← Back to Search
Isolation Of Diterpenes And Flavonoids From A New Type Of Propolis From Saudi Arabia
Sultan Almutairi, R. Edrada-Ebel, J. Fearnley, J. Igoli, Waqas Alotaibi, C. Clements, A. Gray, D. Watson
Published 2014 · Biology
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Abstract The chemical composition and biological activity of a sample of Saudi Arabian propolis were investigated. A new diterpene propsiadin ((ent)-2-oxo-kaur-16-en-6,18-diol) ( 3 ) along with the flavonoids 3,4-dihydro-2-(3,4-dihydroxyphenyl)-2H-chromene-3,7-diol ( 1 ), psiadiarabin ( 2 ) and the diterpene psiadin ( 4 ) were isolated from a Saudi Arabian propolis. Their structures were determined by HR-ESI-MS, 1D and 2D NMR. Compound 1 was inactive against Trypanosoma brucei and Mycobacterium marinum while compounds 2 – 4 had MICs of 30.9, 78.1 and 78.1 μM against T. brucei respectively and 312.1, 312.1 and 69.1 μM against M. marinum . The likely sources of the propolis are Psiadia arabica and Psiadia punctulata and it represents a new type of propolis not described before.
This paper references
X-ray structure of psiadiarabin, a flavone from Psiadia arabica
M. Al-yahya (1987)
Two flavones fromPsiadia arabica
Farouk S. El-Feraly (1990)
A flavone and diterpene from Psiadia arabica
J. Mossa (1992)
Diterpenes from Psiadia arabica
M. M. El-domiaty (1993)
Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
L. Collins (1997)
The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro.
B. Räz (1997)
Rapid, Low-Technology MIC Determination with Clinical Mycobacterium tuberculosis Isolates by Using the Microplate Alamar Blue Assay
S. Franzblau (1998)
Anadanthoside: a flavanol-3-O-β-d-xylopyranoside from Anadenanthera macrocarpa
S. Piacente (1999)
Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs.
Z. Yıldırım (2004)
Application of principal components analysis to 1H-NMR data obtained from propolis samples of different geographical origin.
D. Watson (2006)
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
D. Tobin (2008)
New biologically active compounds from Kenyan propolis.
A. Petrova (2010)
Phenolic characterization of Northeast Portuguese propolis: usual and unusual compounds
S. Falcão (2010)
GC-MS profiling of diterpene compounds in Mediterranean propolis from Greece.
M. Popova (2010)
Propolis research and the chemistry of plant products.
A. Salatino (2011)
Cuban and Brazilian red propolis: botanical origin and comparative analysis by high-performance liquid chromatography-photodiode array detection/electrospray ionization tandem mass spectrometry.
A. L. Piccinelli (2011)
Prenylated cinnamate and stilbenes from Kangaroo Island propolis and their antioxidant activity.
Abdallah Abu-Mellal (2012)
CRC world dictionary of medicinal and poisonous plants : common names, scientific names, eponyms, synonyms, and etymology
Umberto. Quattrocchi (2012)
¹H-NMR simultaneous identification of health-relevant compounds in propolis extracts.
D. Bertelli (2012)
This paper is referenced by
Bee propolis: Production optimization and applications in Nigeria
Samuel Ehiabhi Okhale (2021)
Chemical characterization of Saudi propolis and its antiparasitic and anticancer properties
Samyah Alanazi (2021)
The Strong Anti-Kinetoplastid Properties of Bee Propolis: Composition and Identification of the Active Agents and Their Biochemical Targets
Godwin U. Ebiloma (2020)
Lessons from Exploring Chemical Space and Chemical Diversity of Propolis Components
Trong D Tran (2020)
Standardization of Specific and Non-Specific Parameters of Propolis Extract as Raw Material for Herbal Product
Y. Syukri (2020)
Determination of the effects of propolis ethanolic extract on some properties of fruit yoghurt during storage
Fazıl Güney (2020)
Experimental study and modeling on supercritical CO2 extraction of Indonesian raw propolis using response surface method: Influence of pressure, temperature and CO2 mass flowrate on extraction yield
B. A. Fachri (2020)
European propolis is highly active against trypanosomatids including Crithidia fasciculata
A. Alotaibi (2019)
Antibacterial activity of flavonoids and their structure–activity relationship: An update review
F. Farhadi (2019)
Advances in the Propolis Chemical Composition between 2013 and 2018: A Review
L. Šturm (2019)
Natural Antimicrobial Agents
J. Mérillon (2018)
The phytochemistry of the honeybee.
V. Bankova (2018)
Antileishmanial and Antitrypanosomal Activities of Flavonoids
F. Nardella (2018)
Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction.
C. Garcia (2018)
Flavanones and Flavones from Bashkir Propolis
R. A. Zainullin (2018)
Cytotoxicity of Some Plants of the Asteraceae Family: Antiproliferative Activity of Psiadia punctulata Root Sesquiterpenes
A. Bader (2018)
Phytochemical screening, antioxidant and antibacterial activities of some commercial extract of propolis
T. G. do Nascimento (2018)
Phytochemistry of compounds isolated from the leaf-surface extract of Psiadia punctulata (DC.) Vatke growing in Saudi Arabia.
F. Dal Piaz (2018)
Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review
N. Aminimoghadamfarouj (2017)
Elementery Analysis and anti-Tumor Activity on Glioblastoma Cell Lines of Propolis Samples from Giresun Province of Turkey
Meltem Maraş Atabay (2017)
Elemental content profiles in propolis from several cities of Turkey
C. Aksoy (2017)
Diterpenes as lead molecules against neglected tropical diseases
Marcus Vinícius Oliveira Barros de Alencar (2017)
Bee Products - Chemical and Biological Properties
J. M. Alvarez-Suarez (2017)
The Chemical and Biological Properties of Propolis
Weam Siheri (2017)
Chemical compositions and characteristics of organic compounds in propolis from Yemen
A. Alghamdi (2017)
Isolation and characterization of plant bioactive compounds and assessment of their use in veterinary science
Massimiliano D’Ambola (2017)
Diterpenoids of terrestrial origin.
J. R. Hanson (2016)
Chemical and Antimicrobial Profiling of Propolis from Different Regions within Libya
Weam Siheri (2016)
A Comparison of the Constituents of Propolis from Different Regions of the United Kingdom by Liquid Chromatography-High Resolution Mass Spectrometry using a Metabolomics Approach
K. Saleh (2015)