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Apoptosis In Viral Infections.

E. S. Razvi, R. Welsh
Published 1995 · Biology, Medicine

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Publisher Summary Although apoptosis can be induced by a number of stimuli, it has become apparent that there are common connecting themes linking the diverse systems covered in this chapter. Entry into the cell cycle can sensitize cells to apoptosis and abnormal regulation of growth-promoting genes, such as the protooncogenes c-myc and c-fos or of the transcription factor E2F, which can enhance expression of c-myc, results in apoptosis. Lymphocytes responding to viral infection are also more sensitive to apoptosis when in cycle. A second recurring theme is that the tumor suppressor protein p53 will shunt cells into an apoptotic pathway under the conditions of dysregulated expression of growth-promoting genes, and several viruses encode proteins that hind to p53 and interfere with its function. The protective effect of the Bcl-2 protein against apoptosis has been demonstrated repeatedly in viral systems. Apoptosis induced in target cells by either Sindbis or influenza virus infections is greatly inhibited in cells expressing bcl-2. A fourth theme involves the FasITNF receptor system. Activated lymphocytes responding to viral infections express high levels of Fas and are susceptible to apoptosis. Fas is related to the TNF receptor and both are down-regulated when TNF is added to cells. CTL and NK cells encode proteases (granzymes, fragmentins) that induce apoptosis in target cells. It is, therefore, clear that apoptosis plays a major role in viral infections and in the host response to them. Apoptosis is the mechanism, by which many viruses induce cell death and transforming viruses encode proteins that inhibit cellular apoptotic pathways. CTLs, NK cells, and cytotoxic cytokines, all kill virus-infected target cells through apoptotic pathways. In the infected host, T lymphocyte apoptosis plays a role in the natural history of the T cell responses to viral infection.
This paper references
10.1128/JVI.67.10.5754-5765.1993
Programmed cell death of T lymphocytes during acute viral infection: a mechanism for virus-induced immune deficiency.
E. S. Razvi (1993)
10.1126/SCIENCE.8235617
Multifactorial nature of human immunodeficiency virus disease: implications for therapy.
A. Fauci (1993)
10.1126/SCIENCE.8235659
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
D. J. Kane (1993)
Apoptosis of T lymphocytes in experimental autoimmune encephalomyelitis. Evidence for programmed cell death as a mechanism to control inflammation in the brain.
M. Schmied (1993)
10.1146/ANNUREV.NE.14.030191.002225
Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.
J. Morgan (1991)
10.1084/JEM.177.2.249
Quantitative analysis of the human immunodeficiency virus type 1 (HIV- 1)-specific cytotoxic T lymphocyte (CTL) response at different stages of HIV-1 infection: differential CTL responses to HIV-1 and Epstein- Barr virus in late disease
A. Carmichael (1993)
10.1038/353858A0
lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis
M. Lenardo (1991)
10.1016/0092-8674(93)90230-N
The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
T. Allsopp (1993)
10.1038/362847A0
p53 is required for radiation-induced apoptosis in mouse thymocytes
S. Lowe (1993)
10.1038/362355A0
HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease
G. Pantaleo (1993)
10.1084/JEM.156.1.79
Lymphocytic choriomeningitis virus killer T cells are lethal only in weakly disseminated murine infections
C. Pfau (1982)
10.1126/SCIENCE.1658936
Antibody-mediated clearance of alphavirus infection from neurons.
B. Levine (1991)
10.1146/ANNUREV.IY.09.040191.001331
Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease.
P. Cohen (1991)
10.1016/0042-6822(90)90006-D
Modulation of cellular susceptibility to the cytotoxic/cytostatic action of tumor necrosis factor by adenovirus E1 gene expression is cell type-dependent.
B. Vanhaesebroeck (1990)
10.1038/334124A0
Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product
P. Whyte (1988)
10.1128/JVI.29.1.83-90.1979
Herpes simplex virus type 2 functions expressed during stimulation of human cell DNA synthesis.
L. Kucera (1979)
CD11b (Mac-1): a marker for CD8+ cytotoxic T cell activation and memory in virus infection.
H. I. McFarland (1992)
10.1016/S0065-2776(08)60262-X
MHC-restricted cytotoxic T cells: studies on the biological role of polymorphic major transplantation antigens determining T-cell restriction-specificity, function, and responsiveness.
R. Zinkernagel (1979)
Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.
D. Askew (1991)
Inhibition of IL 2-driven proliferation of murine T lymphocyte clones by supraoptimal levels of immobilized anti-T cell receptor monoclonal antibody.
G. Nau (1987)
10.1182/BLOOD.V82.2.521.BLOODJOURNAL822521
Absence of bcl-2 expression by activated CD45RO+ T lymphocytes in acute infectious mononucleosis supporting their susceptibility to programmed cell death.
Y. Tamaru (1993)
10.1128/JVI.63.6.2504-2509.1989
Cytocidal effect of tumor necrosis factor on cells chronically infected with human immunodeficiency virus (HIV): enhancement of HIV replication.
T. Matsuyama (1989)
Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis.
T. Cotter (1992)
10.1084/JEM.160.2.521
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
R. Ahmed (1984)
10.1073/PNAS.88.22.9979
Wild-type p53 can down-modulate the activity of various promoters.
D. Ginsberg (1991)
10.1172/JCI109175
Cell-mediated immunity during natural measles infection.
H. Whittle (1978)
10.1126/SCIENCE.8372353
Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice.
K. Nakayama (1993)
10.1016/0167-5699(93)90197-S
Programmed cell death, apoptosis and killer genes.
