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The Correlation Of Cell Disruption With Homogenizer Valve Pressure Gradient Determined By Computational Fluid Dynamics

A. Kleinig, A. Middelberg
Published 1996 · Materials Science

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Numerical investigations of the flow and pressure fields within a homogenizer valve have been conducted using the computational fluid dynamics code, PHOENICS 2.1. Results are obtained for two valve seat designs over a range of valve gaps. The dependence of valve gap on operating pressure is measured experimentally and compares well with numerical predictions. A simple expression that uses the numerical results and allows ready calculation of pressure gradient from homogenizer operating and design conditions is presented. Pressure gradient is shown to be a better independent variable for correlating cell disruption than operating pressure over a wide range of operating and design parameters.
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