Online citations, reference lists, and bibliographies.
← Back to Search

Protein-mimetic Peptide Nanofibers: Motif Design, Self-assembly Synthesis, And Sequence-specific Biomedical Applications

Wensi Zhang, X. Yu, Y. Li, Zhiqiang Su, K. Jandt, G. Wei
Published 2017 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract The design and fabrication of self-assembled peptide nanostructures offer an amazing platform for creating functional nanomaterials for various biomedical applications. Utilizing the mechanical and biological advantages of the protein-mimetic peptide (PMP) system, and combining self-assembled PMP nanofibers with other nanomaterials like nanoparticles, the fabricated PMP-based hybrid fibrous nanostructures can serve as promising candidates for advanced technological applications. In this review, we present the design, synthesis, modification, and fabrication of PMP nanofibers by mimicking the properties and functions of several types of proteins, including extracellular matrix proteins, silk proteins, amyloid proteins, and heparin. The sequence and motif design of PMPs, and the relationships between the design of PMP monomers and the fabrication of functional fibrous biomaterials are introduced and discussed. Furthermore, we summarize a basic classification of various peptide motifs, and provide some instructions for the function-based design of peptide nanostructures, in which some issues on the motif design and function tailoring are discussed. Finally, the recent advances in the PMP nanofiber-based functional nanomaterials in biomineralization, cell culture, tissue regeneration, drug delivery, hemostasis, bioimaging, and biosensors are presented in detail. We believe that this review will be very helpful for researchers to understand the property-specific molecular design, controllable supramolecular self-assembly, and motif-specific applications of both peptides and proteins.
This paper references
10.1039/C4TB01324G
Alternate layer-by-layer assembly of graphene oxide nanosheets and fibrinogen nanofibers on a silicon substrate for a biomimetic three-dimensional hydroxyapatite scaffold.
J. Wang (2014)
10.1039/c3cp52166d
Energetics of β-turn formation in a mutant peptide YPGDV from influenza hemagglutinin: an MD simulation study.
Rashmi Tambe Shukla (2013)
10.1016/J.NANTOD.2014.10.002
Advances in nanofibrous scaffolds for biomedical applications: From electrospinning to self-assembly
R. Wade (2014)
10.1016/j.yjmcc.2009.08.024
The extracellular matrix: at the center of it all.
S. Bowers (2010)
10.1021/nn202822f
Self-assembly of collagen-mimetic peptide amphiphiles into biofunctional nanofiber.
Jingnan Luo (2011)
10.1002/ADMA.200500855
Enzyme‐Mediated Degradation of Peptide‐Amphiphile Nanofiber Networks
Ho-Wook Jun (2005)
10.1021/nl103943u
Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up.
A. Gautieri (2011)
10.1038/srep22358
Natural Silk as a Photonics Component: a Study on Its Light Guiding and Nonlinear Optical Properties
S. Kujala (2016)
10.1002/adma.201500275
Sequence Programmable Peptoid Polymers for Diverse Materials Applications.
Abigail S Knight (2015)
10.1021/MA991858F
Generation of Synthetic Elastin-Mimetic Small Diameter Fibers and Fiber Networks
L. Huang (2000)
10.1038/nchem.1123
Multi-hierarchical self-assembly of a collagen mimetic peptide from triple helix to nanofibre and hydrogel.
Lesley E. R. O'Leary (2011)
10.1002/bip.22058
Review self‐assembly of amphipathic β‐sheet peptides: Insights and applications
Charles J. Bowerman (2012)
10.1039/C4TB01944J
Ca2+-induced self-assembly of Bombyx mori silk sericin into a nanofibrous network-like protein matrix for directing controlled nucleation of hydroxylapatite nano-needles.
Mingying Yang (2015)
10.1021/la203322t
Enhanced integrin mediated signaling and cell cycle progression on fibronectin mimetic peptide amphiphile monolayers.
K. Shroff (2012)
10.1002/PAT.3300
Controlled release of doxorubicin and Smac-derived pro-apoptotic peptide from self-assembled KLD-based peptide hydrogels
Eliya Yishay-Safranchik (2014)
10.1016/j.biomaterials.2010.11.054
Synthetic cationic amphiphilic α-helical peptides as antimicrobial agents.
N. Wiradharma (2011)
10.1016/J.PROGPOLYMSCI.2015.07.005
Self-assembling polymer systems for advanced treatment of cancer and inflammation
R. Palao-Suay (2016)
10.1021/acs.langmuir.5b02036
Self-Assembled Peptide Nanofibers Encapsulated with Superfine Silver Nanoparticles via Ag⁺ Coordination.
Y. Hu (2015)
10.1021/bm500856c
Two-Step Self-Assembly of Liposome-Multidomain Peptide Nanofiber Hydrogel for Time-Controlled Release
N. Wickremasinghe (2014)
10.1038/nchem.1290
Metal-directed, chemically-tunable assembly of one-, two- and three-dimensional crystalline protein arrays
Jeffrey D. Brodin (2012)
10.1039/c4cs00381k
Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells.
Ryou Kubota (2015)
10.1021/BC0341573
Promotion of peptide antimicrobial activity by fatty acid conjugation.
A. Chu-Kung (2004)
10.1021/NL025563I
Self-assembly of Surfactant-like Peptides with Variable Glycine Tails to Form Nanotubes and Nanovesicles
Steve Santoso (2002)
10.1182/blood-2010-01-260778
Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing blood.
