Online citations, reference lists, and bibliographies.
← Back to Search

Characterization Of Sodium Phenytoin Co-gelled With Titania For A Controlled Drug-release System

T. López, P. Quintana, E. Ortiz-Islas, Ekaterina P. Vinogradova, J. Manjarrez, D. Aguilar, P. Castillo-Ocampo, C. Magaña, J. A. Azamar
Published 2007 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Sodium phenytoin, C 15 H 11 N 2 NaO 2 , in several concentrations was co-gelled with titania (TiO 2 ), by a sol-gel process. This technique is a promising method to encapsulate several drugs, in this case, phenytoin is an anticonvulsant used to control epileptic seizures. Samples were prepared by adding different concentrations (X=50, 100, 200 and 250 mg per 20 g of titania matrix) of sodium phenytoin (Ph) to a solution of titanium n-butoxide. The resulting titania-Ph-X materials were characterized by transmission electron microscopy (TEM), Fourier transformed infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and Brunauer-Emmet-Teller (BET) surface areas. The porous nanomaterials showed a wide range of particle size, from 10 to 210 nm, with a mean pore diameter of 5 nm. X-ray diffraction showed an amorphous structure of the prepared samples.
This paper references
Effect of the crystallite size in the structural and textural properties of sulfated and phosphated titania
E. Ortiz-Islas (2005)
Characterization and biocompatibility of organogels based on L-alanine for parenteral drug delivery implants.
A. Motulsky (2005)
Drug delivery to the central nervous system: a review.
A. Misra (2003)
Targeted drug delivery for brain cancer treatment.
R. Gutman (2000)
Development of a simple method for the preparation of a silica gel based controlled delivery system with a high drug content.
K. Ohta (2005)
Transient interstitial fluid flow in brain tumors: Effect on drug delivery
Chee Seng Teo (2005)
Colloidal carriers and blood-brain barrier (BBB) translocation: a way to deliver drugs to the brain?
E. García-García (2005)
Sol-gel synthesis of a multifunctional, hierarchically porous silica/apatite composite.
Jenny Andersson (2005)
Effect of sulfation on the photoactivity of TiO2 sol–gel derived catalysts
R. Gómez (2003)
Pharmacokinetics, tissue distribution and bioavailability of clozapine solid lipid nanoparticles after intravenous and intraduodenal administration.
K. Manjunath (2005)
Macroporous interconnected dextran scaffolds of controlled porosity for tissue-engineering applications.
S. Lévesque (2005)
An implantable sol-gel derived titania-silica carrier system for the controlled release of anticonvulsants
T. López (2006)
Polymeric micelles for the solubilization and delivery of cyclosporine A: pharmacokinetics and biodistribution.
H. M. Aliabadi (2005)
Study of the sodium phenytoin effect on the formation of sol–gel SiO2 nanotubes by TEM
T. Lopez (2005)
Complement activation and protein adsorption by carbon nanotubes.
Carolina Salvador-Morales (2006)
Application of nanoparticles for the delivery of drugs to the brain
J. Kreuter (2005)
Brain drug delivery technologies: novel approaches for transporting therapeutics.
Temsamani (2000)
The intracerebral administration of phenytoin using controlled-release polymers reduces experimental seizures in rats
R. Tamargo (2002)

This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar