← Back to Search
Curcumin-loaded Solid Lipid Particles By PGSS Technology
A. S. Pedro, A. S. Pedro, S. Villa, Paolo Caliceti, S. Melo, Elaine Cabral Albuquerque, Alberto Bertucco, Stefano Salmaso
Published 2016 · Chemistry
Download PDFAnalyze on Scholarcy
Abstract Curcumin is a poorly water-soluble and fragile compound that, by virtue of its biological activities, has been considered for a variety of therapeutic applications. In this work, a novel process based on supercritical fluid technology has been used for encapsulating curcumin in solid lipid particles (SLP) to yield curcumin formulations with enhanced biopharmaceutical properties. SLP were obtained by a Particles Generated from Gas Saturated Solution technique (PGSS), where [tristearin + soy phosphatidylcholine (PC)]/[dimethylsulfoxide (DMSO) + curcumin] mixtures were processed. The effects of operative conditions were investigated in order to identify the main parameters that affect the biopharmaceutical properties of the final product. Samples with (tristearin + PC)/(DMSO + curcumin) w/w ratios ranging from 65.6:1 to 3:1 were prepared either in the presence or absence of helium and then processed by PGSS. The drug loading yield was found to be between 30 and 87 drug/lipid w/w%. The particles obtained from lipid mixtures with low DMSO feed were homogeneous in size. The formulation prepared with the highest DMSO feed yielded a bimodal particle size distribution with significant aggregation. Interestingly, the use of helium in the preparation of the lipid mixture was found to improve the biopharmaceutical properties of the SLP, namely drug loading and particle dimensional features. The preparation process was not found to degrade curcumin indicating that PGSS can be properly set-up for the preparation of curcumin lipid particles.
This paper references
Targeted Delivery of Protein Drugs by Nanocarriers
R. Solaro (2010)
A New Stability-Indicating HPLC Method for Simultaneous Determination of Curcumin and Celecoxib at Single Wavelength: an Application to Nanoparticulate Formulation
Dalapathi B Gugulothu (2012)
Chiral separation of a diketopiperazine pheromone from marine diatoms using supercritical fluid chromatography.
Johannes Frenkel (2014)
Biotransformation of Curcumin to Vanillin by Pseudomonas species Isolated from waste water of Aurangabad
N. Ahmed (2017)
Effect of supercritical carbon dioxide pressurized with helium on solute solubility during supercritical fluid extraction
J. King (1995)
9.8 - Precipitation of solids with dense gases
Ž. Knez (2001)
Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability.
Jiabei Sun (2013)
Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process.
S. Salmaso (2009)
Lipid--an emerging platform for oral delivery of drugs with poor bioavailability.
S. Chakraborty (2009)
The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation.
C. Mohanty (2010)
A simple isocratic HPLC method for the simultaneous determination of curcuminoids in commercial turmeric extracts.
W. Wichitnithad (2009)
Proof of concept studies to confirm the delivery of curcumin loaded solid lipid nanoparticles (C-SLNs) to brain.
V. Kakkar (2013)
Development of Characterization Techniques of Thermodynamic and Physical Properties Applied to the CO2-DMSO Mixture
Brice Calvignac (2009)
Analgesic Effects of Intrathecal Curcumin in the Rat Formalin Test
Yong Han (2012)
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
B. Aggarwal (2009)
Supercritical fluid chromatography as a tool for enantioselective separation; a review.
K. Kalíková (2014)
Optimization of supercritical CO2 extraction of different anatomical parts of lovage (Levisticum officinale Koch.) using response surface methodology and evaluation of extracts composition
A. Kemzūraitė (2014)
Curcuminoids-loaded lipid nanoparticles: novel approach towards malaria treatment.
Aditya P Nayak (2010)
Production of insulin-loaded poly(ethylene glycol)/poly(l-lactide) (PEG/PLA) nanoparticles by gas antisolvent techniques.
N. Elvassore (2001)
Nanoprecipitation and the "Ouzo effect": Application to drug delivery devices.
E. Lepeltier (2014)
Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism.
A. Zur Mühlen (1998)
Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy.
J. Witkin (2013)
Enhanced apoptotic effect of curcumin loaded solid lipid nanoparticles.
Kakkar Vandita (2012)
High melting lipid based approach for drug delivery: solid lipid nanoparticles.
Sacheen Kumar (2013)
Novel formulation of solid lipid microparticles of curcumin for anti‐angiogenic and anti‐inflammatory activity for optimization of therapy of inflammatory bowel disease
V. Yadav (2009)
Biopharmaceutical characterisation of insulin and recombinant human growth hormone loaded lipid submicron particles produced by supercritical gas micro-atomisation.
S. Salmaso (2009)
Micronization processes with supercritical fluids: fundamentals and mechanisms.
A. Martín (2008)
Safety assessment of a solid lipid curcumin particle preparation: acute and subchronic toxicity studies.
Paresh Dadhaniya (2011)
Charging Mechanisms for Particles Prior to Electrostatic Separation
K. Lindley (1997)
The effect of dissolved helium on the density and solvation power of supercritical carbon dioxide
Zhouyao Zhang (1997)
Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles.
A. Noack (2012)
Nanocarrier systems for oral drug delivery: do we really need them?
A. Bernkop-Schnürch (2013)
The impact of electrostatic charge in pharmaceutical powders with specific focus on inhalation-powders
S. Karner (2011)
Curcumin Produces an Antihyperalgesic Effect via Antagonism of TRPV1
K. Yeon (2010)
The pharmacology of curcumin: is it the degradation products?
L. Shen (2012)
Supercritical fluids processing of polymers for pharmaceutical and medical applications
E. Reverchon (2009)
Isolation, characterization and formulation of curcuminoids and in vitro release study of the encapsulated particles
T. Perko (2015)
Production of new hybrid systems for drug delivery by PGSS (Particles from Gas Saturated Solutions) process
M. Fraile (2013)
Two-phase homogeneous model for particle formation from gas-saturated solution processes
J. Li (2004)
Production of lipid microparticles containing bioactive molecules functionalized with PEG
K. Vezzù (2010)
Determination of free fatty acids in milk and cheese procedures for extraction, clean up, and capillary gas chromatographic analysis
C. D. Jong (1990)
Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure.
A. Kovačević (2011)
The expulsion of lipophilic drugs from the cores of solid lipid microspheres in diluted suspensions and in concentrates.
J. Pietkiewicz (2006)
Polymeric coating of fluidizing nano-curcumin via anti-solvent supercritical method for sustained release
F. Zabihi (2014)
Improved HPLC method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin.
G. K. Jayaprakasha (2002)
Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin.
V. Kakkar (2011)
International Conference on Harmonisation
R. Guy (2014)
Bioavailability of curcumin: problems and promises.
P. Anand (2007)
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
Nanoparticles production by supercritical antisolvent precipitation: A general interpretation
E. Reverchon (2007)
DMSO produces a new subgel phase in DPPC: DSC and X-ray diffraction study.
S. Tristram-Nagle (1998)
Supercritical antisolvent micronization of PVP and ibuprofen sodium towards tailored solid dispersions
M. Rossmann (2014)
Process design methodology for fractionation of fatty acids from palm fatty acid distillates in countercurrent packed columns with supercritical CO2
G. Brunner (2012)
Evaluation of antihyperalgesic effect of curcumin on formalin‐induced orofacial pain in rat
Niti Mittal (2009)
This paper is referenced by
Using Supercritical Fluid Technology as a Green Alternative During the Preparation of Drug Delivery Systems
Paroma Chakravarty (2019)
Release-controlled curcumin proliposome produced by ultrasound-assisted supercritical antisolvent method
Jingfu Jia (2016)
Technologie mikrokapsułkowania - nowe trendy
Dorota Kawka (2018)
Bread enriched with phytosterols with or without curcumin modulates lipoprotein profiles in hypercholesterolaemic individuals. A randomised controlled trial.
Jessica J A Ferguson (2019)
Preparation and characterization of lipid microcapsules coated with SiO2@Al2O3 core-shell nanoparticles as carries for lipophilic drug delivery
M. Koroleva (2017)
Micronization of curcumin with biodegradable polymer by supercritical anti-solvent using micro swirl mixer
Kimthet Chhouk (2017)
Development of curcumin lipid formulations for food applications: transport, permeability and safety evaluation on a mucus-secreting intestinal epithelial cell model
João Paulo Caseiro Baixinho (2018)
Development of innovative medical devices by dispersing fatty acid eutectic blend on gauzes using supercritical particle generation processes.
J. M. Silva (2019)
Antiinflammatory activity of carnauba wax microparticles containing curcumin
B. Rocha (2020)
A novel and green nanoparticle formation approach to forming low-crystallinity curcumin nanoparticles to improve curcumin’s bioaccessibility
Ali Ubeyitogullari (2019)
Modeling of the Production of Lipid Microparticles Using PGSS® Technique
Clara López-Iglesias (2020)
Current situation and perspectives in drug formulation by using supercritical fluid technology
E. Badens (2017)
Precipitation of curcumin by pressure reduction of CO2-expanded acetone
R. Prasad (2017)
Progress in Supercritical Fluid Technology for Fats and Oils Processing
F. Temelli (2020)
Formation of Bioactive-Carrier Hollow Solid Lipid Micro- and Nanoparticles
Junsi Yang (2016)
Application of supercritical and subcritical fluids in food processing
M. K. Hrnčič (2018)
Coprecipitation of curcumin/PVP with enhanced dissolution properties by the supercritical antisolvent process
R. L. Matos (2019)
Supercritical Fluid Technology: An Emphasis on Drug Delivery and Related Biomedical Applications
Ranjith Kumar Kankala (2017)
Current situation and perspectives in drug formulation by using supercritical fl uid technology
E. Badens (2019)
Elaboration of Innovative Medical Devices by Dispersing Fatty Acid Eutectic Blend on Gauzes Using Supercritical Particle Generation Processes
J. M. Silva (2019)
Dense CO2 technology: Overview of recent applications for drug processing/formulation/delivery
R. L. Matos (2019)
Supercritical Assisted Atomization for the production of curcumin-biopolymer microspheres
R. Adami (2017)