Online citations, reference lists, and bibliographies.
← Back to Search

Low Dose, Low-LET Ionizing Radiation-induced Radioadaptation And Associated Early Responses In Unirradiated Cells.

R. Iyer, B. Lehnert
Published 2002 · Medicine, Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
Numerous investigators have reported that irradiation of cells with a low dose of ionizing radiation (IR) can induce a condition of enhanced radioresistance, i.e. a radioadaptive response. In this report, we investigated the hypothesis that a radioadaptive bystander effect may be induced in unirradiated cells by a transmissible factor(s) present in the supernatants of cells exposed to low dose gamma-rays. Normal human lung fibroblasts (HFL-1) were irradiated with a 1 cGy dose of gamma-rays and their supernatants were transferred to unirradiated HFL-1 as a bystander cell model. Compared with the directly irradiated cells, such treatment resulted in increased clonogenic survival following subsequent gamma-irradiation with 2 and 4 Gy. This radioadaptive bystander effect was found to be preceded by early decreases in cellular levels of TP53 protein, increase in intracellular ROS, and increase in the redox and DNA repair protein AP-endonuclease (APE). The demonstration that radioadaptation can occur in unirradiated cells via a fluid-phase, transferable factor(s) adds to the complexity of the current understanding of mechanisms by which radioadaptive responses can be induced by low dose, low-LET IR.
This paper references
10.1016/S1097-2765(00)80002-7
14-3-3σ Is a p53-Regulated Inhibitor of G2/M Progression
H. Hermeking (1997)
10.1016/0165-3806(94)00212-I
Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains.
Y. Ono (1995)
10.1093/CARCIN/17.2.377
Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis.
L. Harrison (1996)
10.2307/3580049
Alpha particles induce the production of interleukin-8 by human cells.
P. Narayanan (1999)
10.2307/3576936
Characterization of the adaptive response to ionizing radiation induced by low doses of X rays to human lymphocytes.
J. Shadley (1987)
Extracellular factor(s) following exposure to alpha particles can cause sister chromatid exchanges in normal human cells.
B. Lehnert (1997)
10.1126/SCIENCE.280.5366.1066
Inducible repair of thymine glycol detected by an ultrasensitive assay for DNA damage.
X. Le (1998)
10.1016/S0006-2952(97)00448-6
Adaptive response to DNA-damaging agents: a review of potential mechanisms.
C. Stecca (1998)
10.1667/0033-7587(2001)155[0387:IORBAN]2.0.CO;2
Induction of Radioresistance by a Nitric Oxide-Mediated Bystander Effect
H. Matsumoto (2001)
10.1097/00004032-198705000-00020
Intracellular stimulation of biochemical control mechanisms by low-dose, low-LET irradiation.
L. Feinendegen (1987)
10.1016/S1383-5718(98)00102-8
Cytogenetic adaptive response in cultured human lymphocytes: dependence on the time of exposure to adapting and challenging doses of gamma-rays.
N. Ryabchenko (1998)
10.1073/PNAS.011417098
Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha -particle irradiated to nonirradiated cells.
E. Azzam (2001)
10.1093/MUTAGE/5.6.555
Adaptive response in human lymphocytes conditioned with hydrogen peroxide before irradiation with X-rays.
F. Cortés (1990)
Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells.
P. Narayanan (1997)
10.1073/PNAS.95.9.5061
Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals.
C. V. Ramana (1998)
10.2307/3579958
Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium.
C. Mothersill (1998)
10.1148/93.4.879
Chromosomal aberrations induced by plasma from irradiated patients: an indirect effect of X radiation. Further observations and studies of a control population.
Littlefield Lg (1969)
10.2307/3579937
TP53 is not required for the constitutive or induced repair of DNA damage produced by ionizing radiation at the G1/S-phase border.
