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Formulation Of Thymoquinone Loaded Chitosan Nano Vesicles: In-vitro Evaluation And In-vivo Anti-hyperlipidemic Assessment

Aljoufi Fakhria, S. J. Gilani, S. S. Imam, Chandrakala
Published 2019 · Chemistry

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Abstract The present research work was planned to formulate and characterize Thymoquinone (TMQ) loaded chitosan vesicle (CHVs) for the effective treatment of the liver disorder. The formulations were prepared using solvent evaporation and probe sonication method. The formulation (F3) with appropriate characteristics (size = 372.8 nm; zeta potential = 13.12 mV; encapsulation efficiency = 81.38 ± 3.85%; PDI = 0.192 ± 0.015) was selected as optimized thymoquinone chitosan vesicle (TMQCHVopt). The stability study results revealed the non-significant changes in vesicle size, PDI, and encapsulation efficiency. The formulation showed higher drug release (85.11% ± 4.12) and followed Higuchi release mechanism. TMQCHVopt showed significant enhancement in mucoadhesive property (4.4 times) and intestinal permeation (1.9 times) vis-a-vis TMQ suspension. The enhancement in permeation was further confirmed by CLSM study and result supports the permeation result. The pharmacodynamic results exhibited a significant (*P
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