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Synthesis And Characterization Of Chitosan-poly(acrylic Acid) Nanoparticles.
Y. Hu, Xiqun Jiang, Y. Ding, Haixiong Ge, Yuyan Yuan, Changzheng Yang
Published 2002 · Materials Science, Medicine
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Chitosan (CS)-poly(acrylic acid) (PAA) complex nanoparticles, which are well dispersed and stable in aqueous solution, have been prepared by template polymerization of acrylic acid (AA) in chitosan solution. The physicochemical properties of nanoparticles were investigated by using size exclusion chromatography, FT-IR, dynamic light scattering, transmission electron microscope and zeta potential. It was found that the molecular weight of PAA in nanoparticles increased with the increase of molecular weight of CS, indicating that the polymerization of acrylic acid in the chitosan solution was a template polymerization. It was also found that the prepared nanoparticles carried a positive charge and showed the size in the range from 50 to 400 nm. The surface structure and zeta potential of nanoparticles can be controlled by different preparation processes. The experiment of in vitro silk peptide (SP) release showed that these nanoparticles provided a continuous release of the entrapped SP for 10 days, and the release behavior was influenced by the pH value of the medium.
This paper references
Microcapsules of alginate-chitosan. II. A study of capsule stability and permeability.
O. Gåserød (1999)
Preparation, characterization, and drug release behaviors of drug‐loaded ε‐caprolactone/L‐lactide copolymer nanoparticles
Haixiong Ge (2000)
Formulation and Lyoprotection of Poly(Lactic Acid-Co-Ethylene Oxide) Nanoparticles: Influence on Physical Stability and In Vitro Cell Uptake
F. De Jaeghere (2004)
Multiple Morphologies of "Crew-Cut" Aggregates of Polystyrene-b-poly(acrylic acid) Block Copolymers
L. Zhang (1995)
Biochemical significance at exogenous chitins and chitosans in animals and patients
Muzzarelli RAA (1993)
Biodegradable long-circulating polymeric nanospheres.
R. Gref (1994)
Biochemical significance of exogenous chitins and chitosans in animals and patients
R. Muzzarelli (1993)
Clonazepam release from core-shell type nanoparticles of poly(ε-caprolactone)/poly(ethylene glycol)/poly(ε-caprolactone) triblock copolymers
Jae-Gon Ryu (2000)
The study of gelation kinetics and chain-relaxation properties of glutaraldehyde-cross-linked chitosan gel and their effects on microspheres preparation and drug release
F. L. Mi (2000)
Influences of process parameters on nanoparticle preparation performed by a double emulsion pressure homogenization technique.
A. Lamprecht (2000)
Liposomal pulmonary drug delivery. I. In vivo disposition of atropine base in solution and liposomal form following endotracheal instillation to the rabbit lung.
D. Meisner (1989)
Microcapsules of alginate-chitosan--I. A quantitative study of the interaction between alginate and chitosan.
O. Gåserød (1998)
Chitosan: A Biocompatible Material for Oral and Intravenous Administrations
S. Hirano (1990)
Drug release behavior of beads and microgranules of chitosan.
K. Gupta (2000)
A Heterogeneously Structured Composite Based on Poly(lactic-co-glycolic acid) Microspheres and Poly(vinyl alcohol) Hydrogel Nanoparticles for Long-Term Protein Drug Delivery
N. Wang (2004)
Design of microencapsulated chitosan microspheres for colonic drug delivery.
M. L. Lorenzo-Lamosa (1998)
Chitosan-Drug Conjugate Microspheres: Preparation and Drug Release Properties of Microspheres Composed of the Conjugate of 2′- or 3′-(4-Carboxy-butyryl)-5- Fluorouridine with Chitosan
H. Onishi (1996)
Self-consistent field modelling of poly(lactic acid)–poly(ethylene glycol) particles
C. Heald (2001)
Effect of nanoparticles on digitoxin uptake and pharmacologic activity in rat glomerular mesangial cell cultures.
M. Guzmán (2000)
Stability and freeze-drying of cyclosporine loaded poly(D,L lactide-glycolide) carriers.
M. Chacón (1999)
Liposomal ophthalmic drug delivery. III. Pharmacodynamic and biodisposition studies of atropine
D. Meisner (1989)
Polymeric nanocapsules as drug delivery systems. A review
P. Legrand (1999)
Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency.
H. Mao (2001)
Preparation and evaluation of the in vitro drug release properties and mucoadhesion of novel microspheres of hyaluronic acid and chitosan.
S. T. Lim (2000)
A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of chitosan.
J. Ahn (2001)
Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers
P. Calvo (1997)
Chitosan-Gadopentetic Acid Complex Nanoparticles for Gadolinium Neutron-Capture Therapy of Cancer: Preparation by Novel Emulsion-Droplet Coalescence Technique and Characterization
H. Tokumitsu (2004)
Clonazepam release from core-shell type nanoparticles of poly(epsilon-caprolactone)/poly(ethylene glycol)/poly(epsilon-caprolactone) triblock copolymers.
J. Ryu (2000)
Progress in Biomedical Polymers
C. G. Gebelein (1990)
The influence of process parameters on the PLA nanoparticle size distribution, evaluated by means of factorial design
P. Wehrlé (1995)
Template molecular weight effects on the polymerization of acrylic acid
J. Ferguson (1983)
Chitosan/calcium–alginate beads for oral delivery of insulin
P. Hari (1996)
Biological activity of chitosan: ultrastructural study.