N. Whisnant-Hurst (1999)
10.1002/jlb.47.5.440
Flow Cytometric Analysis of Respiratory Burst Activity in Phagocytes With Hydroethidine and 2′,7′‐Dichlorofluorescin
G. Rothe (1990)
10.1667/0033-7587(2000)153[0049:IRAFAL]2.0.CO;2
Ionizing Radiation Alters Fas Antigen Ligand at the Cell Surface and on Exfoliated Plasma Membrane-Derived Vesicles: Implications for Apoptosis and Intercellular Signaling
J. Albanese (2000)
10.1016/S0027-5107(96)00120-0
Radioadaptive response: efficient repair of radiation-induced DNA damage in adapted cells.
T. Ikushima (1996)
10.1002/j.1460-2075.1992.tb05097.x
Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.
S. Xanthoudakis (1992)
10.1016/S0027-5107(96)00115-7
Altered G1 checkpoint control determines adaptive survival responses to ionizing radiation.
D. Boothman (1996)
10.1667/0033-7587(2001)156[0521:HMIIBC]2.0.CO;2
HPRT Mutants Induced in Bystander Cells by Very Low Fluences of Alpha Particles Result Primarily from Point Mutations
L. Huo (2001)
10.1016/0027-5107(91)90185-Q
Adaptive response of human lymphocytes for the repair of radon-induced chromosomal damage.
S. Wolff (1991)
10.1080/09553009514551211
On the reaction kinetics of the radioadaptive response in cultured mouse cells.
M. Sasaki (1995)
Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.
S. Grösch (1998)
10.2307/3579303
Alterations in the progression of cells through the cell cycle after exposure to alpha particles or gamma rays.
D. Gadbois (1996)
Participation of p53 protein in the cellular response to DNA damage.
M. Kastan (1991)
10.1073/PNAS.030420797
Induction of a bystander mutagenic effect of alpha particles in mammalian cells.
H. Zhou (2000)
10.2307/3579300
Small doses of high-linear energy transfer radiation increase the radioresistance of Chinese hamster V79 cells to subsequent X irradiation.
B. Marples (1996)
10.1089/DNA.1993.12.265
Characterization of the DNA-binding properties of the early growth response-1 (Egr-1) transcription factor: evidence for modulation by a redox mechanism.
R. Huang (1993)
10.1016/S0027-5107(96)00117-0
A low, adaptive dose of gamma-rays reduced the number and altered the spectrum of S1- mutants in human-hamster hybrid AL cells.
A. Ueno (1996)
10.1080/095530099139926
Adaptive response and its variation in human normal and tumour cells.
G. Raaphorst (1999)
10.1126/SCIENCE.6695170
Adaptive response of human lymphocytes to low concentrations of radioactive thymidine.
G. Olivieri (1984)
10.1667/0033-7587(2001)155[0335:FRIAGJ]2.0.CO;2
Free Radical-Initiated and Gap Junction-Mediated Bystander Effect due to Nonuniform Distribution of Incorporated Radioactivity in a Three-Dimensional Tissue Culture Model
A. Bishayee (2001)
10.1073/PNAS.95.10.5730
Chromosomal instability in the descendants of unirradiated surviving cells after alpha-particle irradiation.
S. Lorimore (1998)
10.1016/S0027-5107(96)00114-5
Aspects of the adaptive response to very low doses of radiation and other agents.
S. Wolff (1996)



This paper is referenced by
10.1177/0960327107083409
Principles and practice of hormetic treatment of aging and age-related diseases
S. Rattan (2008)
10.1111/1365-2435.12283
Chronic exposure to low-dose radiation at Chernobyl favours adaptation to oxidative stress in birds
I. Galván (2014)
10.1016/j.bbrc.2010.05.121
Alteration of cytokine profiles in mice exposed to chronic low-dose ionizing radiation.
S. C. Shin (2010)
10.1269/JRR.09003S
A new paradigm in radioadaptive response developing from microbeam research.
H. Matsumoto (2009)
10.4049/jimmunol.179.5.3276
Effects of Gamma Radiation on FcεRI and TLR-Mediated Mast Cell Activation1
B. P. Soule (2007)
10.1158/0008-5472.CAN-06-2985
Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis.
Daniel I Portess (2007)
10.1667/RR3196
A Sense of Danger from Radiation1
W. McBride (2004)
Low-dose/low-dose-rate radiation: a feasible strategy to improve cancer radiotherapy?
D. Gridley (2005)
10.1016/j.mrfmmm.2014.11.005
Compartmental stress responses correlate with cell survival in bystander effects induced by the DNA damage agent, bleomycin.
D. Savu (2015)
10.1504/IJLR.2006.012025
DNA repair after low doses of ionising radiation
D. Murray (2006)
10.1080/09553002.2018.1434323
Intercellular communication of DNA damage and oxidative status underpin bystander effects
E. Mladenov (2018)
10.1016/J.JENVRAD.2007.10.001
Radiation-induced adaptive response in fish cell lines.
L. Ryan (2008)
10.1016/j.ejphar.2009.07.028
Ionizing radiation-induced bystander effects, potential targets for modulation of radiotherapy.
J. Rzeszowska-Wolny (2009)
10.2174/157436207780619509
Potential utilization of bystander/abscopal-mediated signal transduction events in the treatment of solid tumors
Matthew E. Peters (2007)
10.1667/RR3083
Interaction between Radiation-Induced Adaptive Response and Bystander Mutagenesis in Mammalian Cells
H. Zhou (2003)
10.1080/09553002.2020.1721597
The role of radiation induced oxidative stress as a regulator of radio-adaptive responses
Mohsen Sisakht (2020)
10.1016/j.jrras.2015.03.003
Targeted and non-targeted effects of ionizing radiation
O. Desouky (2015)
Aalborg Universitet TGF-3 dependent modification of radiosensitivity in reporter cells exposed to serum from whole-body low dose-rate irradiated mice
N. J. Edin (2014)
10.1177/0960327107083411
Low-dose radioimmuno-therapy of cancer
M. Pollycove (2008)
- 0101 Modulation of Radiation Responses by Pre-Exposure to Irradiated Cell Conditioned Medium
P. Maguire (2019)
10.1016/J.RADI.2011.07.003
Cancer risks from low dose exposure to ionising radiation – Is the linear no-threshold model still relevant?
R. Harbron (2012)
10.1667/3163
Expression of the Oxidative Base Excision Repair Enzymes is not Induced in TK6 Human Lymphoblastoid Cells after Low Doses of Ionizing Radiation
M. Inoue (2004)
10.1007/s13246-010-0030-8
Non-targeted effects of ionising radiation and radiotherapy
S. Sjostedt (2010)
10.1016/j.mrfmmm.2009.08.006
Ionizing radiation-induced bystander mutagenesis and adaptation: quantitative and temporal aspects.
Y. Zhang (2009)
10.1080/09553000500140324
Neoplastic transformation in vitro induced by low doses of 232 MeV protons
E. Elmore (2005)
10.1269/JRR.06090
Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses.
H. Matsumoto (2007)
10.1016/J.MRFMMM.2005.03.035
Untargeted effects of ionizing radiation: implications for radiation pathology.
E. Wright (2006)
An in vitro investigation of the impact of radiation induced bystander effect on the therapeutic irradiation of a prostate cancer cell line.
S. Sjostedt (2013)
10.3390/ijms20225527
Extracellular Vesicles in Modifying the Effects of Ionizing Radiation
T. Szatmári (2019)
10.1080/09553000902838558
Effects of low fluences of radiations found in space on cellular systems
K. Held (2009)
10.1038/bjc.2015.146
Non-genetic cancer cell plasticity and therapy-induced stemness in tumour relapse: ‘What does not kill me strengthens me'
A. Pisco (2015)
ELIMINATION OF LOW DOSE HYPER-RADIOSENSITIVITY IN T-47D CELLS : The significance of dose-rate and oxygen level
N. J. Edin (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar