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Lowering Protein Fouling By Rational Processing Of Fluorine-free Hydrophobic Coatings
Connor McGlothin, C. Rosu, L. Jiang, V. Breedveld, D. Hess
Published 2019 · Materials Science
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Abstract Protein fouling has a tremendous economic impact and thus requires persistent endeavors directed towards designing surfaces that are able to suppress this phenomenon. One approach is to use multifunctional protective coatings and reduce protein adhesion. While it is commonly accepted that hydrophilic surfaces repel proteins, conflicting data have lately concerned their hydrophobic counterparts. Here we investigate the potential in reducing protein adhesion of hydrophobic surfaces, glass (GS) and stainless steel (SS), modified by a two-step inorganic and a multi-step organic coatings. The inorganic coating derives from methyltrimethoxysilane (MTMS) and the organic homologue consists of poly(methyl methacrylate) (PMMA). The first part of the study offers new insights into systematically tuning preparation parameters leading to reproducible hydrophobic coating thicknesses that were highly robust and durable, regardless of the substrate nature. Treatment of SS with the two coatings under the same conditions confirmed the results found for GS. The last part of the study found that both MTMS-derived and PMMA-based coatings significantly reduced fetal bovine serum protein fouling with respect to uncoated substrates. The findings revealed that the dual-level coating morphology together with the molecular structure of MTMS and PMMA films are the key features in reducing protein fouling. The study is relevant for biomedical applications that require antifouling surfaces such as implant devices and surgical instruments.
This paper references
Superhydrophobic materials and coatings: a review.
J. Simpson (2015)
Sodium Chloride Dihydrate Crystals: Morphology, Nucleation, Growth, and Inhibition
Arno A. C. Bode (2015)
Progress in silica polypeptide composite colloidal hybrids: from silica cores to fuzzy shells
C. Rosu (2014)
Sol-Gel Science: The Physics and Chemistry of Sol-Gel Processing
C. J. Brinker (1990)
Facile Adhesion-Tuning of Superhydrophobic Surfaces between "Lotus" and "Petal" Effect and Their Influence on Icing and Deicing Properties.
Md J. Nine (2017)
Fabrication of hydrophobic inorganic coatings on natural lotus leaves for nanoimprint stamps
S. Dai (2011)
Study on Micro Morphology of Potassium Dihydrogen Phosphate Crystals Grown at Elevated Temperatures
W. Li (2017)
Chain mobility and film softness mediated protein antifouling at the solid-liquid interface.
D. Liŭ (2016)
Fabrication of nonbiofouling metal stent and in vitro studies on its hemocompatibility
X. Wang (2014)
Inorganic hydrophobic coatings: Surfaces mimicking the nature
J. Reinosa (2013)
A two-step Sol-Gel method to synthesize a ladder polymethylsilsesquioxane nanoparticles
A. Baatti (2017)
Fouling and its control in membrane distillation-A review
L. Tijing (2015)
Fabrication of non-fluorinated hydrophilic-oleophobic stainless steel mesh for oil-water separation
Lu Jiang (2017)
Sculpting the internal architecture of fluorescent silica particles via a template-free approach.
C. Rosu (2016)
Heat Exchanger Fouling: Mitigation and Cleaning Strategies
H. Mueller-Steinhagen (2011)
Ultra-low fouling peptide surfaces derived from natural amino acids.
S. Chen (2009)
Surface-Grafted, Covalently Cross-Linked Hydrogel Brushes with Tunable Interfacial and Bulk Properties
A. Li (2011)
Review: Polymers, Surface-Modified Polymers, and Self Assembled Monolayers as Surface-Modifying Agents for Biomaterials
Abshar Hasan (2015)
Review on Molecular Mechanisms of Antifouling Compounds: An Update since 2012
Lianguo Chen (2017)
Hydrolysis and condensation of silicates: Effects on structure
C. J. Brinker (1988)
Effect of surface composition and roughness on the apparent surface free energy of silica aerogel materials
D. Mahadik (2011)
Electroactive poly(sulfobetaine-3,4-ethylenedioxythiophene) (PSBEDOT) with controllable antifouling and antimicrobial properties† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc03887a
Bin Cao (2016)
Super-hydrophobic covalent organic frameworks for chemical resistant coatings and hydrophobic paper and textile composites
Dinesh Mullangi (2017)
Sol–gel synthesis and characterizations of organically modified silica coatings on knitted cellulose for fixation applications
Y. Yin (2012)
Superhydrophobic behavior achieved from hydrophilic surfaces
J. Wang (2009)
Fabrication of oleophobic paper with tunable hydrophilicity by treatment with non-fluorinated chemicals
Zhenguan Tang (2015)
Polymer-nanotube-enzyme composites as active antifouling films.
