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Acute Immune Thrombocytopenic Purpura: A Comparative Study Of Very High Oral Doses Of Methylprednisolone And Intravenously Administered Immune Globulin.

D. Albayrak, I. Işlek, A. Kalaycí, N. Gürses
Published 1994 · Medicine

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We compared very high doses of methylprednisolone with intravenously administered immune globulin for treatment of acute idiopathic thrombocytopenic purpura. Fifty-seven children were randomly assigned to receive the immune globulin preparation, 0.5 gm/kg per day for 5 consecutive days (n = 19), orally administered methylprednisolone, 30 mg/kg per day for 7 days (n = 19), or orally administered methylprednisolone, 50 mg/kg per day for 7 days (n = 19). There were no differences in the response of the platelet counts among the groups. We conclude that these two therapies were equally effective; choice between them may be made according to cost and therapy-related risks.
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