Online citations, reference lists, and bibliographies.
← Back to Search

Multiple RNA Surveillance Pathways Limit Aberrant Expression Of Iron Uptake MRNAs And Prevent Iron Toxicity In S. Cerevisiae.

Albert Lee, A. Henras, G. Chanfreau
Published 2005 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Tight regulation of the expression of mRNAs encoding iron uptake proteins is essential to control iron homeostasis and avoid intracellular iron toxicity. We show that many mRNAs encoding iron uptake or iron mobilization proteins are expressed in iron-replete conditions in the absence of the S. cerevisiae RNase III ortholog Rnt1p or of the nuclear exosome component Rrp6p. Extended forms of these mRNAs accumulate in the absence of Rnt1p or of the 5'-->3' exonucleases Xrn1p and Rat1p, showing that multiple degradative pathways contribute to the surveillance of aberrant forms of these transcripts. RNase III-deficient cells are hypersensitive to high iron concentrations, suggesting that Rnt1p-mediated RNA surveillance is required to prevent iron toxicity. These results show that RNA surveillance through multiple ribonucleolytic pathways plays a role in iron homeostasis in yeast to avoid the potentially toxic effects of the expression of the iron starvation response in iron-replete conditions.
This paper references
Iron regulation of triosephosphate isomerase transcript stability in the yeast Saccharomyces cerevisiae.
K. Krieger (1994)
Iron regulation of triosephosphate somerase transcript stability in the yeast
K. rieger (1994)
RNase III Cleaves Eukaryotic Preribosomal RNA at a U3 snoRNP-Dependent Site
Sherif Abou Elela (1996)
RNase III cleaves Biol. Chem
Abou Elela (1996)
RNase III cleaves
S. Abou Elela (1996)
Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.
J. Schlegl (1997)
Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively
A. Johnson (1997)
Rat1p and Xrn1p are functionally interhangeable exoribonucleases that are restricted to and required in he nucleus and cytoplasm
A. W. ohnson (1997)
Yeast RNase III as a key processing enzyme in small nucleolar RNAs metabolism.
G. Chanfreau (1998)
Processing of a dicistronic small nucleolar RNA precursor by the RNA endonuclease Rnt1
Guillaume Chanfreau (1998)
rocessing of a dicistronic small nucleolar RNA precursor by the NA endonuclease Rnt1
G. hanfreau (1998)
Functions of the exosome in rRNA, snoRNA and snRNA synthesis
C. Allmang (1999)
Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast
A. van Hoof (2000)
Desferrioxamine-mediated Iron Uptake in Saccharomyces cerevisiae
C. Yun (2000)
Recognition of a conserved class of RNA tetraloops by Saccharomyces cerevisiae RNase III.
G. Chanfreau (2000)
Siderophore-Iron Uptake in Saccharomyces cerevisiae
C. Yun (2000)
Recognition of conserved class of RNA tetraloops by Saccharomyces cerevisiae
G. hanfreau (2000)
A novel family of RNA tetraloop structure forms the recognition site for Saccharomyces cerevisiae RNase III
H. Wu (2001)
Three Cell Wall Mannoproteins Facilitate the Uptake of Iron in Saccharomyces cerevisiae *
O. Protchenko (2001)
In vivo site-directed mutagenesis using oligonucleotides
F. Storici (2001)
Release of U18 snoRNA from its host intron requires interaction of Nop1p with the Rnt1p endonuclease
C. Giorgi (2001)
The Yeast Gene MSC2, a Member of the Cation Diffusion Facilitator Family, Affects the Cellular Distribution of Zinc*
L. Li (2001)
A second iron-regulatory system in yeast independent of Aft1p
J. Rutherford (2001)
Release of 18 snoRNA from its host intron requires interaction of Nop1p with he Rnt1p endonuclease
C. iorgi (2001)
Transition metal transport in yeast.
Anthony Van Ho (2002)
The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake.
C. Philpott (2001)
The response to iron deprivation in Accepted: May 20, 2005 Saccharomyces cerevisiae: expression of siderophore-based sys- Published: June 30, 2005 tems of iron uptake
C C Philpott (2002)
RNAse III-mediated degradation of unspliced pre-mRNAs and lariat introns.
Michal Danin-Kreiselman (2003)
Mfold web server for nucleic acid folding and hybridization prediction
M. Zuker (2003)
A Cytosolic Domain of the Yeast Zrt1 Zinc Transporter Is Required for Its Post-translational Inactivation in Response to Zinc and Cadmium*
R. Gitan (2003)
Induction of the ZRC1 Metal Tolerance Gene in Zinc-limited Yeast Confers Resistance to Zinc Shock*
C. MacDiarmid (2003)
Aft1p and Aft2p Mediate Iron-responsive Gene Expression in Yeast through Related Promoter Elements*
J. Rutherford (2003)
The Snf1 Protein Kinase Controls the Induction of Genes of the Iron Uptake Pathway at the Diauxic Shift in Saccharomyces cerevisiae*
V. Haurie (2003)
The roles of endonucleolytic cleavage and exonucleolytic digestion in the 5'-end processing of S. cerevisiae box C/D snoRNAs.
C. Y. Lee (2003)
RNAse II-mediated degradation of unspliced pre-mRNAs and lariat inrons
M. anin-Kreiselman (2003)
Induction f the ZRC1 metal tolerance gene in zinc-limited yeast confers reistance to zinc shock
C. W. acDiarmid (2003)
The yeast Rat1 exonuclease promotes transcription termination by RNA polymerase II
M. Kim (2004)
Balancing Acts Molecular Control of Mammalian Iron Metabolism
M. Hentze (2004)
Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae.
M. Shakoury-Elizeh (2003)
Transcription of the Yeast Iron Regulon Does Not Respond Directly to Iron but Rather to Iron-Sulfur Cluster Biosynthesis*
O. Chen (2004)
A cotranscriptional model for 3'-end processing of the Saccharomyces cerevisiae pre-ribosomal RNA precursor.
A. Henras (2004)
Intergenic transcription is required to repress the Saccharomyces cerevisiae SER3 gene
J. Martens (2004)
Intergenic trancription is required to repress the Saccharomyces cerevisiae ER 3 gene
J. A. artens (2004)
This work was also Intergenic tran- NIH grant GM61518 to G.C. scription is required to repress the Saccharomyces cerevisiae SER3 gene
Nization Postdoctoral Fellowship (2004)
Coordinated Remodeling of Cellular Metabolism during Iron Deficiency through Targeted mRNA Degradation
Sergi Puig (2005)
UCLA Microarray Core Facility for help with subsequent experiiae

