Online citations, reference lists, and bibliographies.
← Back to Search

Bone Marrow Stromal Cells Regulate Caspase 3 Activity In Leukemic Cells During Chemotherapy.

J. Fortney, W. Zhao, S. Wenger, L. Gibson
Published 2001 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The interaction between leukemic cells and stromal cells of the bone marrow microenvironment has been shown to enhance leukemic cell survival during exposure to chemotherapeutic agents. In the current study we investigated whether association of B lineage acute lymphoblastic leukemic cells with human bone marrow stromal cells altered caspase activation during chemotherapy treatment. Following treatment with Ara-C or VP-16 in vitro, caspase 3 activity in leukemic cells was consistently reduced by co-culture of leukemic cells with human bone marrow stromal cell layers. These observations suggest that the protective effect of the bone marrow microenvironment on leukemic cells may be due, in part, to regulation of caspase 3 activity.
This paper references
10.1126/SCIENCE.281.5381.1312
Caspases: enemies within.
N. Thornberry (1998)
10.1182/BLOOD.V90.3.935.935_935_943
Comparison of apoptosis in wild-type and Fas-resistant cells: chemotherapy-induced apoptosis is not dependent on Fas/Fas ligand interactions.
C. Eischen (1997)
10.1182/BLOOD.V92.9.3381.421K02_3381_3387
Resistance to cytotoxic chemotherapy induced by CD40 ligand in lymphoma cells.
N. Voorzanger-Rousselot (1998)
Proliferation and apoptosis in newly diagnosed and relapsed childhood acute lymphoblastic leukemia.
M. Volm (1999)
10.1038/sj.cdd.4400394
Apoptosis: unmasking the executioner
M. Wilson (1998)
10.1046/j.1365-3083.1997.d01-173.x
Involvement of ICE (Caspase) Family in γ‐Radiation‐Induced Apoptosis of Normal B Lymphocytes
E. Hallan (1997)
10.1038/sj.leu.2401438
Caspase-3-like activity is necessary but not sufficient for daunorubicin-induced apoptosis in Jurkat human lymphoblastic leukemia cells
KJ Turnbull (1999)
10.1038/sj.leu.2401871
The most unkindest cut of all: on the multiple roles of mammalian caspases*
B. Fadeel (2000)
Use of stroma-supported cultures of leukemic cells to assess antileukemic drugs. II. Potent cytotoxicity of 2-chloro-deoxyadenosine in acute lymphoblastic leukemia.
M. Kumagai (1994)
10.1002/IJC.2910520118
Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5‐fluorouracil
C. Wilmanns (1992)
Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells.
C. Blanc (2000)
10.3109/10428199809057599
Vinorelbine induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma cells: a comparison with vincristine.
H. Toh (1998)
10.1080/09553009414551711
Recent developments in the assessment of chromosomal damage.
A. T. Natarajan (1994)
Effects of recombinant human cytokines on precursor-B acute lymphoblastic leukemia cells.
V. Makrynikola (1991)
10.1074/jbc.274.43.30651
Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation*
Beni B Wolf (1999)
10.1038/sj.leu.2401866
Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo
A. Prokop (2000)
10.1006/ABIO.1997.2220
Fluorometric and colorimetric detection of caspase activity associated with apoptosis.
V. Gurtu (1997)
10.1038/sj.cdd.4400476
Emerging roles of caspase-3 in apoptosis
A. Porter (1999)
10.1016/S0167-4838(99)00281-2
Caspases - controlling intracellular signals by protease zymogen activation.
H. Stennicke (2000)
10.1038/sj.cdd.4400601
Serial killers: ordering caspase activation events in apoptosis
EA Slee (1999)
10.1182/BLOOD.V96.5.1926.H8001926_1926_1932
Stromal cells regulate survival of B-lineage leukemic cells during chemotherapy.
R. E. Mudry (2000)
Caspase 2 and caspase 3 as predictors of complete remission and survival in adults with acute lymphoblastic leukemia.
S. Faderl (1999)
10.1016/S0248-4900(99)90273-3
Anthracyclines trigger apoptosis of both G0 G1 and cycling peripheral blood lymphocytes and induce massive deletion of mature T and B cells
C. Ferraro (2000)