N. Pugh (2010)
10.1002/humu.21401
Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes
J. Parkin (2011)
10.1021/jacs.5b13541
Enzyme-Instructed Self-Assembly of Small d-Peptides as a Multiple-Step Process for Selectively Killing Cancer Cells
J. Zhou (2016)
10.1038/srep13967
Real-time Detection of Breast Cancer Cells Using Peptide-functionalized Microcantilever Arrays
H. Etayash (2015)
10.1039/C6NR07249F
When biomolecules meet graphene: from molecular level interactions to material design and applications.
D. Li (2016)
10.1021/nn202566n
Serial silver clusters biomineralized by one peptide.
Yanyan Cui (2011)
10.1016/J.BIOMATERIALS.2006.09.048
The effect of a recombinant elastin-mimetic coating of an ePTFE prosthesis on acute thrombogenicity in a baboon arteriovenous shunt.
S. Jordan (2007)
10.1016/j.actbio.2016.09.011
Regenerative effects of peptide nanofibers in an experimental model of Parkinson's disease.
Melike Sever (2016)
10.1021/bm500091e
A Nanostructured Synthetic Collagen Mimic for Hemostasis
V. Kumar (2014)
10.1039/c5cc05652g
Surface immobilization of a protease through an inhibitor-derived affinity ligand: a bioactive surface with defensive properties against an inhibitor.
Zengchao Tang (2015)
10.1039/c4cs00164h
The physical properties of supramolecular peptide assemblies: from building block association to technological applications.
Lihi Adler-Abramovich (2014)
10.1016/J.PROGPOLYMSCI.2014.07.006
In situ-forming injectable hydrogels for regenerative medicine
J. Yang (2014)
10.1002/ADFM.201300577
Formation of Functionalized Nanowires by Control of Self‐Assembly Using Multiple Modified Amyloid Peptides
Hiroki Sakai (2013)
10.1016/j.actbio.2012.02.006
Cooperative effect of heparan sulfate and laminin mimetic peptide nanofibers on the promotion of neurite outgrowth.
B. Mammadov (2012)
10.1016/j.colsurfb.2013.12.030
Green electrospun pantothenic acid/silk fibroin composite nanofibers: fabrication, characterization and biological activity.
Linpeng Fan (2014)
10.1016/J.ADDR.2007.10.008
Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers.
V. Torchilin (2008)
10.3390/ijms131115279
Molecular Mechanisms of RADA16-1 Peptide on Fast Stop Bleeding in Rat Models
T. Wang (2012)
10.1039/b906701a
Amphiphilic peptides and their cross-disciplinary role as building blocks for nanoscience.
S. Cavalli (2010)
10.1021/la702434p
Effect of linker and spacer on the design of a fibronectin-mimetic peptide evaluated via cell studies and AFM adhesion forces.
Jennifer A. Craig (2008)
10.1016/j.actbio.2008.11.002
Inhibition of cancer cell proliferation by designed peptide amphiphiles.
L. Aulisa (2009)
10.1002/PSSA.201600511
Self‐assembled peptide nanofiber templated ALD growth of TiO2 and ZnO semiconductor nanonetworks
Ruslan Garifullin (2016)
10.1039/C2PY20299A
Controlled peptide coated nanostructures via the self-assembly of functional peptide building blocks
Xiao-Ding Xu (2012)
10.1021/nn401562f
Molecular structure of RADA16-I designer self-assembling peptide nanofibers.
Ashley R Cormier (2013)
10.1039/b806316h
Controlled self-assembly and templated metallization of fibrinogen nanofibrils.
Gang Wei (2008)
10.1021/jacs.6b00073
Tuning Cellular Uptake of Molecular Probes by Rational Design of Their Assembly into Supramolecular Nanoprobes.
Lye Lin Lock (2016)
10.1038/417547a
Nogo-66 receptor antagonist peptide promotes axonal regeneration
T. Grandpre (2002)
10.1016/J.CARBON.2011.01.051
Biomimetic growth of hydroxyapatite on super water-soluble carbon nanotube-protein hybrid nanofibers
Gang Wei (2011)
10.1038/nnano.2011.102
Nanomechanics of functional and pathological amyloid materials.
T. Knowles (2011)
10.1039/c4nr05109b
Mechanical properties of amyloid-like fibrils defined by secondary structures.
Christian Bortolini (2015)
10.1002/AENM.201502329
Silk Nanofiber-Networked Bio-Triboelectric Generator: Silk Bio-TEG
Hyunjun Kim (2016)
10.1021/jacs.6b01570
Nucleation and Growth of Ordered Arrays of Silver Nanoparticles on Peptide Nanofibers: Hybrid Nanostructures with Antimicrobial Properties
Elena Pazos (2016)
10.1002/adma.201003882
Intrafibrillar collagen mineralization produced by biomimetic hierarchical nanoapatite assembly.
Y. Liu (2011)
10.1016/j.actbio.2013.07.007
Glycosaminoglycan mimetic peptide nanofibers promote mineralization by osteogenic cells.
Samet Kocabey (2013)
10.1039/B607657B
A short water-soluble self-assembling peptide forms amyloid-like fibrils.
S. Ray (2006)
10.1016/j.biomaterials.2014.05.019
Mimicking the extracellular matrix with functionalized, metal-assembled collagen peptide scaffolds.
Victor Hernandez-Gordillo (2014)
10.1039/c3cp00067b
Dissecting the structural determinants for the difference in mechanical stability of silk and amyloid beta-sheet stacks.
Senbo Xiao (2013)
10.1039/C5TB00842E
A laminin mimetic peptide SIKVAV-conjugated chitosan hydrogel promoting wound healing by enhancing angiogenesis, re-epithelialization and collagen deposition.
