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Multicomponent Reactions Involving Zwitterionic Intermediates For The Construction Of Heterocyclic Systems: One Pot Synthesis Of Aminofurans And Iminolactones

V. Nair, A. Vinod, N. Abhilash, R. Menon, V. Santhi, R. L. Varma, S. Viji, S. Mathew, R. Srinivas
Published 2003 · Chemistry

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The reaction of 1:1 zwitterionic intermediate generated in situ from dimethyl acetylenedicarboxylate (DMAD) and cyclohexyl isocyanide with aldehydes and quinones is described. The reaction of stoichiometric amounts of DMAD, isocyanide and aldehydes afforded 2-aminofurans in good yields, while the reaction with quinones gave iminolactones.
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