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Isolation Of Diterpenes And Flavonoids From A New Type Of Propolis From Saudi Arabia

Sultan Almutairi, R. Edrada-Ebel, J. Fearnley, J. Igoli, Waqas Alotaibi, C. Clements, A. Gray, D. Watson
Published 2014 · Biology

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Abstract The chemical composition and biological activity of a sample of Saudi Arabian propolis were investigated. A new diterpene propsiadin ((ent)-2-oxo-kaur-16-en-6,18-diol) ( 3 ) along with the flavonoids 3,4-dihydro-2-(3,4-dihydroxyphenyl)-2H-chromene-3,7-diol ( 1 ), psiadiarabin ( 2 ) and the diterpene psiadin ( 4 ) were isolated from a Saudi Arabian propolis. Their structures were determined by HR-ESI-MS, 1D and 2D NMR. Compound 1 was inactive against Trypanosoma brucei and Mycobacterium marinum while compounds 2 – 4 had MICs of 30.9, 78.1 and 78.1 μM against T. brucei respectively and 312.1, 312.1 and 69.1 μM against M. marinum . The likely sources of the propolis are Psiadia arabica and Psiadia punctulata and it represents a new type of propolis not described before.
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