
Direct drug loading into preformed porous solid dosage units by the controlled particle deposition (CPD), a new concept for improved dissolution using SCF-technology.
R. Wischumerski (2008)
The thermodynamic dissociation constants of four non-steroidal anti-inflammatory drugs by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration data.
M. Meloun (2007)
Adsorptive removal of selected pharmaceuticals by mesoporous silica SBA-15.
T. Bui (2009)
Aerosol Process for the In Situ Coating of Nanoparticles with a Polymer Shell
Jalal Poostforooshan (2014)
Physicochemical aspects of fluid extraction
G. Schneider (1983)
Preparation of borneol–methyl-β-cyclodextrin inclusion complex by supercritical carbon dioxide processing
Jun He (2009)
Gas Antisolvent Recrystallization: New Process To Recrystallize Compounds Insoluble in Supercritical Fluids
P. Gallagher (1989)
A novel strategy to design sustained-release poorly water-soluble drug mesoporous silica microparticles based on supercritical fluid technique.
Wang Li-hong (2013)
Supercritical and near-critical CO2 in green chemical synthesis and processing
E. Beckman (2004)
Synthesis of Spherical Carbon Nitride-Based Polymer Composites by Continuous Aerosol-Photopolymerization with Efficient Light Harvesting.
Jalal Poostforooshan (2016)
A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability
G. Amidon (2004)
Amorphization of drugs by adsorptive precipitation from supercritical solutions: A review
P. Gurikov (2018)
Charakterisierung von schwerlöslichen Arzneistoff-Nanopartikeln hergestellt durch das RESS-Verfahren zur Verbesserung der Bioverfügbarkeit
H. Martin (2003)
Advanced experimental analysis of drying kinetics in spray drying
I. Zbiciński (2002)
Production of micro- and nano-composite particles by supercritical carbon dioxide
M. Bahrami (2007)
Manufacture of submicron drug particles with enhanced dissolution behaviour by rapid expansion processes
M. Türk (2009)
Stabilized amorphous state of ibuprofen by co-spray drying with mesoporous SBA-15 to enhance dissolution properties.
Shoucang Shen (2010)
Influence of chemical nature of carrier materials on the dissolution behavior of racemic ibuprofen
Sarah Reiser (2018)
Surface-initiated polymerization on unmodified inorganic semiconductor nanoparticles via surfactant-free aerosol-based synthesis toward core–shell nanohybrids with a tunable shell thickness
M. Shaban (2017)
Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO2
M. Türk (2009)
Nanoparticles production by supercritical antisolvent precipitation: A general interpretation
E. Reverchon (2007)
Characterization of Ketoprofen/Methyl-β-Cyclodextrin Complexes Prepared Using Supercritical Carbon Dioxide
M. Banchero (2013)
Preparation of controlled release nanodrug ibuprofen supported on mesoporous silica using supercritical carbon dioxide
M. Ni (2012)
Facile synthesis of cauliflower-like hydrophobically modified polyacrylamide nanospheres by aerosol-photopolymerization
M. Shaban (2016)
Aerosol synthesis of nanoporous silica particles with controlled pore size distribution
L. Zeng (2014)
Powder generation from polyethyleneglycols with compressible fluids
E. Weidner (1996)
Utilization of supercritical carbon dioxide for complex formation of ibuprofen and methyl-beta-cyclodextrin.
M. Charoenchaitrakool (2002)
Use of supercritical fluid technology for the production of tailor-made aerogel particles for delivery systems
C. García-González (2013)
Physisorption of gases, with special reference to the evaluation of surface area and pore size distribution (IUPAC Technical Report)
M. Thommes (2015)
Spectroscopy of polymer/drug formulations processed with supercritical fluids: in situ ATR-IR and Raman study of impregnation of ibuprofen into PVP.
S. G. Kazarian (2002)
Phase equilibria of organic solid solutes and supercritical fluids with respect to the RESS process
A. Diefenbacher (2002)
Ibuprofen loading into mesostructured silica using liquid carbon dioxide as a solvent
A. Hillerström (2009)
Strategies to Address Low Drug Solubility in Discovery and Development
H. Williams (2013)
Modeling and comparison of dissolution profiles.
P. Costa (2001)
Functional Nanostructured Silica Powders Derived from Colloidal Suspensions by Sol Spraying
F. Iskandar (2001)
Freezing behavior in porous glasses and MCM-41
M. Śliwińska-Bartkowiak (2001)
Synthesis of Single Crystalline ZnO Nanoparticles by Salt-Assisted Spray Pyrolysis
C. Panatarani (2003)
Preparation of novel whey protein-based aerogels as drug carriers for life science applications
M. Betz (2012)
Synthesis of CeO2 nanoparticles by salt-assisted ultrasonic aerosol decomposition
B. Xia (2001)
Particle design using supercritical fluids: Literature and patent survey
Jennifer Jung (2001)
High pressure micronization for food applications
E. Weidner (2009)
The role of salt in nanoparticle generation by salt-assisted aerosol method : Microstructural changes
S. Lee (2007)
Ibuprofen impregnation into submicron polymeric films in supercritical carbon dioxide
Yazan A. Hussain (2012)
Formation of submicron poorly water-soluble drugs by rapid expansion of supercritical solution (RESS): Results for Naproxen
M. Türk (2010)
Ibuprofen-Cyclodextrin Inclusion Complex Formation using Supercritical Carbon Dioxide
Y. Tozuka (2006)
A Standardized Mini Paddle Apparatus as an Alternative to the Standard Paddle
S. Klein (2008)
Complex formation of Ibuprofen and β-Cyclodextrin by controlled particle deposition (CPD) using SC-CO2
M. Türk (2007)
Synthesis of Nanoporous Metal Oxide Particles by a New Inorganic Matrix Spray Pyrolysis Method
S. Kim (2002)
Comparative Evaluation of Ibuprofen/β-Cyclodextrin Complexes Obtained by Supercritical Carbon Dioxide and Other Conventional Methods
K. Hussein (2006)
Micronization of Pharmaceutical Substances by Rapid Expansion of Supercritical Solutions (RESS): Experiments and Modeling
M. Türk (2002)
Effects of Morphology and Structural Characteristics of Ordered SBA-15 Mesoporous Silica on Release of Ibuprofen
Zhengwei Jin (2010)
Aerosol-assisted synthesis of magnetic mesoporous silica spheres for drug targeting
E. Ruiz-Hernandez (2007)
Influence of pore size of MCM-41 matrices on drug delivery rate
P. Horcajada (2004)
Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications.
Y. Kawabata (2011)
Enhancement of dissolution rate of poorly-soluble active ingredients by supercritical fluid processes. Part I: Micronization of neat particles.
M. Perrut (2005)
Application of dense gas techniques for the production of fine particles
N. Foster (2008)
The Effect of Selected Water-Soluble Excipients on the Dissolution of Paracetamol and Ibuprofen
L. R. Shaw (2005)
Micronization by Rapid Expansion of Supercritical Solutions to Enhance the Dissolution Rates of Poorly Water-Soluble Pharmaceuticals
M. Charoenchaitrakool (2000)

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