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Synthesis And Antibacterial Activities Of Quaternary Ammonium Salt Of Chitosan.
Z. Jia, D. Shen, W. Xu
Published 2001 · Medicine, Biology
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Chitosan derivatives with quaternary ammonium salt, such as N,N,N-trimethyl chitosan, N-N-propyl-N,N-dimethyl chitosan and N-furfuryl-N,N-dimethyl chitosan were prepared using different 96% deacetylated chitosan of M(v) 2.14x10(5), 1.9x10(4), 7.8x10(3). Amino groups on chitosan react with aldehydes to from a Schiff base intermediate. Quaternized chitosan were obtained by reaction of a Schiff base with methyl iodide. The yields, degree of quaternization and water-solubility of quaternized chitosan were influenced by the molecular weight of the chitosan sample. The antibacterial activities of quaternized chitosan against Escherichia coli were explored by calculation of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in water, 0.25 and 0.50% acetic acid medium. Results show the antibacterial activities of quaternized chitosan against E. coli is related to its molecular weight. Antibacterial activities of quaternized chitosan in acetic acid medium is stronger than that in water. Their antibacterial activities is increased as the concentration of acetic acid is increased. It was also found that the antibacterial activity of quaternized chitosan against E. coli is stronger than that of chitosan.
This paper references
The N-permethylation of chitosan and the preparation of N-trimethyl chitosan iodide
R. Muzzarelli (1985)
Induction of drug specific antibody and the controlled release of drug by 6-O-carboxymethyl-chitin
S. Tokura (1994)
New method for the quaternization of chitosan
A. Domard (1986)
Synthesis and Antibacterial Activity of Water‐soluble Chitin Derivatives
C. Kim (1997)
Determination of the Mark-Houwink equation for chitosans with different degrees of deacetylation.
W. Wang (1991)
Preparation of low-molecular-weight chitosan using phosphoric acid
M. Hasegawa (1993)
Antibacterial activity of shrimp chitosan against Escherichia coli.
G. Tsai (1999)
Synthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activity
C. Kim (1997)
Structure of the acidic exopolysaccharide of Pseudomonas marginalis strain ATCC 10844.
S. Osman (1993)
Antifungal Activity of Chitosan and Its Preservative Effect on Low-Sugar Candied Kumquat.
Shao W. Fang (1994)
Changes in Calculated Process Times and Drained Weight based on Soaking and Blanching of Kidney and Navy Beans.
K. Wiese (1993)
Antifungal Activity of Chitosan on Two Postharvest Pathogens of Strawberry Fruits
A. E. Ghaouth (1992)
Biochemistry of Antimicrobial Action
T. Franklin (1975)
Preparation and Antibacterial Activities of N-Trimethylammonium Salts of Chitosan
Katsumasa Tsurugai (1994)
Antimicrobial properties of N-carboxybutyl chitosan.
R. Muzzarelli (1990)
N-Acyl derivatives of chitosan and their hydrolysis by chitinase
S. Hirano (1987)
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L. Li (2006)
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J. Vinšová (2008)
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