Shixuan Chen (2015)
10.1016/j.actbio.2016.03.032
RGD and BMP-2 mimetic peptide crosstalk enhances osteogenic commitment of human bone marrow stem cells.
I. Bilem (2016)
10.1039/c4cs00483c
Surface modification and endothelialization of biomaterials as potential scaffolds for vascular tissue engineering applications.
Xiangkui Ren (2015)
10.1021/LA052756N
Design of a novel fibronectin-mimetic peptide-amphiphile for functionalized biomaterials.
Anastasia Mardilovich (2006)
10.1016/j.addr.2009.07.011
Electrospun scaffolds for stem cell engineering.
S. Lim (2009)
10.1021/ic4003059
Role of metal ions in the self-assembly of the Alzheimer's amyloid-β peptide.
P. Faller (2013)
10.1021/bm301887m
Self-assembly of elastin-mimetic double hydrophobic polypeptides.
Duc H. T. Le (2013)
10.1021/acs.nanolett.5b03313
Biomimetic Self-Templated Hierarchical Structures of Collagen-Like Peptide Amphiphiles.
Hyo-Eon Jin (2015)
10.1002/mabi.201400020
Glycopolymer functionalization of engineered spider silk protein-based materials for improved cell adhesion.
John George Hardy (2014)
10.1038/nmat4538
Energy landscapes and function of supramolecular systems
Faifan Tantakitti (2016)
10.1021/nn900472n
Uncovering nanoscale electromechanical heterogeneity in the subfibrillar structure of collagen fibrils responsible for the piezoelectricity of bone.
Majid Minary-Jolandan (2009)
10.1039/C5PY01377A
Robust, highly elastic and bioactive heparin-mimetic hydrogels
Chao He (2015)
10.1039/c1cc12633d
Self-assembly of a peptide amphiphile based on hydrolysed Bombyx mori silk fibroin.
J. Zhang (2011)
10.1039/c5cc10591a
Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors.
Y. Tang (2016)
10.1021/bm500075r
Sequence Effects of Self-Assembling MultiDomain Peptide Hydrogels on Encapsulated SHED Cells
Marci K. Kang (2014)
10.1021/acs.langmuir.5b00196
Three-Dimensional Cell Entrapment as a Function of the Weight Percent of Peptide-Amphiphile Hydrogels.
C. M. Scott (2015)
10.7150/thno.15420
Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells
H. Su (2016)
10.1038/ncomms7892
Predictive modelling-based design and experiments for synthesis and spinning of bioinspired silk fibres.
S. Lin (2015)
10.1002/marc.201400058
Engineering aqueous fiber assembly into silk-elastin-like protein polymers.
Like Zeng (2014)
10.1021/ACSBIOMATERIALS.6B00165
Angiogenic Heparin-Mimetic Peptide Nanofiber Gel Improves Regenerative Healing of Acute Wounds
Gozde Uzunalli (2017)
10.1021/acs.biomac.5b00287
A Top-down Approach to Elucidate the Role of Matrix-Bound Phosphoproteins in Control of Collagen Biomineralization.
Alexander J. Lausch (2015)
10.1038/ncomms4392
Structural and functional features of a collagen-binding matrix protein from the mussel byssus.
M. Suhre (2014)
10.1126/science.273.5274.458
Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin
N. Wrighton (1996)
10.1039/B516805H
Biomimetic self-assembled nanofibers.
Ho-Wook Jun (2006)
10.1016/J.COPBIO.2005.05.005
Protein fibers as performance proteins: new technologies and applications.
T. Scheibel (2005)
10.1021/bm2000605
AFM study of morphology and mechanical properties of a chimeric spider silk and bone sialoprotein protein for bone regeneration.
S. Gomes (2011)
10.1016/j.abb.2012.02.017
Screening of integrin-binding peptides from the laminin α4 and α5 chain G domain peptide library.
Fumihiko Katagiri (2012)
10.1039/b911049f
Animal silks: their structures, properties and artificial production.
C. Fu (2009)
10.1039/c2cs15360b
Designer nanomaterials using chiral self-assembling peptide systems and their emerging benefit for society.
Zhongli Luo (2012)
10.1007/s00018-013-1350-0
Fibronectin in tissue regeneration: timely disassembly of the scaffold is necessary to complete the build
J. Stoffels (2013)
10.1021/ja205524x
Combination of integrin-binding peptide and growth factor promotes cell adhesion on electron-beam-fabricated patterns.
Christopher M. Kolodziej (2012)
10.1002/anie.201402827
Cooperative, reversible self-assembly of covalently pre-linked proteins into giant fibrous structures.
Saadyah E Averick (2014)
10.1016/J.TIBTECH.2004.07.011
Fabrication of molecular materials using peptide construction motifs.
X. Zhao (2004)
10.1002/ADMA.201102963
Aligned macroscopic domains of optoelectronic nanostructures prepared via shear-flow assembly of peptide hydrogels.
Brian D. Wall (2011)
10.1016/j.biomaterials.2015.10.013
A fibronectin mimetic motif improves integrin mediated cell biding to recombinant spider silk matrices.
Mona Widhe (2016)
10.1039/C7PY00935F
Fabrication of graphene–biomacromolecule hybrid materials for tissue engineering application
Dapeng Li (2017)
10.1002/adma.201000669
Mineralization of self-assembled peptide nanofibers for rechargeable lithium ion batteries.
J. Ryu (2010)
10.1016/j.biomaterials.2013.05.046
Bioinspired intrafibrillar mineralization of human dentine by PAMAM dendrimer.
J. Li (2013)
10.1021/nn406309c
Self-assembly of protein fibrils into suprafibrillar aggregates: bridging the nano- and mesoscale.
