Online citations, reference lists, and bibliographies.
← Back to Search

Solid Lipid Nanoparticles (SLN) And Nanostructured Lipid Carriers (NLC) In Cosmetic And Dermatological Preparations.

R. Mueller, M. Radtke, S. Wissing
Published 2002 · Biology, Medicine
Referenced 1 time by Citationsy Users

Cite This
Download PDF
Analyze on Scholarcy
Share
Solid lipid nanoparticles (SLN) were developed at the beginning of the 1990 s as an alternative carrier system to emulsions, liposomes and polymeric nanoparticles. The paper reviews advantages-also potential limitations-of SLN for the use in topical cosmetic and pharmaceutical formulations. Features discussed include stabilisation of incorporated compounds, controlled release, occlusivity, film formation on skin including in vivo effects on the skin. As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented, the structural specialties described and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations. For both SLN and NLC, the technologies to produce the final topical formulation are described, especially the production of highly concentrated lipid nanoparticle dispersions >30-80% lipid content. Production issues also include clinical batch production, large scale production and regulatory aspects (e. g. status of excipients or proof of physical stability).
This paper references
10.1016/S0168-3659(02)00056-1
Solid lipid nanoparticles as carrier for sunscreens: in vitro release and in vivo skin penetration.
S. Wissing (2002)
Solid lipid nanoparticles (SLN)--a novel carrier for UV blockers.
S. Wissing (2001)
10.1016/S0378-5173(00)00378-1
Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids.
V. Jenning (2000)
Investigations on the occlusive properties of solid lipid nanoparticles (SLN).
S. Wissing (2001)
10.1016/S0939-6411(99)00075-2
Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin.
V. Jenning (2000)
10.1016/S0378-5173(99)00413-5
Solid lipid nanoparticles as drug carriers for topical glucocorticoids.
C. A. S. Maia (2000)
10.1016/S0378-5173(00)00462-2
Solid lipid nanoparticles (SLN™) based on binary mixtures of liquid and solid lipids: a 1H-NMR study
V. Jenning (2000)
10.1016/S0939-6411(00)00087-4
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
R. Mueller (2000)
10.1016/S0168-3659(97)00046-1
Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential
K. Westesen (1997)
10.1016/S0939-6411(97)00165-3
Accumulation of sunscreens and other compounds in keratinous substrates.
U. Hagedorn-Leweke (1998)
10.1016/S0169-409X(01)00105-3
Solid lipid nanoparticles: production, characterization and applications.
W. Mehnert (2001)
10.1016/S0939-6411(97)00150-1
Solid lipid nanoparticles (SLN) for controlled drug delivery--drug release and release mechanism.
A. Zur Mühlen (1998)
10.1016/S0168-3659(99)00223-0
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties.
V. Jenning (2000)
Solid lipid nanoparticles (SLN) : an alternative colloidal carrier system for controlled drug delivery
R. Mueller (1995)
10.1016/S0939-6411(03)00040-7
The influence of solid lipid nanoparticles on skin hydration and viscoelasticity--in vivo study.
S. Wissing (2003)
Drug release and release mechanism of prednisolone loaded Solid Lipid Nanoparticles
A. Z. Mühlen (1998)
10.1080/026520499288690
Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products.
A. Dingler (1999)
10.1007/978-3-662-08600-1
Mechanische Verfahrenstechnik 1
M. Stieß (1992)
10.1201/9781482289985
Handbook of Pharmaceutical Controlled Release Technology
D. Wise (2000)
10.1080/02652040010000361
Encapsulation of retinoids in solid lipid nanoparticles (SLN).
V. Jenning (2001)
Solid Lipid Nanoparticles - ein neuartiger Wirkstoff-Carrier für Kosmetika und Pharmazeutika 2. Mitteilung: Wirkstoff-Inkorporation, Freisetzung und Sterilisierbarkeit
W. Mehnert (1997)



