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Controlling Liposome Blood Clearance By Surface-grafted Polymers.
Published 1998 · Chemistry, Medicine
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The incorporation of polymer-lipid conjugates, initially using PEG and subsequently other selected flexible, hydrophilic polymers, into lipid bilayers gives rise to sterically stabilized liposomes that exhibit reduced blood clearance and concomitant changes in tissue distribution largely because of reduced, but not eliminated, phagocytic uptake. Changes in tissue distribution includes 'passive' targeting localization into sites of tumors, infection, inflammation characterized by presence of a 'leaky' vasculature which represent useful applications for drug delivery. The polymer forms a surface coating which has been characterized by physical measurements and it appears to function through steric inhibition of the protein binding and cellular interactions leading to phagocytic uptake. The current understanding of the physical and biological properties are reviewed. Ongoing work in the field involves interests to increase complexity such as addition of (1) selective targeting ligands by chemical conjugation to the exterior surface of the polymer coating, (2) capabilities for intracellular release of encapsulated agents into the cytoplasm, and (3) both simultaneously.
This paper references
Targeted accumulation of polyethylene glycol‐coated immunoliposomes in infarcted rabbit myocardium
V. Torchilin (1992)
The use of glycolipids and hydrophilic polymers in avoiding rapid uptake of liposomes by the mononuclear phagocyte system
T. Allen (1994)
Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy
S. Unezaki (1996)
Phosphatidyl polyglycerols prolong liposome circulation in vivo
K. Maruyama (1994)
Lipid/DNA complexes as an intermediate in the preparation of particles for gene transfer: an alternative to cationic liposome/DNA aggregates
M. Bally (1997)
Modulation of interaction forces between bilayers exposing short-chained ethylene oxide headgroups.
T. Kuhl (1994)
Contact-dependent, immunecomplex-mediated lysis of hapten-sensitized liposomes.
B. Babbitt (1993)
Emulsion formulations as a vector for gene delivery in vitro and in vivo
T. Hara (1997)
Pharmacokinetics and anti‐tumor activity of vincristine encapsulated in sterically stabilized liposomes
T. Allen (1995)
Targeting of stealth liposomes to erbB-2 (Her/2) receptor: in vitro and in vivo studies.
D. Goren (1996)
Toxicity of doxorubicin entrapped within long-circulating liposomes
T. Daemen (1997)
Sialyl Lewis x Liposomes as a Multivalent Ligand and Inhibitor of E-Selectin Mediated Cellular Adhesion
S. A. Defrees (1996)
New amphipatic polymer-lipid conjugates forming long-circulating reticuloendothelial system-evading liposomes.
M. Woodle (1994)
Delivery of Molecular Medicine to Solid Tumors
R. Jain (1996)
Liposomal Arg-Gly-Asp analogs effectively inhibit metastatic B16 melanoma colonization in murine lungs.
N. Oku (1996)
NEW APPROACHES IN THE CHEMICAL DESIGN OF Gd- CONTAINING LIPOSOMES FOR USE IN MAGNETIC RESONANCE IMAGING OF LYMPH NODES
V. Trubetskoy (1994)
Effect of Bilayer Composition on the Phase Behavior of Liposomal Suspensions Containing Poly(ethylene glycol)-Lipids
K. Hristova (1995)
Brain drug delivery of small molecules using immunoliposomes.
J. Huwyler (1996)
Influence of surface hydrophilicity of liposomes on their interaction with plasma protein and clearance from the circulation: studies with poly(ethylene glycol)-coated vesicles.
J. Senior (1991)
Biological factors involved in blood clearance of liposomes by liver
D. Liu (1997)
Antibody-Targeted Liposomes to Deliver Doxorubicin to Ovarian Cancer Cells
G. Storm (1994)
Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity.
V. Torchilin (1994)
Fate and behavior of liposomes in vivo: a review of controlling factors.
J. H. Senior (1987)
Liposome-mediated cytoplasmic delivery of proteins: an effective means of accessing the MHC class I-restricted antigen presentation pathway.
F. Zhou (1994)
Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates.
