Online citations, reference lists, and bibliographies.
← Back to Search

Gene Expression And The Thiol Redox State.

A. Arrigo
Published 1999 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
The intracellular redox status is a tightly regulated parameter which provides the cell with an optimal ability to counteract the highly oxidizing extracellular environment. Intracellular redox homeostasis is regulated by thiol-containing molecules, such as glutathione and thioredoxin. Essential cellular functions, such as gene expression, are influenced by the balance between pro- and antioxidant conditions. The mechanism by which the transcription of specific eukaryotic genes is redox regulated is complex, however, recent findings suggest that redox-sensitive transcription factors play an essential role in this process. This review is focused on the recent knowledge concerning some eukaryotic transcription factors, whose activation and DNA binding is controlled by the thiol redox status of the cell.
This paper references
Activation of Drosophila heat shock factor: conformational change associated with a monomer-to-trimer transition.
J. T. Westwood (1993)
Thiol reducing reagents inhibit the heat shock response. Involvement of a redox mechanism in the heat shock signal transduction pathway.
L. Huang (1994)
NF-κB: Ten Years After
P. Baeuerle (1996)
Evaluation of the micromethod for determination of glutathione using enzymatic cycling and Ellman's reagent.
P. Eyer (1986)
Different Metabolizing Ability of Thiol Reactants in Human and Rat Blood
R. Rossi (2001)
Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species.
D. J. Kane (1993)
Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis.
D. Shrieve (1988)
Amino Acid Analogs Activate NF-κB through Redox-dependent IκB-α Degradation by the Proteasome without Apparent IκB-α Phosphorylation
C. Kretz-remy (1998)
Strategies of antioxidant defense
H. Sies (1993)
Meeting ReviewNF-κB: Ten Years After
Patrick A. Baeuerle (1996)
DNA binding of purified transcription factor NF-kappa B. Affinity, specificity, Zn2+ dependence, and differential half-site recognition.
U. Zabel (1991)
Heat-regulated expression of the hepatitis B virus surface antigen in the human Wish cell line.
M. Dréano (1987)
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.
R. Morimoto (1998)
Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.
D. Bass (1983)
Correlation between glutathione oxidation and trimerization of heat shock factor 1, an early step in stress induction of the Hsp response.
J. Zou (1998)
Thioredoxin and glutaredoxin systems.
A. Holmgren (1989)
Human hsp27, Drosophila hsp27 and human alphaB‐crystallin expression‐mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha‐induced cell death.
P. Mehlen (1996)
Inhibition of I kappa B-alpha phosphorylation and degradation and subsequent NF-kappa B activation by glutathione peroxidase overexpression
C. Kretz-remy (1996)
Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery.
X. Préville (1999)
Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity.
S. Xanthoudakis (1992)
Production of Secretable Proteins Using the Passage In Vivo as Tumours of Cells Carrying Heat-Inducible Expression Constructs
M. Dréano (1988)
Cis-acting elements involved in the regulated expression of a human HSP70 gene.
P. Schiller (1988)
High-level, heat-regulated synthesis of proteins in eukaryotic cells.
M. Dréano (1986)
Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin.
M. Jacquier-Sarlin (1996)
Oxidative stress: from basic research to clinical application.
H. Sies (1991)

This paper is referenced by
Restoration of glutathione levels in vascular smooth muscle cells exposed to high glucose conditions.
L. Powell (2001)
Strategies for manipulating the p53 pathway in the treatment of human cancer.
T. Hupp (2000)
C. Lillig (2009)
Surface Labelling of Gold Nanoparticles with Inorganic Lumophores and Targeting Vectors for Cell Imaging Applications
Christian Stepanek (2017)
Novel role of protein disulfide isomerase in the regulation of NADPH oxidase activity: pathophysiological implications in vascular diseases.
F. Laurindo (2008)
Evaluation of a dithiocarbamate derivative as a model of thiol oxidative stress in H9c2 rat cardiomyocytes.
Jiashu Xie (2014)
Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.
L. Ridnour (2005)
Intravenous Iron: The Iatrogenic Kick to Lose Control over Oxygen?
R. Deicher (2002)
Antioxidant systems and lymphocyte proliferation in the horse, sheep and dog.
E. Chiaradia (2002)
The proteasomal system.
T. Jung (2009)
Arabidopsis MEKK1 can take a short cut: it can directly interact with senescence-related WRKY53 transcription factor on the protein level and can bind to its promoter
Ying Miao (2007)
α-Lipoic acid protects HAECs from high glucose-induced apoptosis via decreased oxidative stress, ER stress and mitochondrial injury
Wenshuang Li (2015)
Polimorfismo da Ala16Val MnSOD na hipercolesterolemia e sua associação com biomarcadores de inflamação e estresse oxidativo
M. Duarte (2010)
Bovine blastocysts with developmental competence to term share similar expression of developmentally important genes although derived from different culture environments.
N. Ghanem (2011)
H(2)S signaling in redox regulation of cellular functions.
Youngjun Ju (2013)
Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells.
Y. O’Malley (2004)
Binding of the aminothiol WR-1065 to transcription factors influences cellular response to anticancer drugs.
H. Shen (2001)
Nitroxide 4-hydroxy-2,2',6,6'-tetramethylpiperidine 1-oxyl (Tempol) inhibits the reductase activity of protein disulfide isomerase via covalent binding to the Cys400 residue on CXXC redox motif at the a'active site.
G. B. Santos (2017)
Effect of Omega-3 and Vitamins E + C Supplements on the Concentration of Serum B-Vitamins and Plasma Redox Aminothiol Antioxidant Status in Elderly Men after Strength Training for Three Months
T. H. Stea (2016)
Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits.
G. Rushworth (2014)
Development and characterization of pro-apoptotic drug candidates for anticancer drug discovery
S. Kanyanda (2013)
Mouse Cumulus-Denuded Oocytes Restore Developmental Capacity Completely When Matured with Optimal Supplementation of Cysteamine, Cystine, and Cumulus Cells1
P. Zhou (2010)
Non-traditional platinum compounds for improved cellular accumulation and tumor targeting
Katherine S. Lovejoy (2009)
Antioxidant and anti-inflammatory properties of curcumin.
V. Menon (2007)
Redox Regulation of Cell Growth and Cell Death
Yong-Won Kwon (2003)
Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line
J. S. Armstrong (2002)
In vivo EPR measurement of glutathione in tumor-bearing mice using improved disulfide biradical probe.
Galina I. Roshchupkina (2008)
Predictability of gene ontology slim-terms from primary structure information in Embryophyta plant proteins
J. Jaramillo-Garzón (2012)
Increased macrophage glutathione content reduces cell-mediated oxidation of LDL and atherosclerosis in apolipoprotein E-deficient mice.
M. Rosenblat (2002)
Analysis of changes in energy and redox states in HepG2 hepatoma and C6 glioma cells upon exposure to cadmium.
M. Yang (2004)
Étude du lien fonctionnel entre le suppresseur de tumeur BRCA1 et la machinerie transcriptionnelle à certains gènes en absence ou présence de stress oxydatif in vivo
Maryse Berthiaume (2008)
Inhibition of glutathione-related enzymes augments LPS-mediated cytokine biosynthesis: involvement of an IκB/NF-κB-sensitive pathway in the alveolar epithelium
J. Haddad (2002)
See more
Semantic Scholar Logo Some data provided by SemanticScholar