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Highly Regioselective N-alkylation Of Nonracemic Betti Base: A Novel One-pot Synthesis Of Chiral N-methyl-N-alkyl Betti Bases

Yanmei Dong, J. Sun, X. Wang, X. Xu, Liya Cao, Yuefei Hu
Published 2004 · Chemistry

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Abstract A novel one-pot preparation of chiral N -methyl- N -alkyl Betti bases has been developed involving a highly regioselective N -alkylation of ( S )-(+)-Betti base. The strategy involved formation-cleavage of the oxazine ring and N -methylation with BtCH 2 OH under neutral conditions.
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