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Has Electrical Growth Cone Guidance Found Its Potential?

C. McCaig, A. Rajnicek, B. Song, M. Zhao
Published 2002 · Biology, Medicine

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Many neurobiologists spurn the existence and use of direct-current (DC) electric fields (EFs) in nervous system development and regeneration. This is despite direct measurement of EFs in embryos and adults, and evidence that EFs are required for normal development, dramatically influence the rate and direction of nerve growth in vitro, and promote nerve regeneration in vivo. The notion that growth cones use EFs as guidance cues was dismissed partly because there was no convincing evidence that naturally occurring EFs influence nerve growth at the single-cell level in vivo. Recent work indicates that growth cones can be guided by EFs in vivo and, intriguingly, that in vitro guidance by chemotropic gradients and EFs might invoke similar mechanisms. Ongoing clinical trials to assess the effectiveness of DC EFs in promoting the regeneration of human spinal cord could allow EFs to achieve their potential.
This paper references
Behavioral recovery
Borgens (1987)
A cell's sense of direction.
C. Parent (1999)
All rights reserved
C. Moorehead (1997)
Functional recovery after spinal cord hemisection in guinea pigs: The effects of applied electric fields
R. Borgens (1990)
The direction of neurite growth in a weak dc electric field depends on the substratum : contributions of substrate adhesivity and surface charge
R. B. Borgens (1998)
Signal transduction underlying growth cone guidance by diffusible factors
H. Song (1999)
Electrical fields in the vicinity of epithelial wounds in the isolated bovine eye.
M. Chiang (1992)
Wound - induced electric fields modulate nerve sprouting cell division and healing
K. R. Robinson (2001)
Ph.D. Editor Jan Vijg (2001)
Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium.
P. Devreotes (1988)
Wound-induced electric fields modulate nerve sprouting cell division and healing
McCaig (2001)
The direction of neurite growth in a weak DC electric field depends on the substratum: contributions of adhesivity and net surface charge.
A. Rajnicek (1998)
Electropotential measurements as a new diagnostic modality for breast cancer
J. Cuzick (1998)
An imposed oscillating electrical field improves the recovery of function in neurologically complete paraplegic dogs.
R. Borgens (1999)
Hippocampal growth cone responses to focally applied electric fields.
R. W. Davenport (1993)
Threedimensional gradients of voltage during development of the nervous system as invisible coordinates for the establishment of embryonic
R. Shi (1995)
The growth of PC 12 neurites is biased toward the anode
C. D. McCaig (1994)
Functional recovery.
J. R. Napier (1951)
Growth and guidance of the fungal hypha.
N. Gow (1994)
Endogenous electrical fields affect the distribution of extracellular protein in Xenopus embryos
M. Messerli (1997)
Endogenous electrical fields affect the distribution of extracellular protein in Xenopus embryos
O. A. Candia (1997)
A physiological electric field directs nerve growth, cell migration and cell division in vivo
B Song (2001)
L. Jaffe (1974)
Behavioral recovery induced by applied electric fields after spinal cord hemisection in guinea pig.
R. Borgens (1987)
cAMP and protein kinase A signaling underlie growth cone turning in a physiological electric field
A. M. Rajnicek (2001)
Endogenous electrical currents and voltage gradients in Xenopus embryos and the consequences of their disruption.
K. Hotary (1994)
Neuronal galvanotropism is independent of external Ca(2+) entry or internal Ca(2+) gradients.
A. M. Palmer (2000)
A small, physiological electric field orients cell division.
M. Zhao (1999)
Neurotrophins enhance electric field‐directed growth cone guidance and directed nerve branching
C. McCaig (2000)
Growth cone neurotransmitter receptor activation modulates electric field-guided nerve growth.
L. Erskine (1995)
In vivo regulation of axon extension and pathfinding by growth-cone calcium transients
T. M. Gomez (1999)
Electric field-directed cell motility involves up-regulated expression and asymmetric redistribution of the epidermal growth factor receptors and is enhanced by fibronectin and laminin.