S. Semerdzhiev (2014)
10.1016/j.bbapap.2008.10.016
Protein aggregation kinetics, mechanism, and curve-fitting: a review of the literature.
A. Morris (2009)
10.1039/c4ob00447g
Self-assembly of peptides to nanostructures.
D. Mandal (2014)
10.1002/ADFM.201402618
Injectable Peptide Decorated Functional Nanofibrous Hollow Microspheres to Direct Stem Cell Differentiation and Tissue Regeneration.
Z. Zhang (2015)
10.1021/nl302810c
Nanocomposite gold-silk nanofibers.
Tzahi Cohen-Karni (2012)
10.1021/JM00073A001
Concepts and progress in the development of peptide mimetics.
G. L. Olson (1993)
10.1021/JA060573X
Self-assembly of peptide-amphiphile nanofibers: the roles of hydrogen bonding and amphiphilic packing.
S. E. Paramonov (2006)
10.1021/bm200957s
Heparin mimetic peptide nanofibers promote angiogenesis.
R. Mammadov (2011)
10.1016/J.CARBON.2015.03.024
Self-assembled peptide nanofibers on graphene oxide as a novel nanohybrid for biomimetic mineralization of hydroxyapatite
J. Wang (2015)
10.1021/bm200035r
Injectable multidomain peptide nanofiber hydrogel as a delivery agent for stem cell secretome.
E. Bakota (2011)
10.1021/nn401667z
Self-assembled Tat nanofibers as effective drug carrier and transporter.
P. Zhang (2013)
10.1021/bm301481v
Self-assembly of ovalbumin into amyloid and non-amyloid fibrils.
C. Lara (2012)
10.1021/BM0341374
Effect of amino acid sequence and pH on nanofiber formation of self-assembling peptides EAK16-II and EAK16-IV.
Y. Hong (2003)
10.1021/bi8000616
Self-assembly and hydrogelation of an amyloid peptide fragment.
M. Krysmann (2008)
10.1039/C4TB00878B
Silk Nanofiber Hydrogels with Tunable Modulus to Regulate Nerve Stem Cell Fate.
S. Bai (2014)
10.1021/bm800824r
Novel biopolymeric template for the nucleation and growth of hydroxyapatite crystals based on self-assembled fibrinogen fibrils.
G. Wei (2008)
10.1021/ja3115983
Supramolecular nanostructures formed by anticancer drug assembly.
A. G. Cheetham (2013)
10.1016/j.actbio.2015.04.032
Improving pancreatic islet in vitro functionality and transplantation efficiency by using heparin mimetic peptide nanofiber gels.
G. Uzunalli (2015)
Detection of changes in near-membrane Ca2+ concentration using a novel membrane-associated Ca2+ indicator.
E. F. Etter (1994)
10.1021/la902571q
Self-assembly of fibronectin mimetic peptide-amphiphile nanofibers.
E. Rexeisen (2010)
10.1016/j.jconrel.2014.06.048
Development and characterization of self-assembling nanoparticles using a bio-inspired amphipathic peptide for gene delivery.
H. McCarthy (2014)
10.1016/J.NANTOD.2009.02.009
Designer self-assembling peptide nanomaterials
Yang Yanlian (2009)
10.1039/c2cc38779d
Design and engineering of silk fibroin scaffolds with biomimetic hierarchical structures.
H. Wang (2013)
10.1002/anie.200703133
Amyloids: not only pathological agents but also ordered nanomaterials.
Izhack Cherny (2008)
10.1038/nnano.2015.238
A multi-phase transitioning peptide hydrogel for suturing ultra-small vessels
D. Smith (2016)
10.1021/nn203343z
Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin.
S. Soukasene (2011)
10.1039/b915923c
Molecular self-assembly and applications of designer peptide amphiphiles.
X. Zhao (2010)
10.1126/science.1205962
Functional Supramolecular Polymers
T. Aida (2012)
10.1007/s00441-009-0891-x
Cell interactions with the extracellular matrix
L. Bruckner-Tuderman (2009)
10.1002/ADFM.201202291
Mussel inspired dynamic cross-linking of self-healing peptide nanofiber network
H. Ceylan (2013)
10.1016/j.jconrel.2007.12.017
A review of stimuli-responsive nanocarriers for drug and gene delivery.
Srinivas Ganta (2008)
10.1021/ja504377s
Self-assembly of fiber-forming collagen mimetic peptides controlled by triple-helical nucleation.
Biplab Sarkar (2014)
10.1073/pnas.1109773109
Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR)
Daliang Li (2011)
10.1021/ja110191f
Nanomechanical stimulus accelerates and directs the self-assembly of silk-elastin-like nanofibers.
Jonathan Chang (2011)
10.1039/c4cs00476k
Nanomaterial-based activatable imaging probes: from design to biological applications.
Jingjing Li (2015)
10.1038/srep16680
Biocompatible fluorescent supramolecular nanofibrous hydrogel for long-term cell tracking and tumor imaging applications
Huaimin Wang (2015)
10.1039/b609047h
Designing peptide based nanomaterials.
R. Ulijn (2008)
10.1021/nn405799t
Subtle charge balance controls surface-nucleated self-assembly of designed biopolymers.
Céline Charbonneau (2014)
10.1016/j.actbio.2015.01.008
Bimolecular based heparin and self-assembling hydrogel for tissue engineering applications.
Teresa Fernández-Muiños (2015)
10.2174/1381612821666150901104821
Self-Assembling Peptide Nanofibrous Hydrogel as a Versatile Drug Delivery Platform.
Zhi-qiang Yu (2015)
10.1016/j.addr.2016.06.013
Recent advances in self‐assembled peptides: Implications for targeted drug delivery and vaccine engineering
S. Eskandari (2017)
10.1016/j.jconrel.2014.05.051
Controlled release of free doxorubicin from peptide-drug conjugates by drug loading.
Z. Chen (2014)
10.1002/PRO.5560030308
β‐Sheet and associated turn signatures in vibrational Raman optical activity spectra of proteins
Z. Wen (1994)
10.1016/j.actbio.2009.07.031
Development of bioactive peptide amphiphiles for therapeutic cell delivery.
M. Webber (2010)
10.1039/C2SM27408F
Catalytic activity of copper ions in the amyloid fibrillation of β-lactoglobulin
Bruno Zappone (2013)
10.1021/bm200641e
Slow release and delivery of antisense oligonucleotide drug by self-assembled peptide amphiphile nanofibers.
S. Bulut (2011)
10.1074/jbc.274.51.36505
Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts*
J. Park (1999)
10.1021/acsnano.7b02298
Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains.
Bolin An (2017)
10.1016/j.biomaterials.2016.07.007
Bio-inspired in situ crosslinking and mineralization of electrospun collagen scaffolds for bone tissue engineering.
C. Dhand (2016)
10.1021/acs.bioconjchem.7b00312
Supramolecular Self-Assembly Bioinspired Synthesis of Luminescent Gold Nanocluster-Embedded Peptide Nanofibers for Temperature Sensing and Cellular Imaging.
Wensi Zhang (2017)
10.1039/C4TB01391C
In vivo assessment of grafted cortical neural progenitor cells and host response to functionalized self-assembling peptide hydrogels and the implications for tissue repair.
A. L. Rodríguez (2014)
10.1002/smll.201402985
Crystal networks in silk fibrous materials: from hierarchical structure to ultra performance.
A. T. Nguyen (2015)
10.1016/j.bios.2010.01.026
Self-assembled, photoluminescent peptide hydrogel as a versatile platform for enzyme-based optical biosensors.
J. Kim (2011)
10.1021/acs.langmuir.6b00287
Interplay between Intrinsic Conformational Propensities and Intermolecular Interactions in the Self-Assembly of Short Surfactant-like Peptides Composed of Leucine/Isoleucine.
P. Zhou (2016)
10.1021/la403414t
Self-assembly of protein-based biomaterials initiated by titania nanotubes.
Jacob H Forstater (2013)
10.1016/j.biomaterials.2008.05.014
Enhancement of neurite outgrowth using nano-structured scaffolds coupled with laminin.
H. S. Koh (2008)
10.1002/JRS.2237
Ultraviolet resonance Raman spectroscopy of a β‐sheet peptide: a model for membrane protein folding
H. S. Shafaat (2009)
10.1021/bm501514w
Enhanced plastic deformations of nanofibrillated cellulose film by adsorbed moisture and protein-mediated interactions.
Jani-Markus Malho (2015)
10.1002/bip.22582
Beaded nanofibers assembled from double‐hydrophobic elastin‐like block polypeptides: Effects of trifluoroethanol
Duc H. T. Le (2015)
10.1016/j.addr.2015.12.007
Elastin-like polypeptides in drug delivery.
J. Rodríguez-Cabello (2016)
10.1021/bm300472y
Elastin-like peptide amphiphiles form nanofibers with tunable length.
S. Aluri (2012)
10.1021/bm2005752
Wet-spinning of amyloid protein nanofibers into multifunctional high-performance biofibers.
C. Meier (2011)
10.1038/nnano.2014.199
Strong underwater adhesives made by self-assembling multi-protein nanofibres.
C. Zhong (2014)
10.1039/c6cs00542j
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology.
G. Wei (2017)
10.1016/J.BBAMEM.2007.03.029
Peptide degradation is a critical determinant for cell-penetrating peptide uptake.
C. Palm (2007)
10.1021/jacs.7b03878
Programmable Assembly of Peptide Amphiphile via Noncovalent-to-Covalent Bond Conversion
K. Sato (2017)
10.1038/srep16975
Antitumor potential of a synthetic interferon-alpha/PLGF-2 positive charge peptide hybrid molecule in pancreatic cancer cells
H. Yin (2015)
10.1039/C5RA26752H
Hydroxyapatite-containing silk fibroin nanofibrous scaffolds for tissue-engineered periosteum
Xili Ding (2016)
10.1021/acsami.6b02528
One-Dimensional Peptide Nanostructure Templated Growth of Iron Phosphate Nanostructures for Lithium-Ion Battery Cathodes.
Hepi Hari Susapto (2016)
10.1002/adma.201503215
Biomimetic and Bioinspired Synthesis of Nanomaterials/Nanostructures.
Guangtao Zan (2016)
10.1038/nchem.2349
Co-assembly, spatiotemporal control and morphogenesis of a hybrid protein-peptide system.
Karla E. Inostroza-Brito (2015)
10.1016/S0734-9750(02)00026-5
Emerging biological materials through molecular self-assembly.
S. Zhang (2002)
10.1021/nl200116d
Preparation of mineralized nanofibers: collagen fibrils containing calcium phosphate.
M. Maas (2011)
10.1021/ar8000475
Peptide and protein mimetics inhibiting amyloid beta-peptide aggregation.
T. Takahashi (2008)
10.1021/JM00035A001
Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries.
M. Gallop (1994)
10.1038/NMAT964
Molecular biomimetics: nanotechnology through biology
M. Sarikaya (2003)
10.1016/j.bbamem.2013.04.012
ATR-FTIR: a "rejuvenated" tool to investigate amyloid proteins.
