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Thermo-responsive Copolymer Coated MnFe2O4 Magnetic Nanoparticles For Hyperthermia Therapy And Controlled Drug Delivery

S. Shah, M. H. Asdi, M. U. Hashmi, M. F. Umar, S. U. Awan
Published 2012 · Materials Science

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Abstract This study is about multifunctional magnetic nanoparticles surface-modified with bilayer oleic acid, and coated with a thermo-responsive copolymer poly(N-isopropylacrylamide-co-acrylamide) by emulsion polymerization, for controlled drug delivery and magnetic hyperthermia applications. Nanoparticles were loaded with anticancer drug doxorubicin into the copolymer chains at 25 °C. Composite nanoparticles (hydrated) of average diameter 45 nm were of core–shell structure having magnetic core of about 18 nm and shell was composed of organic compounds and water. Magnetic core was superparamagnetic lacking coercive force and remanance due to the pseudo-single domain nanostructure. Lower critical solution temperature (LCST) of the thermo-responsive copolymer was observed to be around 39 °C. Below this temperature, copolymer was hydrophilic, hydrated and swelled. But above LCST, copolymer became hydrophobic, dehydrated and shrank in volume. UV visible spectrophotometer was used to investigate the drug loading and releasing profile at different temperatures as well as under magnetic heating. There was almost absence of drug release at around 37 °C (normal body temperature). Drug was released at temperatures above LCST, which is significant for controlled drug delivery. Magnetic heat-generation was studied by exposing the magnetic fluid to alternating magnetic field of 7.2 kA m−1 having frequency 70 kHz. A simple magnetic capturing system (simulating a blood vessel) was used to analyze the capturing of magnetic nanoparticles under various applied fields for drug targeting purpose.
This paper references
Hydrogels for biomedical applications.
A. Hoffman (2002)
Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery.
Challa S. S. R. Kumar (2011)
A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide-based nanoparticles for conjugation with cell targeting agents.
N. Kohler (2004)
Magnetic mesoporous silica spheres for hyperthermia therapy.
F. Martín-Saavedra (2010)
Cytotoxicity and cell signalling induced by continuous mild hyperthermia in freshly isolated mouse hepatocytes.
M. J. Santos-Marques (2006)
Summary, conclusions and recommendations: adverse temperature levels in the human body
L. Goldstein (2003)
An overview of the structure and magnetism of spinel ferrite nanoparticles and their synthesis in microemulsions
Daliya S. Mathew (2007)
Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system
T. Neuberger (2005)
Thermo- and pH-responsive polymers in drug delivery.
D. Schmaljohann (2006)
Poly(N-isopropylacrylamide): experiment, theory and application
H. G. Schild (1992)
Magnetic drug-targeting carrier encapsulated with thermosensitive smart polymer: core-shell nanoparticle carrier and drug release response.
J. Zhang (2007)
Incorporation and in vitro release of doxorubicin in thermally sensitive micelles made from poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide)-b-poly(D,L-lactide-co-glycolide) with varying compositions.
S. Liu (2005)
A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides.
R. Suto (1995)
Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery.
Ron (1998)
Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly(N-isopropylacrylamide) hydrogels.
D. Coughlan (2004)
Radiosensitivity and recovery from radiation damage in cultured CHO cells exposed to hyperthermia at 42.5 or 45.5 degrees C.
G. Raaphorst (1979)
Magnetic Hyperthermia for Cancer Treatment
M. U. Hashmi (2012)
Effect of aligning magnetic field on the magnetic and calorimetric properties of ferrimagnetic bioactive glass ceramics for the hyperthermia treatment of cancer
S. Shah (2011)
Remotely Triggered Release from Magnetic Nanoparticles
Austin M. Derfus (2007)
Magnetic and bioactivity evaluation of ferrimagnetic ZnFe2O4 containing glass ceramics for the hyperthermia treatment of cancer
S. Shah (2010)
Study of an anisotropic ferrimagnetic bioactive glass ceramic for cancer treatment
S. Shah (2010)
The cellular and molecular basis of hyperthermia.
B. Hildebrandt (2002)
Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications.
A. Gupta (2005)
Design of carboxylated Fe3O4/poly(styrene-co-acrylic acid) ferrofluids with highly efficient magnetic heating effect
T. Luong (2011)
Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery.
S. Sershen (2000)
Preparation and characterization of temperature-responsive magnetic composite particles for multi-modal cancer therapy
A. Yao (2011)
Thermoresponsive core-shell magnetic nanoparticles for combined modalities of cancer therapy.
S. Purushotham (2009)