M. Zhao (1999)
Extracellular current measurements with a vibrating probe
L. Jaffe (1985)
The direction of growth of differentiating neurones and myoblasts from frog embryos in an applied electric field.
L. Hinkle (1981)
Embryonic neuroepithelial sodium transport, the resulting physiological potential, and cranial development.
R. Shi (1994)
Intrinsic electric fields promote epithelization of wounds in the newt, Notophthalmus viridescens.
M. Chiang (1991)
The direction of neurite growth in a weak dc electric field depends on the substratum: contributions of substrate adhesivity and surface charge
Rajnicek (1998)
The neural tube of the Xenopus embryo maintains a potential difference across itself.
K. Hotary (1991)
Behavioral recovery induced by applied electric fields after hemisection in guinea pig
R. B. Borgens (1987)
A physiological electric field directs nerve growth , cell migration and cell division in vivo
C. D. McCaig (2001)
The growth of PC12 neurites is biased towards the anode of an applied electrical field.
R. Cork (1994)
The growth of PC12 neurites is biased toward the anode
Cork (1994)
Endogenous lateral electric fields around bovine corneal lesions are necessary for and can enhance normal rates of wound healing
D. D. Sta Iglesia (1998)
Dynamic aspects of amphibian neurite growth and the effects of an applied electric field.
C. McCaig (1986)
Physiological electrical fields modify cell behaviour.
C. McCaig (1997)
Endogenous electrical currents and the resultant voltage gradients in the chick embryo.
K. Hotary (1990)
Nerve branching is induced and oriented by a small applied electric field.
C. McCaig (1990)
Reactions of cells to the galvanic current in tissue culture
S. Ingvar (1920)
cAMP and protein kinase A signaling underlie growth cone turning in a physiological electric field
A. M. Palmer (2001)
Spatial control of actin polymerization during neutrophil chemotaxis
O. Weiner (1999)
Growth and guidance of the hyphal apex
M. Messerli (1994)
Migration of human keratinocytes in electric fields requires growth factors and extracellular calcium.
K. Fang (1998)
The responses of cells to electrical fields: a review
K. Robinson (1985)
Large and persistent electrical currents enter the transected lamprey spinal cord.
R. Borgens (1980)
Electrical stimulation to heal dermal wounds.
G. D. Gentzkow (1993)
Radiological evidence of response to electrochemical treatment of breast cancer.
E. Azavedo (1991)
J. Neurosci
Trends in Neurosciences
H. J. Gamble (1980)
Electrical Activity Modulates Growth Cone Guidance by Diffusible Factors
G. Ming (2001)
Effects of applied electric fields on clinical cases of complete paraplegia in dogs.
R. Borgens (1993)
Calcium channel subtypes and intracellular calcium stores modulate electric field-stimulated and -oriented nerve growth.
R. Stewart (1995)
Three‐dimensional gradients of voltage during development of the nervous system as invisible coordinates for the establishment of embryonic pattern
R. Shi (1995)
Transport of Na, Cl, and water by the rabbit corneal epithelium at resting potential.
S. Klyce (1975)
Short-circuit current related to active transport of chloride in frog cornea: effects of furosemide and ethacrynic acid.
O. Candia (1973)
Re-orientation and faster, directed migration of lens epithelial cells in a physiological electric field.
E. Wang (2000)
Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential
R. Borgens (1995)
Evidence of a role for endogenous electrical fields in chick embryo development.
K. Hotary (1992)
Modification of retrograde degeneration in transected spinal axons of the lamprey by applied DC current
E. Roederer (1983)
Electric embryos : the embryonic epithelium as a generator of developmental information
C. D. McCaig (1996)
Reaction of cells to the galvanic current in tissue cultures
Sven Ingvar (1920)
Radiological evidence
E Azavedo (1991)
Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields.
K. Fang (1999)
The cell biology of neuronal navigation
H. Song (2001)
Nerve growth and nerve guidance in a physiological electric field
C. McCaig (1996)
Electric embryos: the embryonic epithelium as a generator of developmental information
Robinson K.R (1996)
An imposed oscillating
R Borgens (1999)
Weak applied voltages interfere with amphibian morphogenesis and pattern
M. E. M. Metcalf (1994)
Pollen tube targeting and axon guidance: parallels in tip growth mechanisms.
