Online citations, reference lists, and bibliographies.
← Back to Search

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Kills Glucocorticoid-sensitive Thymocytes In Vivo.

D. McConkey, S. Orrenius
Published 1989 · Biology, Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The effect of in vivo exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on glucocorticoid- and calcium ionophore-induced DNA fragmentation in rat thymocytes was investigated. TCDD dose-dependently abolished DNA fragmentation in response to both agents after 7 days of exposure. Analysis of the time dependence of the effect revealed that after 1 or 2 days TCDD potentiated DNA fragmentation in untreated and glucocorticoid-treated thymocyte suspensions relative to controls. The DNA fragmentation in untreated thymocyte suspensions from TCDD-treated rats was completely prevented by inhibitors that block glucocorticoid-induced thymocyte suicide. Our results suggest that TCDD-induced thymic atrophy is due to Ca2+-dependent endonuclease activation.
This paper references
10.1126/SCIENCE.3262923
2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation.
D. McConkey (1988)
10.1016/0003-9861(89)90119-7
Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration.
D. McConkey (1989)
10.1038/326798A0
CD4+ murine T cells develop from CD8+ precursors in vivo
L. Smith (1987)
10.1038/337181A0
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
C. A. Smith (1989)
Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.
J. Cohen (1984)
10.1016/S0074-7696(08)62312-8
Cell death: the significance of apoptosis.
A. Wyllie (1980)
10.1084/JEM.158.5.1654
Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5
R. Ceredig (1983)
10.1016/0041-008X(78)90195-3
The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs.
E. E. Mcconnell (1978)
10.1002/PATH.1711420112
Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis
A. Wyllie (1984)
10.1038/284555A0
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
A. Wyllie (1980)
10.1042/BJ0620315
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.
Kenneth Burton (1956)



This paper is referenced by
10.1016/S0305-0491(97)00220-4
Luminal peroxides in intestinal thiol-disulfide balance and cell turnover.
T. Y. Aw (1997)
10.1016/0300-483X(93)90141-E
Early effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on rat thymocytes in vitro.
R. Kurl (1993)
10.1016/S0192-0561(98)00013-7
2,3,7,8-Tetrachlorodibenzo-p-dioxin co-stimulates Staphylococcal Enterotoxin β (SEB) cytokine production and phenotypic cell cycling in Long-Evans rats
W. Huang (1998)
10.1006/TAAP.1996.8049
Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo.
A. B. Kamath (1997)
10.1016/S0300-483X(02)00276-7
Role of the aryl hydrocarbon receptor in cell cycle regulation.
A. Puga (2002)
10.1080/10408440008951122
Molecular Mechanisms of Apoptosis Induced by Cytotoxic Chemicals
J. D. Robertson (2000)
10.1016/B978-0-12-330220-5.50022-X
17 – Immune System
H. Schuurman (1991)
10.1210/ENDO.139.10.6264
Dioxin perturbs, in a dose- and time-dependent fashion, steroid secretion, and induces apoptosis of human luteinized granulosa cells.
I. Heimler (1998)
10.1016/0891-5849(90)90052-K
Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
S. Stohs (1990)
10.1016/0192-0561(93)90069-B
Anti-CD3-induced T-cell activation--II. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
C. M. Neumann (1993)
10.1177/074823379901500808
Regulations and Advisories
H. Abadin (1999)
10.1016/S0006-2952(00)00403-2
The transcriptional signature of dioxin in human hepatoma HepG2 cells.
A. Puga (2000)
10.1289/EHP.95103366
Dioxin activates HIV-1 gene expression by an oxidative stress pathway requiring a functional cytochrome P450 CYP1A1 enzyme.
Y. Yao (1995)
10.1074/JBC.M404315200
The Aryl Hydrocarbon Receptor Displaces p300 from E2F-dependent Promoters and Represses S Phase-specific Gene Expression*
J. Marlowe (2004)
Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine 1 – 4
Tak Yee Aw ()
10.1016/0378-4274(94)03236-Z
Alterations in splenocyte protein kinase C (PKC) activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo.
N. E. Zorn (1995)
10.1093/AJCN/70.4.557
Molecular and cellular responses to oxidative stress and changes in oxidation-reduction imbalance in the intestine.
T. Y. Aw (1999)
10.1016/J.TOX.2006.07.010
Effects of 2,3,7,8-tetrachloro-dibenzo-p-dioxin on the extracellular matrix of the thymus in juvenile marmosets (Callithrix jacchus).
Christian Nottebrock (2006)
10.1111/j.1749-6632.1992.tb38670.x
Calcium‐Dependent Cell Death Role of the Endonuclease, Protein Kinase C, and Chromatin Conformation
M. Mccabe (1992)
Inhibitory actions of Ah receptor agonists and indole-containing compounds in breast cancer cell lines and mouse models
K. Walker (2005)
10.1080/08923970500418752
Effects of PCBs 52 and 77 on Th1/Th2 Balance in Mouse Thymocyte Cell Cultures
S. Sandal (2005)
LIPI 27(4).book(LIPI_A_141858.fm)
Suleyman Sandal (2005)
10.1016/0045-6535(92)90491-9
Tetrachlorodibenzo-p-dioxin (TCDD) and 3,3′,4,4′,5,5′,-hexachlorobiphenyl (HxCB) enhance anti-CD3-induced T cell activation
C. M. Neumann (1992)
10.3109/10408449709089900
Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin, bis(tri-n-butyltin) oxide and cyclosporine on thymus histophysiology.
E. De Waal (1997)
10.1016/0006-291X(91)91773-6
Dexamethasone and 2,3,7,8-tetrachlorodibenzo-p-dioxin can induce thymic atrophy by different mechanisms in mice.
K. Lundberg (1991)
10.1080/15287399309531744
The role of chemical-induced stress responses in immunosuppression: a review of quantitative associations and cause-effect relationships between chemical-induced stress responses and immunosuppression.
S. Pruett (1993)
10.1074/jbc.275.4.2943
Aromatic Hydrocarbon Receptor Interaction with the Retinoblastoma Protein Potentiates Repression of E2F-dependent Transcription and Cell Cycle Arrest*
A. Puga (2000)
10.1016/S0006-2952(97)00417-6
Sustained increase in intracellular free calcium and activation of cyclooxygenase-2 expression in mouse hepatoma cells treated with dioxin.
A. Puga (1997)
10.1016/j.tox.2010.06.005
Alteration of the PKC theta-Vav1 complex and phosphorylation of Vav1 in TCDD-induced apoptosis in the lymphoblastic T cell line, L-MAT.
Masato Ishida (2010)
10.1016/S0300-483X(98)00043-2
Methylcholanthrene causes increased thymocyte apoptosis.
C. Lutz (1998)
10.1016/B978-0-12-334163-1.50006-1
CHAPTER 18 – Nitro Compounds and Related Phenolic Pesticides
T. Gasiewicz (1991)
10.1016/S0009-2797(02)00068-6
Ah receptor and NF-κB interactions: mechanisms and physiological implications
Y. Tian (2002)
See more
Semantic Scholar Logo Some data provided by SemanticScholar