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How Important Are NK1 Receptors For Influencing Microvascular Inflammation And Itch In The Skin? Studies Using Phoneutria Nigriventer Venom.

S. Costa, A. Starr, S. Hyslop, D. Gilmore, S. Brain
Published 2006 · Medicine, Chemistry

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Pain and itch sensations are induced by depolarization of C-fibre nerves and possibly other types of fibres. We have evidence from several species, including mice, that skin plasma extravasation induced by the Phoneutria nigriventer spider venom (PNV) is dependent on tachykinin NK(1) receptors. We have now investigated the itching measured as bouts of scratching in response to intradermal (i.d.) PNV in wildtype (NK(1)(+/+)) and NK(1) receptor knockout (NK(1)(-/-)) mice. Mice, either NK(1)(+/+) or NK(1)(-/-), were given a single i.d. injection (0.05 ml) of test agent or vehicle into the shaved dorsal skin, in the intercostal region, in a randomized way. The bouts of scratching were recorded in a blinded manner for 60 min. Oedema formation was concomitantly assessed by the extravascular accumulation of i.v. injected (125)I-albumin. The i.d. injection of either substance P (at a high dose of 100 nmol/site), or PNV (0.3-10 microg/site) induced oedema formation in NK(1)(+/+) but substantially less was observed in NK(1)(-/-) mice, as previously reported. PNV also induced scratching, but significantly less scratching was observed in NK(1)(-/-) compared with NK(1)(+/+) mice. In contrast, SP did not induce significant scratching at amounts up to 100 nmol in NK(1)(+/+) mice. Experiments with an NK(1) receptor antagonist SR140333 (at doses that blocked PNV-induced oedema) revealed that whilst a local co-injection i.d. (1 nmol) in NK(1)(+/+) mice had no effect on PNV (3 microg/site)-induced scratching (18.5+/-3.7 vs. 14.4+/-3.5 bouts, mean+/-S.E.M., n=5-7), systemic treatment with SR140333 (120 nmol/kg, i.v.) significantly inhibited scratching (14+/-3.5 vs. 3.1+/-1.2 bouts, n=4-6; P<0.05). These results indicate that NK(1) receptors are involved in mediating PNV-induced scratching and that the location of the receptors is unlikely to be skin. Thus, a distinct separation between endogenous microvascular and PNV nociceptive NK(1)-dependent effects is suggested.
This paper references
10.1016/0041-0101(92)90045-7
Phoneutria nigriventer (armed spider) venom induces increased vascular permeability in rat and rabbit skin in vivo.
E. Antunes (1992)
10.1001/ARCHDERM.139.11.1475
Neurophysiology of pruritus: interaction of itch and pain.
A. Ikoma (2003)
10.1016/S0014-2999(97)01387-3
Phoneutria nigriventer spider venom induces oedema in rat skin by activation of capsaicin sensitive sensory nerves.
S. Costa (1997)
10.1046/J.0022-202X.2001.01585.X
Involvement of leukotriene B(4) in substance P-induced itch-associated response in mice.
T. Andoh (2001)
10.1046/j.1468-2982.1991.1104175.x
Pain, Tenderness, Wheal and Flare Induced by Substance-P, Bradykinin and 5-Hydroxytryptamine in Humans
K. Jensen (1991)
10.1038/82924
Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch
D. Andrew (2001)
10.1007/s004030000149
Immunolocalization of substance P in human skin mast cells
M. Toyoda (2000)
10.1080/000155598433386
Modulation of cutaneous SP receptors in atopic dermatitis after UVA irradiation.
V. Staniek (1998)
10.1046/j.1365-2133.2002.04722.x
Experimental itch in sodium lauryl sulphate‐inflamed and normal skin in humans: a randomized, double‐blind, placebo‐controlled study of histamine and other inducers of itch
J. Thomsen (2002)
10.1124/JPET.102.032797
Cellular Mechanisms of Neurogenic Inflammation
J. D. Richardson (2002)
10.1016/J.EJPHAR.2003.08.007
Involvement of central μ-opioid system in the scratching behavior in mice, and the suppression of it by the activation of κ-opioid system
Hideo Umeuchi (2003)
10.1016/J.EJPHAR.2004.03.047
Involvement of substance P in scratching behaviour in an atopic dermatitis model.
T. Ohmura (2004)
Substance P induction of itch-associated response mediated by cutaneous NK1 tachykinin receptors in mice.
T. Andoh (1998)
10.1113/EXPPHYSIOL.1913.SP000144
VASO‐DILATOR AXON‐REFLEXES
A. N. Bruce (1913)
10.1001/ARCHDERM.139.11.1463
Neurophysiology of pruritus: cutaneous elicitation of itch.
S. Ständer (2003)
10.1111/1523-1747.EP12515092
Flare and itch induced by substance P in human skin.
O. Haegermark (1978)
10.1007/s004030050167
Density and fine structure of peripheral nerves in various skin lesions of atopic dermatitis
H. Sugiura (1997)
10.1152/ajplung.1997.273.5.L1073
Rat alveolar macrophages express preprotachykinin gene-I mRNA-encoding tachykinins.
C. R. Killingsworth (1997)
10.1016/S0305-4179(98)00125-9
Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model.
O. Löfgren (1999)
10.1159/000234752
Interaction of neuropeptides with human mast cells.
M. Church (1989)
10.1097/01.ALL.0000010985.57414.74
Allergen uptake and presentation by dendritic cells
B. Lambrecht (2001)
10.1016/j.brainres.2004.06.041
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom
Eliane Maria Zanchet (2004)
10.1111/1523-1747.EP12330326
Skin-nervous system interactions.
J. Ansel (1996)
10.1067/MJD.2001.110059
Treatment of prurigo nodularis with topical capsaicin.
S. Ständer (2001)
10.1046/j.1365-2133.2002.04803.x
Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis
M. Toyoda (2002)
10.1016/J.JNEUROIM.2005.08.012
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model
Á. Bánvölgyi (2005)
10.1038/sj.bjp.0705240
Phoneutria nigriventer spider venom activates 5‐HT4 receptors in rat‐isolated vagus nerve
S. Costa (2003)
10.1007/s00535-004-1464-0
Suppression of interleukin-1β- and tumor necrosis factor-·-induced inflammatory responses by leukocytapheresis therapy in patients with ulcerative colitis
A. Andoh (2004)
10.4049/jimmunol.170.7.3866
Modulation of Cutaneous Inflammation by Angiotensin-Converting Enzyme1
T. Scholzen (2003)
10.1111/j.1365-2133.1990.tb06261.x
Neuropeptides in skin from patients with atopic dermatitis: an immunohistochemical study
C. Pincelli (1990)
10.1016/S0165-6147(97)01107-3
The dual nature of the tachykinin NK1 receptor
C. A. Maggi (1997)
10.1046/J.1523-1747.2000.00142.X
Acute effects of substance P and calcitonin gene-related peptide in human skin--a microdialysis study.
C. Weidner (2000)
10.1111/j.1476-5381.1988.tb16555.x
Characterization of neuropeptide‐induced histamine release from human dispersed skin mast cells
M. A. Lowman (1988)
10.1007/BF00169165
The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture
A. Parenti (2004)
10.1152/ajpregu.1999.277.2.R476
Use of NK1 knockout mice to analyze substance P-induced edema formation.
T. Cao (1999)
10.1007/978-3-642-18891-6_14
Role of Tachykinins in Neurogenic Inflammation of the Skin and Other External Surfaces
A. Rawlingson (2004)
10.1016/S0162-3109(97)00055-6
Sensory neuropeptides: their role in inflammation and wound healing.
S. Brain (1997)
10.1111/J.1476-5381.1967.TB01984.X
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin.
