Online citations, reference lists, and bibliographies.
← Back to Search

Cellular Toxicity Of Inorganic Nanoparticles: Common Aspects And Guidelines For Improved Nanotoxicity Evaluation

S. Soenen, Pilar Rivera-Gil, J. Montenegro, W. Parak, S. Smedt, K. Braeckmans
Published 2011 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
Summary The safe use of inorganic nanoparticles (NPs) in biomedical applications remains an unresolved issue. The present review presents an overview of the cytotoxic effects of commonly used inorganic NPs: quantum dots, gold and iron oxide nanoparticles. The main focus is on presenting recent findings and identifying similar cytotoxic effects which appear common to all these NPs. Next, several considerations are provided for optimizing cell–NP interaction studies which could aid in improving our understanding of NP toxicity. Finally, several critical NP parameters are discussed and suggestions are made on how to optimize NP design in view of minimal cytotoxicity.
This paper references
10.1039/B402025A
Magnetic nanoparticle design for medical diagnosis and therapy
S. Mornet (2004)
10.1038/nmat2442
Understanding biophysicochemical interactions at the nano-bio interface.
A. Nel (2009)
10.1016/j.phrs.2010.01.009
Nanopharmacy: Inorganic nanoscale devices as vectors and active compounds.
Pilar Rivera Gil (2010)
10.1002/jbm.a.32972
Superparamagnetic iron oxide nanoparticles change endothelial cell morphology and mechanics via reactive oxygen species formation.
K. Buyukhatipoglu (2011)
10.1016/J.BIOMATERIALS.2007.01.043
Nanotoxicity of iron oxide nanoparticle internalization in growing neurons.
T. R. Pisanic (2007)
10.1289/ehp.8284
A Toxicologic Review of Quantum Dots: Toxicity Depends on Physicochemical and Environmental Factors
R. Hardman (2006)
10.1021/nl103264u
Sizing nanomatter in biological fluids by fluorescence single particle tracking.
K. Braeckmans (2010)
10.1016/j.taap.2009.03.009
Nuclear penetration of surface functionalized gold nanoparticles.
Yanjuan Gu (2009)
10.1002/SMLL.200600218
Evaluation of quantum dot cytotoxicity based on intracellular uptake.
E. Chang (2006)
10.1186/1471-2121-11-22
Functional investigations on human mesenchymal stem cells exposed to magnetic fields and labeled with clinically approved iron nanoparticles
R. Schaefer (2009)
10.1016/j.biomaterials.2010.06.051
Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods.
Y. Qiu (2010)
10.1002/anie.200906927
Gold nanorods in photodynamic therapy, as hyperthermia agents, and in near-infrared optical imaging.
Wen-Shuo Kuo (2010)
10.1016/S0958-1669(02)00282-3
Luminescent quantum dots for multiplexed biological detection and imaging.
W. Chan (2002)
10.1016/J.NANO.2007.03.005
Cell selective response to gold nanoparticles.
H. K. Patra (2007)
10.1021/nn901392m
Quantifying the cellular uptake of antibody-conjugated Au nanocages by two-photon microscopy and inductively coupled plasma mass spectrometry.
L. Au (2010)
10.1002/wnan.58
Characterization of nanomaterials for toxicity assessment.
C. Sayes (2009)
10.1002/smll.200800199
Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles and nanoparticle aggregates.
B. Díaz (2008)
10.1002/anie.200901566
Highly water-dispersible biocompatible magnetite particles with low cytotoxicity stabilized by citrate groups.
J. Liu (2009)
10.1002/smll.201000528
Quantitative evaluation of cellular uptake and trafficking of plain and polyethylene glycol-coated gold nanoparticles.
C. Brandenberger (2010)
10.1148/RADIOL.2293021215
Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging.
A. Arbab (2003)
10.1007/s11095-010-0260-1
PEG-Functionalized Magnetic Nanoparticles for Drug Delivery and Magnetic Resonance Imaging Applications
Murali M Yallapu (2010)
10.1021/ES8023385
Quantum dot weathering results in microbial toxicity.
