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Development Of Non-viral Vectors For Systemic Gene Delivery.
F. Liu, L. Huang
Published 2002 · Biology, Medicine
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One of the major challenges for gene therapy is systemic delivery of a nucleic acid directly into an affected tissue. This requires developing a vehicle which is able to protect the nucleic acid from degradation, while delivering the gene of interest to the specific tissue and specific subcellular compartment. In this review, we summarize some of the recent advances in new non-viral delivery systems for systemic administration. Two types of gene delivery systems are described: (i) LPD1 (cationic liposome-entrapped, polycation-condensed DNA, type 1), and (ii) retention-time mediated naked DNA delivery. Hypothesized mechanisms for these systemic gene transfers are also discussed.
This paper references
Mechanism of oligonucleotide release from cationic liposomes.
O. Zelphati (1996)
α-Helix–double helix interaction shown in the structure of a protamine-transfer RNA complex and a nucleoprotamine model
R. W. Warrant (1978)
Mechanism of DNA release from cationic liposome/DNA complexes used in cell transfection.
Y. Xu (1996)
RB-mediated suppression of spontaneous multiple neuroendocrine neoplasia and lung metastases in Rb+/- mice.
A. Y. Nikitin (1999)
Hypothesis: naked plasmid DNA is taken up by cells in vivo by a receptor‐mediated process
V. Budker (2000)
Protamine sulfate enhances lipid-mediated gene transfer
F. Sorgi (1997)
Improving plasmid DNA‐mediated liver gene transfer by prolonging its retention in the hepatic vasculature
F. Liu (2001)
Plasmid DNA entry into postmitotic nuclei of primary rat myotubes.
M. Dowty (1995)
Novel Lipidic Vectors for Gene Transfer
S. Li (1999)
Sequential injection of cationic liposome and plasmid DNA effectively transfects the lung with minimal inflammatory toxicity.
Y. Tan (2001)
DNA activates human immune cells through a CpG sequence‐dependent manner
M. Bauer (1999)
Transfer of full-length Dmd to the diaphragm muscle of Dmd(mdx/mdx) mice through systemic administration of plasmid DNA.
F. Liu (2001)
Potentiation of cationic liposome-mediated gene delivery by polycations.
X. Gao (1996)
Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid (*)
J. Zabner (1995)
Enhanced gene expression in mouse lung by prolonging the retention time of intravenously injected plasmid DNA
YK Song (1998)
Factors controlling the efficiency of cationic lipid-mediated transfection in vivo via intravenous administration
F. Liu (1997)
Influence of membrane-active peptides on lipospermine/DNA complex mediated gene transfer.
A. Kichler (1997)
DNA transfection mediated by cationic liposomes containing lipopolylysine: characterization and mechanism of action.
X. Zhou (1994)
Nuclear import of DNA in digitonin-permeabilized cells.
J. Hagstrom (1997)
Mechanisms of Cationic Liposome-Mediated Transfection of the Lung Endothelium
D. Liu (1999)
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
P. Felgner (1987)
Import of DNA into mammalian nuclei by proteins originating from a plant pathogenic bacterium.
A. Ziemienowicz (1999)
In vivo gene transfer via intravenous administration of cationic lipid–protamine–DNA (LPD) complexes
S. Li (1997)
Cationic lipids enhance cytokine and cell influx levels in the lung following administration of plasmid: cationic lipid complexes.
B. Freimark (1998)
Cationic lipids are essential for gene delivery mediated by intravenous administration of lipoplexes
L. Barron (1999)
The Perplexing Delivery Mechanism of Lipoplexes
L. Barron (1999)
pH-sensitive immunoliposomes mediate target-cell-specific delivery and controlled expression of a foreign gene in mouse.
C. Y. Wang (1987)
Characterization of cationic lipid-protamine–DNA (LPD) complexes for intravenous gene delivery
S. Li (1998)
Effect of immune response on gene transfer to the lung via systemic administration of cationic lipidic vectors.
Song Li (1999)
Dynamic changes in the characteristics of cationic lipidic vectors after exposure to mouse serum: implications for intravenous lipofection
S. Li (1999)
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Nanomedicine for respiratory diseases.
H. Swai (2009)
Biophysical characterization of anionic lipoplexes.
S. Patil (2005)
Innate immune response induced by gene delivery vectors.
H. Sakurai (2008)
Cyclen-based double-tailed lipids for DNA delivery: Synthesis and the effect of linking group structures.
Yi-mei Zhang (2015)
The headgroup evolution of cationic lipids for gene delivery.
Defu Zhi (2013)
Efficient downregulation of VEGF in retinal pigment epithelial cells by integrin ligand-labeled liposome-mediated siRNA delivery
Cheng-Wei Chen (2013)
Specific targeting of human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer cells by polyethylene glycol-grafted polyethyleneimine modified with anti-HER2 single-domain antibody
Batoul Saqafi (2018)
Bioreducible, hydrolytically degradable and targeting polymers for gene delivery.
I. Ullah (2017)
Biophysical properties and supramolecular structure of self-assembled liposome/ε-peptide/DNA nanoparticles: correlation with gene delivery.
Jiang Yan (2012)
Effect of cationic lipid type in cationic liposomes for siRNA delivery into the liver by sequential injection of chondroitin sulfate and cationic lipoplex
Y. Hattori (2018)
Preparation and characterization of chitosan‐coated hydroxyapatite nanoparticles as a promising non‐viral vector for gene delivery
Jian-wen Wang (2011)
Arginine-grafted bioreducible poly(disulfide amine) for gene delivery systems.
Tae-Il Kim (2009)
Cell-Specific Targeting of Lipid-Based Carriers for ODN and DNA
M. Bartsch (2005)
Cationic liposome-DNA complexes as gene delivery vectors: Development and behaviour towards bone-like cells.
A. Oliveira (2009)
Toroid formation in charge neutralized flexible or semi‐flexible biopolymers: potential pathway for assembly of DNA carriers
M. X. Tang (2005)
Gene Therapy for Cancer
K. Brand (2003)
Engineered smart biomaterials for gene delivery
R. Amini (2012)
Lipid-based vectors for siRNA delivery
S. Zhang (2012)
Tumor-targeted gene delivery via anti-HER2 antibody (trastuzumab, Herceptin) conjugated polyethylenimine.
Shih-Jiuan Chiu (2004)
Chemical modification of chitosan for efficient gene therapy.
Hu-Lin Jiang (2014)
In vitro physicochemical evaluation of DNA nanoparticles
M. Hosseinkhani (2011)
Amphiphilic polymers formed from ring-opening polymerization: a strategy for the enhancement of gene delivery.
Yi-mei Zhang (2017)
Biologically responsive carrier-mediated anti-angiogenesis shRNA delivery for tumor treatment
Junyi Che (2016)
Toxicity evaluation of dextran-spermine polycation as a tool for genetherapy in vitro
Fatemah Abedini (2010)
Subcellular drug targeting, pharmacokinetics and bioavailability
S. Leucuţa (2014)
Intratumoral dispersion, retention, systemic biodistribution, and clearance of a small-size tumor necrosis factor-α-expressing MIDGE vector after nonviral in vivo jet-injection gene transfer.
Nele R. Galling (2012)
Plasmid Regulation and Systems-Level Effects on Escherichia coli Metabolism
D. Ow (2009)
A guanidinylated bioreducible polymer with high nuclear localization ability for gene delivery systems.
Tae-Il Kim (2010)
PEGylation enhances tumor targeting of plasmid DNA by an artificial cationized protein with repeated RGD sequences, Pronectin.
H. Hosseinkhani (2004)
Chitosan-based nanostructures: a delivery platform for ocular therapeutics.
M. de la Fuente (2010)
Enhancement of transfection activity in HEK293 cells by lipoplexes containing cholesteryl nitrogen-pivoted aza-crown ethers
Alisha Sewbalas (2012)
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