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Pulsed Field Gradient NMR On Polybutylcyanoacrylate Nanocapsules.

M. Wohlgemuth, C. Mayer
Published 2003 · Chemistry, Medicine

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The applicability of pulsed field gradient nuclear magnetic resonance spectroscopy to nanocapsule systems is demonstrated on dispersed poly-n-butylcyanoacrylate nanocapsules as a model system. Spectroscopic data are presented that allow for the structural characterization of the inner cavities, the observation of Brownian motion of the capsules and the detection of rapid molecular exchange through the capsule walls. An analytical formula is proposed that yields equilibrium populations and average residence times of a given tracer molecule, thus leading to crucial information regarding the permeability of the capsule walls. Based on these analytical methods, two varieties of nanocapsules are compared that derive from two different preparation procedures. It is found that thinner capsule walls obtained under acidic conditions of the organic phase during interfacial polymerization lead to correspondingly higher exchange rates of benzene as a tracer molecule.
This paper references
NMR: Tomography, Diffusometry, Relaxometry
R. Kimmich (2001)
10.1007/BFB0111025
Pulsed field gradient NMR studies of emulsions: droplet sizes and concentrated emulsions
O. Söderman (1997)
10.1002/JPS.2600750408
Physicochemical and morphological characterization of polyisobutyl cyanoacrylate nanocapsules.
J. Rollot (1986)
10.1021/JP9711611
PFG-NMR Diffusion as a Method To Investigate the Equilibrium Adsorption Dynamics of Surfactants at the Solid/Liquid Interface
M. Schönhoff (1997)
10.1016/0378-5173(86)90236-X
Development of a new process for the manufacture of polyisobutylcyanoacrylate nanocapsules
N. A. K. Fallouh (1986)
10.1016/0021-9797(92)90079-2
Optimization of polyalkylcyanoacrylate nanoparticle preparation: Influence of sulfur dioxide and pH on nanoparticle characteristics
F. Lescure (1992)
10.1080/026520400405697
Improved preparation and physical studies of polybutylcyanoacrylate nanocapsules.
M. Wohlgemuth (2000)
10.1111/j.2042-7158.1979.tb13544.x
Potentially biodegradable microcapsules with poly (alkyl 2‐cyanoacrylate) membranes
A. Florence (1979)
10.1016/0168-3659(94)00060-8
Polyisobutylcyanoacrylate nanoparticles as sustained release system for calcitonin
C. Tasset (1994)
10.1016/0168-3659(90)90013-J
Nanocapsules as carriers for oral peptide delivery
C. Damgé (1990)
10.1016/S0378-5173(02)00184-9
Structural analysis of nanocapsules by nuclear magnetic resonance.
C. Mayer (2002)
10.1111/j.2042-7158.1991.tb05437.x
The Effect of Site of Administration in the Gastrointestinal Tract on the Absorption of Insulin from Nanocapsules in Diabetic Rats
C. Michel (1991)
10.1016/0378-5173(91)90110-A
Preparation and purification of polyisohexylcyanoacrylate nanocapsules
F. Chouinard (1991)
10.1063/1.480970
Cross polarization induced by temporary adsorption: NMR investigations on nanocapsule dispersions
D. Hoffmann (2000)
10.1023/A:1007597508478
Solid State NMR Investigations on Nanosized Carrier Systems
C. Mayer (2004)
10.1016/0378-5173(81)90025-9
Formation of poly(butyl 2-cyanoacrylate) microcapsules and the microencapsulation of aqueous solutions of [125I]-labelled proteins
D. A. Wood (1981)
10.1016/S0079-6565(02)00004-3
Nuclear magnetic resonance on dispersed nanoparticles
C. Mayer (2002)
10.1111/j.2042-7158.1979.tb13510.x
Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties
P. Couvreur (1979)
10.1111/j.2042-7158.1986.tb04547.x
Polyalkyl cyanoacrylate nanocapsules
M. El-Samaligy (1986)
10.1016/0021-9797(91)90406-X
Characterization of emulsions by NMR methods
Ingrid Lönnqvist (1991)
10.1016/0378-5173(93)90075-Q
Study of the mechanisms of formation of nanoparticles and nanocapsules of polyisobutyl-2-cyanoacrylate
M. Gallardo (1993)
Ph
李幼升 (1989)
10.3109/10731199409117926
Submicron biodegradable polymer membrane hemoglobin nanocapsules as potential blood substitutes: a preliminary report.
W. Yu (1994)
10.1016/S0939-6411(97)00117-3
Pharmaceutical and therapeutic applications of artificial cells including microencapsulation.
T. Chang (1998)
10.1002/JPS.2600710717
Toxicity of polyalkylcyanoacrylate nanoparticles II: Doxorubicin-loaded nanoparticles.
P. Couvreur (1982)