Rabia Sarroukh (2013)
10.1038/nmat4089
Bioinspired structural materials.
U. Wegst (2015)
10.1021/nn4057269
Cell-penetrating peptides: design, synthesis, and applications.
D. Copolovici (2014)
10.1038/nmat3776
Stimuli-responsive nanocarriers for drug delivery.
S. Mura (2013)
10.1002/bip.22425
Temperature-sensitive elastin-mimetic dendrimers: Effect of peptide length and dendrimer generation to temperature sensitivity.
Chie Kojima (2014)
10.1002/JBM.A.10394
Fibronectin fibrillogenesis on sulfonated polystyrene surfaces.
N. Pernodet (2003)
10.1021/bm501882b
Nanofibrous heparin and heparin-mimicking multilayers as highly effective endothelialization and antithrombogenic coatings.
Chuanxiong Nie (2015)
10.1002/smll.201500208
Tunable Fabrication of Molybdenum Disulfide Quantum Dots for Intracellular MicroRNA Detection and Multiphoton Bioimaging.
Wenhao Dai (2015)
10.1039/C5TB00764J
8DSS-promoted remineralization of demineralized dentin in vitro.
Kunneng Liang (2015)
10.1039/b921448h
Designer self-assembling peptide nanofiber biological materials.
C. A. Hauser (2010)
10.1038/modpathol.2010.142
Fibroblast-activation protein: a single marker that confidently differentiates morpheaform/infiltrative basal cell carcinoma from desmoplastic trichoepithelioma
O. Abbas (2010)
10.1021/ja9032742
Peptide synthesis in aqueous environments: the role of extreme conditions on peptide bond formation and peptide hydrolysis.
E. Schreiner (2009)
10.1002/anie.201506262
Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer‐Associated Fibroblast Activation
T. Ji (2016)
10.1039/C0SM01037E
Novel 1-D biophotonic nanohybrids: protein nanofibers meet quantum dots
Gang Wei (2011)
10.1038/ncomms9612
Aqueous multiphoton lithography with multifunctional silk-centred bio-resists
Yun-Lu Sun (2015)
10.1002/psc.2606
Nanostructures from the self‐assembly of α‐helical peptide amphiphiles
Qingbin Meng (2014)
10.1002/MACP.201500370
Bioactive Nanofiber Matrices Functionalized with Fibronectin‐Mimetic Peptides Driving the Alignment and Tubular Commitment of Adult Renal Stem Cells
A. Sciancalepore (2016)
10.1016/j.actbio.2017.06.009
Angiogenic peptide nanofibers repair cardiac tissue defect after myocardial infarction.
A. J. Rufaihah (2017)
10.1002/1521-3773(20020201)41:3<390::AID-ANIE390>3.0.CO;2-B
Heparin-protein interactions.
I. Capila (2002)
10.1021/bm500001n
Multifunctional adhesive silk fibroin with blending of RGD-bioconjugated mussel adhesive protein.
Y. J. Yang (2014)
10.1021/bi1018573
Self-assembly of short collagen-related peptides into fibrils via cation-π interactions.
Chia-Ching Chen (2011)
10.1038/ncomms1767
Graphene-based wireless bacteria detection on tooth enamel.
M. S. Mannoor (2012)
10.1039/C0SM00321B
Fibronectin-mimetic peptide-amphiphile nanofiber gels support increased cell adhesion and promote ECM production
Kamlesh Shroff (2010)
10.1039/C6TB02659A
Design, fabrication, and biomedical applications of bioinspired peptide-inorganic nanomaterial hybrids.
Xiaoqing Yu (2017)
10.1016/j.biomaterials.2012.06.003
Controlled release of dexamethasone from peptide nanofiber gels to modulate inflammatory response.
M. Webber (2012)
10.1016/j.cell.2014.02.053
Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling
B. Liu (2014)
10.1021/acs.biomac.5b01134
Double-Chambered Ferritin Platform: Dual-Function Payloads of Cytotoxic Peptides and Fluorescent Protein.
S. Kim (2016)
10.1021/la5037663
Programming pH-triggered self-assembly transitions via isomerization of peptide sequence.
A. Ghosh (2014)
10.1016/j.biomaterials.2017.04.040
Heparin mimetic peptide nanofiber gel promotes regeneration of full thickness burn injury.
Fatih Yergoz (2017)
10.1111/aos.13047
Effects of peptide ratios in nanofibre‐based hydrogels for the prevention of capsular opacification
Lisanne M. Nibourg (2016)
10.1039/c4cc02858a
A modular electrochemical peptide-based sensor for antibody detection.
Mihaela Puiu (2014)
10.1016/j.biomaterials.2014.10.048
Molecular mechanisms for intrafibrillar collagen mineralization in skeletal tissues.
Zhijun Xu (2015)
10.1016/J.ACTBIO.2005.04.002
Self-assembling peptide amphiphile nanofiber matrices for cell entrapment.
E. Beniash (2005)
10.1002/ADFM.201502506
Motif-designed peptide nanofibers decorated with graphene quantum dots for simultaneous targeting and imaging of tumor cells
Z. Su (2015)
10.1021/MZ400639Y
Directed Growth of Silk Nanofibrils on Graphene and Their Hybrid Nanocomposites
Shengjie Ling (2014)
10.1016/j.mcn.2014.10.002
TDP6, a brain-derived neurotrophic factor-based trkB peptide mimetic, promotes oligodendrocyte myelination
A. W. Wong (2014)
10.1038/nnano.2015.310
Amyloid-carbon hybrid membranes for universal water purification.
