Online citations, reference lists, and bibliographies.
← Back to Search

Synthesis Of Gentamicin-grafted-chitosan With Improved Solubility And Antibacterial Activity

Tingting Yan, Chengpeng Li, Ouyang Qianqian, D. Zhang, Zhong Qingkun, Puwang Li, S. Li, Ziming Yang, Tao Wang, Qingxia Zhao
Published 2019 · Chemistry

Cite This
Download PDF
Analyze on Scholarcy
Share
Abstract Due to superior properties, chitosan (CS) has been widely applied in health field. However its acid-solubility and poor antimicrobial activity compromise its safety and applications, respectively. To enhance its water-solubility and antimicrobial activity, gentamicin-grafted-chitosan (GT-CS) is synthesized for the first time, which is then confirmed by various characteristic methods and the graft ratio for gentamicin is about 22.1%. Particularly, it is the first study, disclosing there are degradation and crosslinking involved simultaneously during CS oxidation. Furthermore, GT-CS shows greatly improved water solubility (10.0w%). Compared to CS, the antibacterial activity of GT-CS is improved significantly, approaching the pure gentamicin. It should be noted that the antimicrobic mechanism may not be the target-specific interactions but the nonspecific interactions with the bacterial membrane as shown by scanning electron microscope. To sum up, GT-CS is a superior antimicrobial with good solubility.
This paper references
10.1016/j.ijbiomac.2017.11.119
Enhanced Antibacterial effect of chitosan film using Montmorillonite/CuO nanocomposite.
A. Nouri (2018)
10.1016/j.msec.2017.08.037
Cross-linked branched polyethylenimine used as a nitric oxide donor for prolonged nitric oxide release.
Y. Ji (2017)
10.1016/J.POLYMDEGRADSTAB.2012.11.001
Degradation of chitosan by hydrodynamic cavitation
Y. Huang (2013)
10.1016/J.POLYMDEGRADSTAB.2018.09.005
Accessibility of chitin and chitosan in enzymatic hydrolysis: A review
Daria N. Poshina (2018)
10.1016/j.ijbiomac.2018.05.205
Modified chitosan-based bioactive material for antimicrobial application: Synthesis and characterization.
Elton Marks de Araújo Braz (2018)
10.1007/s00289-016-1880-3
Swelling-assisted reduction of chitosan molecular weight in the solid state using hydrogen peroxide
Nguyên Công Minh (2016)
10.1016/J.REACTFUNCTPOLYM.2017.03.001
Developing a potential antibacterial long-term degradable electrospun gelatin-based composites mats for wound dressing applications
R. Morsy (2017)
10.1016/j.carbpol.2017.09.053
Development of chitosan-sodium phytate nanoparticles as a potent antibacterial agent.
J. Yang (2017)
10.1016/J.CARBPOL.2005.04.006
Optimal routine conditions for the determination of the degree of acetylation of chitosan by 1H-NMR
E. Fernandez-Megia (2005)
10.1016/j.ijbiomac.2018.07.074
Development of antibacterial ε-polylysine/chitosan hybrid films and the effect on citrus.
Yana Li (2018)
10.1016/j.foodres.2018.05.038
The simultaneous loading of catechin and quercetin on chitosan-based nanoparticles as effective antioxidant and antibacterial agent.
F. Li (2018)
10.1016/J.CARRES.2005.01.002
Periodate oxidation of chitosans with different chemical compositions.
I. M. N. Vold (2005)
10.1016/j.ijbiomac.2018.07.038
Carboxymethyl chitosan as an antifungal agent on gauze.
Mardiyah Kurniasih (2018)
10.1155/2015/675714
Chitosan Prevents Gentamicin-Induced Nephrotoxicity via a Carbonyl Stress-Dependent Pathway
Chu-Kung Chou (2015)
10.1016/j.ijbiomac.2018.10.085
Synthesis of novel chitosan-PVC conjugates encompassing Ag nanoparticles as antibacterial polymers for biomedical applications.
S. T. Gaballah (2019)
10.1016/j.carbpol.2017.09.095
Fabrication and characterization of copper(II)-chitosan complexes as antibiotic-free antibacterial biomaterial.
L. Gritsch (2018)
10.1271/BBB.57.1929
Measurement of degree of deacetylation in D-glucosamine oligosaccharides by UV absorption
E. Muraki (1993)
10.1016/J.FOODCONT.2013.10.032
Inhibitory effects of chitosan in combination with antibiotics on Listeria monocytogenes biofilm
H. Mu (2014)
10.1016/J.FOODHYD.2018.04.040
Chitosan-coated liposomes as delivery systems for improving the stability and oral bioavailability of acteoside
Fei Zhou (2018)
10.1016/J.CARBPOL.2005.09.023
Water-solubility of chitosan and its antimicrobial activity
Caiqin Qin (2006)
10.1016/J.FOODHYD.2016.09.009
Polysaccharide-based films and coatings for food packaging: A review
Patricia Cazón (2017)
10.1016/j.msec.2017.02.154
Synthesis, characterization and antibacterial study on the chitosan-functionalized Ag nanoparticles.
Linhai Biao (2017)
10.1016/J.CEJ.2016.09.124
2D-alumina platelets enhance mechanical and abrasion properties of PA612 via interfacial hydrogen-bond interactions