S. Zalipsky (1995)
Transport of oligonucleotides across natural and model membranes.
V. Vlassov (1994)
Long Circulating Liposomes: Old Drugs, New Therapeutics
M. Woodle (1998)
Sterically stabilized liposome therapeutics
M. Woodle (1995)
Poly(ethylene glycol)-modified phospholipids prevent aggregation during covalent conjugation of proteins to liposomes.
T. Harasym (1995)
Why do Polyethylene Glycol-Coated Liposomes Circulate So Long?: Molecular Mechanism of Liposome Steric Protection with Polyethylene Glycol: Role of Polymer Chain Flexibility
V. P. Torchilinl (1994)
Development of anti-p185HER2 immunoliposomes for cancer therapy.
J. Park (1995)
Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo
A. Mori (1991)
Specific targeting with poly(ethylene glycol)-modified liposomes: coupling of homing devices to the ends of the polymeric chains combines effective target binding with long circulation times.
G. Blume (1993)
Antibody-targeted delivery of doxorubicin entrapped in sterically stabilized liposomes can eradicate lung cancer in mice.
I. Ahmad (1993)
Tumour uptake of doxorubicin in polyethylene glycol-coated liposomes and therapeutic effect against a xenografted human pancreatic carcinoma.
J. Vaage (1997)
Synthesis of an end-group functionalized polyethylene glycol-lipid conjugate for preparation of polymer-grafted liposomes.
S. Zalipsky (1993)
Effect of serum protein binding on real-time trafficking of liposomes with different charges analyzed by positron emission tomography.
N. Oku (1996)
Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target.
A. Klibanov (1991)
Fluorescence imaging studies for the disposition of daunorubicin liposomes (DaunoXome) within tumor tissue.
E. Forssen (1996)
Liposomal Vincristine: The Central Role of Drug Retention in Defining Therapeutically Optimized Anticancer Formulations
N. Boman (1998)
Targeted delivery of DNA using YEE(GalNAcAH)3, a synthetic glycopeptide ligand for the asialoglycoprotein receptor.
J. Merwin (1994)
Polymer-Grafted Liposomes: Physical Basis for the “Stealth” Property
D. Needham (1992)
Poly(ethylene glycol)-lipid conjugates promote bilayer formation in mixtures of non-bilayer-forming lipids.
J. W. Holland (1996)
A novel strategy affords high-yield coupling of antibody Fab' fragments to liposomes.
S. Shahinian (1995)
Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface‐grafted poly(ethylene glycol)
D. Kirpotin (1996)
Sterically stabilized liposomes.
M. Woodle (1992)
Recent advances in liposomal drug-delivery systems.
A. Chonn (1995)
Lipid composition is important for highly efficient target binding and retention of immunoliposomes.
K. Maruyama (1990)
Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo.
V. Torchilin (1994)
Cobra venom factor immunoconjugates: effects of carbohydrate-directed versus amino group-directed conjugation.
J. Zara (1995)
Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cells in vitro.
D. Kirpotin (1997)
Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma.
S. Huang (1992)
Doubly-lipid-modified protein sequence motifs exhibit long-lived anchorage to lipid bilayer membranes.
S. Shahinian (1995)
Synthesis and applications of a new poly(ethylene glycol) derivative for the crosslinking of amines with thiols.
T. Haselgrübler (1995)
Insertion of poly(ethylene glycol) derivatized phospholipid into pre‐formed liposomes results in prolonged in vivo circulation time
P. S. Uster (1996)
Lung specific stealth liposomes: stability, biodistribution and toxicity of liposomal antitubercular drugs in mice.
P. Deol (1997)
Long circulating, cationic liposomes containing amino‐PEG‐phosphatidylethanolamine
S. Zalipsky (1994)
In vivo trafficking of long-circulating liposomes in tumour-bearing mice determined by positron emission tomography.
N. Oku (1996)
Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis.
R. Lee (1994)
Selective in vivo localization of daunorubicin small unilamellar vesicles in solid tumors.
E. Forssen (1992)
Poly(ethylene glycol)--lipid conjugates regulate the calcium-induced fusion of liposomes composed of phosphatidylethanolamine and phosphatidylserine.