R. Palanivelu (2000)
Spinal neurite reabsorption and regrowth in vitro depend on the polarity of an applied electric field.
C. McCaig (1987)
The distribution of free calcium in transected spinal axons and its modulation by applied electrical fields
A. F. Strautman (1990)
Effects of applied
Borgens (1993)
The glabrous epidermis of cavies contains a powerful battery.
A. T. Barker (1982)

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Linjie Pan (2012)
Of Minds and Embryos: Left-Right Asymmetry and the Serotonergic Controls of Pre-Neural Morphogenesis
M. Levin (2006)
Glial Cell Engineering in Neural Regeneration
L. Yao (2018)
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Matthew L Baer (2015)
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Elisabeth M. Steel (2018)
monophosphate and phosphatidylinositol signaling Switching direction in electric-signal-induced cell migration by cyclic guanosine
C. McCaig (2009)
In vitro and in vivo studies of electroactive reduced graphene oxide-modified nanofiber scaffolds for peripheral nerve regeneration.
J. Wang (2019)
Directed migration in neural tissue engineering.
Melissa R. Wrobel (2014)
TiO2 surfaces support neuron growth during electric field stimulation.
M. Canillas (2017)
Calcium signalling in growth cone migration.
S. Bolsover (2005)
Clinical effectiveness of acupuncture for carpal tunnel syndrome.
Chien-Yi Ho (2014)
Implantable microdevice for peripheral nerve regeneration: materials and fabrications
D. Bennet (2011)
Temporally and spatially coordinated roles for Rho, Rac, Cdc42 and their effectors in growth cone guidance by a physiological electric field
A. Rajnicek (2006)
EGF receptor signalling is essential for electric-field-directed migration of breast cancer cells
Jin Pu (2007)
Protective Effect of Moderate Exogenous Electric Field Stimulation on Activating Netrin-1/DCC Expression Against Mechanical Stretch-Induced Injury in Spinal Cord Neurons
Meili Liu (2018)
[Significance of the composition of conduit internal environment for the activation of axon growth in patients with extended peripheral nerve defects].
V F Pyatin (2019)
Deer antler innervation and regeneration.
M. Nieto-Díaz (2012)
Factors promoting neurite outgrowth during deer antler regeneration
W. Pita-Thomas (2010)
Nanostructured Coatings for Improved Charge Delivery to Neurons
Takashi D. Y. Kozai (2014)
Electric field-guided neuron migration: a novel approach in neurogenesis.
L. Yao (2011)
Short-duration, DC electrical stimulation increases chick embryo DRG neurite outgrowth.
M. Wood (2006)
Golgi polarization in a strong electric field
Jin Pu (2005)
Effects of Atorvastatin and l-Arginine Treatments on Electrical Field Stimulation-mediated Relaxations in Pulmonary Arterial Rings of Monocrotaline-Induced Pulmonary Hypertensive Rats
Elif Inci Ozturk (2010)
Guidance by Galvanotaxis
J. Davies (2013)
Electroactive polymers for tissue regeneration: Developments and perspectives.
C. Ning (2018)
Electrical Stimulation Promotes Wound Healing by Enhancing Dermal Fibroblast Activity and Promoting Myofibroblast Transdifferentiation
M. Rouabhia (2013)
Strict perpendicular orientation of neural crest‐derived neurons in vitro is dependent on an extracellular gradient of voltage
Linjie Pan (2012)
Electroconductive neural interfaces for neural tissue applications
J. Lee (2010)
Cerámica y Vidrio Materials directed to implants for repairing Central Nervous System
M. Canillas (2015)
Application of direct current electric fields to cells and tissues in vitro and modulation of wound electric field in vivo
B. Song (2007)
Direct visualization of a stratified epithelium reveals that wounds heal by unified sliding of cell sheets
M. Zhao (2003)
Measuring membrane potential and electric field of brainstem neurons in vitro by confocal microscopy.
J. Ma (2004)
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