This paper is referenced by
10.1007/978-1-4020-9597-9_8
Apoptosis and the Tumor Microenvironment in Hematologic Malignancies
Danielle N. Yarde (2009)
10.1016/J.LEUKRES.2004.04.018
Interaction of bone marrow stromal cells with lymphoblasts and effects of predinsolone on cytokine expression.
Shuling Wu (2005)
10.1182/blood-2011-08-376061
Notch signaling in acute lymphoblastic leukemia: any role for stromal microenvironment?
A. H. Nwabo Kamdje (2011)
10.1007/978-1-4020-9597-9
Apoptosis in Carcinogenesis and Chemotherapy
G. Chen (2009)
10.3389/fonc.2014.00099
Role of Integrin Alpha4 in Drug Resistance of Leukemia
S. Shishido (2014)
10.1182/BLOOD-2003-06-2071
Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia.
T. Kindler (2004)
10.1016/J.CANLET.2003.10.033
Stromal cells expressing elevated VCAM-1 enhance survival of B lineage tumor cells.
B. M. Hall (2004)
10.1182/blood-2010-12-326694
Notch-3 and Notch-4 signaling rescue from apoptosis human B-ALL cells in contact with human bone marrow-derived mesenchymal stromal cells.
A. H. Nwabo Kamdje (2011)
10.1158/1541-7786.MCR-15-0474
Bone Marrow Microenvironment Niche Regulates miR-221/222 in Acute Lymphoblastic Leukemia
B. Moses (2016)
10.1016/S0145-2126(01)00056-X
Life and death of ALL cells in the milieu of bone marrow stroma.
Y. Yoshida (2001)
10.1007/s12026-008-8038-9
Novel molecular and cellular therapeutic targets in acute lymphoblastic leukemia and lymphoproliferative disease
V. Brown (2008)
10.1038/s41388-018-0594-4
Bone marrow T helper cells with a Th1 phenotype induce activation and proliferation of leukemic cells in precursor B acute lymphoblastic leukemia patients
Sabrina Traxel (2018)
10.1016/J.LEUKRES.2003.10.033
Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt.
L. Wang (2004)
10.3892/ol.2017.6509
Exosomes derived from bone marrow stromal cells decrease the sensitivity of leukemic cells to etoposide.
Jianling Wang (2017)
10.4161/cc.4.3.1533
Activated EGFR Promotes the Survival of B-Lineage Acute Leukemia in the Absence of Stromal Cells
Justin D Spengeman (2005)
10.3109/10428194.2013.811579
Rapamycin interacts synergistically with idarubicin to induce T-leukemia cell apoptosis in vitro and in a mesenchymal stem cell simulated drug-resistant microenvironment via Akt/mammalian target of rapamycin and extracellular signal-related kinase signaling pathways
Kangni Wu (2014)
10.1158/1535-7163.MCT-06-0684
Wnt3/RhoA/ROCK signaling pathway is involved in adhesion-mediated drug resistance of multiple myeloma in an autocrine mechanism
M. Kobune (2007)
ResearchA mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease
Bruce P. Ayati (2010)
10.1158/1078-0432.CCR-06-0719
The Thalidomide Analogue, CC-4047, Induces Apoptosis Signaling and Growth Arrest in Childhood Acute Lymphoblastic Leukemia Cells In vitro and In vivo
Shabnam Shalapour (2006)
10.1111/ejh.12729
The role of ubiquitin‐specific protease 14 (USP14) in cell adhesion‐mediated drug resistance (CAM‐DR) of multiple myeloma cells
X. Xu (2017)
10.1186/1745-6150-5-28
A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease
Bruce P. Ayati (2010)
10.1038/nrc1475
Opportunities for cancer epidemiology in developing countries
Tanuja Rastogi (2004)
10.1016/j.bcmd.2015.07.017
Modulatory effects of mesenchymal stem cells on leucocytes and leukemic cells: A double-edged sword?
Jun How Low (2015)
10.1016/J.DRUP.2005.05.001
The role of caspases in cell death and differentiation.
L. Oliver (2005)
10.1007/s12185-008-0030-6
Effects of human bone marrow stromal cell line (HFCL) on the proliferation, differentiation and apoptosis of acute myeloid leukemia cell lines U937, HL-60 and HL-60/VCR
R. Liang (2008)
10.1038/sj.leu.2403643
VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli
L. Wang (2005)
10.1002/cbdv.200700427
Astilbotriterpenic Acid Induces Growth Arrest and Apoptosis in HeLa Cells through Mitochondria‐Related Pathways and Reactive Oxygen Species (ROS) Production
Y. Zhang (2009)
10.1124/jpet.118.255984
The MitoNEET Ligand NL-1 Mediates Antileukemic Activity in Drug-Resistant B-Cell Acute Lymphoblastic Leukemia
W. Geldenhuys (2019)
10.1007/978-90-481-9704-0_11
Targeting the TumorMicroenvironment for Enhancing Chemotherapy in HematologicMalignancies
Luis A. Crespo (2011)
10.1016/S0145-2126(02)00227-8
In vitro culture of human acute lymphoblastic leukemia (ALL) cells in serum-free media; a comparison of native ALL blasts, ALL cell lines and virus-transformed B cell lines.
Ø. Bruserud (2003)
10.1016/J.BLRE.2005.08.003
Tumor microenvironment and drug resistance in hematologic malignancies.
Z. Li (2006)
10.4061/2011/362326
Cancer Tissue Engineering: A Novel 3D Polystyrene Scaffold for In Vitro Isolation and Amplification of Lymphoma Cancer Cells from Heterogeneous Cell Mixtures
Carlos E. Caicedo-Carvajal (2011)
See more
Semantic Scholar Logo Some data provided by SemanticScholar