Please confirm you are human (Sign Up for free to never see this)
← Back to Search
Constrained Nucleoside Analogues – Crystal And Molecular Structure Of 6,5′-O-anhydrouridines Fixed In The Anti Conformation
Published 2015 · Chemistry
Abstract A series of analogues of anhydrouridine have been synthesized and their crystal structures established using X-ray diffraction. For all cases, the ribose ring has O(4′)-exo, C(4′)-endo pucker and the pyrimidine base is in the anti conformation. Investigated compounds crystallize in different crystal systems (monoclinic, orthorhombic), have different space group symmetry ( P 2 1 , P 2 1 2 1 2 1 ) and exhibit different intermolecular interactions (halogen and hydrogen bonds) among molecules in their crystal lattices. Moreover, in the case of the 5-benzyl-6,5′- O -anhydrouridine a significant positional disorder is present with the phenyl rings existing in two orientations.