L. M. Schwartz (1993)
10.1128/JVI.65.6.3095-3105.1991
The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus form a complex and function together to down-regulate the epidermal growth factor receptor.
A. Tollefson (1991)
10.1038/347286A0
Death of mature T cells by separate ligation of CD4 and the T-cell receptor for antigen
M. Newell (1990)
10.1084/JEM.175.1.23
Inhibition of cytotoxic T lymphocyte-induced target cell DNA fragmentation, but not lysis, by inhibitors of DNA topoisomerases I and II
W. Nishioka (1992)
10.1126/SCIENCE.1900951
Peripheral selection of the T cell repertoire.
B. Rocha (1991)
10.1038/363728A0
HIV induces thymus depletion in vivo
M. Bonyhadi (1993)
10.1016/0968-0004(94)90170-8
Dicing with death: dissecting the components of the apoptosis machinery.
S. J. Martin (1994)
10.1038/314743A0
A novel serine esterase expressed by cytotoxic T lymphocytes
M. Pasternack (1985)
10.1016/0092-8674(90)90409-8
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
M. Scheffner (1990)
IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.
R. C. Duke (1986)
10.1006/VIRO.1993.1389
Virus-induced immunosuppression. 1. Age at infection relates to a selective or generalized defect.
A. Tishon (1993)
10.1146/ANNUREV.IY.09.040191.001021
A central role of perforin in cytolysis?
E. Podack (1991)
10.1093/INTIMM/5.6.625
Activation interferes with the APO-1 pathway in mature human T cells.
C. Klas (1993)
10.1016/0167-5699(94)90018-3
Oxidative stress as a mediator of apoptosis.
T. Buttke (1994)
10.1038/357077A0
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
M. Murakami (1992)
10.1172/JCI115188
Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.
C. Terai (1991)
10.1128/JVI.66.5.2952-2965.1992
Cytotoxicity of a replication-defective mutant of herpes simplex virus type 1.
P. Johnson (1992)
10.1042/BJ2670303
Reversible cell damage by T-cell perforins. Calcium influx and propidium iodide uptake into K562 cells in the absence of lysis.
J. Jones (1990)
10.1084/JEM.178.5.1541
Mechanisms of class I restricted immunopathology. A transgenic mouse model of fulminant hepatitis
K. Ando (1993)
10.1084/JEM.178.2.461
Autoimmune disease in mice due to integration of an endogenous retrovirus in an apoptosis gene
J. Wu (1993)
10.1038/362359A0
Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS
J. Embretson (1993)
10.1055/S-0028-1135624
Das Verhalten der kutanen Tuberkulinreaktion während der Masern
C. Pirquet (1908)
10.1084/JEM.178.2.427
The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory
A. Akbar (1993)
10.1128/JVI.64.1.9-15.1990
Human cytomegalovirus induces expression of cellular topoisomerase II.
J. D. Benson (1990)
10.1016/0092-8674(92)90123-T
Induction of apoptosis in fibroblasts by c-myc protein
G. Evan (1992)
10.1128/JVI.65.6.3344-3348.1991
A chimpanzee-passaged human immunodeficiency virus isolate is cytopathic for chimpanzee cells but does not induce disease.
M. Watanabe (1991)
10.1016/s0021-9258(17)39328-6
Isolation of a lytic, pore-forming protein (perforin) from cytolytic T-lymphocytes.
D. Masson (1985)
T lymphocytes in infectious mononucleosis. I. T cell death in vitro.
D. Moss (1985)
10.1128/JVI.66.7.4606-4611.1992
Adenovirus E1A makes two distinct contacts with the retinoblastoma protein.
N. Dyson (1992)
10.1016/0092-8674(82)90356-7
Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
P. Sarnow (1982)
10.1016/0092-8674(90)90420-J
Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
S. Webb (1990)
10.1126/SCIENCE.8108732
Premature p34cdc2 activation required for apoptosis.
L. Shi (1994)
10.1016/0006-291X(80)91088-8
Calcium and A23187-induced cytolysis of mouse thymocytes.
S. Durant (1980)
10.1002/j.1460-2075.1990.tb07491.x
Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non‐structural proteins.
P. Caillet-Fauquet (1990)
10.1084/JEM.172.6.1873
Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells
S. Scott (1990)
10.1016/0092-8674(88)90559-4
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
J. DeCaprio (1988)
10.1093/INTIMM/5.10.1285
T cell deletion follows chronic antigen specific T cell activation in vivo.
C. Mamalaki (1993)
10.1002/EJI.1830190124
Expression of cytoplasmic granules with T cell‐associated serine proteinase‐1 activity in Ly‐2(CD8) T lymphocytes responding to lymphocytic choriomeningitis virus in vivo
M. Kramer (1989)
Cytotoxic effects of antigen- and mitogen-induced T cells on various targets.
M. Bevan (1975)
10.1073/PNAS.90.6.2189
Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.
G. Deng (1993)
10.1126/SCIENCE.1352911
Programmed death of T cells in HIV-1 infection.
L. Meyaard (1992)
10.1016/0092-8674(93)90326-L
Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family
T. Suda (1993)
10.1016/0092-8674(89)90944-6
Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor
G. Wong (1989)
10.1084/JEM.179.2.769
Susceptibility to cytotoxic T lymphocyte-induced apoptosis is a function of the proliferative status of the target
W. Nishioka (1994)
10.1016/0092-8674(91)90007-L
Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell death
S. Henderson (1991)
The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo.
M. Kasaian (1989)
10.1073/PNAS.88.6.2151
Receptor-stimulated death pathway is opened by antigen in mature T cells.
J. H. Russell (1991)
10.1002/j.1460-2075.1993.tb05799.x
Programmed cell death by bcl‐2‐dependent and independent mechanisms in B lymphoma cells.
E. Cuende (1993)
10.1016/0022-1759(91)90396-W
Detection of apoptosis of immature CD4+8+ thymocytes by flow cytometry.
W. Swat (1991)
Superantigen-driven peripheral deletion of T cells. Apoptosis occurs in cells that have lost the alpha/beta T cell receptor.
L. Huang (1993)
10.1038/bjc.1972.33
Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics
J. Kerr (1972)
Target cell DNA fragmentation is mediated by lymphotoxin and tumor necrosis factor.
D. Schmid (1987)
10.1128/JVI.51.3.682-686.1984
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo.
J. Byrne (1984)
10.1126/SCIENCE.2537532
The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product.
N. Dyson (1989)
Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.
L. Radvanyi (1993)
10.1016/S0065-2776(08)60197-2
The virology and immunobiology of lymphocytic choriomeningitis virus infection.
M. Buchmeier (1980)
The natural killer cell
C. Lewis (1992)
10.1096/fasebj.7.10.8344485
A comparison of the biological activities of wild‐type and mutant p53
G. Zambetti (1993)
10.1016/S0923-2516(06)80057-9
Apoptosis and subacute spongiform encephalopathies.
G. Di Guardo (1993)
10.7326/0003-4819-119-3-199308010-00001
Delayed-Type Hypersensitivity Skin Testing Predicts Progression to AIDS in HIV-infected Patients
S. Blatt (1993)
IL-2-independent activity of IL-7 in the generation of secondary antigen-specific cytotoxic T cell responses in vitro.
F. Kos (1993)
10.1128/JVI.66.4.1899-1906.1992
BHRF1 of Epstein-Barr virus, which is homologous to human proto-oncogene bcl2, is not essential for transformation of B cells or for virus replication in vitro.
M. A. Lee (1992)
10.1182/BLOOD.V80.2.452.BLOODJOURNAL802452
Apoptotic cell death of primed CD45RO+ T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis.
T. Uehara (1992)
10.1126/SCIENCE.2787530
Monoclonal antibody-mediated tumor regression by induction of apoptosis.
B. Trauth (1989)
10.1073/PNAS.86.24.9886
Specific disruption of intermediate filaments and the nuclear lamina by the 19-kDa product of the adenovirus E1B oncogene.
E. White (1989)
10.1084/JEM.169.6.2159
In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection [published erratum appears in J Exp Med 1989 Dec 1;170(6):2191]
L. Young (1989)
10.1038/362543A0
Neurotoxicity of a prion protein fragment
G. Forloni (1993)
10.1016/0092-8674(91)90362-3
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
A. Strasser (1991)
10.1084/JEM.178.5.1693
Protease inhibitors selectively block T cell receptor-triggered programmed cell death in a murine T cell hybridoma and activated peripheral T cells
A. Sarin (1993)
10.1038/353765A0
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
S. Hartley (1991)
10.1002/EJI.1830230834
T cell immunity after a viral infection versus T cell tolerance induced by soluble viral peptides
D. Kyburz (1993)
10.1002/EJI.1830191132
Antigen‐induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*
E. Jenkinson (1989)
10.1038/359552A0
Apoptotic cell death induced by c-myc is inhibited by bcl-2
R. Bissonnette (1992)
10.1002/EJI.1830161215
A specific serine proteinase is inducible in Lyt‐2+, L3T4− and Lyt‐2−, L3T4+ T cells in vitro but is mainly associated with Lyt‐2+, L3T4− effector cells in vivo
M. Simon (1986)
10.1002/EJI.1830230724
Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle
S. Boehme (1993)
10.1038/359554A0
Cooperative interaction between c-myc and bcl-2 proto-oncogenes
A. Fanidi (1992)
10.1016/B978-0-12-364932-4.50010-1
Apoptosis: mechanisms and roles in pathology.
M. Arends (1991)
10.1016/0092-8674(93)80066-N
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
D. Hockenbery (1993)
10.1084/JEM.170.3.933
Induction of target cell DNA release by the cytotoxic T lymphocyte granule protease granzyme A
M. P. Hayes (1989)
Class I-restricted cytotoxic T lymphocytes are directly cytopathic for their target cells in vivo.
K. Ando (1994)
10.1073/PNAS.90.12.5455
EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.
L. Székely (1993)
10.1084/JEM.176.4.1099
Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis
N. Banda (1992)
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
K. Sellins (1987)
10.1038/364806A0
Lethal effect of the anti-Fas antibody in mice
J. Ogasawara (1993)
10.1093/ICB/29.2.511
The Cell Cycle
A. Murray (1989)
10.1146/ANNUREV.IY.04.040186.002443
The membrane attack complex of complement.
H. Müller-Eberhard (1986)
10.1016/0092-8674(86)90362-4
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
M. Cleary (1986)
10.1002/EJI.1830170707
The immune response of the mouse to lymphocytic choriomeningitis virus V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection
D. Moskophidis (1987)
10.1128/JVI.66.12.7383-7388.1992
Chicken anemia virus causes apoptosis of thymocytes after in vivo infection and of cell lines after in vitro infection.
S. H. Jeurissen (1992)
10.1038/367277A0
Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
J. Woronicz (1994)
10.1093/NAR/20.15.4083
Repression of the basal c-fos promoter by wild-type p53.
N. Kley (1992)
10.1128/JVI.67.4.2168-2174.1993
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif.
N. Crook (1993)
DNA of human Raji target cells is damaged upon lymphocyte-mediated lysis.
S. Gromkowski (1986)
10.1073/PNAS.79.24.7837
Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.
