← Back to Search
The Transient Existence Of 'en Passant' Nerve Terminals In Normal Embryonic Rat Skeletal Muscle.
P. Sheard, M. Duxson
Published 1997 · Biology, Medicine
Save to my Library
Download PDFAnalyze on Scholarcy
In a recent examination of labeled normal embryonic rat nerve terminals we have found evidence of synaptic specialisation at non-terminal regions of axons ('en passant' terminals). The specialisation typically consists of a vesicle-filled axonal swelling lying in close apposition to a zone of thickened sarcolemma, with the two structures separated by a basal lamina-filled cleft. Such 'en passant' terminals are never seen in normal mature rat muscle, where all synaptic sites form at the true termination of axonal branches. These terminals thus appear to be a transient feature of developing neuromuscular relations. Analogous structures may arise in mature muscle when axons undergo ultraterminal sprouting in response to paralysis or partial denervation. We discuss our finding in relation to the role such terminals may play in normal development and in partially denervated mature muscle.
This paper references
Neuromuscular transmission in new‐born rats
P. A. Redfern (1970)
Development of neuromuscular junctions in rat embryos.
M. Dennis (1981)
Muscle reinnervation—II. Sprouting, synapse formation and repression
A. Gorio (1983)
The extent of sprouting of remaining motor units in partly denervated immature and adult rat soleus muscle
W. Thompson (1977)
Dynamics of nerve-muscle interaction in developing and mature neuromuscular junctions.
A. Grinnell (1995)
Morphological and electrophysiological study of distal motor nerve fiber degeneration and sprouting after irreversible cholinesterase inhibition
M. Kawabuchi (1991)
Embryonic growth and innervation of rat skeletal muscles. I. Neural regulation of muscle fibre numbers.
A. Harris (1981)
Formation of primary and secondary myotubes in aneural muscles in the mouse mutant peroneal muscular atrophy.
P. Ashby (1993)
Formation of primary and secondary myotubes in rat lumbrical muscles.
J. J. Ross (1987)
Regulation of myogenesis in paralyzed muscles in the mouse mutants peroneal muscular atrophy and muscular dysgenesis.
P. Ashby (1993)
Muscle reinnervation—III. Motoneuron sprouting capacity, enhancement by exogenous gangliosides
A. Gorio (1983)
Composition of newly forming motor units in prenatal rat intercostal muscle
P. Sheard (1996)
Nerve growth from nodes of Ranvier in inactive muscle
W. G. Hopkins (1981)
Induction of motor neuron sprouting in vivo by ciliary neurotrophic factor and basic fibroblast growth factor
M. Gurney (1992)
Motor neurone sprouting induced by prolonged tetrodotoxin block of nerve action potentials
M. Brown (1977)
RECEPTOR PROPERTIES OF DEVELOPING MUSCLE
D. Fambrough (1974)
Early nerve-muscle synapses in vitro release transmitter over postsynaptic membrane having low acetylcholine sensitivity.
S. Cohen (1980)
Formation of myotubes in aneural rat muscles.
S. Wilson (1993)
Development of neuromuscular synapses.
M. Bennett (1983)
Localization of acetylcholine receptors and synaptic ultrastructure at nerve-muscle contacts in culture: dependence on nerve type
MW Cohen (1980)
THE FINE STRUCTURE OF MOTOR ENDPLATE MORPHOGENESIS
A. Kelly (1969)
Development of the myotomal neuromuscular junction in Xenopus laevis: an electrophysiological and fine-structural study.
R. W. Kullberg (1977)
Transfer of differentiated synaptic terminals from primary myotubes to new-formed muscle cells during embryonic development in the rat
M. Duxson (1986)
Changes in synaptic potential properties during acetylcholine receptor accumulation and neurospecific interactions in Xenopus nerve-muscle cell culture.
Y. Kidokoro (1980)
Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors
P. Caroni (1990)
The onset and development of transmission in the chick ciliary ganglion
L. Landmesser (1972)
Neuromuscular transmission to identified primary and secondary myotubes: a reevaluation of polyneuronal innervation patterns in rat embryos.
P. Sheard (1991)
Motor nerve sprouting.
M. C. Brown (1981)
The Neuromuscular Junction
A. Engel (1985)
The origin of secondary myotubes in mammalian skeletal muscles: ultrastructural studies.
M. Duxson (1989)
Interactions between nerve and muscle: synapse elimination at the developing neuromuscular junction.
H. Colman (1993)
The regulation of intramuscular nerve branching during normal development and following activity blockade.
L. M. Dahm (1988)
Development of muscle fiber specialization in the rat hindlimb
N. Rubinstein (1981)
Morphological aspects of the elimination of polyneuronal innervation of skeletal muscle fibres in newborn rats
H. Korneliussen (1976)
Formation of new myotubes occurs exclusively at the multiple innervation zones of an embryonic large muscle
M. Duxson (1995)
The relationship of nerve to myoblasts and newly-formed secondary myotubes in the fourth lumbrical muscle of the rat foetus
M. Duxson (1992)
A central role for denervated tissues in causing nerve sprouting
M. C. Brown (1979)
Nerve sprouting in muscle is induced and guided by processes extended by schwann cells
Young-Jin Son (1995)
Staining for nerve fiber and cholinesterase activity in fresh frozen sections.
T. Namba (1967)
This paper is referenced by
Neural control of tuneable skin iridescence in squid
T. Wardill (2012)
The α1 subunit of nicotinic acetylcholine receptors in the inner ear: transcriptional regulation by ATOH1 and co‐expression with the γ subunit in hair cells
D. Scheffer (2007)
Development of the vertebrate neuromuscular junction.
J. Sanes (1999)
Increased neuromuscular activity causes axonal defects and muscular degeneration
J. L. Lefebvre (2004)
Neuromuscular synaptogenesis: coordinating partners with multiple functions
H. Darabid (2014)