N. Jancsó (1967)
10.1016/S0002-9440(10)63933-8
Functional significance of inducible nitric oxide synthase induction and protein nitration in the thermally injured cutaneous microvasculature.
A. Rawlingson (2003)
10.1016/0304-3940(95)12062-9
Substance P and nitric oxide mediate wound healing of ultraviolet photodamaged rat skin: evidence for an effect of nitric oxide on keratinocyte proliferation
J. Benrath (1995)
10.1111/j.0906-6705.2004.0178.x
Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
S. Ständer (2004)
10.1111/j.1468-3083.1999.tb00800.x
Characterization of [3H]substance P binding sites in human skin
B. Bianchi (1999)
10.1152/JN.01139.2002
Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens.
M. Schmelz (2003)
10.1113/jphysiol.1901.sp000831
On the origin from the spinal cord of the vaso‐dilator fibres of the hind‐limb, and on the nature of these fibres 1
W. Bayliss (1901)
10.1111/j.1476-5381.1996.tb15402.x
The effect of a tachykinin NK1 receptor antagonist, SR140333, on oedema formation induced in rat skin by venom from the Phoneutria nigriventer spider
R.T. Palframan (1996)
10.1097/00001756-200111160-00020
Histamine-induced itch converts into pain in neuropathic hyperalgesia
R. Baron (2001)
10.1016/S0014-2999(03)01604-2
Peripheral tackykinin and excitatory amino acid receptors mediate hyperalgesia induced by Phoneutria nigriventer venom.
Eliane Maria Zanchet (2003)
10.1016/S0306-3623(97)00078-5
Neurogenic vasodilatation and plasma leakage in the skin.
P. Holzer (1998)
10.1523/JNEUROSCI.17-20-08003.1997
Specific C-Receptors for Itch in Human Skin
M. Schmelz (1997)
10.1590/S0036-46652000000100003
A clinico-epidemiological study of bites by spiders of the genus Phoneutria.
F. Bucaretchi (2000)
10.1111/j.1600-0625.1998.tb00307.x
Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems
T. Scholzen (1998)
10.1038/sj.bjp.0705004
Nitric oxide enhances substance P‐induced itch‐associated responses in mice
T. Andoh (2003)
10.4049/jimmunol.166.2.1285
Neutral Endopeptidase Terminates Substance P-Induced Inflammation in Allergic Contact Dermatitis1
T. Scholzen (2001)
10.1016/0165-5728(94)90164-3
Eosinophils within the healthy or inflamed human intestine produce substance P and vasoactive intestinal peptide
A. Metwali (1994)
10.1248/BPB.26.896
Inhibitory effect of the repeated treatment with Unsei-in on substance P-induced itch-associated responses through the downregulation of the expression of NK(1) tachykinin receptor in mice.
T. Andoh (2003)
10.1111/1523-1747.EP12470630
Neuropeptides enhance irritant and allergic contact dermatitis.
J. Gutwald (1991)
10.1007/BF00402226
Substance P and calcitonin gene-related peptide modulate leukocyte infiltration to mouse skin during allergic contact dermatitis
M. Goebeler (2004)
10.1016/0304-3959(89)90079-1
Dose-dependent pain and mechanical hyperalgesia in humans after intradermal injection of capsaicin
D. Simone (1989)



This paper is referenced by
10.11606/D.42.2016.TDE-12082016-103639
Avaliação farmacológica de uma nanodispersão contendo GYY4137 (doador de liberação lenta de H2S) na psoríase experimental.
Tuanny P. Schmidt (2016)
10.1016/j.pharmthera.2009.10.005
The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation.
Khadija M Alawi (2010)
Sepsis-induced cardiac dysfunction: Pathophysiology and experimental treatments
J. Chen (2016)
Recent Advances in the Study of Itching
A. Ikoma (2013)
10.2218/gtopdb/f62/2019.4
Tachykinin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
J. Barrett (2019)
10.1248/BPB.B13-00435
Updated neurophysiology of itch.
