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Uptake And Controlled Release Of A Dye From Thermo-sensitive Polymer P(NIPAM-co-Vim)
Tomasz Śliwa, M. Jarzębski, M. Jarzębski, E. Andrzejewska, M. Szafran, J. Gapiński
Published 2017 · Chemistry
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Abstract Copolymers of N -isopropylacrylamide (PNIPAM) are one of the most promising microgel materials for medical applications, especially as a drug carrier. PNIPAMs present unique properties, such as size variation with changing pH and/or temperature. The results of a study on the uptake and release of a dye (Orange II) by microgels of N -isopropylacrylamide copolymer with 1-vinylimidazole (P(NIPAM-co-Vim) are presented. The dye was used as a model low-molecular substance. Hydrodynamic radius ( R h ) of P(NIPAM-co-Vim) particles was measured by dynamic light scattering as a function of temperature in two pH environments: acidic and basic. The dye particles contraction was monitored as a function of temperature at pH 4. The measurements of the zeta potential indicated a positive charge of P(NIPAM-co-Vim) particles at pH 4 and a negative one at pH 9. The key experiments were the internalization and the release of the dye. The effectiveness of this process was measured by UV-Vis spectroscopy on the supernatant derived from centrifuged P(NIPAM-co-Vim) suspension. At room temperature the efficiency of trapping of the dye by the microgel at pH 4 was 87%. Changing pH of a sample initially saturated with the dye from 4 to 9 led to a complete release of the trapped dye.
This paper references
Salting-in effect of ionic liquids on poly(N-vinylimidazole) hydrogels
C. S. Renamayor (2013)
Synthesis and Characterization of Thermally Reversible Bioconjugates Composed of α-chymotrypsin and poly(N-isopropylacrylamide-co-acrylamido-2-deoxy -D-glucose)
H. K. Kim (1999)
Synthesis of cationic poly(methyl methacrylate)-poly(N-isopropyl acrylamide) core-shell latexes via two-stage emulsion copolymerization
A. M. Santos (2005)
pH/temperature-sensitive polymers for macromolecular drug loading and release
Y. Kim (1994)
Thermoresponsive poly(N-isopropylacrylamide-co-N-vinylimidazole) hydrogels by redox polymerization
Belma Işık (2003)
Cytotoxic evaluation of N-isopropylacrylamide monomers and temperature-sensitive poly(N-isopropylacrylamide) nanoparticles
Aniket S. Wadajkar (2009)
Hydrogels for biomedical applications.
A. Hoffman (2002)
Pulsatile local delivery of thrombolytic and antithrombotic agents using poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels
C. Brazel (1996)
Geometrical characteristics of polyelectrolyte nanogel particles and their polyelectrolyte complexes studied by dynamic and static light scattering.
E. Kokufuta (2007)
Hybrid nanogels for sustainable positive thermosensitive drug release.
Y. Shin (2001)
Poly (N-isopropylacrylamide) microgel-based assemblies for organic dye removal from water.
D. Parasuraman (2011)
Polyglycol-templated synthesis of poly(N-isopropyl acrylamide) microgels with improved biocompatibility
T. Chastek (2009)
A one-step strategy for thermal- and pH-responsive graphene oxide interpenetrating polymer hydrogel networks
Shengtong Sun (2011)
Temperature-sensitive aqueous microgels.
R. Pelton (2000)
Simultaneous and sequential micro-porous semi-interpenetrating polymer network hydrogel films for drug delivery and wound dressing applications
T. T. Reddy (2009)
METAL—POLYELECTROLYTE COMPLEXES. VIII. THE POLY-N-VINYLIMIDAZOLE—COPPER(II) COMPLEX
Daniel H. Gold (1960)
Thermal analysis of the volume phase transition with N-isopropylacrylamide gels
K. Otake (1990)
In Situ Encapsulation and Release Kinetics of pH and Temperature Responsive Nanogels
Sasmita Nayak (2012)
Thermally reversible hydrogels: II. Delivery and selective removal of substances from aqueous solutions
Allan S. Huffman (1986)
Synthesis of aminated poly(1-vinylimidazole) for a new pH-sensitive DNA carrier.
S. Asayama (2007)
Cytotoxicity and drug release behavior of PNIPAM grafted on silica-coated iron oxide nanoparticles
Yi-Hsin Lien (2011)
1H NMR investigation of thermally triggered insulin release from poly(N-isopropylacrylamide) microgels.
C. Nolan (2006)
Synthesis, characterization and in vitro studies of doxorubicin-loaded magnetic nanoparticles grafted to smart copolymers on A549 lung cancer cell line
A. Akbarzadeh (2012)
Self-assembled thermo- and pH responsive micelles of poly(10-undecenoic acid-b-N-isopropylacrylamide) for drug delivery.
H. Wei (2006)
Thermal property changes of poly(N-isopropylacrylamide) microgel particles and block copolymers
K. Tauer (2009)
Light-Scattering Study of Coil-to-Globule Transition of a Poly(N-isopropylacrylamide) Chain in Deuterated Water
Xiaoying Wang (1999)
Preparation and characterization of microgels sensitive toward copper II ions.
M. Muratalin (2013)
Thermosensitive polymer-conjugated albumin nanospheres as thermal targeting anti-cancer drug carrier.
Zheyu Shen (2008)
Hydrogels for biomedical purposes
J. Rosiak (1995)
Preparation of monodisperse poly(N-isopropylacrylamide) microgel particles with homogenous cross-link density distribution.
Roberta Acciaro (2011)
Intracellular localisation, geno- and cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480).
Pratap C. Naha (2010)
CONTIN: A general purpose constrained regularization program for inverting noisy linear algebraic and integral equations
S. Provencher (1984)
Preparation of Thermosensitive Submicrometer Gel Particles with Anionic and Cationic Charges
S. Ito (1999)
Influence of charge density on the swelling of colloidal poly(N-isopropylacrylamide-co-acrylic acid) microgels
K. Kratz (2000)
Thermo-sensitive polymers as on-off switches for drug release
Y. Bae (1987)
Design of aminated poly(1-vinylimidazole) for a new pH-sensitive polycation to enhance cell-specific gene delivery.
S. Asayama (2007)
Stimuli-Responsive PNIPAM Based Copolymers: Modeling and Light Scattering Investigations
T. Śliwa (2014)
Thermally programmable pH buffers.
Dara Van Gough (2012)
Conjugation of Trypsin by Temperature‐Sensitive Polymers Containing a Carbohydrate Moiety: Thermal Modulation of Enzyme Activity
H. Lee (1998)
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Fluorescein ether-ester dyes for labeling of fluorinated methacrylate nanoparticles
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Ke Li (2018)
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Modification of cellulose nanocrystal with dual temperature- and CO2-responsive block copolymers for ion adsorption applications
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Coating of optical fiber with a smart thermosensitive polymer for the separation of phthalate esters by solid-phase microextraction.
H. Hashemi-Moghaddam (2018)
Future of additive manufacturing in healthcare
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Microgels as efficient adsorbents for the removal of pollutants from aqueous medium
K. Naseem (2018)
Synthesis of coumarin-containing multi-responsive CNC-grafted and free copolymers with application in nitrate ion removal from aqueous solutions.
Zahra Abousalman-Rezvani (2019)
Thermoresponsive Nanogels Based on Different Polymeric Moieties for Biomedical Applications
Sobhan Ghaeini-Hesaroeiye (2020)