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Evidence For The Medullary Visceral Zone As A Neural Station Of Neuroimmunomodulation

Z. Yang, Z. Rao, G. Ju
Published 2000 · Medicine

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The aim of the present study was to test the possibility that the catecholaminergic projectional pathway from the vagus nerve to the medullary visceral zone (MVZ) thence to the paraventricular nucleus of hypothalamus (PVN) was involved in the cytokine-to-brain communication. A triple labeling method in which WGA-HRP retrograde tracing was combined with anti-Fos and -TH immunohistochemical staining was used. WGA-HRP was stereotaxically injected into unilateral PVN in the rat, after a survival of 48 h, animals received intraperitoneal injection of lipopolysaccharide (LPS). The distribution of the HRP retrogradely labeled neurons, Fos protein positive and catecholaminergic neurons (tyrosine hydroxylase as marker) in the MVZ was observed. Subdiaphragmatic vagotomy (SDV) and sham surgery were also used to observe the different Fos expression in the MVZ after intraperitoneal administration of lipopolysaccharide (LPS) or pyrogen-free saline (NS). Under light microscope, seven types of positively stained neurons could be distinguished within the MVZ, namely neurons single-labeled with Fos, HRP or TH, respectively; neurons double-labeled with Fos/TH, Fos/HRP or HRP/TH separately; and neurons triple-labeled with Fos, HRP and TH staining. Intraperitoneal LPS caused lots of robust Fos expression within the MVZ in the sham surgery groups and this response in the MVZ was markedly inhibited in the vagotomized rats. The results suggested that some catecholaminergic neurons in the MVZ could send projections to the PVN and this pathway might be involved in the relay of peripheral immune information via vagus nerve. MVZ was a neural relay station in the immune-to-brain communication and might play a significant role in the neuroimmunomodulation via vagus-MVZ-PVN pathway.
This paper references
10.1006/BRBI.1995.1023
Lipopolysaccharide and Interleukin-1 Depress Food-Motivated Behavior in Mice by a Vagal-Mediated Mechanism
J. Bret-Dibat (1995)
10.1016/S0166-2236(97)01138-7
Mechanisms of CNS response to systemic immune challenge: the febrile response
J. Elmquist (1997)
10.1016/0006-8993(94)91118-5
Visceral noxious stimulation induced expression of Fos protein in medullary catecholaminergic neurons projecting to nucleus accumbens in the rat: a study with triple labeling method of HRP tracing combined with Fos and TH immunohistochemistry
G. Jin (1994)
Distribution of SPR-like immunoreactivity in the medullary visceral zone of the rat and changes following acute myocardial ischemia induced by intravenous injection of vasopressin.
W. Gao (1998)
10.1523/JNEUROSCI.14-02-00897.1994
A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons
A. Ericsson (1994)
10.1523/JNEUROSCI.19-07-02799.1999
Interleukin-1β in Immune Cells of the Abdominal Vagus Nerve: a Link between the Immune and Nervous Systems?
L. Goehler (1999)
10.1016/0006-8993(92)91424-D
Differential effects of central and peripheral injection of interleukin-1β on brain c-fos expression and neuroendocrine functions
S. Rivest (1992)
10.1159/000126959
Differential pattern of c-fos mRNA in rat brain following central and systemic administration of interleukin-1-beta: implications for mechanism of action.
H. Day (1996)
10.1016/0304-3940(91)90289-6
Activation of corticotropin-releasing factor-containing neurons in the paraventricular nucleus of the hypothalamus by interleukin-1 in the rat
G. Ju. (1991)
10.1152/AJPREGU.1997.273.1.R407
The vagus nerve in the thermoregulatory response to systemic inflammation.
A. Romanovsky (1997)
10.1159/000097330
Evidence for hypothalamic paraventricular nucleus as an integrative center of neuroimmunomodulation.
H. Yang (1997)
10.1210/ENDO-125-6-3096
In the Rat, Interleukin- lα and -β Stimulate Adrenocorticotropin and Catecholamine Release*
C. Rivier (1989)
10.1016/S0006-8993(97)01183-9
Noxious somatic stimulation-induced expression of Fos-like immunoreactivity in catecholaminergic neurons with habenular nucleus projection in the medullary visceral zone of rat
Tao Li (1998)
10.1007/BF03182876
Morphology of the medullary visceral zone
Z. Rao (1999)
10.1002/CNE.902740107
Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus
E. Cunningham (1988)
10.1016/0024-3205(88)90522-X
Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone.
A. Dunn (1988)
Medullary catecholaminergic neurons projecting to lateral hypothalamic area and expressing Fos after chemical stimulation of the stomach in the rat.
Y. X. Dong (1997)
10.1006/brbi.1995.1014
Peripheral Catecholamines Are Involved in the Neuroendocrine and Immune Effects of LPS
C. Delrueperollet (1995)
10.1210/ENDO-126-6-2837
Central corticotropin-releasing factor mediates the suppressive effect of stress on natural killer cytotoxicity.
M. Irwin (1990)
10.1016/0361-9230(93)90044-C
The effects of stress on splenic immune function are mediated by the splenic nerve
Wan Weihua (1993)
10.1152/AJPREGU.1995.268.5.R1327
Subdiaphragmatic vagotomy blocks induction of IL-1 beta mRNA in mice brain in response to peripheral LPS.
S. Layé (1995)
10.1016/0165-5728(91)90126-R
The parasympathetic nervous system takes part in the immuno-neuroendocrine dialogue
I. Rinner (1991)
10.1016/S0361-9230(98)00045-8
Area postrema removal abolishes stimulatory effects of intravenous interleukin-1β on hypothalamic-pituitary-adrenal axis activity and c-fos mRNA in the hypothalamic paraventricular nucleus
H. Y. Lee (1998)
10.1016/0024-3205(95)02047-M
Cytokine-to-brain communication: a review & analysis of alternative mechanisms.
L. Watkins (1995)



