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Incorporation Of Cα-methyl Amino Acids By Solid Phase Peptide Synthesis In A Peptide Sequence
Published 1996 · Chemistry
Abstract (S)-αMethylmethionine, (S)-αMethylleucine, 2-aminoisobutyric acid and (S)-αMethylphenylalanine have been incorporated by solid phase peptide strategy in a peptide sequence. The coupling reactions of these Boc-αMe amino acids and of the following residue in the sequence were readily achieved after silylation with chlorotrimethylsilane of the amine function on the resin.