R. Taub (1982)
10.1038/332035A0
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
J. Kappler (1988)
Apoptosis: The Molecular Basis of Cell Death
L. D. Tomei (1991)
10.1006/VIRO.1994.1026
HIV-1 induces down-regulation of bcl-2 expression and death by apoptosis of EBV-immortalized B cells: a model for a persistent "self-limiting" HIV-1 infection.
A. De Rossi (1994)
10.1002/CYTO.990140604
The use of flow cytometry for the investigation of cell death.
V. Afanasyev (1993)
The immunodepressive action of lymphocytic choriomeningitis virus in mice.
C. Mims (1968)
10.1038/330581A0
Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF
M. Chen (1987)
10.1128/JVI.65.4.1863-1869.1991
Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence.
M. Salvato (1991)
Acute, lethal, natural killer cell-resistant myeloproliferative disease induced by polyomavirus in severe combined immunodeficient mice.
E. Szomolanyi-Tsuda (1994)
T lymphocytes in infectious mononucleosis. II. Response in vitro to interleukin-2 and establishment of T cell lines.
C. Bishop (1985)
10.1126/SCIENCE.1962198
Prevention of apoptosis by a baculovirus gene during infection of insect cells.
R. Clem (1991)
10.1038/337562A0
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
D. Nemazee (1989)
10.1128/MCB.13.4.2432
Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2.
A. Wagner (1993)
10.1007/978-3-642-71726-0_8
Regulation and role of large granular lymphocytes in arenavirus infections.
R. Welsh (1987)
10.1093/INTIMM/3.4.343
The E1b oncogene of adenovirus confers cellular resistance to cytotoxicity of tumor necrosis factor and monoclonal anti-Fas antibody.
S. Hashimoto (1991)
Natural cytotoxicity against mouse hepatitis virus-infected target cells. I. Correlation of cytotoxicity with virus binding to leukocytes.
K. Holmes (1986)
10.1038/339625A0
Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
Y. Shi (1989)
10.1128/MCB.10.1.120
Role of adenovirus E1B proteins in transformation: altered organization of intermediate filaments in transformed cells that express the 19-kilodalton protein.
E. White (1990)
10.1099/0022-1317-74-11-2347
Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells.
T. Takizawa (1993)
H-2 compatibility requirement for virus-specific T cell-mediated effector functions in vivo. I. Specificity of T cells conferring antiviral protection against lymphocytic choriomeningitis virus is associated with H-2K and H-2D.
R. Zinkernagel (1976)
10.1084/JEM.178.4.1247
The bcl-2 gene product inhibits clonal deletion of self-reactive B lymphocytes in the periphery but not in the bone marrow
S. Nisitani (1993)
THE PATHOGENESIS OF LYMPHOCYTIC CHORIOMENINGITIS IN MICE: THE EFFECTS OF DIFFERENT INOCULATION ROUTES AND THE FOOTPAD RESPONSE.
J. Hotchin (1963)
10.1038/367281A0
Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77
Z. Liu (1994)
Apoptosis in Burkitt lymphoma cells is driven by c-myc.
A. Milner (1993)
10.1073/PNAS.76.10.5308
Electrophoretically pure mouse interferon exerts multiple biologic effects.
I. Gresser (1979)
10.1099/0022-1317-70-6-1465
Target and effector cell fusion accounts for B lymphocyte-mediated lysis of mouse hepatitis virus-infected cells.
M. Wysocka (1989)
10.1099/0022-1317-71-2-369
The interaction between bovine herpesvirus type 1 and activated bovine T lymphocytes.
P. Griebel (1990)
10.1111/j.1600-065X.1991.tb00822.x
Cell Death Mechanisms and the Immune System
P. Golstein (1991)
10.1126/SCIENCE.2125367
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo.
K. Murphy (1990)
10.1038/348334A0
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
D. Hockenbery (1990)
10.1038/284555A0
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
A. Wyllie (1980)
10.1128/JVI.67.7.4391-4394.1993
An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1.
J. Neilan (1993)
10.1128/JVI.64.9.4076-4083.1990
Lymphocytic choriomeningitis virus-induced immunodepression: inherent defect of B and T lymphocytes.
M. F. Saron (1990)
10.1016/0022-1759(91)90198-O
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry.
I. Nicoletti (1991)
High expression of the c-myc oncogene renders melanoma cells prone to lysis by natural killer cells.
R. Versteeg (1989)
10.1016/0167-5699(93)90181-J
A possible role for bcl-2 in regulating T-cell memory--a 'balancing act' between cell death and survival.
A. Akbar (1993)
10.1128/MCB.12.6.2570
The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor alpha.
E. White (1992)
10.1016/0092-8674(92)90531-G
Cell death and control of cell survival in the oligodendrocyte lineage
B. Barres (1992)
10.1128/MCB.13.3.1415
p53-mediated cell death: relationship to cell cycle control.
E. Yonish-Rouach (1993)
B cells induce apoptosis via a novel mechanism in fibroblasts infected with mouse hepatitis virus.
Nishioka Wk (1993)
10.1002/JCP.1041500308
Treatment of myeloid leukemic cells with the phosphatase inhibitor okadaic acid induces cell cycle arrest at either G1/S or G2/M depending on dose
Y. Ishida (1992)
10.1006/CIMM.1993.1272
Correlation between induction of lymphocyte apoptosis and prostaglandin E2 production by macrophages infected with HIV.
A. Mastino (1993)
10.1172/JCI114698
Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men.