S. Mahendra (2008)
10.1002/smll.200901158
Effect of surface properties on nanoparticle-cell interactions.
Ayush Verma (2010)
10.1002/wnan.62
Probing dynamic fluorescence properties of single and clustered quantum dots toward quantitative biomedical imaging of cells.
Hyeonggon Kang (2010)
10.1021/BC049951I
Toxicity of gold nanoparticles functionalized with cationic and anionic side chains.
Catherine M Goodman (2004)
10.1016/J.TOXLET.2006.09.007
CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals.
W. Chan (2006)
10.2217/17435889.4.2.177
Magnetoliposomes: versatile innovative nanocolloids for use in biotechnology and biomedicine.
S. Soenen (2009)
10.1002/JBM.A.31682
Solubilization and bioconjugation of QDs and their application in cell imaging.
Hai-qiao Wang (2008)
10.1016/j.biomaterials.2010.08.075
Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling.
Stefaan J.H. Soenen (2011)
10.1016/j.taap.2008.09.030
Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line.
N. Monteiro-Riviere (2009)
10.1007/s00109-004-0629-x
Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots
Jasmina Lovrić (2004)
10.1021/nl8022498
Tailored magnetic nanoparticles for direct and sensitive detection of biomolecules in biological samples.
A. Fornara (2008)
10.1146/annurev.publhealth.031308.100155
Potential health impact of nanoparticles.
Tian-dong Xia (2009)
10.1038/nnano.2007.260
Intrinsic peroxidase-like activity of ferromagnetic nanoparticles.
Lizeng Gao (2007)
10.1016/j.biomaterials.2009.03.040
Addressing the problem of cationic lipid-mediated toxicity: the magnetoliposome model.
S. Soenen (2009)
10.1039/b711069c
Chemical sensing and imaging with metallic nanorods.
C. Murphy (2008)
10.3109/17435390903471463
Gold nanoparticles cellular toxicity and recovery: Effect of size, concentration and exposure time
T. Mironava (2010)
10.1021/NL047996M
Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles.
C. Kirchner (2005)
10.1021/nn901884d
Spatiotemporal temperature distribution and cancer cell death in response to extracellular hyperthermia induced by gold nanorods.
Huang-Chiao Huang (2010)
10.1021/ja8040477
Oxidative quenching and degradation of polymer-encapsulated quantum dots: new insights into the long-term fate and toxicity of nanocrystals in vivo.
M. C. Mancini (2008)
10.1021/nl801323y
In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR.
L. Mortensen (2008)
10.1016/j.biomaterials.2008.07.025
The biocompatibility of quantum dot probes used for the targeted imaging of hepatocellular carcinoma metastasis.
Liang-dong Chen (2008)
10.1021/nn101557e
Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response.
G. Maiorano (2010)
10.1021/nn1025687
Correlating physico-chemical with toxicological properties of nanoparticles: the present and the future.
Pilar Rivera Gil (2010)
10.1007/s00109-007-0274-2
Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells
A. Choi (2007)
10.1289/ehp.11566
Acute Toxicity and Prothrombotic Effects of Quantum Dots: Impact of Surface Charge
J. Geys (2008)
10.1002/NBM.991
Labeling of cells with ferumoxides–protamine sulfate complexes does not inhibit function or differentiation capacity of hematopoietic or mesenchymal stem cells
A. Arbab (2005)
10.1002/mrm.20342
Sizing it up: Cellular MRI using micron‐sized iron oxide particles
E. Shapiro (2005)
10.1002/mrm.22290
Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles
D. Kedziorek (2010)
10.1002/smll.200902049
Transfer of quantum dots from pregnant mice to pups across the placental barrier.
Maoquan Chu (2010)
10.1021/nn9006994
Cathepsin L digestion of nanobioconjugates upon endocytosis.