A. Ikoma (2013)
10.1111/exd.12528
Neurokinin‐1 receptor antagonist orvepitant is an effective inhibitor of itch‐associated response in a Mongolian gerbil model of scratching behaviour
Michael K. Trower (2014)
10.1016/j.sder.2011.04.001
Anatomy and neurophysiology of pruritus.
A. Ikoma (2011)
10.1097/WNR.0b013e328337310a
Dorsal horn neurons expressing NK-1 receptors mediate scratching in rats
E. Carstens (2010)
10.1055/s-0039-1679918
Mechanisms and Treatments of Pruritus in Primary Biliary Cholangitis.
Raj A Shah (2019)
10.11606/D.42.2012.TDE-18092012-093925
Efeito de doadores do H2S no controle do prurido e inflamação cutânea em camundongos.
Leandro Rodrigues (2012)
10.1517/13543784.2013.813932
Investigational drugs for pruritus
H. Benecke (2013)
10.11606/T.42.2009.tde-09022010-112603
Ativação do receptor ativado por protease 2, um sinal para resposta imunológica inata na articulação temporomandibular.
Alexandre Denadai Souza (2009)
10.1007/978-1-84882-322-8_9
Experimental Models of Itch
Ulysse Pereira (2010)
10.1007/978-94-007-6646-4_18-1
Pain Modulating Peptides in Spider Venoms: Good and Evil
S. Diochot (2015)
10.1111/j.1468-3083.2011.04395.x
A randomized two‐sided placebo‐controlled study on the efficacy and safety of atmospheric non‐thermal argon plasma for pruritus
J. Heinlin (2013)
10.1016/j.nbd.2015.05.002
N-acetyl-l-tryptophan delays disease onset and extends survival in an amyotrophic lateral sclerosis transgenic mouse model
Wenming Li (2015)
10.1016/j.phrs.2016.09.030
Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice.
S. A. Coavoy-Sánchez (2016)
10.1016/j.toxicon.2008.10.006
Characterization of the mechanisms underlying the inflammatory response to Polistes lanio lanio (paper wasp) venom in mouse dorsal skin.
L. Yshii (2009)
10.1080/15563650802258524
Systemic envenomation caused by the wandering spider Phoneutria nigriventer, with quantification of circulating venom
F. Bucaretchi (2008)
The basis of topical superoxide dismutase antipruritic activity.
C. Diehl (2009)
Investigation of vascular dysfunction in pre-clinical models of sepsis
C. Sand (2014)
10.1016/j.ejpain.2008.09.012
Participation of peripheral tachykinin NK1 receptors in the carrageenan‐induced inflammation of the rat temporomandibular joint
A. Denadai-Souza (2009)
10.1124/jpet.115.226787
Pharmacological Characterization of the Edema Caused by Vitalius dubius (Theraphosidae, Mygalomorphae) Spider Venom in Rats
T. Rocha-e-Silva (2016)
10.1097/ACI.0b013e3282a644d2
Neuroimmune interactions in allergic skin diseases
F. Cevikbas (2007)
10.1016/j.nbd.2011.05.018
Transient receptor potential vanilloid 1 channels modulate the synaptic effects of TNF-α and of IL-1β in experimental autoimmune encephalomyelitis
G. Musumeci (2011)
10.1007/978-94-017-7438-3_63
Envenomation by Wandering Spiders (Genus Phoneutria )
F. Bucaretchi (2018)
10.1111/j.1755-5949.2010.00201.x
Role of Spinal Neurotransmitter Receptors in Itch: New Insights into Therapies and Drug Development
F. Cevikbas (2011)
10.1016/j.phrs.2016.11.006
Protective effects of exogenous and endogenous hydrogen sulfide in mast cell‐mediated pruritus and cutaneous acute inflammation in mice
L. Rodrigues (2017)
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