Prashanth Asuri (2007)
Advances in polymers for anti-biofouling surfaces
S. Krishnan (2008)
Drastically lowered protein adsorption on microbicidal hydrophobic/hydrophilic polyelectrolyte multilayers.
Sze Yinn Wong (2012)
Growth and fire resistance of colloidal silica-polyelectrolyte thin film assemblies.
Galina Laufer (2011)
Highly Specific Binding on Antifouling Zwitterionic Polymer-Coated Microbeads as Measured by Flow Cytometry
E. van Andel (2017)
Antifouling coatings: recent developments in the design of surfaces that prevent fouling by proteins, bacteria, and marine organisms.
I. Banerjee (2011)
Reducing protein adsorption with polymer-grafted hyaluronic acid coatings.
M. H. Ramadan (2014)
Nonfouling property of zwitterionic cysteine surface.
Peter J. Lin (2014)
Superhydrophobic silica nanocomposite coating by a low-temperature process
W. Daoud (2004)
Preparation of durable insecticide cotton fabrics through sol–gel treatment with permethrin
M. Ardanuy (2014)
Evaluation of Protein Adsorption on Atmospheric Plasma Deposited Coatings Exhibiting Superhydrophilic to Superhydrophobic Properties
C. P. Stallard (2012)
Hydrogel brushes grafted from stainless steel via surface-initiated atom transfer radical polymerization for marine antifouling
J. Wang (2016)
A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein
E. Ostuni (2001)
Thermal stability and flame retardancy of polyester, cotton, and relative blend textile fabrics subjected to sol–gel treatments
J. Alongi (2011)
Bioactive zwitterionic polymer brushes grafted from silicon wafers via SI-ATRP for enhancement of antifouling properties and endothelial cell selectivity
Y. Wei (2017)
Fabrication of transparent superhydrophobic polytetrafluoroethylene coating
Raad A. Alawajji (2018)
Synthesis, characterization and resistant performance of α-Fe2O3@SiO2 composite as pigment protective coatings
S. Sultan (2016)
Adsorption of Proteins to Hydrophobic Sites on Mixed Self-Assembled Monolayers†
E. Ostuni (2003)
Silica aerogels formed from soluble silicates and methyl trimethoxysilane (MTMS) using CO2 gas as a gelation agent
X. Wu (2018)
Inorganic precursor peroxides for antifouling coatings
S. Olsen (2008)
Antifouling Biomimetic Liquid-Infused Stainless Steel: Application to Dairy Industrial Processing.
Sawsen Zouaghi (2017)
Preparation of organic–inorganic hybrid silica nanoparticles with contact antibacterial properties and their application in UV-curable coatings
Huiwen Ge (2017)
Protein adsorption and cell adhesion on polyurethane/Pluronic surface with lotus leaf-like topography.
J. Zheng (2010)
Fabrication of super-hydrophobic film from PMMA with intrinsic water contact angle below 90°
Yonghong Ma (2007)
Functional short-chain zwitterion coated silica nanoparticles with antifouling property in protein solutions.
Fenglin Hu (2015)
Anti-fouling behavior of polymer brush immobilized surfaces
Y. Higaki (2016)
Sustainable and long-time 'rejuvenation' of biomimetic water-repellent silica coating on polyester fabrics induced by rough mechanical abrasion.
C. Rosu (2018)
Wettability of porous surfaces
A. Cassie (1944)
Quantitative and qualitative evaluation of adsorption/desorption of bovine serum albumin on hydrophilic and hydrophobic surfaces.
Y. L. Jeyachandran (2009)
Modification of polyurethane‐coated fabrics by sol–gel thin films
Maja Somogyi Škoc (2014)
Preparation of hexadecyltrimethoxysilane-modified silica nanocomposite hydrosol and superhydrophobic cotton coating
Lihui Xu (2015)
Functionalizable low-fouling coatings for label-free biosensing in complex biological media: advances and applications
Hana Vaisocherová (2015)
Structural Change of Methyltrimethoxysilane in the Early Stage of Sol–Gel Coating via Silsesquioxane
H. Ando (2015)
Nanofunctionalized Superhydrophobic Antifouling Coatings for Environmental Sensor Applications—Advancing Deployment with Answers from Nature
J. Chapman (2012)
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