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FRUCTOSE-INDUCED HYPERURICÆMIA

P.-U. Heuckenkamp, K. Raivio
Published 1967 · Medicine

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Abstract The effect of intravenous or oral fructose, 0.5 g. per kg. body-weight, has been determined in children with hereditary fructose intolerance (H.F.I.), control children, and a man with essential fructosuria. Uric-acid levels in both urine and serum rose dramatically, indicating increased uric-acid production, in controls and children with H.F.I. but not in the man with essential fructosuria. The rise was associated with increased lactic-acid generation. It is suggested that this fructose-induced hyperuricaemia is brought about by the intracellular acidosis in the liver caused by overproduction of lactic acid, and that the uric acid comes from the free purine nucleotides, D.N.A., and R.N.A.
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