Online citations, reference lists, and bibliographies.
← Back to Search

Development Of Allergen-specific T-cell Memory In Atopic And Normal Children

S. Prescott, C. Macaubas, T. Smallacombe, B. Holt, P. Sly, P. Holt
Published 1999 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
BACKGROUND In the past 20-30 years, there has been an increase in prevalence of allergic respiratory diseases, particularly amongst children. This study is a prospective analysis of the postnatal maturation of T-helper cell (Th) responses to aeroallergens in atopic and non-atopic infants. METHODS We measured mononuclear-cell proliferative and cytokine responses to specific allergens and tetanus toxoid in blood samples from atopic and non-atopic infants every 6 months from birth to 2 years of age. Cytokine analyses of responses to housedust-mite allergen used ELISA and reverse-transcriptase PCR. We also measured responses to Fel d1 (cat allergen) and tetanus toxoid. FINDINGS Samples from 18 atopic and 13 non-atopic infants showed low-level Th2-skewed allergen-specific responses at birth, with little accompanying specific interferon-gamma production. Neonatal Th2 responses were lower in the atopic group than in the non-atopic group; the differences were significant for interleukin-4 (mRNA: beta-actin ratio 0.48 [SE 0.15] vs 0.15 [0.06], p=0.049), interleukin-6 (4750 [48] vs 1352 [51] pg/mL culture fluid, p=0.003), interleukin-10 (1162 [228] vs 485 [89], p=0.015), and interleukin-13 (7.1 [0.9] vs 0.9 [0.3], p=0.008). There was rapid suppression of Th2 responses during the first year of life in non-atopic children, but there was consolidation of responses in atopic children, associated with defective neonatal interferon-gamma production. INTERPRETATION The continuation of fetal allergen-specific Th2 responses during infancy is a defining feature of the inductive phase of atopic disease, and is associated with decreased capacity for production of the Th1 cytokine interferon y by atopic neonates. These findings provide a plausible mechanism for persistence of the fetal Th2 responses during early childhood in atopic individuals and subsequent expression of disease.
This paper references
Decreased production of interferon-gamma by human neonatal cells. Intrinsic and regulatory deficiencies.
C. Wilson (1986)
Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.
E. Wierenga (1990)
Genetic ‘risk’ for atopy is associated with delayed postnatal maturation of T‐cell competence
P. G. HOLT (1992)
Induction of TH1 and TH2 responses: a key role for the 'natural' immune response?
S. Romagnani (1992)
Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?
T. Wegmann (1993)
Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema?
J. Warner (1994)
Role of viral infections in the inception of asthma and allergies during childhood: could they be protective?
F. Martinez (1994)
A potential vaccine strategy for asthma and allied atopic diseases during early childhood
P. Holt (1994)
Changing prevalence of asthma in Australian children
J. Peat (1994)
Is the increase in asthma prevalence linked to increase in allergen load?
A. J. Woolcock (1995)
Postnatal maturation of immune competence during infancy and childhood
P. Holt (1995)
Inhalant allergen‐specific T‐cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum‐free medium
J. Upham (1995)
Abnormal production of T helper 2 cytokines interleukin‐4 and interleukin‐5 by T cells from newborns with atopic parents
M. Piccinni (1996)
Measles and atopy in Guinea-Bissau
S. Shaheen (1996)
Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood
P. Holt (1996)
Allergic respiratory disease: strategic targets for primary prevention during childhood.
P. Holt (1997)
Atopic versus infectious diseases in childhood: a question of balance?
P. Holt (1997)
The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction.
N. Sudo (1997)
Development of long-term tolerance versus sensitisation to environmental allergens during the perinatal period.
P. Holt (1997)
TH2‐polarized immunological memory to inhalant allergens in atopies is established during infaney and early childhood
A. Yabuhara (1997)
Inverse Association between Tuberculin Responses and Atopic Disorder
J. Hopkin (1997)
The Inverse Association Between Tuberculin Responses and Atopic Disorder
T. Shirakawa (1997)
Developing patterns of T cell memory to environmental allergens in the first two years of life.
S. Prescott (1997)
Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile.
S. Prescott (1998)

This paper is referenced by
The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review
J. Poles (2021)
Allergen Exposure in Murine Neonates Promoted the Development of Asthmatic Lungs
Jeng-Chang Chen (2021)
Evironmental Factors Related To Atopic Dermatitis
Jaeyong Shin (2021)
Post-transplant food anaphylaxis in an adult cord blood transplant recipient (Ms. No. IJHM-D-20-01037R1)
A. Kawahara (2021)
Too Many User-Reviews! What Should App Developers Look at First?
Ehsan Noei (2021)
Immunomodulatory effect of different extracts from Angiostrongylus cantonensis on airway inflammation in an allergic asthma model.
V. F. Pascoal (2020)
Epigenetics in Food Allergies
S. Bar-El Dadon (2020)
Linkage between residential green spaces and allergic rhinitis among Asian children (case study: Taiwan)
Hsiao-Yun Lee (2020)
Immunomodulatory drugs suppress Th1-inducing ability of dendritic cells but enhance Th2-mediated allergic responses.
V. Phan (2020)
Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health
E. Semmes (2020)
Maturation of the Acute Hepatic TLR4/NF-κB Mediated Innate Immune Response Is p65 Dependent in Mice
M. Zarate (2020)
Distinct immune phenotypes in infants developing asthma during childhood
A. H. Thysen (2020)
Neonatal T Cells: A Reinterpretation.
B. D. Rudd (2020)
The early life education of the immune system: Moms, microbes and (missed) opportunities
N. Jain (2020)
Thinking bigger: How early‐life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease
H. Sbihi (2019)
Digestive tract mycobiota and microbiota and the effects on the immune system
N. Gouba (2019)
The environmental microbiota and asthma
Pirkka V Kirjavainen (2019)
Statins can suppress DC‐mediated Th2 responses through the repression of OX40‐ligand and CCL17 expression
N. Inagaki-Katashiba (2019)
Exposition antigénique dans la petite enfance: intérêt à l'officine
David Castagnet (2019)
Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease
R. Pretorius (2019)
La consommation de prébiotiques par la mère limite la survenue d’allergie chez la descendance
M. Bodinier (2019)
An Investigation into the Mechanistic Interplay between Th1 and Th2 Cells in Allergic Disease
C. Marie (2019)
Birth order and paediatric allergic disease: A nationwide longitudinal survey
T. Kikkawa (2018)
Day-care center attendance and risk of Asthma-A systematic review.
C. Sangrador (2018)
Anti-Inflammatory Effects of a Mixture of Lactic Acid Bacteria and Sodium Butyrate in Atopic Dermatitis Murine Model.
J. Kim (2018)
Cord Blood CD8+ T Cells Have a Natural Propensity to Express IL-4 in a Fatty Acid Metabolism and Caspase Activation-Dependent Manner
Y. Zhang (2018)
Trajectories of childhood immune development and respiratory health relevant to asthma and allergy
H. Tang (2018)
Wheezing after the use of acetaminophen and or ibuprofen for first episode of bronchiolitis or respiratory tract infection
P. Walsh (2018)
Non-Digestible Oligosaccharides Can Suppress Basophil Degranulation in Whole Blood of Peanut-Allergic Patients
S. M. Hayen (2018)
The immunological mechanisms underlying the development of immune tolerance in childhood
Louise J Michaelis (2018)
Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study
S. El-Heis (2018)
Antiapoptotic serine protease inhibitors contribute to survival of allergenic TH2 cells
M. Shamji (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar