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Encapsulation Of Vitamin B2 In Solid Lipid Nanoparticles Using Supercritical CO2

R. Couto, V. H. Álvarez, F. Temelli
Published 2017 · Chemistry

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Abstract Solid lipid nanoparticles (SLN) are spherical particles prepared from solid fats, which can be used as delivery systems by encapsulating bioactives. In this study, particles from gas-saturated solutions (PGSS) were produced by a modified process, using fully hydrogenated canola oil (FHCO) to encapsulate Vitamin B2, a hydrophilic bioactive. Four operating parameters were studied in terms of their influence on encapsulation efficiency, bioactive load and particle size: pressure (10.0–25.0 MPa), Vitamin B2 concentration (0.25–2%, w/w), surfactant (sodium lauryl sulfate, SLS) concentration (1–7.5%, w/w) and stabilizer (polyethylene glycol, PEG) molecular weight (2,000–35,000 Da). The optimal conditions were determined as 15.0 MPa, 2% Vitamin B2, 5% SLS and 35,000 Da PEG, resulting in an encapsulation efficiency of 12 ± 0.03%, bioactive load of 0.54 ± 0.05 mg/g and bimodal particle size distribution with a main peak at 104 ± 5.7 nm, showing that it is possible to generate nano-scale solid lipid particles with a high content of a hydrophilic bioactive; however, further fine tuning is needed.
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