C. V. van Noesel (1990)
10.1002/JCB.240530410
Adenovirus genes that modulate the sensitivity of virus‐infected cells to lysis by TNF
W. Wold (1993)
10.1073/PNAS.80.20.6361
Endogenous endonuclease-induced DNA fragmentation: an early event in cell-mediated cytolysis.
R. C. Duke (1983)
10.1126/SCIENCE.2157286
Association of human papillomavirus types 16 and 18 E6 proteins with p53.
B. Werness (1990)
Target structures involved in natural killing (NK): characteristics, distribution, and candidate molecules.
W. Storkus (1991)
10.1128/JVI.64.3.1353-1356.1990
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein.
N. Dyson (1990)
10.1016/s0021-9258(18)48081-7
Vaccinia virus encapsidates a novel topoisomerase with the properties of a eucaryotic type I enzyme.
R. Shaffer (1987)
10.7326/0003-4819-107-2-234
Immunology of human immunodeficiency virus infection and the acquired immunodeficiency syndrome. An update.
M. Seligmann (1987)
10.1038/361739A0
Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene
B. Levine (1993)
10.1038/349245A0
Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B
Y. Kawabe (1991)
10.1096/fasebj.7.10.8393817
The retinoblastoma gene: role in cell cycle control and cell differentiation
K. Wiman (1993)
Induction of activation-driven death (apoptosis) in activated but not resting peripheral blood T cells.
S. Wesselborg (1993)
10.1126/SCIENCE.6093251
Transmission of HTLV-III infection from human plasma to chimpanzees: an animal model for AIDS.
H. Alter (1984)
10.1016/S0092-8674(85)80070-2
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18
A. Bakhshi (1985)
Apoptosis. The role of the endonuclease.
M. Arends (1990)
10.1016/0092-8674(91)90636-D
Molecular themes in oncogenesis
J. Bishop (1991)
10.1073/PNAS.88.17.7605
Repression of the interleukin 6 gene promoter by p53 and the retinoblastoma susceptibility gene product.
U. Santhanam (1991)
10.1016/0167-5699(93)90215-7
Phagocyte recognition of cells undergoing apoptosis.
J. Savill (1993)
10.1016/S0959-437X(05)80340-5
Tumor-suppressor p53 and the cell cycle.
M. Perry (1993)
T cell receptor/CD3-signaling induces death by apoptosis in human T cell receptor gamma delta + T cells.
O. Janssen (1991)
10.1128/JVI.56.3.904-911.1985
Proteolytic cleavage of the E2 glycoprotein of murine coronavirus: activation of cell-fusing activity of virions by trypsin and separation of two different 90K cleavage fragments.
L. Sturman (1985)
10.1126/SCIENCE.1378649
Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.
Y. Shi (1992)
Tumor necrosis factor. New insights into the molecular mechanisms of its multiple actions.
J. Vilcek (1991)
10.1016/0092-8674(92)90547-P
The natural immune system. The natural killer cell: Edited by C. E. Lewis and J. O'D. McGee. Oxford: IRL Press at Oxford University Press. (1992). 248 pp. $40.00
M. Trucco (1992)
10.1073/PNAS.90.10.4409
Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.
J. H. Russell (1993)
10.1101/GAD.7.4.546
Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.
M. Debbas (1993)
10.1038/362849A0
Thymocyte apoptosis induced by p53-dependent and independent pathways
A. Clarke (1993)
10.1128/JVI.65.8.4114-4123.1991
The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor.
L. Gooding (1991)
10.1098/rspb.1976.0011
The mechanism of T cell mediated cytotoxicity II. morphological studies of cell death by time-lapse microcinematography
C. Sanderson (1976)
10.1073/PNAS.89.16.7742
The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.
L. Rao (1992)
10.1093/INTIMM/4.5.599
Peripheral tolerance through clonal deletion of mature CD4-CD8+ T cells.
D. Carlow (1992)
10.1016/0092-8674(91)90361-2
bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
C. Sentman (1991)
10.1038/356314A0
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
R. Watanabe-Fukunaga (1992)
10.1038/356397A0
Social controls on cell survival and cell death
M. Raff (1992)
10.1038/352345A0
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
E. Yonish-Rouach (1991)
10.1038/278261A0
T antigen is bound to a host protein in SY40-transformed cells
D. Lane (1979)
10.1128/JVI.65.6.2968-2978.1991
Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins.
E. White (1991)
10.1016/0960-9822(93)90211-6
The cell cycle and cell death
L. Rubin (1993)
10.1038/366274A0
Bcl-2 associates with the ras-related protein R-rasp23
M. J. fernandez-Sarabia (1993)
10.1128/JVI.65.6.3083-3094.1991
The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells.
L. Gooding (1991)
10.1128/MCB.8.5.2140
Complexity of the early genetic response to growth factors in mouse fibroblasts.
J. Almendral (1988)
10.1038/335448A0
Structure and function of human perforin
M. Lichtenheld (1988)
Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.
A. Sarin (1994)
10.1093/INTIMM/4.7.821
Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing.
D. Vaux (1992)
10.1002/PATH.1711690207
Ultrastructural features of fetal erythroid precursors infected with parvovirus B19 in vitro: Evidence of cell death by apoptosis
A. Morey (1993)
10.1073/PNAS.91.2.444
Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.
P. Aichele (1994)
10.1084/JEM.175.2.331
Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals
H. Groux (1992)
10.1089/AID.1993.9.553
Programmed cell death in AIDS-related HIV and SIV infections.
M. Gougeon (1993)
10.1002/j.1460-2075.1993.tb05666.x
Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death).
M. Peitsch (1993)
10.1111/j.1600-065X.1993.tb01517.x
Effector T‐Cell Induction and T‐Cell Memory versus Peripheral Deletion of T Cells
R. Zinkernagel (1993)
10.1146/ANNUREV.IY.09.040191.003525
Superantigens: mechanism of T-cell stimulation and role in immune responses.
A. Herman (1991)
10.1111/j.1600-065X.1983.tb01074.x
Internal Disintegration Model of Cytotoxic Lymphocyte‐Induced Target Damage
J. H. Russell (1983)
10.1128/JVI.68.6.3667-3673.1994
Apoptosis: a mechanism of cell killing by influenza A and B viruses.
V. Hinshaw (1994)
10.1038/ICB.1977.38
Death of cells by apoptosis following attachment of specifically allergized lymphocytes in vitro.
M. Don (1977)
10.1128/JVI.66.8.4757-4762.1992
Inhibition of viral and cellular promoters by human wild-type p53.
M. Subler (1992)
Activation-induced apoptosis in lymphoid systems.
D. Green (1992)
10.1128/JVI.65.5.2408-2414.1991
Mechanism of leukemogenesis induced by mink cell focus-forming murine leukemia viruses.
J. P. Li (1991)
Cytolytic lymphocytes induce both apoptosis and necrosis in target cells.
A. Zychlinsky (1991)
10.1128/JVI.65.5.2629-2639.1991
Adenovirus E3 14.7K protein functions in the absence of other adenovirus proteins to protect transfected cells from tumor necrosis factor cytolysis.
T. Horton (1991)
10.1083/JCB.119.3.493
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
Y. Gavrieli (1992)
In vivo administration of monoclonal antibodies to the CD3 T cell receptor complex induces cell death (apoptosis) in immature thymocytes.
Y. Shi (1991)
10.1073/PNAS.89.15.7003
Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice.
R. Siegel (1992)
10.1016/0014-4827(91)90438-Z
Co-localization of the retinoblastoma protein and the Epstein-Barr virus-encoded nuclear antigen EBNA-5.
W. Jiang (1991)
10.1016/0092-8674(93)90719-7
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
S. Lowe (1993)
10.1128/JVI.67.7.3730-3738.1993
Apoptosis reduces both the in vitro replication and the in vivo infectivity of a baculovirus.
R. Clem (1993)
10.1093/INFDIS/154.5.896
Vaginal transmission of human immunodeficiency virus (HIV) to a chimpanzee.
P. Fultz (1986)
10.1126/SCIENCE.7509084
T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis.
J. Critchfield (1994)
10.1016/0092-8674(93)80065-M
Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
D. Veis (1993)
10.1084/JEM.177.1.213
Interferon gamma inhibits apoptotic cell death in B cell chronic lymphocytic leukemia
M. Buschle (1993)
10.1073/PNAS.87.17.6922
A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.
F. Kaye (1990)
10.1084/JEM.179.1.145
The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus
W. Tao (1994)
10.1016/0006-291X(73)90740-7
Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease.
D. Hewish (1973)
10.1016/0092-8674(91)90614-5
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
N. Itoh (1991)
10.1097/00002030-199107000-00007
Immunological and virological markers in individuals progressing from seroconversion to AIDS.
R. Gruters (1991)
10.1126/SCIENCE.4001943
Microinjected c-myc as a competence factor.
L. Kaczmarek (1985)
10.1128/JVI.66.9.5525-5533.1992
Site-specific mutagenesis of the 35-kilodalton protein gene encoded by Autographa californica nuclear polyhedrosis virus: cell line-specific effects on virus replication.
P. A. Hershberger (1992)
10.1016/0092-8674(88)90154-7
A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor
L. Gooding (1988)
Differential expression of apoptosis-related Fas antigen on lymphocyte subpopulations in human peripheral blood.
T. Miyawaki (1992)
10.1016/0042-6822(92)90511-M
The E3-14.5K integral membrane protein of adenovirus that is required for down-regulation of the EGF receptor and for prevention of TNF cytolysis is O-glycosylated but not N-glycosylated.
P. Krajcsi (1992)
Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.
G. Núñez (1990)
Transient depletion of cortical thymocytes induced by chicken anaemia agent.
S. H. Jeurissen (1989)
10.1128/IAI.36.2.598-602.1982
Cytotoxic T cells are induced in mice infected with lymphocytic choriomeningitis virus strains of markedly different pathogenicities.
C. Pfau (1982)
10.1073/PNAS.90.21.10340
The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.
J. Drappa (1993)
10.1146/ANNUREV.BI.61.070192.002301
Animal cell cycles and their control.
C. Norbury (1992)
Separation of immortalization from tumor induction with polyoma large T mutants that fail to bind the retinoblastoma gene product.
R. Freund (1992)
Hormone-regulated apoptosis results from reentry of differentiated prostate cells onto a defective cell cycle.
M. Colombel (1992)
10.1093/clinids/8.6.850
Immunosuppression in Viral Infections
B. Rouse (1986)
10.1016/0092-8674(88)90570-3
The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
W. C. Phelps (1988)
10.1128/JVI.67.4.2159-2167.1993
Characterization of mutants within the gene for the adenovirus E3 14.7-kilodalton protein which prevents cytolysis by tumor necrosis factor.
T. S. Ranheim (1993)
10.1016/0008-8749(88)90026-3
Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium ionophore.
Z. Tabi (1988)
10.1128/JVI.67.1.455-463.1993
Identification and characterization of the p35 gene of Bombyx mori nuclear polyhedrosis virus that prevents virus-induced apoptosis.
S. G. Kamita (1993)
10.1172/JCI117105
Programmed death of T cells in human immunodeficiency virus infection. No correlation with progression to disease.