This paper is referenced by
10.1016/j.jcis.2011.01.018
Oil droplet size determination in complex flavor delivery systems by diffusion NMR spectroscopy.
Wolfgang Fieber (2011)
10.1007/3-540-32702-9_4
Molecular Exchange Through Capsule Membranes Observed by Pulsed Field Gradient NMR
C. Mayer (2006)
10.1002/SMLL.200600540
Molecular exchange through membranes of poly(2-vinylpyridine-block-ethylene oxide) vesicles.
A. Leson (2007)
10.1016/J.JCONREL.2004.07.013
Restricted diffusion and release of aroma molecules from sol-gel-made porous silica particles.
Susanne R. Veith (2004)
10.1063/1.2807239
Pulsed field gradient NMR study of phenol binding and exchange in dispersions of hollow polyelectrolyte capsules.
R. Choudhury (2007)
10.1002/wnan.15
Synthesis of poly(alkyl cyanoacrylate)-based colloidal nanomedicines.
J. Nicolas (2009)
10.3109/1061186X.2015.1020426
Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems
Shiya Gao (2015)
10.1016/S0066-4103(04)55004-4
NMR Studies of Nanoparticles
Christian C Mayer (2005)
Estudo físico-químico comparativo de sistemas nanoestruturados contendo indometacina ou seu éster etílico e avaliação in vivo da atividade antiedematogênica
L. Cruz (2005)
10.1016/J.CPLETT.2007.07.023
Water permeation through block-copolymer vesicle membranes
A. Leson (2007)
Synthesis of poly(alkyl cyanoacrylate)-based colloidal
Patrick Couvreur (2009)
10.1007/978-3-319-41421-8_5
Methods for the Preparation of Nanoparticles by Polymerization
C. Vauthier (2016)
10.1016/j.tifs.2020.05.010
Going deep inside bioactive-loaded nanocarriers through Nuclear Magnetic Resonance (NMR) spectroscopy
Roya Koshani (2020)
Nanocápsulas de poliaminoácidos para la liberación selectiva de fármacos antitumorales
F. Farmacia (2012)
10.1080/10611860701603372
Design aspects of poly(alkylcyanoacrylate) nanoparticles for drug delivery
C. Vauthier (2007)
Poly(alkycyanoacrylate) nanoparticlesforenhanced deliveryoftherapeutics-isthere realpotential?
Anja Graf (2009)
10.1517/17425240902870413
Poly(alkycyanoacrylate) nanoparticles for enhanced delivery of therapeutics – is there real potential?
A. Graf (2009)
10.1063/1.1697378
Molecular exchange through vesicle membranes: a pulsed field gradient nuclear magnetic resonance study.
A. Rumplecker (2004)
10.1016/j.jcis.2016.06.034
Permeability profile of poly(alkyl cyanoacrylate) nanocapsules.
Christian Martin Dr.-Ing. Erdmann (2016)
10.1007/978-94-007-1248-5_9
Poly(Alkyl Cyanoacrylate) Nanosystems
J. Nicolas (2011)
10.1021/jp5003098
Polyalkylcyanoacrylate nanocapsules: variation of membrane permeability by chemical cross-linking.
C. Groß-Heitfeld (2014)
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