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Intranasal Insulin Delivery And Therapy1Abbreviations: α-CD, α-cyclodextrin; β-CD, β-cyclodextrin; γ-CD, γ-cyclodextrin; AUC, Area Under The Plasma/serum Concentration Versus Time Curve; Cmax, Maximum Or Peak Plasma/serum Concentration; Cmin, Minimum Plasma/serum Concentration; DDPC, Didecanoyl-L-α-phosphatidylcholine; DM-β-CD, Dimethyl-β-cyclodextrin; EDTA, Ethylenediaminetetraacetic Acid; FITC, Fluorescein Isothiocyanate; HLB, Hydrophile–lipophile Balance; HGH, Human Growth Hormone; HP-β-CD, Hydroxy-propyl-β-cyclodextrin; HPC, Hydroxypropylcellulose; HSA, Human Serum Albumin; Hyaff 11, Hyaluronic Acid Ester; IDDM, Insulin-dependent Diabetes Mellitus; Ig, Immunoglobulin; Laureth-9, Polyoxyethylene-9-lauryl Ether; LPC, Lysophosphatidylcholine; LPG, Lysophosphatidylglycerol; MCC, Microcrystalline Cellulose; MTR, Mucociliary Transport Rate; NIDDM, Non-insulin-dependent Diabetes Mellitus; PC, Phosphatidylcholine; RAMEB, Randomly Methylated β-cyclodextrin; SDC, Sodium Deoxycholate; SGC, Sodium Glycocholate; STDHF, Sodium Taurodihydrofusidate; 99mTc, 99mtechnetium; TER, Transepithelial Resistance.1

Michael Hinchcliffe, Lisbeth Illum

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