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Endogenous Bacterial Endophthalmitis: An East Asian Experience And A Reappraisal Of A Severe Ocular Affliction.

J. Wong, T. K. Chan, H. M. Lee, S. Chee
Published 2000 · Medicine
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PURPOSE To report 32 eyes of 27 patients with endogenous bacterial endophthalmitis seen over a 4 year period. Features and outcomes of this condition in the current series and the cases reported in the literature from 1986-1998 were reviewed. DESIGN Retrospective noncomparative case series. PARTICIPANTS All patients with this condition seen at the three participating general hospitals were included. INTERVENTION A review of the systemic and ocular characteristics, therapeutic methods, and final outcomes in patients afflicted with this condition. MAIN OUTCOME MEASURES Features studied included patients' demographic characteristics, microbiology, source of infection, ocular features, therapeutic interventions, final visual and anatomic outcomes. RESULTS Nineteen (70%) of the 27 incriminating organisms in this case series were gram negative microbes, with Klebsiella pneumoniae infections alone being responsible in 16 (60%) cases. Hepatobiliary tract infection was the source of bacteremia in 13 (48%) patients. Only nine (28%) eyes obtained good final visual acuity (20/120 or better), and two eyes were enucleated/eviscerated. A literature review of 209 patients with endogenous endophthalmitis over a 12 year period showed a similar increase in the frequency of gram negative microbes as the responsible organism, especially among the East Asian population. Overall, 22% had bilateral involvement; two thirds of patients had predisposing factor(s) or underlying illness(es), and diabetes mellitus was present in 46%. Thirty-four percent of all eyes obtained counting finger or better final vision, and 16% had their eyes eviscerated or enucleated. Infections with virulent organisms (gram negative rods, Serratia, Bacillus) usually denoted a grave visual prognosis; however, a media that was not opaque on presentation was usually associated with a good prognosis. CONCLUSION Metastatic ocular infection is not uncommon despite the availability of modern antibiotic therapy. Among the East Asian population, the patient at highest risk is a diabetic patient with Klebsiella pneumoniae hepatobiliary infection. In contrast, in the Caucasian population, this condition occurs in predisposed patients with gram-positive bacteremia arising from endocarditis or skin/joint infections. The final visual outcome in patients with endogenous bacterial endophthalmitis in the recent 12 years has not differed significantly from five decades ago.



This paper is referenced by
10.4103/0971-5916.169209
A study on the characterization of Propionibacterium acnes isolated from ocular clinical specimens
Murali Sowmiya (2015)
10.1016/j.preteyeres.2016.04.007
Modeling intraocular bacterial infections
R. Astley (2016)
10.2147/OPTH.S67396
Stenotrophomonas maltophilia endogenous endophthalmitis: clinical presentation, antibiotic susceptibility, and outcomes
Jay Chhablani (2014)
10.1128/CMR.00001-19
Hypervirulent Klebsiella pneumoniae
Thomas A Russo (2019)
10.1007/978-3-319-29231-1_13
Endophthalmitis in Immunocompromised and Diabetic Patients
Yingna Liu (2016)
10.1038/eye.2017.284
A British Ophthalmological Surveillance Unit Study on metastatic endogenous endophthalmitis
Samuel Maling (2018)
10.1167/iovs.18-23783
Epidemiology and Mortality-Related Prognostic Factors in Endophthalmitis.
Tzu-Heng Weng (2018)
10.1097/IAE.0000000000001994
ENDOGENOUS KLEBSIELLA PNEUMONIAE ENDOPHTHALMITIS IN NORTHERN CALIFORNIA
Ryan A. Shields (2019)
Endogenous endophthalmitis and liver abscesses.
Say Seng. Koay (2012)
10.1016/j.ajem.2014.03.038
Endogenous Klebsiella pneumoniae endophthalmitis.
Wenpeng Yin (2014)
10.7861/clinmed.2019-0187
Images of the month 3: Bilateral group B Streptococcus endophthalmitis - more than meets the eye.
Ray Peng Khoon Peh (2019)
10.1016/J.ORET.2018.08.009
Characteristics and Outcomes of Endogenous Endophthalmitis: Eight-Year Experience at a Tertiary Care Center.
Bobeck S. Modjtahedi (2019)
10.1016/J.JFO.2015.11.007
Endophtalmies endogènes bactériennes et fongiques au CHU de Nice : revue des cas sur 15 ans
C. Landre (2016)
10.1136/bcr-2015-209887
Serratia marcescens endogenous endophthalmitis in an immunocompetent host
Muhammad Memon (2016)
10.1007/s10156-012-0468-6
Case of endogenous endophthalmitis caused by Klebsiella pneumoniae with magA and rmpA genes in an immunocompetent patient
Akira Sawada (2013)
10.4009/JSDT.49.599
A case of endogenous endophthalmitis due to group G Streptococcus in a septic hemodialysis patient
Hiroko Nagase-Sasamoto (2016)
10.9734/BJMMR/2014/12352
Bilateral endogenous endophthalmitis in an Asian female.
Jesa Nadine V. Protasio (2014)
10.1097/IAE.0b013e3182a2e705
ENDOGENOUS ENDOPHTHALMITIS IN THE KOREAN POPULATION: A Six-Year Retrospective Study
Han Woong Lim (2014)
10.1097/SCS.0b013e31824e6a5b
Forehead abscess caused by Klebsiella oxytoca with undiagnosed type 2 diabetes.
Won-Il Sohn (2012)
10.7324/japs.2014.40123
Medicinal plants as source of antibacterial agents to counter Klebsiella pneumoniae.
Gowsiya Shaik (2014)
10.1155/2013/174869
Enterococcus faecalis Endogenous Endophthalmitis from Valvular Endocarditis
Sidnei Barge (2013)
10.1097/IPC.0000000000000275
Hypermucovirulent Klebsiella pneumoniae: An Emerging Threat in the United States
Lohit Garg (2015)
10.1016/j.annder.2013.07.023
[Endogenous endophthalmitis as a complication in erysipelas].
C. Pâquier-Valette (2013)
Endopthalmitis-Microbiological Profile at a Tertiary Eye Care Hospital in Hyderabad
Dr. Bhavani (2019)
10.4103/njo.njo_14_17
Endogenous presumed bacterial endophthalmitis of the right eye following cellulitis of the right leg
Godswill I. Nathaniel (2018)
10.9734/IJTDH/2016/21476
Invasive Klebsiella pneumoniae Liver Abscess with Multiple Septic Metastatic Complications - Case Report and Review of Literature
Kashif Mehboob Khan (2016)
10.1097/IAE.0b013e3181a3b7a1
ENDOGENOUS ENDOPHTHALMITIS CAUSED BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)
Thomas Ness (2009)
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Caroline François-Fiquet (2012)
10.1016/j.survophthal.2010.09.002
Post-traumatic Infectious Endophthalmitis.
Neelakshi Bhagat (2011)
10.3904/KJM.2012.82.2.200
Klebsiella pneumoniae as the Most Frequent Pathogen of Endogenous Endophthalmitis
Gayoung Park (2012)
10.1097/IAE.0b013e3180323f96
ENDOPHTHALMITIS: A Review of Current Evaluation and Management
C. A. Lemley (2007)
10.1136/bmj.c3073
An “unforeseen” complication of urinary tract infection in a patient with diabetes
M. Yuen (2010)
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