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Mammalian Mitochondrial Nucleoids: Organizing An Independently Minded Genome.

I. Holt, J. He, Chih-Chieh Mao, Jerome D Boyd-Kirkup, P. Martinsson, H. Sembongi, A. Reyes, J. N. Spelbrink
Published 2007 · Biology, Medicine

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Mitochondrial DNA is arranged in nucleoprotein complexes, or nucleoids. Nucleoid proteins include not only factors involved in replication and transcription but also structural proteins required for mitochondrial DNA maintenance. Although several nucleoid proteins have been identified and characterized in yeast over the course of the past decade, little was known of mammalian mitochondrial nucleoids until recently. Two publications in the past year have expanded considerably the pool of putative mammalian mitochondrial nucleoid proteins; and analysis of one of the candidates, ATAD3p, suggests that mitochondrial nucleoid formation and division are orchestrated, not random, events.
This paper references
10.1146/ANNUREV.GENET.38.072902.091252
Plasmid segregation mechanisms.
G. Ebersbach (2005)
10.1074/jbc.M604501200
Human Mitochondrial DNA Nucleoids Are Linked to Protein Folding Machinery and Metabolic Enzymes at the Mitochondrial Inner Membrane*
Yousong Wang (2006)
mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases.
C. Moraes (1991)
10.1128/.180.23.6424-6428.1998
Role of the C terminus of FtsK in Escherichia coli chromosome segregation.
X. Yu (1998)
10.1038/sj.emboj.7601392
Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand
T. Yasukawa (2006)
10.1126/SCIENCE.289.5480.782
Role of adenine nucleotide translocator 1 in mtDNA maintenance.
J. Kaukonen (2000)
10.1083/jcb.200306132
A function for the mitochondrial chaperonin Hsp60 in the structure and transmission of mitochondrial DNA nucleoids in Saccharomyces cerevisiae
Brett A. Kaufman (2003)
10.1126/SCIENCE.1106391
Aconitase Couples Metabolic Regulation to Mitochondrial DNA Maintenance
X. Chen (2005)
10.1128/MCB.8.8.3496
Purification and characterization of human mitochondrial transcription factor 1.
R. P. Fisher (1988)
10.1091/MBC.E02-07-0399
Composition and dynamics of human mitochondrial nucleoids.
N. Garrido (2003)
10.1016/J.YEXCR.2004.10.013
Detection of mitochondrial DNA depletion in living human cells using PicoGreen staining.
Neil Ashley (2005)
10.1093/HMG/DDH342
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number.
H. Tyynismaa (2004)
10.1038/NG0398-231
Mitochondrial transcription factor A is necessary for mtDNA maintance and embryogenesis in mice
N. Larsson (1998)
10.1038/nrg1708
The organization and inheritance of the mitochondrial genome
X. Chen (2005)
10.1073/PNAS.92.14.6562
Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.
D. Dunbar (1995)
10.1074/mcp.M300035-MCP200
Protein Components of Mitochondrial DNA Nucleoids in Higher Eukaryotes*
D. Bogenhagen (2003)
10.1046/j.1365-2958.1998.00986.x
FtsK is a bifunctional protein involved in cell division and chromosome localization in Escherichia coli
G. Liu (1998)
10.1002/(SICI)1521-1878(200006)22:6<564::AID-BIES9>3.0.CO;2-4
No sex please, we're mitochondria: a hypothesis on the somatic unit of inheritance of mammalian mtDNA.
H. T. Jacobs (2000)
10.1038/90058
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria
J. N. Spelbrink (2001)
10.1038/ng1769
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A. Bender (2006)
10.1016/0092-8674(82)90049-6
Replication of animal mitochondrial DNA
D. Clayton (1982)
10.1186/1741-7007-2-9
The functional organization of mitochondrial genomes in human cells
F. Iborra (2003)
10.1038/ng1765
MPV17 encodes an inner mitochondrial membrane protein and is mutated in infantile hepatic mitochondrial DNA depletion
A. Spinazzola (2006)
10.1093/NAR/GKG251
Human mitochondrial DNA is packaged with TFAM.
Tanfis Istiaq Alam (2003)
10.1016/J.MOLCEL.2005.05.002
A bidirectional origin of replication maps to the major noncoding region of human mitochondrial DNA.
T. Yasukawa (2005)
10.1128/MCB.5.5.1163
Ethidium bromide-induced loss of mitochondrial DNA from primary chicken embryo fibroblasts.
Paul R. E. Desjardins (1985)
10.1073/PNAS.74.4.1348
Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication.
M. Albring (1977)
10.1038/ng1778
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Y. Kraytsberg (2006)
10.1242/jcs.01134
Organization and dynamics of human mitochondrial DNA
Frédéric Legros (2004)
10.1111/J.1567-1364.2006.00132.X
The helicase CaHmi1p is required for wild-type mitochondrial DNA organization in Candida albicans.
Priit Jõers (2007)
Mutational bisection of the mitochondrial DNA stability and amino acid biosynthetic functions of ilv5p of budding yeast.
J. M. Bateman (2002)
10.1093/emboj/19.4.767
The numbers of individual mitochondrial DNA molecules and mitochondrial DNA nucleoids in yeast are co‐regulated by the general amino acid control pathway
D. MacAlpine (2000)
10.1083/jcb.200609158
The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization
J. He (2007)
10.1038/nrm1684
AAA+ proteins: have engine, will work
P. Hanson (2005)
10.1038/331717A0
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
I. Holt (1988)
10.1016/0022-2836(78)90269-3
Mechanism of mitochondrial DNA replication in mouse L-cells: kinetics of synthesis and turnover of the initiation sequence.
D. Bogenhagen (1978)
10.1038/nature02517
Premature ageing in mice expressing defective mitochondrial DNA polymerase
A. Trifunović (2004)
10.1093/HMG/6.8.1251
Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background.
I. Holt (1997)
10.1083/JCB.145.2.291
Mgm101p Is a Novel Component of the Mitochondrial Nucleoid That Binds DNA and Is Required for the Repair of Oxidatively Damaged Mitochondrial DNA
Shelly Meeusen (1999)
10.1074/jbc.M308028200
Mammalian Mitochondrial DNA Replicates Bidirectionally from an Initiation Zone*
Mark Bowmaker (2003)
10.1073/PNAS.140063197
In organello formaldehyde crosslinking of proteins to mtDNA: identification of bifunctional proteins.
B. A. Kaufman (2000)
10.1093/NAR/20.18.4913
The 66 kDa component of yeast SFI, stimulatory factor I, is hsp60.
J. Smiley (1992)
10.1126/SCIENCE.2814477
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.
M. P. King (1989)