This paper is referenced by
An Internal Promoter Drives the Expression of a Truncated Form of CCC1 Capable of Protecting Yeast from Iron Toxicity
Catarina Amaral (2021)
Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties
S. Dyshlovoy (2020)
The Paf1 Complex Broadly Impacts the Transcriptome of Saccharomyces cerevisiae
M. Ellison (2019)
A new pathway of pre-tRNA surveillance in yeast
Matthew J. Payea (2019)
The Paf1 complex broadly impacts the transcriptome of Saccharomyces cerevisiae
M. Ellison (2019)
In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation
A. K. Gillingham (2019)
Regulation of mammalian IRE1α : co-chaperones and their importance
Niko Amin-Wetzel (2018)
The secret life of kinases: insights into non-catalytic signalling functions from pseudokinases.
A. Jacobsen (2017)
Interplay Between DNA-Binding/Catalytic Functions and Oligomerization of Retroviral Integrases Studied by a Combination of Time-Resolved Fluorescence Anisotropy, Fluorescence Correlation Spectroscopy and Resonance Energy Transfer
O. Delelis (2016)
The contribution of Saccharomyces cerevisiae cap binding complex to small nuclear and small nucleolar RNA processing
S. Szczepaniak (2016)
Potato dehydrins present high intrinsic disorder and are differentially expressed under ABA and abiotic stresses
S. Charfeddine (2017)
Transcriptome Wide Annotation of Eukaryotic RNase III Reactivity and Degradation Signals
Jules Gagnon (2015)
Repression of the Low Affinity Iron Transporter Gene FET4
Soraia M. Caetano (2015)
Cellular sensing and transport of metal ions: implications in micronutrient homeostasis.
A. Bird (2015)
The functional role of peroxiredoxin 3 in reactive oxygen species, apoptosis, and chemoresistance of cancer cells
Lianqin Li (2015)
Stress-Induced Nuclear RNA Degradation Pathways Regulate Yeast Bromodomain Factor 2 to Promote Cell Survival
K. Roy (2014)
The RNA exosome affects iron response and sensitivity to oxidative stress.
Borislava Tsanova (2014)
An evolutionarily conserved RNase‐based mechanism for repression of transcriptional positive autoregulation
Elisabeth J. Wurtmann (2014)
Iron content of Saccharomyces cerevisiae cells grown under iron-deficient and iron-overload conditions.
Gregory P Holmes-Hampton (2013)
Novel Repression Mechanisms for Metal Transport Genes in Saccharomyces cerevisiae
Camille R. Nery (2013)
RNA polymerase I stability couples cellular growth to metal availability.
Yueh-Jung Lee (2013)
Recruitment of Tup 1 p and Cti 6 p regulates heme-deficient expression of Aft 1 p target genes
R. J. Crisp (2013)
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress
H. Whitaker (2013)
Post-Transcriptional Regulation of Iron Homeostasis in Saccharomyces cerevisiae
M. Martínez-Pastor (2013)
The Role of the Yap5 Transcription Factor in Remodeling Gene Expression in Response to Fe Bioavailability
C. Pimentel (2012)
Rat1 and Xrn2: The Diverse Functions of the Nuclear Rat1/Xrn2 Exonuclease.
Michal Krzyszton (2012)
Regulation of conditional gene expression by coupled transcription repression and RNA degradation
M. Lavoie (2011)
Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease.
R. Teasdale (2012)
Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation
Defne E. Egecioglu (2011)
RNA-dependent regulation of the cell wall stress response
M. Catala (2012)
Sphingolipid signaling mediates iron toxicity.
Yueh-Jung Lee (2012)
Air proteins control differential TRAMP substrate specificity for nuclear RNA surveillance.
Karyn M. Schmidt (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar