Online citations, reference lists, and bibliographies.
← Back to Search

Premotor Input To Hypoglossal Motoneurons From Kölliker-Fuse Neurons In Decerebrate Cats.

S. Kuna, J. Remmers
Published 1999 · Medicine, Chemistry

Save to my Library
Download PDF
Analyze on Scholarcy
Share
Experiments were performed in 18 paralysed, ventilated, decerebrate adult cats to characterise projections from the Kölliker-Fuse nucleus(KFN) to hypoglossal(HG) motoneurons. Efferent neural activity was recorded from the medial branch of both HG nerves, right recurrent laryngeal(RL) nerve, and C3 branch of the left phrenic nerve. Electrical stimulation(1 Hz, 1 msec pulse duration) of discrete areas within the KFN coordinates elicited a preferential, predominantly ipsilateral burst of HG action potentials with an average stimulus-response latency of 8 msec. Tonic stimulation(5-20 Hz) frequently produced considerable HG temporal summation and the appearance of phasic inspiratory HG activity. Injection of 40-100 nl kainic acid(6.37 mM) into the rostral pontine site with the lowest electrical threshold for HG activation elicited a prolonged tonic HG activation. Following kainate injection, the electrical stimulation threshold for HG excitation increased. Pressure injections of 5-100 nl of 2 mM N-methyl-D-aspartic acid (NMDA)and 2 mM(+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrobromide(AMPA) into the KFN were associated with activation and/or suppression of HG motor output. The results indicate that HG motoneurons innervating protrusor tongue muscles receive a selective projection from the KFN that can be activated by glutamate receptors on KF neurons.
This paper references
10.1016/0014-4886(87)90091-4
Pneumotaxic mechanisms influence phrenic, hypoglossal, and trigeminal activities
Walter M. St John (1987)
10.1152/JAPPL.1994.76.3.1138
Role of N-methyl-D-aspartate receptors in the pontine pneumotaxic mechanism in the cat.
L. Ling (1994)
10.1016/0165-1838(92)90247-E
Salivary secretion elicited by activation of the parabrachial nuclei in the cat.
T. Dick (1992)
10.1016/0006-8993(89)90681-1
Inspiratory-modulated neurons of the rostrolateral pons: effects of pulmonary afferent input
Chen-Fu Shaw (1989)
10.1002/CNE.901800208
In situ injection of kainic acid: A new method for selectively lesioning neuronal cell bodies while sparing axons of passage
J. Coyle (1978)
10.1093/BRAIN/100.2.265
The organization of the bulbar fibre connections to the trigeminal, facial and hypoglossal motor nuclei. II. An autoradiographic tracing study in cat.
G. Holstege (1977)
10.1016/0006-8993(94)91025-1
Pontine respiratory neurons in anesthetized cats
T. Dick (1994)
10.1002/CNE.903570305
Differential innervation of protruder and retractor muscles of the tongue in rat
E. Dobbins (1995)
10.1016/0006-8993(93)90372-T
Respiratory responses to microinjection of excitatory amino acid agonists in ventrolateral regions of the lateral parabrachial nucleus in the cat
K. Takayama (1993)
10.1016/0304-3940(79)90024-7
Topographical arrangement of hypoglossal motoneurons: An HRP study in the cat
M. Uemura (1979)
10.1016/0165-0173(84)90012-2
Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat
C. Fulwiler (1984)
10.1152/JAPPL.1986.60.4.1373
Inhibition of inspiratory upper airway motoneuron activity by phasic volume feedback.
S. Kuna (1986)
10.1016/0304-3940(84)90364-1
Distribution of premotor neurons for the hypoglossal nucleus in the cat
M. Takada (1984)
10.1016/0006-8993(87)90930-9
The ultrastructural morphology and distribution of trigeminohypoglossal connections labeled with horseradish peroxidase
R. Borke (1987)
10.1523/JNEUROSCI.14-11-06500.1994
Topographic organization of respiratory responses to glutamate microstimulation of the parabrachial nucleus in the rat
N. Chamberlin (1994)
10.1007/BF00227237
Neurons of the motor trigeminal nucleus project to the hypoglossal nucleus in the rat
S. Manaker. (2004)
10.1016/0006-8993(83)90961-7
Brain stem afferents of hypoglossal neurons in the rat
R. Borke (1983)
10.1016/0006-8993(79)90970-3
Somatotopic organization of the hypoglossal nucleus: a HRP study in the rat
E. Krammer (1979)
Fibre composition of the hypoglossal nerve in the rat.
P. O'Reilly (1990)
10.1016/0306-4522(80)90025-1
Functional and morphological consequences of kainic acid microinjections into a pontine respiratory area of the cat
M. Denavit-Saubie´ (1980)
10.1002/CNE.902200303
Afferent projections to the oral motor nuclei in the rat
J. Travers (1983)
10.1152/JN.1959.22.1.33
Respiratory neuronal activity in pons of cat.
M. Cohen (1959)
10.1016/0006-8993(76)90629-6
Powerful inhibition of pontine respiratory neurons by pulmonary afferent activity
J. Feldman (1976)
10.1016/0304-3940(90)90090-V
Depressant effect of raphe stimulation on inspiratory activity of the hypoglossal nerve: In vitro study in the newborn rat
D. Morin (1990)
10.1016/0006-8993(89)91351-6
Inhibitory influences on hypoglossal neural activity by stimulation of midpontine dorsal tegmentum in decerebrate cat
K. Kawahara (1989)
10.1016/0034-5687(86)90136-2
Influence of reticular mechanisms upon hypoglossal, trigeminal and phrenic activiteis
W. S. John (1986)
10.1016/0304-3940(79)96111-1
Respiratory neurons of the pneumotaxic center during sleep and wakefulness
R. Lydic (1979)
10.1152/PHYSREV.1995.75.1.1
Central control of breathing in mammals: neuronal circuitry, membrane properties, and neurotransmitters.
A. Bianchi (1995)
10.1016/0014-4886(80)90162-4
Pneumotaxic area neuronal discharge during sleep-waking states in the cat
G. Sieck (1980)
10.1002/CNE.903220106
Raphespinal and reticulospinal axon collaterals to the hypoglossal nucleus in the rat
S. Manaker. (1992)
10.1007/BF00233430
Quantitative study of anatomical distribution of respiration related neurons in the pons
F. Bertrand (2004)



This paper is referenced by
10.1002/cne.10974
Effects of anesthetics on hypoglossal nerve discharge and c‐fos expression in brainstem hypoglossal premotor neurons
F. Roda (2004)
10.1523/JNEUROSCI.21-18-07384.2001
Changes in Monoamine Release in the Ventral Horn and Hypoglossal Nucleus Linked to Pontine Inhibition of Muscle Tone: An In Vivo Microdialysis Study
Y. Y. Lai (2001)
10.1016/j.lfs.2017.05.020
Phrenic and hypoglossal nerve activity during respiratory response to hypoxia in 6‐OHDA unilateral model of Parkinson's disease
K. Andrzejewski (2017)
10.1113/EP087329
Control of hypoglossal pre‐inspiratory discharge
M. Ghali (2020)
10.1007/978-4-431-55750-0_14
Central Pattern Generators
Y. Sugiyama (2016)
10.1093/SLEEP/31.3.355
Systemic vs. central administration of common hypnotics reveals opposing effects on genioglossus muscle activity in rats.
E. Park (2008)
10.1016/j.brainres.2011.06.025
Glutamatergic Kölliker–Fuse nucleus neurons innervate hypoglossal motoneurons whose axons form the medial (protruder) branch of the hypoglossal nerve in the rat
S. Yokota (2011)
NEURAL DRIVE TO HUMAN RESPIRATORY MUSCLES
J. P. Saboisky (2008)
10.1016/j.resp.2009.07.008
Respiratory activity of the neonatal dorsolateral pons in vitro
A. Arata (2009)
10.1523/JNEUROSCI.1019-08.2008
Endogenous Glutamatergic Control of Rhythmically Active Mammalian Respiratory Motoneurons In Vivo
H. Steenland (2008)
10.1186/1465-9921-10-74
Corticomotor control of the genioglossus in awake OSAS patients: a transcranial magnetic stimulation study
F. Sériès (2009)
10.1016/j.neuroscience.2014.02.027
Inhibition of the pontine Kölliker-Fuse nucleus abolishes eupneic inspiratory hypoglossal motor discharge in rat
T. Bautista (2014)
10.1111/j.1440-1843.2010.01858.x
The central motor conductivity of genioglossus in obstructive sleep apnoea
W. Wang (2010)
10.1007/s00429-012-0384-7
Kölliker–Fuse neurons send collateral projections to multiple hypoxia-activated and nonactivated structures in rat brainstem and spinal cord
G. Song (2012)
10.1111/j.1460-9568.2006.04858.x
Neuronal circuitry and synaptic organization of trigeminal proprioceptive afferents mediating tongue movement and jaw–tongue coordination via hypoglossal premotor neurons
P. Luo (2006)
10.1212/01.WNL.0000073624.13436.32
Obstructive sleep apnea is related to a thalamic cholinergic deficit in MSA
S. Gilman (2003)
10.1111/jnc.15041
Neurochemistry of the Kölliker-Fuse nucleus from a respiratory perspective.
Adrienn G. Varga (2020)
Cough and laryngeal muscle discharges in brainstem lesioned anaesthetized cats.
I. Poliaček (2005)
10.1002/cphy.c110023
Neural control of the upper airway: integrative physiological mechanisms and relevance for sleep disordered breathing.
R. Horner (2012)
10.1016/j.resp.2004.04.015
Development of adaptive behaviour of the respiratory network: implications for the pontine Kölliker-Fuse nucleus
M. Dutschmann (2004)
10.1016/j.resp.2004.06.016
Pontine influences on breathing: an overview
G. Alheid (2004)
10.1016/j.resp.2009.12.009
Early abnormalities of post-sigh breathing in a mouse model of Rett syndrome
N. Voituron (2010)
10.1007/s00405-015-3861-9
The Kölliker-Fuse nucleus: a review of animal studies and the implications for cranial nerve function in humans
Nanna Browaldh (2015)
10.1016/j.jchemneu.2019.02.005
Variable colocalisation of GABAA receptor subunits and glycine receptors on neurons in the human hypoglossal nucleus
H. Waldvogel (2019)
10.1113/jphysiol.2006.121889
Genioglossus premotoneurons and the negative pressure reflex in rats
N. Chamberlin (2007)
10.1152/japplphysiol.00797.2009
State-dependent vs. central motor effects of ethanol on breathing.
L. Vecchio (2010)
10.1002/cphy.c100015
Pontine mechanisms of respiratory control.
M. Dutschmann (2012)
10.1016/j.resp.2013.06.019
The emerging role of the parabrachial complex in the generation of wakefulness drive and its implication for respiratory control
D. Martelli (2013)
10.1016/j.neuroscience.2006.04.020
Distribution and medullary projection of respiratory neurons in the dorsolateral pons of the rat
K. Ezure (2006)
Neural Bases of Breathing in the Mouse : Monosynaptic Tracing and Genetic Dissection of Phrenic Premotor Neurons
Jinjin Wu (2016)
10.1016/j.brainres.2016.08.020
Orexinergic fibers are in contact with Kölliker-Fuse nucleus neurons projecting to the respiration-related nuclei in the medulla oblongata and spinal cord of the rat
S. Yokota (2016)
10.1113/expphysiol.2007.037572
Interaction between genioglossus and diaphragm responses to transcranial magnetic stimulation in awake humans
W. Wang (2007)
See more
Semantic Scholar Logo Some data provided by SemanticScholar