V. Sée (2009)
10.1002/smll.200800972
Cancer-cell-phenotype-dependent differential intracellular trafficking of unconjugated quantum dots.
Sutapa Barua (2009)
10.1016/j.tiv.2010.03.017
Assessment of cytocompatibility of surface-modified CdSe/ZnSe quantum dots for BALB/3T3 fibroblast cells.
Sanjeev Kumar Mahto (2010)
10.1021/NL048715D
Physicochemical Properties and Cellular Toxicity of Nanocrystal Quantum Dots Depend on Their Surface Modification
A. Hoshino (2004)
10.1016/j.biomaterials.2009.03.032
The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles.
D. Huang (2009)
10.1038/nnano.2009.202
A novel magnetic crystal-lipid nanostructure for magnetically guided in vivo gene delivery.
Y. Namiki (2009)
Nanotoxicity: From In Vivo and In Vitro Models to Health Risks
S. Sahu (2009)
10.3727/096368910X543367
Use of a Clinically Approved Iron Oxide MRI Contrast Agent to Label Human Hepatocytes
J. Puppi (2011)
10.1063/1.3486681
Calcium-enhanced exocytosis of gold nanoparticles
Ran Chen (2010)
10.1002/cphc.200900849
Ion and pH sensing with colloidal nanoparticles: influence of surface charge on sensing and colloidal properties.
F. Zhang (2010)
10.1021/NL035172J
Hydrophobic Nanocrystals Coated with an Amphiphilic Polymer Shell: A General Route to Water Soluble Nanocrystals
T. Pellegrino (2004)
10.1117/1.3269675
Whole-body, real-time preclinical imaging of quantum dot fluorescence with time-gated detection.
A. May (2009)
10.1021/mp7001285
Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats.
Tapan Jain (2008)
10.1002/smll.201001619
Advanced optical imaging reveals the dependence of particle geometry on interactions between CdSe quantum dots and immune cells.
J. Aaron (2011)
10.1088/0957-4484/19/03/035701
Photostability of quantum dots with amphiphilic polymer-based passivation strategies.
D. Nida (2008)
10.1002/smll.200902084
High intracellular iron oxide nanoparticle concentrations affect cellular cytoskeleton and focal adhesion kinase-mediated signaling.
S. Soenen (2010)
10.2217/17435889.4.2.219
Toxicity of therapeutic nanoparticles.
Melissa A. Maurer-Jones (2009)
10.1039/c0nr00733a
Irreversible changes in protein conformation due to interaction with superparamagnetic iron oxide nanoparticles.
M. Mahmoudi (2011)
10.1002/SMLL.200500492
Adverse effects of citrate/gold nanoparticles on human dermal fibroblasts.
N. Pernodet (2006)
10.1016/j.tiv.2009.06.020
Intracellular oxidative stress and cadmium ions release induce cytotoxicity of unmodified cadmium sulfide quantum dots.
K. Li (2009)
10.1002/ADMA.200701853
GOLD NANOPARTICLES INDUCE OXIDATIVE DAMAGE IN LUNG FIBROBLASTS IN VITRO
J. J. Li (2008)
10.1016/j.addr.2008.08.004
Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer.
P. Juzenas (2008)
10.1038/nbt764
Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots
X. Wu (2003)
10.1002/SMLL.200700217
Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells.
Tanya S. Hauck (2008)
10.1021/nn1017044
Silica-polymer dual layer-encapsulated quantum dots with remarkable stability.
X. Hu (2010)
10.1148/RADIOL.2442060599
Transferrin receptor upregulation: in vitro labeling of rat mesenchymal stem cells with superparamagnetic iron oxide.
R. Schaefer (2007)
10.1016/j.biomaterials.2008.08.001
Mechanisms of unmodified CdSe quantum dot-induced elevation of cytoplasmic calcium levels in primary cultures of rat hippocampal neurons.
Mingliang Tang (2008)
10.1021/la104278m
Stabilization of magnetic iron oxide nanoparticles in biological media by fetal bovine serum (FBS).
H. Wiogo (2011)
10.1016/j.toxlet.2009.03.013
UV-enhanced cytotoxicity of thiol-capped CdTe quantum dots in human pancreatic carcinoma cells.
Shuquan Chang (2009)
10.1002/smll.200900126
Cytotoxicity and immunological response of gold and silver nanoparticles of different sizes.
Hung-Jen Yen (2009)
10.2217/nnm.10.106
Assessing iron oxide nanoparticle toxicity in vitro: current status and future prospects.
Stefaan J.H. Soenen (2010)
10.1093/toxsci/kfp188
State of Academic Knowledge on Toxicity and Biological Fate of Quantum Dots
Jennifer L. Pelley (2009)
10.1021/nn9011187
Interaction of gold nanoparticles with common human blood proteins.
S. Lacerda (2010)
10.1016/j.biomaterials.2009.08.050
The role of nanoparticle concentration-dependent induction of cellular stress in the internalization of non-toxic cationic magnetoliposomes.
S. Soenen (2009)
10.1016/J.BIOMATERIALS.2003.09.095
Lactoferrin and ceruloplasmin derivatized superparamagnetic iron oxide nanoparticles for targeting cell surface receptors.
A. Gupta (2004)
10.1186/1477-3155-8-2
Optical characterization of colloidal CdSe quantum dots in endothelial progenitor cells
Mátyás Molnár (2010)
10.3109/17435390903276925
An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signalling in vitro
M. J. Clift (2010)
10.1002/smll.200901770
Fluorescent-magnetic hybrid nanoparticles induce a dose-dependent increase in proinflammatory response in lung cells in vitro correlated with intracellular localization.
Andrea D. Lehmann (2010)
10.1038/nnano.2009.248
Protein-nanoparticle interactions: What does the cell see?
I. Lynch (2009)
10.1007/s11051-010-9911-8
Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?
A. AlKilany (2010)
10.1021/jp8018606
Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots.
A. Anas (2008)
10.1021/ja9102698
Nuclear targeting of gold nanoparticles in cancer cells induces DNA damage, causing cytokinesis arrest and apoptosis.
B. Kang (2010)
10.1002/cbic.200700327
Optimal Conditions for Labelling of 3T3 Fibroblasts with Magnetoliposomes without Affecting Cellular Viability
S. Soenen (2007)
10.1039/B413175D
Semiconductor quantum dots and free radical induced DNA nicking.
M. Green (2005)
10.1002/cbic.200700165
Molecular Effects of Uptake of Gold Nanoparticles in HeLa Cells
J. Khan (2007)
10.1002/SMLL.200700378
Size-dependent cytotoxicity of gold nanoparticles.
Y. Pan (2007)
10.3390/ijms10020441
Quantum Dots for Live Cell and In Vivo Imaging
Maureen A. Walling (2009)
10.1080/17435390802245708
Cytotoxicity of aged cadmium-telluride quantum dots to rainbow trout hepatocytes
F. Gagné (2008)
10.2217/nnm.09.9
Quantum dots and their potential biomedical applications in photosensitization for photodynamic therapy.
E. Yaghini (2009)
10.1038/nnano.2010.251
Biomagnification of cadmium selenide quantum dots in a simple experimental microbial food chain.
R. Werlin (2011)
10.1016/J.ACTBIO.2006.11.004
Cytotoxic effects of aggregated nanomaterials.
K. Soto (2007)
10.1021/ES060691K
In vitro interactions between DMSA-coated maghemite nanoparticles and human fibroblasts: A physicochemical and cyto-genotoxical study.
M. Auffan (2006)
10.1021/nl802746w
Near-infrared gold nanocages as a new class of tracers for photoacoustic sentinel lymph node mapping on a rat model.
K. Song (2009)
10.1002/NBM.970
A model of lysosomal metabolism of dextran coated superparamagnetic iron oxide (SPIO) nanoparticles: implications for cellular magnetic resonance imaging
A. Arbab (2005)
10.1002/SMLL.200400071
On the development of colloidal nanoparticles towards multifunctional structures and their possible use for biological applications.
T. Pellegrino (2005)
10.3109/02656731003745740
Magnetic nanoparticle hyperthermia for prostate cancer
M. Johannsen (2010)
10.1093/TOXSCI/KFL165
Particokinetics in vitro: dosimetry considerations for in vitro nanoparticle toxicity assessments.
J. Teeguarden (2007)
10.1126/SCIENCE.1114397
Toxic Potential of Materials at the Nanolevel
A. Nel (2006)
10.1016/j.biomaterials.2010.04.014
Autophagy and oxidative stress associated with gold nanoparticles.
J. J. Li (2010)
10.1002/SMLL.200400093
Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity.
E. E. Connor (2005)
10.1002/smll.201000763
Intracellular nanoparticle coating stability determines nanoparticle diagnostics efficacy and cell functionality.
S. Soenen (2010)
10.1002/ADMA.200801395
Toxicity Evaluation for Safe Use of Nanomaterials: Recent Achievements and Technical Challenges
S. Hussain (2009)
10.1021/LA060093J
Long-term exposure to CdTe quantum dots causes functional impairments in live cells.
S. J. Cho (2007)
10.1088/0953-8984/18/38/S26
Magnetic particle hyperthermia : nanoparticle magnetism and materials development for cancer therapy
R. Hergt (2006)
10.3109/17435390.2010.528847
Toxicity of gold-nanoparticles: Synergistic effects of shape and surface functionalization on micromotility of epithelial cells
M. Tarantola (2011)
10.1073/pnas.0608582104
Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles
T. Cedervall (2007)
10.1021/nn1010792
Penetration of lipid membranes by gold nanoparticles: insights into cellular uptake, cytotoxicity, and their relationship.
Jiaqi Lin (2010)
10.1002/smll.201001532
Effects of gold nanorod concentration on the depth-related temperature increase during hyperthermic ablation.
Boseung Jang (2011)
10.1016/j.taap.2010.03.011
The inhibitory effect of superparamagnetic iron oxide nanoparticle (Ferucarbotran) on osteogenic differentiation and its signaling mechanism in human mesenchymal stem cells.
Ying-chun Chen (2010)
10.1021/JA0386905
Semiconductor quantum dots for photodynamic therapy.
A. C. Samia (2003)
10.1016/J.NANTOD.2010.10.007
Emerging links between surface nanotechnology and endocytosis: impact on nonviral gene delivery.
Andrew F Adler (2010)
10.1002/cmmi.282
Assessing cytotoxicity of (iron oxide-based) nanoparticles: an overview of different methods exemplified with cationic magnetoliposomes.
S. Soenen (2009)
10.1186/1743-8977-6-14
Comparative toxicity of 24 manufactured nanoparticles in human alveolar epithelial and macrophage cell lines
S. Lanone (2009)
10.1038/nnano.2009.195
A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles.
C. Roecker (2009)
10.1080/17435390701314761
Toxicology of nanoparticles: A historical perspective
G. Oberdoerster (2007)
10.1021/nl803647n
Tailoring the structure of nanopyramids for optimal heat generation.
Warefta Hasan (2009)
10.1088/0957-4484/21/39/395103
Degradability of superparamagnetic nanoparticles in a model of intracellular environment: follow-up of magnetic, structural and chemical properties.
M. Levy (2010)
10.1016/J.BIOMATERIALS.2004.05.022
Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles.
A. Gupta (2005)
10.1039/c1nr10326a
Engineered nanoparticles for biomolecular imaging.
M. Mahmoudi (2011)
10.1002/wnan.122
Magnetoliposomes as magnetic resonance imaging contrast agents.
S. Soenen (2011)
10.1002/NBM.925
Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis
Lisa Kostura (2004)
10.1016/j.biomaterials.2009.04.009
NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials.
N. Singh (2009)
10.1186/1477-3155-5-1
Quantum dot-induced cell death involves Fas upregulation and lipid peroxidation in human neuroblastoma cells
A. Choi (2007)
10.2147/IJN.S10458
Toxic effects of iron oxide nanoparticles on human umbilical vein endothelial cells
X. Wu (2010)
10.1016/j.biomaterials.2010.08.003
Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes.
Oleg Lunov (2010)
10.1016/j.addr.2008.03.018
Magnetic nanoparticles in MR imaging and drug delivery.
C. Sun (2008)
10.1289/ehp.7339
Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
G. Oberdörster (2005)
10.1002/smll.200700595
Cytotoxicity of nanoparticles.
Nastassja Lewinski (2008)
10.3109/17435390903374001
The suitability of different cellular in vitro immunotoxicity and genotoxicity methods for the analysis of nanoparticle-induced events
Tobias Pfaller (2010)
10.1166/JBN.2010.1128
Global gene expression analysis of the effects of gold nanoparticles on human dermal fibroblasts.
Yamin Yang (2010)
10.1021/nn9006835
Research priorities to advance eco-responsible nanotechnology.
P. Alvarez (2009)
10.1073/pnas.0805135105
Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts
M. Lundqvist (2008)
10.1038/nbt1340
Renal clearance of quantum dots
H. Choi (2007)
10.1007/s11671-009-9334-6
Assessment of the In Vivo Toxicity of Gold Nanoparticles
Yangyang Chen (2009)
10.1021/NL0603350
Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements.
T. Zhang (2006)
10.2217/17435889.2.1.113
Functionalized gold nanoparticles for drug delivery.
G. Han (2007)
10.1016/J.FREERADBIOMED.2004.01.016
Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages.
Albrecht Stroh (2004)
10.1002/smll.200801546
Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects.
A. AlKilany (2009)
10.1186/1477-3155-8-7
Long-term exposure of CdTe quantum dots on PC12 cellular activity and the determination of optimum non-toxic concentrations for biological use
B. R. Prasad (2010)
10.1016/J.NANTOD.2010.05.003
Functionalisation of nanoparticles for biomedical applications
Nguyen T. K. Thanh (2010)



This paper is referenced by
10.2147/IJN.S127799
Negatively charged silver nanoparticles with potent antibacterial activity and reduced toxicity for pharmaceutical preparations
L. Salvioni (2017)
10.1021/mp3002705
Maghemite functionalization for antitumor drug vehiculization.
K. Rudzka (2012)
10.1016/j.ijpharm.2017.07.009
Photo-stimulation of persistent luminescence nanoparticles enhances cancer cells death.
G. Ramírez-García (2017)
10.1016/j.actbio.2017.10.031
A cyclo-trimer of acetonitrile combining fluorescent property with ability to induce osteogenesis and its potential as multifunctional biomaterial.
Xujie Liu (2018)
Potential Environmental and Health Risks from Nanoparticles and III-V Materials Used in Semiconductor Manufacturing
Chao Zeng (2017)
ASSESSMENT OF SIZE BASED ORAL TOXICITY OF SILVER NANOPARTICLES ON SERUM LIPID PROFILE, LIVER AND KIDNEY FUNCTION OF MALE WISTAR RATS
Utkarsh Kaushik (2016)
10.1073/pnas.1616400113
One low-dose exposure of gold nanoparticles induces long-term changes in human cells
P. Falagan-Lotsch (2016)
10.3109/17435390.2015.1039092
Cytotoxicity of Au, ZnO and SiO2 NPs using in vitro assays with mussel hemocytes and gill cells: Relevance of size, shape and additives
A. Katsumiti (2016)
10.1021/nn3059295
Polymer-coated nanoparticles interacting with proteins and cells: focusing on the sign of the net charge.