J. W. Holland (1996)
Influence of partial hepatectomy on theophylline pharmacokinetics in rats.
A. Maza (1996)
Oligonucleotides as Research, Diagnostic, and Therapeutic Agents(*)
L. Gold (1995)
Surface modification of haemoglobin-containing liposomes with polyethylene glycol prevents liposome aggregation in blood plasma.
H. Yoshioka (1991)
Thermosensitive liposomes: extravasation and release of contents in tumor microvascular networks.
M. H. Gaber (1996)
Chemically optimized antimyosin Fab conjugates with chelating polymers: importance of the nature of the protein-polymer single site covalent bond for biodistribution and infarction localization.
V. Trubetskoy (1993)
Factors influencing the retention and chemical stability of poly(ethylene glycol)-lipid conjugates incorporated into large unilamellar vesicles.
M. J. Parr (1994)
In vitro cell interaction and in vivo biodistribution of poly(lactide-co-glycolide) nanospheres surface modified by poloxamer and poloxamine copolymers
S. E. Dunn (1997)
Liposome circulation time and tumor targeting: implications for cancer chemotherapy
A. Gabizon (1995)
Liposomes : from biophysics to therapeutics
M. Ostro (1987)
Sterically Stabilized pH-sensitive Liposomes
V. Slepushkin (1997)
Evaluation of blood clearance rates and biodistribution of poly(2-oxazoline)-grafted liposomes.
S. Zalipsky (1996)
Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.
D. Papahadjopoulos (1991)
Highly efficient DNA delivery mediated by pH-sensitive immunoliposomes.
C. Y. Wang (1989)
Intrahepatic Distribution of Long-Circulating Liposomes Containing Polyethylene Glycol) Distearoyl Phosphatidylethanolamine
G. Scherphof (1994)
Colloidal systems for tumor targeting.
G. Storm (1997)
Surface-modified liposomes: assessment and characterization for increased stability and prolonged blood circulation.
M. Woodle (1993)
Liposomes: From Physics to Applications
D. Lasič (1993)
Daunoxome® Treatment of Solid Tumors: Preclinical and Clinical Investigations
E. Forssen (1994)
Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes
S. Moghimi (1994)
A new application for liposomes in cancer therapy
M. Vingerhoeds (1993)
Innovations in avoiding particle clearance from blood by Kupffer cells: cause for reflection.
S. Moghimi (1994)
In vitro tests to predict in vivo performance of liposomal dosage forms.
S. Amselem (1993)
Interactions of liposome bilayers composed of 1,2-diacyl-3-succinylglycerol with protons and divalent cations.
A. Tari (1994)
Sterically Stabilized Vesicles
D. Lasič (1994)
Antibody-Mediated Targeting of Long-Circulating (StealthR) Liposomes
T. Allen (1994)
Clinical studies of liposome-encapsulated doxorubicin.
A. Gabizon (1994)
Interfacial thickness of liposomes containing poly(ethylene glycol)-cholesterol from electrophoresis.
J. Janzen (1996)
Initial Clinical Evaluation of Pegylated-Liposomal Doxorubicin in Solid Tumors
A. Gabizon (1998)
Cationic lipid is not required for uptake and selective inhibitory activity of ICAM-1 phosphorothioate antisense oligonucleotides in keratinocytes.
F. Nestle (1994)
Population pharmacokinetics and pharmacodynamics of pegylated‐liposomal doxorubicin in patients with AIDS‐related Kaposi's sarcoma
M. Amantea (1997)
Molecular mechanism of the lipid vesicle longevity in vivo.
G. Blume (1993)
Liposomes, viruses and membrane fusion
M. C. Lima (1994)
Phase behavior of fluorocarbon di-O-alkyl-glycerophosphocholines and glycerophosphoethanolamines and long-term shelf stability of fluorinated liposomes.
V. Ravily (1997)
Range and magnitude of the steric pressure between bilayers containing phospholipids with covalently attached poly(ethylene glycol).
A. Kenworthy (1995)
Structure and phase behavior of lipid suspensions containing phospholipids with covalently attached poly(ethylene glycol).