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10.1111/j.1365-2826.2006.01528.x
The Role of the Vagus Nerve in Mediating the Long‐Term Anorectic Effects of Leptin
C. Sachot (2007)
10.3748/WJG.V12.I20.3271
Effects of nuclei ambiguus and dorsal motor nuclei of vagus on gastric H+ and HCO3- secretion in rats
Xue-Ying Zhang (2006)
10.1002/ar.23528
Thalamic dopaminergic neurons projects to the paraventricular nucleus‐rostral ventrolateral medulla/C1 neural circuit
Olalekan M. Ogundele (2017)
10.3748/WJG.V10.I1.117
Ultrastructure of junction areas between neurons and astrocytes in rat supraoptic nuclei.
Li Duan (2004)
Named Series: Twenty Years of Brain, Behavior, and Immunity Brain-immune communication pathways
N. Quan (2007)
10.3892/etm.2012.770
FOS protein expression and role of the vagus nerve in the rat medullary visceral zone in multiple organ dysfunction syndrome caused by subarachnoid hemorrhage
Y. He (2013)
10.1212/WNL.0b013e3181aebd43
Autonomic-mediated immunomodulation and potential clinical relevance
E. Benarroch (2009)
10.1016/j.neuroscience.2005.05.065
Monosynaptic circuitry of trigeminal proprioceptive afferents coordinating jaw movement with visceral and laryngeal activities in rats
J. Zhang (2005)
10.4149/ENDO_2009_01_3
Brain response to induced peripheral cancer development in rats: dual fos-tyrosine hydroxylase and fos-oxytocin immunohistochemistry.
B. Mravec (2009)
10.1016/S1567-7443(07)00215-3
Inflammatory Mediators Affect the Autonomic Nervous System
R. Straub (2007)
10.1016/j.bbi.2007.05.005
Brain-immune communication pathways
N. Quan (2007)
10.1016/S0899-9007(02)00781-5
Neural-immune gut-brain communication in the anorexia of disease.
G. Schwartz (2002)
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