This paper is referenced by
10.3233/JPB-140127
Mitochondrial disease during infancy and childhood
R P Saneto (2016)
10.1371/journal.pone.0187516
Expanded repertoire of kinetoplast associated proteins and unique mitochondrial DNA arrangement of symbiont-bearing trypanosomatids
Silvana Sant Anna de Souza (2017)
10.1016/j.exger.2014.03.027
In D-loop: 40years of mitochondrial 7S DNA
T. Nicholls (2014)
10.1007/978-3-319-28637-2_1
An Introduction to Mitochondria, Their Structure and Functions
Eve M. Simcox (2016)
10.1093/nar/gkt988
Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication
Nina Rajala (2014)
10.1016/j.bbagen.2012.09.021
Death receptors and mitochondria: two prime triggers of neural apoptosis and differentiation.
S. Solá (2013)
Disturbances in mitochondrial DNA maintenance in neuromuscular disorders and valproate-induced liver toxicity
Tuomas Komulainen (2015)
10.1007/978-1-59745-521-3_7
Inducible expression in human cells, purification, and in vitro assays for the mitochondrial DNA helicase Twinkle.
S. Goffart (2009)
10.17863/CAM.17440
Defining the cellular and molecular mechanism of maternally inherited hearing loss
P. Kullar (2018)
10.1016/j.fob.2012.06.001
The manner in which DNA is packaged with TFAM has an impact on transcription activation and inhibition
R. Furukawa (2012)
10.1074/jbc.M708444200
The Layered Structure of Human Mitochondrial DNA Nucleoids*
D. Bogenhagen (2008)
10.1007/978-81-322-2172-2_20
Plant Mitochondrial Omics: State-of-the-Art Knowledge
Mustafa Malik Ghulam (2015)
10.1371/journal.pgen.1008923
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases
A. Reyes (2020)
Fisiopatología mitocondrial en la sepsis experimental: papel de la óxido nítrico sintasa mitocondrial constitutiva y la melatonina
Ortíz García (2013)
10.1074/jbc.M111.307512
Mgm101 Is a Rad52-related Protein Required for Mitochondrial DNA Recombination*
MacMillan Mbantenkhu (2011)
10.1016/j.jprot.2009.06.011
Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS.
N. Lefort (2009)
10.1073/pnas.1109263108
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
Christian Kukat (2011)
10.1016/j.cell.2011.06.051
The Human Mitochondrial Transcriptome
T. Mercer (2011)
10.1016/j.biochi.2013.09.017
To be or not to be a nucleoid protein: a comparison of mass-spectrometry based approaches in the identification of potential mtDNA-nucleoid associated proteins.
F. Hensen (2014)
10.7275/HRP5-5Q82
Analysis of the spatiotemporal localization of mitochondrial DNA polymerases in Trypanosoma brucei
Jeniffer Concepcon-Acevedo (2012)
10.1042/BST20160162
Mitochondrial DNA replication: a PrimPol perspective
L. Bailey (2017)
10.7363/050215
Introduction to embryonic and adult neural stem cells: from the metabolic circuits of the niches to the metabolome
M. Marcialis (2016)
10.1093/nar/gkr208
Coordinated regulation of mitochondrial topoisomerase IB with mitochondrial nuclear encoded genes and MYC
G. Zoppoli (2011)
10.1016/j.yexcr.2010.10.008
Human mitochondrial transcription factor A is required for the segregation of mitochondrial DNA in cultured cells.
K. Kasashima (2011)
10.2353/ajpath.2008.071163
Expression and maintenance of mitochondrial DNA: new insights into human disease pathology.
G. Shadel (2008)
Cytochrome c Oxidase from Rhodobacter sphaeroides: Oligomeric Structure in the Phospholipid Bilayer and the Structural and Functional Effects of a C-Terminal Truncation in Subunit III
Teresa L. Cvetkov (2010)
10.1371/journal.pone.0054799
Atad3 Function Is Essential for Early Post-Implantation Development in the Mouse
Tobias Goller (2013)
10.1016/j.siny.2011.04.011
Mitochondrial DNA mutations and depletion in pediatric medicine.
A. Spinazzola (2011)
10.2147/IJN.S2482
The mitochondrial genome, a growing interest inside an organelle
Marco Crimi (2008)
loop strands and complete mtDNA replication
Dusanka Milenkovic (2013)
10.1016/j.arr.2015.03.003
DAMPs activating innate immune responses in sepsis
J. Kang (2015)
MECHANISMS AND EFFECTS OF MITOCHONDRIAL DNA INSTABILITY AND COPY NUMBER MANIPULATION
E. Ylikallio (2011)
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