L. Meyaard (1994)
10.1038/363166A0
Continuous c-fos expression precedes programmed cell death in vivo
Richard J Smeyne (1993)
10.1146/ANNUREV.CB.07.110191.003311
Mechanisms and functions of cell death.
R. Ellis (1991)
10.1128/JVI.64.9.4059-4066.1990
Topoisomerase II cleavage of herpes simplex virus type 1 DNA in vivo is replication dependent.
S. Ebert (1990)
10.1002/CYTO.990130802
Features of apoptotic cells measured by flow cytometry.
Z. Darzynkiewicz (1992)
Generation of large granular T lymphocytes in vivo during viral infection.
C. Biron (1986)
Cytotoxic cells induced during lymphocytic choriomeningitis virus infection of mice: natural killer cell activity in cultured spleen leukocytes concomitant with T-cell-dependent immune interferon production.
R. Welsh (1980)
10.1016/0167-5699(93)90231-9
Activation-induced cell death (apoptosis) of mature peripheral T lymphocytes.
D. Kabelitz (1993)
10.1016/0955-0674(93)90118-A
Apoptosis and signal transduction: clues to a molecular mechanism.
S. Lee (1993)
10.1016/0092-8674(92)90359-K
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin and granzyme A
J. Shiver (1992)
10.1128/JVI.68.1.346-351.1994
A single chicken anemia virus protein induces apoptosis.
M. Noteborn (1994)
10.1126/SCIENCE.1411535
E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.
J. Nevins (1992)
10.1128/JVI.67.12.7340-7349.1993
Molecular determinants of macrophage tropism and viral persistence: importance of single amino acid changes in the polymerase and glycoprotein of lymphocytic choriomeningitis virus.
M. Matloubian (1993)
10.1002/EJI.1830240417
The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis
M. Salmon (1994)
Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor.
P. Duerksen-Hughes (1989)
10.1038/335440A0
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
D. Vaux (1988)
10.1128/JVI.64.8.3726-3733.1990
Mechanism of killing by virus-induced cytotoxic T lymphocytes elicited in vivo.
R. Welsh (1990)
10.1038/348331A0
Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
A. Strasser (1990)
10.1111/j.1365-2184.1990.tb01345.x
Disruption of microtubules induces an endogenous suicide pathway in human leukaemia HL‐60 cells
S. Martin (1990)
10.1182/BLOOD.V82.11.3392.BLOODJOURNAL82113392
Accelerated apoptosis in peripheral blood mononuclear cells (PBMCs) from human immunodeficiency virus type-1 infected patients and in CD4 cross-linked PBMCs from normal individuals.
N. Oyaizu (1993)
10.1146/ANNUREV.IY.08.040190.002531
Developmental biology of T cells in T cell-receptor transgenic mice.
H. Boehmer (1990)
Human tumor necrosis factor-alpha kills herpesvirus-infected but not normal cells.
Koff Wc (1986)
10.1016/0092-8674(86)90019-X
The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides
A. Townsend (1986)
10.1073/PNAS.88.18.8252
Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of antigen-presenting cells and lymph follicle structure.
B. Odermatt (1991)
10.1084/JEM.179.1.91
Interleukin 10 induces apoptotic cell death of B-chronic lymphocytic leukemia cells
A. C. Fluckiger (1994)
10.1073/PNAS.90.22.10459
Ligation of major histocompatibility complex class II molecules mediates apoptotic cell death in resting B lymphocytes.
M. K. Newell (1993)
10.1084/JEM.170.4.1451
Purified perforin induces target cell lysis but not DNA fragmentation
R. C. Duke (1989)
10.1084/JEM.175.2.553
A natural killer cell granule protein that induces DNA fragmentation and apoptosis
L. Shi (1992)
10.1146/ANNUREV.IY.08.040190.002225
Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link.
K. Ullman (1990)
10.1016/0304-419X(89)90041-3
Topoisomerase-targeting antitumor drugs.
P. D'Arpa (1989)
10.1073/PNAS.86.1.247
Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.
D. Lowrey (1989)
10.1084/JEM.176.5.1319
Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression
M. Dancescu (1992)
10.1002/CYTO.990150309
Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes.
M. Hotz (1994)
10.1146/ANNUREV.BI.61.070192.004113
myc function and regulation.
K. Marcu (1992)
10.1038/362758A0
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
D. Moskophidis (1993)
10.1128/JVI.67.5.2429-2433.1993
Apoptosis induced by tumor necrosis factor in cells chronically infected with feline immunodeficiency virus.
K. Ohno (1993)
Natural cytotoxicity against mouse hepatitis virus-infected cells. II. A cytotoxic effector cell with a B lymphocyte phenotype.
R. Welsh (1986)
10.1016/0092-8674(93)90508-N
bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
L. Boise (1993)
Lymphocytic choriomeningitis virus-induced immunosuppression: a virus-induced macrophage defect.
R. Jacobs (1976)
10.1126/SCIENCE.1411528
Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene.
I. García (1992)
10.1073/PNAS.88.13.5533
Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins.
R. Williams (1991)
10.1128/JVI.65.3.1236-1244.1991
The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cells.
P. Duerksen-Hughes (1991)
10.1038/337181A0
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
C. A. Smith (1989)
10.1101/GAD.7.12A.2277
Death-defying acts: a meeting review on apoptosis.
E. White (1993)
10.1016/0092-8674(93)90509-O
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
Zoltán N. Oltval (1993)
10.1128/JVI.65.11.5991-6000.1991
BHRF1, the Epstein-Barr virus gene with homology to Bc12, is dispensable for B-lymphocyte transformation and virus replication.