R. Muzzarelli (1988)
Chitosan microspheres prepared by spray drying.
P. He (1999)
Studies on modified chitosan membranes. I. Preparation and characterization
M. Qurashi (1992)
Development of positively charged colloidal drug carriers: Chitosan-coated polyester nanocapsules and submicron-emulsions
P. Calvo (1997)
This paper is referenced by
POLY (D, L- LACTIDE-CO-GLYCOLIDE) AND CHITOSAN PARTICLES FOR ORAL DELIVERY OF MODEL LIPOPHILIC VITAMIN
A Thesis (2009)
PHOTOPOLYMERISATION OF ACRY LIC ACID AND CHI TOSAN GELS ( I ) . INFLUENCE OF PREPARATION METHOD ON THE FORMATION AND KI NETI C BEHAVI OUR OF INTERPENETRATI NG COMPLEXES
N. Davidenko (2008)
Functional Chitosan: Drug Delivery and Biomedical Applications
Sougata Jana (2019)
Light-scattering and turbidimetric detection of silica colloids in size-exclusion chromatography
Zarina Aspanut (2008)
Nanomedicine for targeted drug delivery
D. K. Kim (2009)
HERBAL EXTRACT ENCAPSULATED IN CHITOSAN NANOPARTICLE: A NOVEL STRATEGY FOR THE TREATMENT OF UROLITHIASIS
J. U. Chandirika (2018)
Layer-by-layer films of poly(o-ethoxyaniline) and chitosan-potly(methacrylic acid) nanoparticles
C.E. Borato (2005)
Biodegradable nanoparticles for drug delivery and targeting
M. Hans (2002)
A water-soluble and biocompatible polymeric nanolabel based on naphthalimide grafted poly(acrylic acid) for the two-photon fluorescence imaging of living cells and C. elegans.
Shucai Liang (2016)
Development and characterization of cotton, organic cotton flat knit fabrics coated with chitosan, sodium alginate, calcium alginate polymers, and antibiotic drugs for wound healing
O. Shanmugasundaram (2012)
Advances in chitosan-based hydrogels: Evolution from covalently crosslinked systems to ionotropically crosslinked superabsorbents
K. Ravishankar (2020)
Chitosan-coated poly(lactic-co-glycolic) acid nanoparticles as an efficient delivery system for Newcastle disease virus DNA vaccine
K. Zhao (2014)
Chitosan nanoparticles: a contribution to nanomedicine
H. Peniche (2011)
Interpolymer complex microparticles based on polymethacrylic acid‐chitosan for oral insulin delivery
S. Sajeesh (2006)
Preparation of mucoadhesive chitosan-poly(acrylic acid) microspheres by interpolymer complexation and solvent evaporation method II.
Sang-Min Cho (2005)
Pilocarpine-loaded chitosan-PAA nanosuspension for ophthalmic delivery
H. Lin (2007)
Novel pH responsive polymethacrylic acid-chitosan-polyethylene glycol nanoparticles for oral peptide delivery.
S. Sajeesh (2006)
Comparative and Competitive Study of LDH/Diatomite and Chitosan/Diatomite for Adsorptive Removal of Chloride Ion from Aqueous Solution
F. Abbasian (2020)
PLGA/polymeric liposome for targeted drug and gene co-delivery.
H. Wang (2010)
Disulfide cross-linked biodegradable polyelectrolyte nanoparticles for the oral delivery of protein drugs
Shujun Shu (2009)
Synthesis of β-cyclodextrin modified chitosan-poly(acrylic acid) nanoparticles and use as drug carriers.
X. Wang (2012)
Radiation-synthesis of chitosan/poly (acrylic acid) nanogel for improving the antitumor potential of rutin in hepatocellular carcinoma
R. Radwan (2020)
Chondroitin sulfate-based smart hydrogels for targeted delivery of oxaliplatin in colorectal cancer: preparation, characterization and toxicity evaluation
K. Barkat (2019)
Synthesis and characterization of graphene oxide/modified poly( N -isopropylacrylamide) nanocomposite
E. Jafarnejad (2016)
“The Good, the Bad and the Ugly” of Chitosans
B. Bellich (2016)
Experimental improvement of preparation of acrylic acid-modified middle deacetylated chitosan and its application in absorbing paraquat
Shih-Tong Hsu (2013)
Synthesis, characterization and cytotoxicity studies of chitosan-coated tea polyphenols nanoparticles.
J. Liang (2011)
EFFECTS OF MONOCARBOXYLIC ACIDS AND POTASSIUM PERSULFATE ON PREPARATION OF CHITOSAN NANOPARTICLES
E. Kusrini (2015)
Implantable applications of chitin and chitosan.
E. Khor (2003)
Metal ions doped chitosan-poly(acrylic acid) nanospheres: Synthesis and their application in simultaneously electrochemical detection of four markers of pancreatic cancer.
Q. Rong (2016)
One-step fabrication in aqueous solution of a granular alginate-based hydrogel for fast and efficient removal of heavy metal ions
W. Wang (2013)
Role of nanoparticle size, shape and surface chemistry in oral drug delivery.
Amrita Banerjee (2016)See more