A. Kenworthy (1995)
Fluorinated phosphatidylcholine-based liposomes: H+/Na+ permeability, active doxorubicin encapsulation and stability, in human serum.
F. Frézard (1994)
Amphipathic poly(ethylene glycol) 5000-stabilized dioleoylphosphatidylethanolamine liposomes accumulate in spleen.
D. C. Litzinger (1992)
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Sterically stable liposomes improve the therapeutic effect of hepatic stimulator substance on fulminant hepatic failure in rats.
F. Li (2011)
A Facile and General Method for the Encapsulation of Different Types of Imaging Contrast Agents Within Micrometer-Sized Polymer Beads.
Meng-Yi Bai (2012)
Stealth Liposomes:A Novel Approach of Targeted Drug Delivery In Cancer Therapy
S. BangaleG. (2014)
DRUG AND CELL DELIVERY FOR CARDIOVASCULAR REGENERATION SYSTEM
D. D. Gaikwad (2015)
Controlled release of a sparingly water-soluble anticancer drug through pH-responsive functionalized gold-nanoparticle-decorated liposomes.
C. Adhikari (2015)
Composition and properties of complexes between anionic liposomes and diblock copolymers with cationic and poly(ethylene oxide) blocks
O. V. Ivashkov (2017)
Amphiphilic Functionalized Oligomers: A Promising Strategy for the Postfabrication Functionalization of Liposomes
C. Wölk (2020)
Fabrication of nanoparticles within polymeric pores for controlled release of drug.
M. Asif (2006)
Comparison of photodynamic efficacy of tetraarylporphyrin pegylated or encapsulated in liposomes: in vitro studies.
Kinga Nawalany (2009)
Anti-tumor activity of paclitaxel through dual-targeting carrier of cyclic RGD and transferrin conjugated hyperbranched copolymer nanoparticles.
Q. Xu (2012)
Eric P. Holowka (2014)
Drug delivery of siRNA therapeutics: potentials and limits of nanosystems.
D. Reischl (2009)
Nanomaterial processing using self-assembly-bottom-up chemical and biological approaches.
R. Thiruvengadathan (2013)
Current and Emerging Detoxification Therapies for Critical Care
B. Howell (2010)
Targeted synthetic gene delivery vectors.
D. V. Schaffer (2000)
Xuedong Yan (2005)
Myoblast Cell Interaction with Polydopamine Coated Liposomes
Rebecca Westen (2012)
Development of PEGylated polyacridine peptides for in vivo gene delivery of plasmid DNA
Christian A. Fernandez (2010)
Stimuli-responsive liposome fusion mediated by gold nanoparticles.
Dissaya Pornpattananangkul (2010)
Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics
R. Bakalova (2011)
Biodistribution of pH-responsive liposomes for MRI and a novel approach to improve the pH-responsiveness.
K. Løkling (2004)
An improved large-scale synthesis of PEG-peptides for gene delivery.
C. Chen (2004)
pH-Sensitive Multi-PEGylated Block Copolymer as a Bioresponsive pDNA Delivery Vector
Tsz Chung Lai (2010)
Silicone-stabilized liposomes as a possible novel nanostructural drug carrier.
J. Lewandowska-Łańcucka (2016)
Interactions between self-assembled polyelectrolyte shells and tumor cells.
Hua Ai (2005)
Biological and Engineering Considerations for Developing Tumor-Targeting Metallic Nanoparticle Drug-Delivery Systems
G. Paciotti (2007)
Nanosizing: a formulation approach for poorly-water-soluble compounds.
E. Merisko-Liversidge (2003)
Therapeutic applications of colloidal drug carriers.
Nanopharmaceuticals: A New Perspective of Drug Delivery System
Md. Zubayer Hossain Saad (2012)
eview argeting nanoparticles to cancer
. Wanga (2010)
In vivo biodistribution of prion- and GM1-targeted polymersomes following intravenous administration in mice.
Katica Stojanov (2012)
Biomaterials for mRNA delivery.
M. A. Islam (2015)See more