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Chemistry Of Fluoroalkyl-substituted 1,2,3-triazoles

B. I. Usachev
Published 2018 · Chemistry

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Abstract This review is devoted to the chemistry of fluoroalkyl-substituted 1,2,3-triazoles: their synthesis and chemical properties. Synthesis of C-fluoroalkyl-substituted 1,2,3-triazoles and N-fluoroalkyl-substituted 1,2,3-triazoles is considered. C-Fluoroalkyl-substituted 1,2,3-triazoles can be prepared via 1,3-dipolar cycloaddition, cyclizations of RF-vinyl azides, deoxyfluorination of alcohols, transformation of CO into CF2H, transformation of CO2H into CF3, electrophilic α-fluorination of 4/5-alkyl-1,2,3-triazoles, and using other methods. N-Fluoroalkyl-substituted 1,2,3-triazoles can be prepared via N-difluoromethylation of 1,2,3-triazoles, their N-trifluoromethylation with Togni’s reagent, N-fluoroalkylation with haloethylenes, using 1,3-dipolar cycloaddition and other methods. Fluoroalkyl-substituted 1,2,3-triazoles are chemically reactive substances, and they can be used as building-blocks for the preparation of medicinally and biologically beneficial compounds.
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