Mengbo Qian (2017)
10.1016/j.ultsonch.2015.04.019
Synergistic degradation of chitosan by impinging stream and jet cavitation.
Y. Huang (2015)
10.3390/md15100328
Release Behavior and Antibacterial Activity of Chitosan/Alginate Blends with Aloe vera and Silver Nanoparticles
Luisa Fernanda Gómez Chabala (2017)
10.1016/j.carbpol.2015.06.034
Preparation and characterization of antibacterial thiosemicarbazide chitosan as efficient Cu(II) adsorbent.
Mudasir Ahmad (2015)
10.1088/1742-6596/853/1/012042
The synthesis and characterization of hydrogel chitosan-alginate with the addition of plasticizer lauric acid for wound dressing application
Djony Izak Rudyardjo (2017)
10.1016/j.taap.2011.10.015
Integrated transcriptomic and proteomic evaluation of gentamicin nephrotoxicity in rats.
E. Com (2012)
10.1016/j.ijbiomac.2009.03.003
Antibacterial activity of quaternary ammonium chitosan containing mono or disaccharide moieties: preparation and characterization.
Warayuth Sajomsang (2009)
10.1016/j.carbpol.2016.11.081
Original method for synthesis of chitosan-based antimicrobial agent by quaternary ammonium grafting.
Ernesto Oyervides-Muñoz (2017)
10.1016/j.ijbiomac.2017.01.121
Gentamicin modified chitosan film with improved antibacterial property and cell biocompatibility.
Y. Liu (2017)
10.1016/J.IJPHARM.2004.09.021
A chemical method of gentamicin bonding to gelatine-sealed prosthetic vascular grafts.
G. Ginalska (2005)
10.1002/ADFM.201707440
Dendritic Fe3O4@Poly(dopamine)@PAMAM Nanocomposite as Controllable NO‐Releasing Material: A Synergistic Photothermal and NO Antibacterial Study
S. Yu (2018)
10.1016/j.carbpol.2016.07.061
Peculiar behavior of starch 2,3-dialdehyde towards sulfanilamide and sulfathiazole.
Sherif M. A. S. Keshk (2016)
10.1016/j.ijbiomac.2018.09.122
Preparation of biocompatible wound dressings with long-term antimicrobial activity through covalent bonding of antibiotic agents to natural polymers.
Shengxue Hu (2019)
10.1016/J.CARBPOL.2009.08.022
Degradation of chitosan by an electrochemical process
Quanyuan Cai (2010)
10.1016/J.CARBPOL.2010.09.046
Oligoamines conjugated chitosan derivatives: Synthesis, characterization, in vitro and in vivo biocompatibility evaluations
Y. Jia (2011)
10.1016/J.JCONREL.2006.10.025
Chitosan-graft-polyethylenimine as a gene carrier.
Hu-Lin Jiang (2007)
10.1007/s00289-013-1030-0
A comparative study on antibacterial activities of chitosan based products and their combinations with gentamicin against S. epidermidis and E. coli
Z. Yalinca (2013)
10.1016/j.carbpol.2013.12.076
Structure and properties of cotton fabrics treated with functionalized dialdehyde chitosan.
X. He (2014)
10.1016/J.REACTFUNCTPOLYM.2018.01.012
Synthesis of photo-responsive chitosan-cinnamate for efficient entrapment of β-galactosidase enzyme
M. Monier (2018)
10.1016/S0963-9969(00)00024-7
Master curve for concentration dependence of semi-dilute solution viscosity of chitosan homologues: the Martin equation
M. Kasaai (2000)
10.1002/adma.201704661
Granular Nanostructure: A Facile Biomimetic Strategy for the Design of Supertough Polymeric Materials with High Ductility and Strength.
Pingan Song (2017)
10.1039/C8TB00620B
Balancing antimicrobial activity with biological safety: bifunctional chitosan derivative for the repair of wounds with Gram-positive bacterial infections.
M. Zhu (2018)
10.1016/j.carbpol.2017.08.027
An unexpected reactivity during periodate oxidation of chitosan and the affinity of its 2, 3-di-aldehyde toward sulfa drugs.
Sherif M. A. S. Keshk (2017)
10.1007/s10856-008-3611-2
In vitro gentamicin sustained and controlled release from chitosan cross-linked films
M. G. N. Campos (2009)
10.1016/j.carbpol.2016.01.073
Enhanced water-solubility, antibacterial activity and biocompatibility upon introducing sulfobetaine and quaternary ammonium to chitosan.
Y. Chen (2016)
10.1016/j.carbpol.2017.08.129
Antibacterial cotton fabric with enhanced durability prepared using silver nanoparticles and carboxymethyl chitosan.
Q. Xu (2017)
10.1016/j.carbpol.2017.12.051
Fabrication of cellulose nanowhiskers reinforced chitosan-xylan nanocomposite films with antibacterial and antioxidant activities.
Y. Bao (2018)
10.1016/j.carbpol.2014.10.010
Preparation, characterization, and antimicrobial activity of chitin nanofibrils reinforced carrageenan nanocomposite films.
S. Shankar (2015)
10.1016/j.carres.2010.02.011
Periodate oxidation of polysaccharides for modification of chemical and physical properties.
K. A. Kristiansen (2010)
10.1016/j.carbpol.2017.09.055
Chitosan as an effective inhibitor of multidrug resistant Acinetobacter baumannii.
E. Costa (2017)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar