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A New Route To Acyclic Nucleosides Via Palladium-mediated Allylic Alkylation And Cross-metathesis

F. Amblard, S. Nolan, Isabelle Gillaizeau, L. Agrofoglio
Published 2003 · Chemistry

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A method for the syntheses of E-unsaturated acyclic nucleosides via a combination of palladium-catalyzed allylic alkylation and ruthenium-based cross metathesis is described. This approach provides a concise, efficient and reliable route to new nucleoside analogues.
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