Dominik Hühn (2013)
10.1016/j.actbio.2018.12.024
Cosmetic reconstruction in breast cancer patients: Opportunities for nanocomposite materials.
Karthika Prasad (2019)
10.1186/s12989-017-0222-4
Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo
M. Pérez-Hernández (2017)
10.1016/j.ijpharm.2017.07.015
Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice.
G. Ramírez-García (2017)
10.1039/c5nr08358c
Platinum nanozymes recover cellular ROS homeostasis in an oxidative stress-mediated disease model.
Mauro Moglianetti (2016)
10.3389/fphys.2018.00728
Nervous System Injury in Response to Contact With Environmental, Engineered and Planetary Micro- and Nano-Sized Particles
Tatiana Borisova (2018)
10.15386/cjmed-573
Advances in cancer research using gold nanoparticles mediated photothermal ablation
L. Mocan (2016)
10.1016/J.NANTOD.2013.01.001
Intracellular oxidative stress caused by nanoparticles: What do we measure with the dichlorofluorescein assay?
P. Hoet (2013)
10.1007/s11051-015-3148-5
Iron oxide nanoparticles surface coating and cell uptake affect biocompatibility and inflammatory responses of endothelial cells and macrophages
A. Orlando (2015)
10.1371/journal.pone.0048617
Real-Time Monitoring of Photocytotoxicity in Nanoparticles-Based Photodynamic Therapy: A Model-Based Approach
H. Benachour (2012)
10.7150/thno.15217
Recent Progress in Light-Triggered Nanotheranostics for Cancer Treatment
P. Zhang (2016)
10.2147/IJN.S119618
Biosynthesis of gold nanoparticles by the extreme bacterium Deinococcus radiodurans and an evaluation of their antibacterial properties
Jiulong Li (2016)
10.1007/978-3-319-04924-3_1
Antibody-Functionalized Inorganic NPs: Mimicking Nature for Targeted Diagnosis and Therapy
A. Quarta (2014)
A comparative investigation of transgene expression and gene silencing of non-functionalized layered double hydroxides versus amino-acid functionalized hydrotalcites.
N. Nundkumar (2017)
10.1002/smll.201900669
Mesoporous Silica-Based Materials with Bactericidal Properties.
Andrea Bernardos (2019)
10.3390/MET7120516
Collagen-Nanoparticles Composites for Wound Healing and Infection Control
M. Grigore (2017)
10.3390/nano9060821
Current Applications of Nanoemulsions in Cancer Therapeutics
E. Sánchez-López (2019)
10.1016/j.ijbiomac.2017.11.065
Allicin functionalized locust bean gum nanoparticles for improved therapeutic efficacy: An in silico, in vitro and in vivo approach.
R. S. Soumya (2018)
10.1039/d0nr03771k
A thieno-isoindigo derivative-based conjugated polymer nanoparticle for photothermal therapy in the NIR-II bio-window.
Zuwu Wei (2020)
10.1080/17435390.2017.1342011
Toxicogenomics of iron oxide nanoparticles in the nematode C. elegans
L. Gonzalez-Moragas (2017)
10.1039/C3RA47319H
Colloidal stability of polyethylene glycol functionalized Co0.5Zn0.5Fe2O4 nanoparticles: effect of pH, sample and salt concentration for hyperthermia application
Dipali S. Nikam (2014)
10.1155/2016/1920475
Synthesis and Characterization of Nontoxic Hollow Iron Oxide α-Fe2O3 Nanoparticles Using a Simple Hydrothermal Strategy
Rabia Riasat (2016)
10.1081/E-ENN3-140000044
Single-Particle Inductively Coupled Plasma Mass Spectrometry: Gold Nanoparticles in Biological Fluids
C. M. Cirtiu (2014)
10.1002/wnan.1192
In situ labeling and imaging of endogenous neural stem cell proliferation and migration.
G. Vande Velde (2012)
See more
Semantic Scholar Logo Some data provided by SemanticScholar