A. Marchini (1991)
Etoposide-induced cytotoxicity in two human T-cell leukemic lines: delayed loss of membrane permeability rather than DNA fragmentation as an indicator of programmed cell death.
D. Catchpoole (1993)



This paper is referenced by
10.1100/tsw.2002.214
Regulation of Apoptosis in African Swine Fever Virus–Infected Macrophages
L. Zsak (2002)
10.1158/0008-5472.CAN-09-2408
Oncolytic viral therapy for prostate cancer: efficacy of reovirus as a biological therapeutic.
C. Thirukkumaran (2010)
10.1016/J.FSI.2004.07.002
Frequent occurrence of apoptosis is not associated with pathogenic infectious pancreatic necrosis virus (IPNV) during persistent infection.
M. Imajoh (2005)
10.1099/0022-1317-79-5-1225
Herpes simplex virus hepatitis in macrophage-depleted mice: the role of massive, apoptotic cell death in pathogenesis.
H. Irie (1998)
10.1371/journal.pone.0092678
Multi-Organ Lesions in Suckling Mice Infected with SARS-Associated Mammalian Reovirus Linked with Apoptosis Induced by Viral Proteins μ1 and σ1
L. Song (2014)
10.1128/JVI.72.11.8605-8612.1998
A Protein Critical for a Theiler’s Virus-Induced Immune System-Mediated Demyelinating Disease Has a Cell Type-Specific Antiapoptotic Effect and a Key Role in Virus Persistence
G. Ghadge (1998)
Apoptosis, oncosis, and necrosis. An overview of cell death.
G. Majno (1995)
10.1006/VIRO.1999.9757
Involvement of a p53-dependent pathway in rubella virus-induced apoptosis.
K. Megyeri (1999)
10.1002/(SICI)1096-9071(199809)56:1<66::AID-JMV11>3.0.CO;2-U
High levels of HIV‐1 replication show a clear correlation with downmodulation of Bcl‐2 protein in peripheral blood lymphocytes of HIV‐1‐seropositive subjects
Maria Carla Re (1998)
10.1080/03079459508419046
Chicken anaemia virus infection: molecular basis of pathogenicity.
M. Noteborn (1995)
10.1016/S0378-1135(00)00198-X
Apoptosis in the lymphatic organs of piglets inoculated with classical swine fever virus.
M. Sato (2000)
10.3390/v10040161
Invertebrate Iridoviruses: A Glance over the Last Decade
İ. A. İnce (2018)
Preliminary Studies of Edible Bird Nest ( EBN ) Extract Reduced H 1 N 1 Virus Induced Apoptosis on Cultured Cells-In Vitro
Nur Ain (2017)
10.1099/0022-1317-80-7-1657
Rubella virus-induced cytopathic effect in vitro is caused by apoptosis.
J. Hofmann (1999)
10.1089/152581600419143
Human T cell leukemia virus type II increases telomerase activity in uninfected CD34+ hematopoietic progenitor cells.
M. C. Re (2000)
10.1093/INTIMM/13.4.411
Suicide induced by cytolytic activity controls the differentiation of memory CD8(+) T lymphocytes.
J. Opferman (2001)
10.1046/j.1365-2958.1996.471410.x
Salmonella spp. are cytotoxic for cultured macrophages
L. Chen (1996)
10.1007/978-1-4899-1834-5_10
Regulation of Programmed Cell Death by Baculoviruses
R. Clem (1997)
10.1006/VIRO.1997.8562
Bovine herpesvirus 1-induced apoptosis occurs at the G0/G1 phase of the cell cycle.
E. Hanon (1997)
Leading to T-Cell Apoptosis Epstein-Barr Virus Induces Fas (CD95) in T Cells and Fas Ligand in B Cells
Jerome E. Tanner (2013)
10.1023/A:1026487609215
A C-terminal domain of HIV-1 accessory protein Vpr is involved in penetration, mitochondrial dysfunction and apoptosis of human CD4+ lymphocytes
C. Arunagiri (2004)
10.1007/s007050070049
Pseudorabies virus induces apoptosis in tissue culture cells
A. Cheung (2000)
10.1089/088282403322017956
Fowlpox virus infection causes a lymphoproliferative response in chickens.
P. Singh (2003)
10.1155/2010/262415
Towards an Understanding of the Herpes Simplex Virus Type 1 Latency-Reactivation Cycle
G. Perng (2010)
10.1126/SCIENCE.283.5408.1745
Linear differentiation of cytotoxic effectors into memory T lymphocytes.
J. Opferman (1999)
10.1016/S0166-3542(99)00018-2
Induction of apoptotic cell death by IFNbeta on HPV-16 transformed human keratinocytes.
F. De Marco (1999)
10.1182/BLOOD.V97.3.700
The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection.
F. Plunkett (2001)
10.1007/s004010050781
Apoptotic cell death in experimental rabies in suckling mice
A. Jackson (1998)
10.1099/0022-1317-79-10-2405
The Semliki Forest virus vector induces p53-independent apoptosis.
G. M. Glasgow (1998)
10.1099/0022-1317-79-7-1745
Bovine viral diarrhoea virus induces apoptosis in blood mononuclear cells by a mechanism largely dependent on monocytes.
M. Lambot (1998)
10.3389/fmicb.2018.01056
Orf Virus Encoded Protein ORFV119 Induces Cell Apoptosis Through the Extrinsic and Intrinsic Pathways
W. Li (2018)
10.1006/VIRO.2001.1329
Matrix protein mutations contribute to inefficient induction of apoptosis leading to persistent infection of human neural cells by vesicular stomatitis virus.
M. Desforges (2002)
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