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FeMn2O4 nanoparticles coated dual responsive temperature and pH-responsive polymer as a magnetic nano-carrier for controlled delivery of letrozole anti-cancer
M. Amoli-Diva (2017)
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Neda Akhlaghi (2020)
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Jahanzeb Khan (2018)
Intrinsic dependence of the magnetic properties of CoFe2O4 nanoparticles prepared via chemical methods with addition of chelating agents
E. C. Mendonça (2015)
Multifunctional Polymeric Platform of Magnetic Ferrite Colloidal Superparticles for Luminescence, Imaging, and Hyperthermia Applications.
Z. Iatridi (2016)
Dual-responsive polymer coated superparamagnetic nanoparticle for targeted drug delivery and hyperthermia treatment.
S. Patra (2015)
Synergetic Effect of Calcium Doping on Catalytic Activity of Manganese Ferrite: DFT Study and Oxidation of Hydrocarbon
Zahoor Iqbal (2020)
Induction heating and in vitro cytotoxicity studies of MnZnFe2O4 nanoparticles for self-controlled magnetic particle hyperthermia
S. Jadhav (2018)
Synthesis and characterization of polymer-coated manganese ferrite nanoparticles as controlled drug delivery
G. Wang (2018)
Radiofrequency-Triggered Drug Release from Nanoliposomes with Millimeter-Scale Resolution Using a Superimposed Static Gating Field.
J. Liu (2018)
Chapter 10 – Tumor-Targeted Therapy
Mohan Pauliah (2018)
Low-temperature combustion synthesis of cobalt magnesium ferrite magnetic nanoparticles: effects of fuel-to-oxidizer ratio and sintering temperature
C. Ehi-Eromosele (2015)
Fabrication and potential application of a di-functional magnetic system: magnetic hyperthermia therapy and drug delivery
B. Shen (2016)
Magnetic nanoparticles and nanocomposites for remote controlled therapies.
Anastasia K. Hauser (2015)
Facile and green synthesis of cobalt oxide nanoparticles using ethanolic extract of Trigonella foenumgraceum (Fenugreek) leaves
Neda Akhlaghi (2020)
Reversible multistimuli-responsive manganese–zinc ferrite/P(NIPAAM-AAc-AAm) core-shell nanoparticles: A programmed ferrogel system
A. H. Monfared (2019)
Water Transfer of Hydrophobic Nanoparticles: Principles and Methods
M. Branca (2014)
Effect of Cu2+ doping on structural, morphological, optical and magnetic properties of MnFe2O4 particles/sheets/flakes-like nanostructures
J. J. Vijaya (2015)
Nanoparticles in biomedical applications
K. McNamara (2017)
Emulsion-based techniques for encapsulation in biomedicine, food and personal care.
M. Kakran (2014)
Extraction, preconcentration and spectrometric determination of Al (III) and Cr (III) ions using modified MnFe2O4 nanoparticles as an efficient adsorbent
Kamyar Pourghazi (2017)
Nanoengineered Injectable Hydrogels for On-Demand and Localized Therapeutic Delivery
Nima A. Jalili (2016)
Doxorubicin-loaded photosensitive magnetic liposomes for multi-modal cancer therapy.
S. Shah (2016)
Magnetic mesoporous silica nanoparticles coated with thermo-responsive copolymer for potential chemo- and magnetic hyperthermia therapy
Z. Tian (2018)
Effect of surface functionalization on the heating efficiency of magnetite nanoclusters for hyperthermia application
Molongnenla Jamir (2021)
Silica coated LSMO magnetic nanoparticles for the pH-Responsive delivery of 5-Fluorouracil anticancer drug
C. O. Ehi-Eromosele (2017)
Enhanced specific absorption rate of bi-magnetic nanoparticles for heating applications
M. Hammad (2017)
Synthesis, Magneto-structural Properties and Colloidal Stability Studies of Ni0.3Zn0.7Fe2O4 Nanoparticles Coated with Pluronic P123 Block Copolymer for Potential Biomedical Applications
C. Ehi-Eromosele (2018)
Inorganic nanomaterials as delivery systems for proteins, peptides, DNA, and siRNA
M. Malmsten (2013)
Recent advancements in manganite perovskites and spinel ferrites based magnetic nanoparticles for biomedical theranostic applications.
G. Kandasamy (2019)
Stimuli-responsive poly(N-isopropyl acrylamide)-co-tyrosine@gadolinium: Iron oxide nanoparticle-based nanotheranostic for cancer diagnosis and treatment.
E. Roy (2016)
Silica coated LSMO magnetic nanoparticles for the pH-Responsive delivery of 5-Fluorouracil anticancer drug
C. O. Ehi-Eromoselea (2017)
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