Sreenath Bolisetty (2016)
10.1021/bi400625v
Distinct β-sheet structure in protein aggregates determined by ATR-FTIR spectroscopy.
Bhavana Shivu (2013)
10.1039/c4cc01290a
Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors.
Adam McQuistan (2014)
10.1002/BIP.360250307
Examination of the secondary structure of proteins by deconvolved FTIR spectra
D. Byler (1986)
10.1021/la3035215
Self-assembled peptide nanofiber templated one-dimensional gold nanostructures exhibiting resistive switching.
H. Acar (2012)
10.1016/S1367-5931(02)00385-X
Mimicry of bioactive peptides via non-natural, sequence-specific peptidomimetic oligomers.
J. Patch (2002)
10.1039/C4BM00121D
The bioactivity of composite Fmoc-RGDS-collagen gels.
Ricardo M Gouveia (2014)
10.1021/bm3010897
Growth factor binding on heparin mimetic peptide nanofibers.
R. Mammadov (2012)
10.1002/chem.201501793
Self-Assembly of Tetraphenylalanine Peptides.
Enric Mayans (2015)
10.1021/bm301141h
Amyloid inspired self-assembled peptide nanofibers.
Goksu Cinar (2012)
10.1002/adma.201200051
Multifunctional materials through modular protein engineering.
Rebecca L DiMarco (2012)
10.1039/C2SM27496E
Nanoparticle Formation from Hybrid, Multiblock Copolymers of Poly(Acrylic Acid) and VPGVG Peptide.
Sarah E. Grieshaber (2013)
10.1039/B807150K
Self-Assembled Collagen-like Peptide Fibers as Templates for Metallic Nanowires.
Daniel Gottlieb (2008)
10.1002/ADFM.201403190
A Tumor Targeted Chimeric Peptide for Synergistic Endosomal Escape and Therapy by Dual‐Stage Light Manipulation
K. Han (2015)
10.1016/J.BPC.2007.03.012
Analysis of insulin amyloid fibrils by Raman spectroscopy.
C. Ortiz (2007)
10.1021/bm400233x
Bioinspired self-assembled peptide nanofibers with thermostable multivalent α-helices.
So-hee Han (2013)
10.1002/adma.201300904
Hybrid nanocomposites of gold single-crystal platelets and amyloid fibrils with tunable fluorescence, conductivity, and sensing properties.
C. Li (2013)
10.1088/0034-4885/76/4/046601
The self-assembly, aggregation and phase transitions of food protein systems in one, two and three dimensions.
R. Mezzenga (2013)
10.1073/pnas.1321797111
Designed amyloid fibers as materials for selective carbon dioxide capture
D. Li (2013)
10.1016/j.actbio.2012.01.036
Self-assembling glucagon-like peptide 1-mimetic peptide amphiphiles for enhanced activity and proliferation of insulin-secreting cells.
S. Khan (2012)
10.1016/S0065-3233(05)70003-6
The structure of α-helical coiled coils
A. Lupas (2005)
10.1038/srep16460
Basal Lamina Mimetic Nanofibrous Peptide Networks for Skeletal Myogenesis
Immihan Ceren Yasa (2015)
10.1021/acs.nanolett.5b02859
Peptide Bioink: Self-Assembling Nanofibrous Scaffolds for Three-Dimensional Organotypic Cultures.
Yihua Loo (2015)
10.1021/MZ500213W
Electrostatic Assembly of Peptide Nanofiber–Biomimetic Silver Nanowires onto Graphene for Electrochemical Sensors
Jinhui Wang (2014)
10.1039/c4sm01065e
The position of hydrophobic residues tunes peptide self-assembly.
Christian Bortolini (2014)
10.1021/BM070121S
Synthesis and in vitro hydroxyapatite binding of peptides conjugated to calcium-binding moieties.
Matthew B. Murphy (2007)
10.1021/nn405356r
Heat-generating iron oxide nanocubes: subtle "destructurators" of the tumoral microenvironment.
Jelena Kolosnjaj-Tabi (2014)
10.1002/adhm.201300491
Bioactive supramolecular peptide nanofibers for regenerative medicine.
E. Arslan (2014)
10.1039/c2cc35384a
Directed patterning of the self-assembled silk-elastin-like nanofibers using a nanomechanical stimulus.
S. Johnson (2012)
10.1021/ACSBIOMATERIALS.5B00396
Collagen-Based Artificial Corneal Scaffold with Anti-Infective Capability for Prevention of Perioperative Bacterial Infections
A. Riau (2015)
10.1021/nn204214x
Amyloid-derived peptide forms self-assembled monolayers on gold nanoparticle with a curvature-dependent β-sheet structure.
C. P. Shaw (2012)
10.1016/j.actbio.2013.12.002
Bioactive self-assembled peptide nanofibers for corneal stroma regeneration.
G. Uzunalli (2014)
10.1021/ja3006868
Sequence, structure, and function of peptide self-assembled monolayers.
Ann K. Nowinski (2012)
10.3390/ma9010053
Bottom-Up Synthesis and Sensor Applications of Biomimetic Nanostructures
L. Wang (2016)
10.1021/jacs.5b10304
Dissecting Electrostatic Contributions to Folding and Self-Assembly Using Designed Multicomponent Peptide Systems.
A. Parmar (2016)
10.1021/bm4005645
The robust hydrogel hierarchically assembled from a pH sensitive peptide amphiphile based on silk fibroin.
H. Guo (2013)
10.1021/acs.analchem.5b03970
Protein-Coupled Fluorescent Probe To Visualize Potassium Ion Transition on Cellular Membranes.
Tomoya Hirata (2016)



This paper is referenced by
10.1002/SLCT.201901671
The Investigation of a Multi‐Functional Peptide as Gelator, Dyes Separation Agent and Metal Ions Adsorbent
Zhenghao Li (2019)
10.3390/s19224962
DNA-Polylactide Modified Biosensor for Electrochemical Determination of the DNA-Drugs and Aptamer-Aflatoxin M1 Interactions
V. Stepanova (2019)
10.1016/j.nanoms.2019.09.011
Bio-inspired synthesis of nanomaterials and smart structures for electrochemical energy storage and conversion
M. Ding (2019)
10.1002/9783527603978.mst0491
Electrohydrodynamic Jet Printing – Principles and Applications in High Sensitivity Biosensing
Gaofeng Zheng (2020)
10.3390/nano9020276
Removing Metal Ions from Water with Graphene–Bovine Serum Albumin Hybrid Membrane
X. Yu (2019)
10.3390/s19173762
Opportunities, Challenges, and Prospects in Electrochemical Biosensing of Circulating Tumor DNA and Its Specific Features
Susana Campuzano (2019)
10.1016/j.bioactmat.2020.03.003
Mineralization of calcium phosphate controlled by biomimetic self-assembled peptide monolayers via surface electrostatic potentials
Shuo Wang (2020)
10.1186/s40580-019-0209-y
Current progress in application of polymeric nanofibers to tissue engineering
Sorour Nemati (2019)
10.1557/MRC.2019.69
Coupling synthetic biology and programmable materials to construct complex tissue ecosystems.
Catherine S Millar-Haskell (2019)
10.1002/mabi.201800080
Dentin Phosphoprotein Mimetic Peptide Nanofibers Promote Biomineralization.
Gulcihan Gulseren (2019)
10.1016/J.COELEC.2018.05.017
Building switchable peptide-architectures on gold/composite surfaces: New perspectives in electrochemical bioassays
Mihaela Puiu (2018)
10.1186/s12951-020-00636-z
Graphene oxide nanofilm and the addition of l-glutamine can promote development of embryonic muscle cells
M. Zielińska-Górska (2020)
10.1039/c9tb02844g
Nanostructure-based photoelectrochemical sensing platforms for biomedical applications.
Zhenli Qiu (2020)
10.3390/polym11030451
Effect of Silk Fibroin on Cell Viability in Electrospun Scaffolds of Polyethylene Oxide
Gabriela Carrasco-Torres (2019)
10.1007/s00216-018-1142-3
Interactions between elastin-like peptides and an insulating poly(ortho-aminophenol) membrane investigated by AFM and XPS
M. E. Carbone (2018)
10.1007/S10118-019-2297-X
Enhanced Mechanical Properties of Poly(arylene sulfide sulfone) Membrane by Co-electrospinning with Poly(m-xylene adipamide)
L. Chen (2020)
10.1039/c9nr00218a
Hierarchical nanomaterials via biomolecular self-assembly and bioinspiration for energy and environmental applications.
Coucong Gong (2019)
10.3390/molecules24081450
Using Self-Assembling Peptides to Integrate Biomolecules into Functional Supramolecular Biomaterials
Renjie Liu (2019)
10.1002/tcr.201800084
Developing Graphene-Based Nanohybrids for Electrochemical Sensing.
H. Song (2019)
10.1016/J.POLYMER.2018.10.009
Multilevel structural stereocomplex polylactic acid/collagen membranes by pattern electrospinning for tissue engineering
Y. Kang (2018)
10.21203/rs.3.rs-19279/v1
Graphene oxide nanofilm and the addition of l-glutamine can promote development of embryonic muscle cells
M. Zielińska-Górska (2020)
10.1016/J.MATLET.2019.126540
Modulation of structure and mechanical properties of self-assembled peptide nanofibrils and nanosheets
Hangshuai Jin (2019)
10.1039/c9tb01508f
Biotinylated and fluorophore-incorporated polymeric mixed micelles for tumor cell-specific turn-on fluorescence imaging of Al3.
Caixia Wang (2019)
10.1016/J.CCLET.2019.06.032
Self-assembled thermosensitive luminescent nanoparticles with peptide-Au conjugates for cellular imaging and drug delivery
Xiaoyuan Zhang (2020)
10.1002/adfm.201803969
Functional Peptide Nanofibers with Unique Tumor Targeting and Enzyme-Induced Local Retention Properties.
Vanessa Bellat (2018)
10.1016/j.ccr.2020.213342
Enzyme-based hybrid nanoflowers with high performances for biocatalytic, biomedical, and environmental applications
Yiduo Li (2020)
10.1039/c9tb02936b
Biomolecule conjugated metal nanoclusters: bio-inspiration strategies, targeted therapeutics, and diagnostics.
S. Zhang (2020)
10.1016/J.NANTOD.2019.03.003
Recent progresses in graphene based bio-functional nanostructures for advanced biological and cellular interfaces
Chuanxiong Nie (2019)
10.1039/C8TB03326A
NIR light-responsive short peptide/2D NbSe2 nanosheets composite hydrogel with controlled-release capacity
Can Wu (2019)
10.1016/j.biomaterials.2020.120055
Targeting self-assembly peptide for inhibiting breast tumor progression and metastasis.
S. Luo (2020)
10.1186/s12951-020-0582-z
Enhance transgene responses through improving cellular uptake and intracellular trafficking by bio-inspired non-viral vectors
Xi-Xi Ma (2020)
10.3390/membranes8030062
A Review on Properties of Natural and Synthetic Based Electrospun Fibrous Materials for Bone Tissue Engineering
Deval Prasad Bhattarai (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar