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An Efficient Copper-catalyzed Coupling Of Aryl Halides With Imidazoles

Ayumu Kiyomori, J. Marcoux, S. L. Buchwald
Published 1999 · Chemistry

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Abstract Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf) 2 ·benzene as a copper source and Cs 2 CO 3 as a base in xylenes at 110–125 °C. Addition of 1,10-phenanthroline (phen) and trans,trans -dibenzylideneacetone (dba) was crucial to the success of the process. The products, N -arylimidazoles, were isolated in high yields.
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