A Simple Approach To Design Chitosan Functionalized Fe3O4 Nanoparticles For PH Responsive Delivery Of Doxorubicin For Cancer Therapy
Mahesh G Adimoolam, Narsireddy Amreddy, Madhusudana Rao Nalam, Manorama V. Sunkara
Published 2018 · Physics
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Abstract The use of magnetic nanoparticles (MNPs) in cancer therapy offer many advantages due to their unique size, physical and biocompatible properties. In this study we have developed a formulation, comprising of anti-cancer drug doxorubicin (Dox) conjugated to iron oxide nanoparticles via a pH sensitive imine linker. Different amounts of chitosan functionalized superparamagnetic iron oxide nanoparticles (Fe3O4-CHI) were synthesized in-situ by a simple hydrolysis method at room temperature. The synthesized nanoparticles were well characterized by TEM, Zeta Potential, TOC, XPS, TGA and VSM for their physicochemical properties. Dox was conjugated to the Fe3O4-CHI nanoparticles via a glutaraldehyde cross linker with the imine ( C N ) bond, which is sensitive to cleavage in the pH range of 4.4–6.4. The synthesized Fe3O4-Dox nanoparticles exhibited enhanced drug release in lower pH conditions which mimics the tumor microenvironment or intracellular organelles such as endosomes/lysosomes. The cell uptake and therapeutic efficacy of Fe3O4-Dox nanoparticles carried out in ovarian cancer cell (SK-OV-3) and breast cancer cell line (MCF7) showed improved therapeutic efficacy of Dox by nearly four-fold with Fe3O4-Dox nanoparticles.
This paper references
A novel fluorometric detection of Cu(2+) based on self-assembled bilayers.
Xiang-ying Sun (2004)
Folate receptor targeted, carboxymethyl chitosan functionalized iron oxide nanoparticles: a novel ultradispersed nanoconjugates for bimodal imaging.
Dipsikha Bhattacharya (2011)
Sequence-dependent synergy of the proteasome inhibitor bortezomib and cytarabine in mantle cell lymphoma
Oliver Weigert (2007)
Editorial: Recent advances and new challenges of occupational and environmental health of nanotechnology
C. James Tsai (2009)
Magnetic forces enable controlled drug delivery by disrupting endothelial cell-cell junctions
Yongzhi Qiu (2017)
In situ preparation of high relaxivity iron oxide nanoparticles by coating with chitosan: A potential MRI contrast agent useful for cell tracking
Zei-Tsan Tsai (2010)
Newly Engineered Magnetic Erythrocytes for Sustained and Targeted Delivery of Anti-Cancer Therapeutic Compounds
Caterina Cinti (2011)
A Simple Approach to the Design and Functionalization of Fe3O4–Au Nanoparticles for Biomedical Applications
A. H. N. Reddy (2012)
Drug Delivery Systems: Entering the Mainstream
Theresa M. Allen (2004)
Biomedical Applications of Advanced Multifunctional Magnetic Nanoparticles.
Nguyễn Việt Long (2015)
Hybrid Nanostructures Containing Sulfadiazine Modified Chitosan as Antimicrobial Drug Carriers
B. Munteanu (2016)
Fast and safe fabrication of a free-standing chitosan/alginate nanomembrane to promote stem cell delivery and wound healing
Yi Kong (2016)
Doxorubicin delivered to MCF-7 cancer cells by superparamagnetic iron oxide nanoparticles: effects on subcellular distribution and cytotoxicity
Emilie Munnier (2011)
Chitosan-Based Particles as Controlled Drug Delivery Systems
Mani Prabaharan (2005)
Nucleophilic cross-linked, dextran coated iron oxide nanoparticles as basis for molecular imaging: synthesis, characterization, visualization and comparison with previous product.
R. Borny (2015)
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems.
Oktay Tacar (2013)
pH-Controlled reversible assembly and disassembly of gold nanorods.
Zhenhua Sun (2008)
Synthesis, characterization and MRI application of dextran-coated Fe3O4 magnetic nanoparticles
R. Y. Hong (2008)
Polymer-Drug Nanoparticles Combine Doxorubicin Carrier and Heparin Bioactivity Functionalities for Primary and Metastatic Cancer Treatment.
Ling Mei (2017)
Magnetic nanocarriers of doxorubicin coated with poly(ethylene glycol) and folic acid: relation between coating structure, surface properties, colloidal stability, and cancer cell targeting.
Karine Kaaki (2012)
Thermal and magnetic properties of chitosan-iron oxide nanoparticles.
Paula Poli Soares (2016)
A practical glucose biosensor based on Fe(3)O(4) nanoparticles and chitosan/nafion composite film.
Liuqing Yang (2009)
Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology.
Jinwoo Cheon (2008)
Evaluation of different strategies for magnetic particle functionalization with DNA aptamers.
Elena Pérez-Ruiz (2016)
Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications.
Aziliz Hervault (2016)
Amperometric Hydrogen Peroxide Biosensor Based on Horseradish Peroxidase Immobilized on Fe3O4/Chitosan Modified Glassy Carbon Electrode
Xuecai Tan (2009)
A pH-responsive prodrug delivery system of 10-HCPT for controlled release and tumor targeting
Yang Liu (2017)
Chitosan magnetic nanoparticles for drug delivery systems
Farnaz Assa (2017)
Synthesis of chitosan-stabilized gold nanoparticles in the absence/presence of tripolyphosphate.
Haizhen Huang (2004)
A Simple Method To Construct Bifunctional Fe3O4/Au Hybrid Nanostructures and Tune Their Optical Properties in the Near-Infrared Region
Yang Wang (2010)
Tumor-targeted and pH-controlled delivery of doxorubicin using gold nanorods for lung cancer therapy
Narsireddy Amreddy (2015)
Superparamagnetic iron oxide nanoparticles coated with different polymers and their MRI contrast effects in the mouse brains
Songbo Xie (2015)
Enhancement of magnetofection efficiency using chitosan coated superparamagnetic iron oxide nanoparticles and calf thymus DNA.
Z. Sohrabijam (2017)
Chemical modification of chitosan by phosphorylation: an XPS, FT-IR and SEM study
I. Amaral (2005)
Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery
Xuân Núi Phạm (2016)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
Ajay Kumar Gupta (2005)
Functionalization of iron oxide nanoparticles with biosurfactants and biocompatibility studies.
Jeyabalan Sangeetha (2013)
XPS study of Fe(II)-Fe(III) (oxy)hydroxycarbonate green rust compounds
Martine Mullet (2008)
Development of high efficacy peptide coated iron oxide nanoparticles encapsulated amphotericin B drug delivery system against visceral leishmaniasis.
Rajendra Kumar (2017)
Light-induced release of DNA from gold nanoparticles: nanoshells and nanorods.
Ryan Huschka (2011)
Doxorubicin conjugated gold nanoparticles as water-soluble and pH-responsive anticancer drug nanocarriers
Santosh Aryal (2009)
Poly(N-isopropylacrylamide) hydrogel/chitosan scaffold hybrid for three-dimensional stem cell culture and cartilage tissue engineering.
A. Mellati (2016)
Synthesis optimization and characterization of chitosan-coated iron oxide nanoparticles produced for biomedical applications
Gozde Unsoy (2012)
Release of Doxorubicin by a Folate-Grafted, Chitosan-Coated Magnetic Nanoparticle
Chung-Lin Yang (2017)
Immobilization of Pycnoporus sanguineus laccase on magnetic chitosan microspheres
Desheng Jiang (2005)
Organic-inorganic hybrid nanoparticles controlled delivery system for anticancer drugs.
Antonio Di Martino (2017)
X-ray photoelectron spectroscopy and atomic force microscopy studies on crosslinked chitosan thin film
Wing Fen Yap (2011)
Nanoscale assembly of amine functionalized colloidal iron oxide.
K. C. Barick (2009)
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An investigation on synthesis of Fe3O4@nSiO2@mSiO2 hybrid particles and peroxidation
Yanji Zhu (2019)
Magnetic MCM-41 nanoparticles as support for the immobilization of organometallic catalyst of palladium and its application in C-C coupling reactions
Bahman Tahmasbi (2019)
Thermosensitive magnetoliposome – Novel carrier for targeted delivery and triggered release of coix seed oil
Jingxia Zheng (2020)
Stimuli-responsive hybrid cluster bombs of PEGylated chitosan encapsulated DOX-loaded superparamagnetic nanoparticles enabling tumor-specific disassembly for on-demand drug delivery and enhanced MR imaging.
Pengwei Xie (2019)
In Vitro and In Vivo Assessment of Designed Melphalan Loaded Stealth Solid Lipid Nanoparticles for Parenteral Delivery
V.S.A. Pavan Rudhrabatla (2020)
Study of iron oxide magnetic nanoparticles obtained via pulsed laser ablation of iron in air
Valery A. Svetlichnyi (2018)
Environmental impacts of oil spills and their remediation by magnetic nanomaterials
Harpreet Singh (2020)
Preparation of chitosan-based nanoparticles for enzyme immobilization.
Deqiang Wang (2019)
Magnetic iron oxide nanoparticles for drug delivery: applications and characteristics
Thomas Vangijzegem (2019)
Chitosan-based nanotherapeutics for ovarian cancer treatment
Leila Alizadeh (2019)
Covalent immobilization of doxorubicin in glycine functionalized hydroxyapatite nanoparticles for pH-responsive release
Gunjan Verma (2018)
Enhanced saturation magnetization and stability of magnetic nanofluids based on FeCo@CoFe2O4 nanoparticles
Rongzhang Guan (2019)
In silico study on core-shell pseudodendrimeric glycoside structures in drug delivery related usages
Rahim Ghadari (2019)
A pH-sensitive delivery system based on N-succinyl chitosan-ZnO nanoparticles for improving antibacterial and anticancer activities of curcumin.
Seyed-Behnam Ghaffari (2020)
A review of small molecules and drug delivery applications using gold and iron nanoparticles
Hossein Jahangirian (2019)
The influence of carboxylate moieties for efficient loading and pH-controlled release of doxorubicin in Fe3O4 magnetic nanoparticles
Endang Saepudin (2020)
Supported organometallic palladium catalyst into mesoporous channels of magnetic MCM-41 nanoparticles for phosphine-free CC coupling reactions
Arash Ghorbani-Choghamarani (2019)
Horizons of nanotechnology applications in female specific cancers.
Balney Rajitha (2019)
Sonosynthesis and characterization of a fluorescent Trojan Horse based on magnetic nanoparticles
D. Reyman (2020)