This paper is referenced by
10.2147/IJN.S45313
Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect
H. Rahman (2013)
10.1016/j.ijpharm.2009.10.011
The evidence for solid lipid nanoparticles mediated cell uptake of resveratrol.
K. Teskač (2010)
10.4137/DTI.S0
Polymeric Nanoparticles, Nanospheres and Nanocapsules, for Cutaneous Applications
S. Guterres (2007)
10.3109/10837450.2012.717947
Comparison of spray congealing and melt emulsification methods for the incorporation of the water-soluble salbutamol sulphate in lipid microparticles
S. Scalia (2013)
10.7324/japs.2019.91002
In vitro penetration activity of ionic liquid-Gnetum gnemon seed extract loaded solid lipid nanoparticles
Elsa Trinovita (2019)
10.1208/s12249-016-0519-x
Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers
Wenxi Wang (2016)
Review paper Niosome and Proniosome-Vesicular Structured Dosage Form for Targeted Drug Delivery System
Yashavantsinh Chavda (2011)
Matériaux particulaires chargés d'agents actifs pour administration topique
Frederik Hendrik Monsuur (2015)
10.1586/eop.10.19
Current efforts and the potential of nanomedicine in treating fungal keratitis
T. Gratieri (2010)
Influence of Formulation Variables of Nanostructured Lipid Carriers on Their Physicochemical and Drug Release Properties
Jaleh Varshosaz (2012)
10.1080/1539445X.2011.582914
Antioxidant Activity of Solid Lipid Nanoparticles Loaded with Umbelliferone
I. Lăcătuşu (2013)
10.2147/DDDT.S104395
Design of a nanostructured lipid carrier intended to improve the treatment of tuberculosis
M. Pinheiro (2016)
Traceability of Polyethylcyanoacrylate nanoparticles through the Stratum Corneum
R. Díaz-Torres (2010)
FORMULATION DEVELOPMENT OF BMP-NLC ENRICHED GEL
Premanand A. Nighojkar (2012)
10.2147/IJN.S34489
Application of poly(ethylene glycol)–distearoylphosphatidylethanolamine (PEG-DSPE) block copolymers and their derivatives as nanomaterials in drug delivery
Rongrong Wang (2012)
10.17169/REFUBIUM-15652
Nanostructured Lipid Carriers (NLC) in dermal and personal care formulations
A. Hommoss (2009)
10.1016/j.xphs.2017.08.024
Nose to Brain Delivery of Rivastigmine by In Situ Gelling Cationic Nanostructured Lipid Carriers: Enhanced Brain Distribution and Pharmacodynamics.
Preeti Wavikar (2017)
10.1155/2017/3282693
Formulation and Characterization of Hydroquinone Nanostructured Lipid Carriers by Homogenization Emulsification Method
Pey-Shiuan Wu (2017)
10.1016/j.ejpb.2016.10.021
Effect of drug solubility and lipid carrier on drug release from lipid nanoparticles for dermal delivery
Gaith Zoubari (2017)
10.9734/BJPR/2014/7055
Formulation and Characterization of Nystatinloaded Nanostructured Lipid Carriers for Topical Delivery against Cutaneous Candidiasis.
R. Khalil (2014)
10.1002/JBM.B.30395
Study on the drug release property of cholesteryl end‐functionalized poly(ε‐caprolactone) microspheres
L. Yu (2006)
10.25258/IJDDT.V7I03.9563
Design, Development and Invivo Pharmacokinetic Evaluation of Cardiovascular Drug Loaded Nano Structured Lipid Carrier System
S. B. Raj (2017)
10.1002/9781119247159.CH6
Nanostructured Lipid Carriers
Jingyuan Wen (2018)
10.1016/j.nano.2015.03.002
Advances in drug delivery systems (DDSs) to release growth factors for wound healing and skin regeneration.
G. Gainza (2015)
10.1016/j.ijpharm.2015.08.088
Lipid-polyethylene glycol based nano-ocular formulation of ketoconazole.
S. Kakkar (2015)
10.1007/978-981-10-9026-4_11
Nanoparticles as Quorum Sensing Inhibitor: Prospects and Limitations
Faizan Abul Qais (2018)
10.1080/17425247.2016.1182492
Exploitation of lipid-polymeric matrices at nanoscale for drug delivery applications
Débora Sgorla (2016)
10.1016/j.ijpharm.2019.03.042
Comparative assessment of efficacy and safety potential of multifarious lipid based Tacrolimus loaded nanoformulations.
S. Jain (2019)
10.3109/21691401.2013.769446
Eradication of superficial fungal infections by conventional and novel approaches: a comprehensive review
L. Kumar (2014)
10.3892/ijmm.2012.1086
Solid lipid nanoparticles of paclitaxel strengthened by hydroxypropyl-β-cyclodextrin as an oral delivery system.
J. Baek (2012)
10.2174/1877912305666150417232826
Nanocosmetics: Past, Present and Future Trends
Mohammad Ajazzuddin (2015)
10.1211/jpp.60.8.0014
PEGylated nanostructured lipid carriers loaded with 10‐hydroxycamptothecin: an efficient carrier with enhanced anti‐tumour effects against lung cancer
X. Zhang (2008)
See more
Semantic Scholar Logo Some data provided by SemanticScholar